CN107789657A - A kind of contact lens,hard conditioning liquid - Google Patents
A kind of contact lens,hard conditioning liquid Download PDFInfo
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- CN107789657A CN107789657A CN201610784184.4A CN201610784184A CN107789657A CN 107789657 A CN107789657 A CN 107789657A CN 201610784184 A CN201610784184 A CN 201610784184A CN 107789657 A CN107789657 A CN 107789657A
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- Prior art keywords
- contact lens
- conditioning liquid
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- parts
- hard conditioning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/14—Boron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/29—Sulfates of polyoxyalkylene ethers
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2065—Polyhydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
Abstract
The invention discloses a kind of contact lens,hard conditioning liquid, including following components and the ratio of each component are：Buffer：0.02 20 parts, osmotic pressure regulator：0.01 10 parts, cleaning agent：0.001 30 parts, disinfectant：0.005 1.0 parts, tackifier：0.02 20 parts.Contact lens,hard conditioning liquid prepared by the present invention can efficiently complete the functions such as cleaning, flushing, sterilization, lubrication, moisturizing, immersion and the storage to contact lens,hard eyeglass, extend the service life of eyeglass, keep wearing the definition of mirror after-vision, reduce complication caused by wearing contact mirror.
Description
Technical field
The present invention relates to the technical field of contact lenses, more particularly to a kind of contact lens,hard conditioning liquid.
Background technology
Common contact lenses are mainly used in correcting defects of vision in the market, protect eyeball or increase the aesthetic feeling of eyes, root
It is divided into hydrophilic contact lenses and non-hydrophilic contact lenses, also known as contact lens,soft and hard contact according to its material property
Mirror.Contact lens,soft is made up of the polymeric material of many hydrophilic chemical groups, typically with high-moisture, surface hydrophilicity,
Easily by features such as environment and pollutant effects, and pollutant especially organic molecule is easily penetrated into lens materials matrix,
Cause in eyeglass and lens surface has sediment.Contact lens,hard typically also possesses following a few point features because of material property：1)
Aperture is smaller, and sediment is typically not easy to penetrate into the matrix of eyeglass, remains in surface more；2) material hydrophilic is weak, often results in
The reduction of lens surface wettability is even hydrophobic, adds the mechanical friction of eyeglass and eyelid and produces precipitation；3) silicon in material
Glue oxygen chain group easily absorbs protein precipitation；4) fluorine compounds in material are easily by lipid encapsulation.
The sediment on contact lens surface is generally from lacrimal secretion thing and surrounding environment physics and chemistry product and foreign matter, tool
The sediment species of body generally comprises biomembrane, proteins precipitate, lipid precipitation thing, inorganic salts, pathogenic microorganism etc..Eyeglass
On the one hand the deposition of a large amount of sediments in surface can make being changed with suitable characteristic for eyeglass, eye can on the other hand occurred different
The pathological change of degree, thus the nursing of contact lenses is essential.
Contact lens,soft and contact lens,hard difference in terms of the nursing procedure of eyeglass are little, and require nursing liquid energy
The wettability of eyeglass is maintained, but contact lens,soft needs high osmosis conditioning liquid, and it is heavy in lens materials matrix effectively to remove
Form sediment；And contact lens,hard needs the conditioning liquid of appropriate viscosity, extend attachment time of the conditioning liquid on eyeglass, play efficient clear
Clean, sterilization and the function of moisturizing.In the market generally existing be contact lens,soft conditioning liquid, and to contact lens,hard
The cleaning of surface sediment and pathogenic microorganism, disinfecting power are also very limited amount of.
The content of the invention
It is a primary object of the present invention to provide a kind of contact lens,hard conditioning liquid, contact lens,hard prepared by the present invention protects
Reason liquid can efficiently complete the functions such as cleaning, flushing, sterilization, lubrication, moisturizing, immersion and storage to contact lens,hard eyeglass, prolong
The service life of long eyeglass, keep wearing the definition of mirror after-vision, reduce complication caused by wearing contact mirror.
Technical scheme is as follows：
A kind of contact lens,hard conditioning liquid, it is characterised in that：Ratio including following components and each component is：Buffer：
0.02-20 parts, osmotic pressure regulator：0.01-10 parts, cleaning agent：0.001-30 parts, disinfectant：0.005-1.0 parts, tackifier：
0.02-20 parts.
The pH scopes of the contact lens,hard conditioning liquid are 7.0~8.0.
The buffer is that the one or more in borate buffer, PB, citrate buffer agent are mixed
Close.
The purpose for adding buffer is the pH value of adjustment and maintenance contact lens,hard conditioning liquid, contact lens,hard conditioning liquid
PH value will influence effect of the contact lens,hard conditioning liquid to lens parameters, as contact lens,hard conditioning liquid is favourable in slight alkali environment
Lipid precipitation in the sediment of cleaning contact lens,hard surface.And boric acid and borate not only have pH adjustment effects, also
It can be used as disinfectant and bacteriostatic preservative, aid antibacteria agent kills pathogenic microorganism and strengthens the clear of contact lens,hard conditioning liquid
Except the ability of deposition albumen, therefore preferentially from borate buffer solution as buffer.
The osmotic pressure regulator is that the one or more in sodium chloride, potassium chloride, glucose, propane diols, sorbierite are mixed
Close.
The purpose for adding osmotic pressure regulator is to control the osmotic pressure of contact lens,hard conditioning liquid, to ensure contact lens,hard
Conditioning liquid and normal tear fluid substantially isotonic, avoid the stimulation to eyes, and the osmotic pressure of contact lens,hard conditioning liquid is preferably 220~
350mOsm/kgH2O, the osmotic pressure of further contact lens,hard conditioning liquid is preferably 240~320mOsm/kgH2O.Sodium chloride
As tension regulator, propane diols can not only be used as non-ionic tonicity agents regulation osmotic pressure, can also be with glycerine or sorbierite
Cooperation is used as wetting agent, therefore preferentially from the mixture of sodium chloride and propane diols as osmotic pressure regulator.
The cleaning agent is poloxamer188, sorbierite, ethylenediamine tetra-acetic acid (EDTA), aminotriacetic acid (NTA), two
Ethylenetriamine pentacetic acid and its salt, laureth sodium sulfovinate, alevaire, citric acid (CA), tartaric acid (TA) and Portugal
One or more mixing in grape saccharic acid (GA).
The purpose for adding cleaning agent is to remove the sediment on eyeglass, and wherein sediment is generally lipid, protein and nothing
Machine salt precipitates.Removing lipid needs to select the excellent reagent with performances such as excellent decontamination, emulsifications, preferentially from pool soluble in water
Luo Shamu 407 and laureth sodium sulfovinate.Ca is generally comprised in protein and inorganic salts2+、Mg2+Deng metal ion, it is necessary to
Metal chelating agent is selected to remove, it is preferential to select sorbierite and disodium ethylene diamine tetraacetate, and sorbierite uses with mixed with propylene glycol
The moisture retention of eyeglass can be increased, disodium ethylene diamine tetraacetate can strengthen inhibitory action of the disinfectant to pseudomonas aeruginosa.
The disinfectant is in phenylmercuric nitrate, benzene purple bromine ammonium, Chlorhexidine, poly the third ammonia biguanides and poly quaternary compounds
One or more mixing.
The purpose for adding disinfectant is to kill the pathogenic microorganism of lens surface, and pathogenic microorganism generally comprises bacterium, true
Bacterium, virus and protozoon.Gluconate Chlorhexidine can effectively kill in Gram-positive and negative bacterium, fungi, protozoon spine Ah
Trophozoite and encapsulated forms of rice bar category etc.；Poly- aminopropyl ammonia biguanides is more notable compared to its efficiency for general disinfectants, and with
The Percentage bound of rigid contact lens materials is also relatively small, easily rinses.Therefore preferentially from gluconate Chlorhexidine and poly- aminopropyl
The mixture of ammonia biguanides is as disinfectant.
The tackifier is carboxymethyl cellulose, methylcellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, PVP, poly- second two
One or more mixing in alcohol, xanthans, poloxamer, sodium hyaluronate.
Often hydrophily is weak for rigid contact lens materials composition, and tear and pollutant are easily deposited in contact lens,hard surface,
And tackifier is added in contact lens,hard conditioning liquid, the increase of contact lens,hard conditioning liquid viscosity can be made, protect contact lens,hard
Reason liquid is easy to be attached on eyeglass, ensures contact lens,hard high-efficiency cleaning.And the sodium hyaluronate aqueous solution is viscoelastic fluid, have compared with
Strong lubrication sense, adhesive force are strong, can increase contact area, the time of contact of contact lens,hard conditioning liquid and contact lens,hard, carry
The cleaning effect of high contact lens,hard conditioning liquid；And the certain density sodium hyaluronate aqueous solution also has the fibroplastic work of influence
With the formation of cicatricial tissue and adhesion can be prevented, wound healing can protective epithelium.Therefore preferentially select sodium hyaluronate conduct
Tackifier.
Beneficial effects of the present invention are as follows：
Contact lens,hard conditioning liquid prepared by the present invention contact lens,hard nursing process suitable for can efficiently remove egg
In vain, lipid and inorganic salts precipitation, high-efficiency antimicrobial, and can be directly pleasing to the eye.Wherein, adding buffer can effectively adjust, remain hard
The pH value of property contact lense conditioning liquid；The osmotic pressure of contact lens,hard conditioning liquid can effectively be controlled by adding osmotic pressure regulator, be ensured
Contact lens,hard conditioning liquid and normal tear fluid substantially isotonic, avoid the stimulation to eyes；Eyeglass can effectively be removed by adding cleaning agent
On sediment；The pathogenic microorganism of lens surface can effectively be killed by adding disinfectant；Contact lens,hard can be made by adding tackifier
The increase of conditioning liquid viscosity, makes contact lens,hard conditioning liquid be easy to be attached on eyeglass, ensures contact lens,hard high-efficiency cleaning；Hardness
The propane diols moisture retention that can increase in contact lens,hard nursing process mixed with sorbierite in contact lense conditioning liquid, enhance hard
The cleaning effect of property contact lense conditioning liquid.Contact lens,hard conditioning liquid prepared by the present invention can the hardness that is attached on of long period connect
Touch on mirror eyeglass, and the sedimentation of tear and pollutant in lens surface can be hindered, be easy to rinse；And can be efficiently to lens surface
Protein, lipid and inorganic salt precipitates cleaned, and with strong antibacterial wide spectrum and low with contact lens,hard Percentage bound
Characteristic.The contact lens,hard conditioning liquid can efficiently complete cleaning to contact lens,hard eyeglass, flushing, sterilization, lubrication, guarantor
The function such as wet, immersion and storage, extend the service life of eyeglass, keep wearing the definition of mirror after-vision, reduce wearing contact mirror
Caused complication.
Embodiment
With reference to embodiment, the present invention is described in further detail, it is clear that described embodiment is only
Only it is the part of the embodiment to the present invention, is not whole embodiments.Based on the embodiment in the present invention, this area it is general
Other all embodiments that logical technical staff is obtained under the premise of creative work is not made, belong to the protection of the present invention
Scope.
Embodiment：
1. the formula of contact lens,hard conditioning liquid
Contact lens,hard conditioning liquid in the present invention includes：
Buffer：Borate buffer (includes boric acid and borax)；
Osmotic pressure regulator：Propane diols, sodium chloride；
Cleaning agent：Poloxamer188, laureth sodium sulfovinate, sorbierite, disodium ethylene diamine tetraacetate；
Disinfectant：Gluconate Chlorhexidine, poly- aminopropyl ammonia biguanides；
Tackifier：Sodium hyaluronate.
Specific proportioning such as following table:
2. the preparation process of contact lens,hard conditioning liquid：
Weigh the sodium hyaluronate of ormal weight respectively by the proportioning 1-5 in the formula of contact lens,hard conditioning liquid, disperseed
It is stirred in water for injection after the heating, predissolve 40-60 minutes, stops stirring, after limited swelling 1-2 hours, is carried out
Discontinuous stirs；The sorbierite for weighing ormal weight is added into the aqueous solution, continues to stir, and ensures that sorbierite thoroughly dissolves.With
After cooling water is cooled to room temperature (about one hour), the poloxamer188 and EDTA-2Na of ormal weight are weighed, is added into the aqueous solution
In, stirring and dissolving.The laureth sodium sulfovinate of ormal weight is weighed, is added into the aqueous solution, stirring and dissolving.Claim respectively again
The chlorhexidine gluconate of ormal weight and poly- aminopropyl ammonia biguanides are taken, is added into the aqueous solution, stirring and dissolving.Finally distinguish
Borax, boric acid, sodium chloride and the propane diols of ormal weight are weighed, is added into the aqueous solution, stirring and dissolving.
3. cleaning effect detects
The sediment of lens surface arises primarily at the sediment relevant with tear：Mainly include bacteriolyze in tear component
Enzyme, lipid, albumin, mucus, immunoglobulin, lactoglobulin and inorganic salts, proteins precipitate main constituents are molten
Bacterium enzyme, accounts for 87%, is due to Dai Jinghou immune responses increase, caused by bacteriolyze enzyme secretion increase；Lipid precipitation thing mainly has courage
Sterol etc..
The compound method of artificial tears is：Quantitative cholesterol, lysozyme, glycerine, polyvinyl alcohol are weighed, adds 100mL
Water for injection, be slowly stirred 24 hours at a temperature of 35 DEG C, thoroughly dissolving mixes stand-by.
Conventional normal saline solution is chosen as comparison liquid.
Select 36 contact lens,hards do not worn to immerse in quantitative artificial tears, place 2 days at room temperature, then take out
Eyeglass is respectively placed in contact lens,hard conditioning liquid made of proportioning 1, contact lens,hard conditioning liquid, the system of proportioning 3 made of proportioning 2
Into contact lens,hard conditioning liquid, proportioning 4 made of contact lens,hard conditioning liquid, proportioning 5 made of contact lens,hard conditioning liquid
In comparison liquid (physiological saline), soak 4 hours；Eyeglass is taken out, dries, whether has with examination with slitlamp microscope lens surface
Sediment is present.
For the eluent of eyeglass, respectively with BCA protein concentration detection methods, i.e., with ultraviolet-visible photometer in wavelength
The elution protein content in solution is detected at 280nm；The cholesterol in eluent is measured with high performance liquid chromatography.It is logical
Cross standard curve calculate elution under antalzyme protein content and cholesterol level, then and artificial tears quantitative in advance in
Content and comparison liquid are contrasted, and calculate albumen clearance rate and lipid clearance rate, specific data such as following table：
Five kinds of proportioning solution of the design in the present invention are equal in elution albumen and two aspects of lipid as can be seen from the above table
It is better than physiological saline effect；Contact lens,hard conditioning liquid made of five kinds of proportionings of contrast, wherein contact lens,hard made of proportioning 2
The albumen clearance rate of conditioning liquid reaches 90%, and lipid clearance rate reaches 88%, and cleaning effect is optimal.Hardness made of proportioning 4 connects
Touch mirror conditioning liquid and be not added with tackifier composition, albumen and lipid elimination effect than contact lens,hard conditioning liquid made of other proportionings
Effect it is poor, illustrate add tackifier contact lens,hard nursing liquid energy extend contact lens,hard conditioning liquid be attached on eyeglass
Time, strengthen cleaning effect.Contact lens,hard conditioning liquid made of proportioning 5 uses single osmotic pressure regulator and cleaning agent,
Albumen and lipid elimination effect are poorer than the effect of contact lens,hard conditioning liquid made of proportioning 1 to proportioning 3.
4. Disinfection Effect
The disinfectant used in the formula of the present invention is gluconate Chlorhexidine and poly- aminopropyl ammonia biguanides, in buffer
Boric acid can be used as disinfectant and bacteriostatic preservative, aid antibacteria agent kills pathogenic microorganism, and disodium ethylene diamine tetraacetate can
Strengthen inhibitory action of the disinfectant to pseudomonas aeruginosa.
Pseudomonas aeruginosa, staphylococcus aureus, Escherichia coli, Candida albicans and Solanaceae sickle-like bacteria are chosen as experimental bacteria
Strain.Using sterile saline as comparison liquid.
Select 18 contact lens,hards do not worn immerse respectively contact lens,hard conditioning liquid made of quantitative proportioning 1,
Match contact lens,hard conditioning liquid made of 2, match contact lens,hard conditioning liquid made of 3, contact lens,hard made of proportioning 4
In contact lens,hard conditioning liquid and comparison liquid (sterile saline) made of conditioning liquid, proportioning 5；Connect in the hardness that five match again
Touch in mirror conditioning liquid and comparison liquid (sterile saline) and be separately added into 1.0 × 107CFU/mL~1.0 × 108CFU/mL experiment
Bacterium bacteria suspension, it is standing and soak for 4 hours.The amount of test organisms used does not represent possible microbial biomass in practice in this experiment,
And it is to provide countable amount to estimate microbial activity reduced rate and degree.It is standing and soak for taking quantitative immersion after 4 hours respectively
Liquid carries out detection viable count using agar medium colony counting method, and bactericidal effect is as follows：
As can be seen from the above table eyeglass soak within 4 hours using contact lens,hard conditioning liquid made of five kinds of proportionings
Afterwards, the average reduced value of every milliliter of restoration ecosystem bacterium number of every kind of experimental bacteria is higher than 5.0logs, i.e. Disinfection Effect reaches
99.999%.
Claims (7)
- A kind of 1. contact lens,hard conditioning liquid, it is characterised in that：Ratio including following components and each component is：Buffer： 0.02-20 parts, osmotic pressure regulator：0.01-10 parts, cleaning agent：0.001-30 parts, disinfectant：0.005-1.0 parts, tackifier： 0.02-20 parts.
- A kind of 2. contact lens,hard conditioning liquid according to claim 1, it is characterised in that：The contact lens,hard conditioning liquid PH scopes be 7.0 ~ 8.0.
- A kind of 3. contact lens,hard conditioning liquid according to claim 1, it is characterised in that：The buffer delays for borate One or more mixing in electuary, PB, citrate buffer agent.
- A kind of 4. contact lens,hard conditioning liquid according to claim 1, it is characterised in that：The osmotic pressure regulator is chlorine Change one or more mixing in sodium, potassium chloride, glucose, propane diols, sorbierite.
- A kind of 5. contact lens,hard conditioning liquid according to claim 1, it is characterised in that：The cleaning agent is poloxamer 407th, sorbierite, ethylenediamine tetra-acetic acid (EDTA), aminotriacetic acid (NTA), diethylene-triamine pentaacetic acid and its salt, laruyl alcohol One or more mixing in polyethers sodium sulfovinate, alevaire, citric acid (CA), tartaric acid (TA) and gluconic acid (GA).
- A kind of 6. contact lens,hard conditioning liquid according to claim 1, it is characterised in that：The disinfectant is nitric acid benzene One or more mixing in mercury, benzene purple bromine ammonium, Chlorhexidine, poly the third ammonia biguanides and poly quaternary compounds.
- A kind of 7. contact lens,hard conditioning liquid according to claim 1, it is characterised in that：The tackifier is carboxylic first fiber Element, methylcellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, PVP, polyethylene glycol, xanthans, poloxamer, sodium hyaluronate In one or more mixing.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109042725A (en) * | 2018-08-27 | 2018-12-21 | 欧普康视科技股份有限公司 | A kind of conditioning liquid and preparation method thereof for cleaning contact lens,hard |
| CN109722347A (en) * | 2019-01-03 | 2019-05-07 | 山东省药学科学院 | A kind of moisturizing lubricating composition containing xanthan gum and its application |
| CN110755465A (en) * | 2019-11-04 | 2020-02-07 | 海昌隐形眼镜有限公司 | Eye care solution and preparation method and application thereof |
| CN110819464A (en) * | 2019-10-11 | 2020-02-21 | 陕西仁康药业有限公司 | Hard corneal contact lens care solution and preparation method thereof |
| CN111035615A (en) * | 2020-01-15 | 2020-04-21 | 欧普康视科技股份有限公司 | Gel type hard contact lens lubricating liquid |
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| CN109722347A (en) * | 2019-01-03 | 2019-05-07 | 山东省药学科学院 | A kind of moisturizing lubricating composition containing xanthan gum and its application |
| WO2020140365A1 (en) * | 2019-01-03 | 2020-07-09 | 山东省药学科学院 | Moisturizing and lubricating composition containing xanthan gum and use thereof |
| CN110819464A (en) * | 2019-10-11 | 2020-02-21 | 陕西仁康药业有限公司 | Hard corneal contact lens care solution and preparation method thereof |
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