JP2012177901A - Liquid agent for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel liquid agent which uses a cationic antibacterial agent having high safety as a liquid agent for contact lens and, even when using together an anionic surfactant capable of maintaining and enhancing a cleaning effect, allows attainment of their desired goals.SOLUTION: The liquid agent for contact lens contains (a) at least one kind of cationic antibacterial agent selected from a group consisting of polyquaternium-4, polyquaternium-6, polyquaternium-11, polyquaternium-16, and polyquaternium-22, (b) an anionic surfactant, and (c) nonionic surfactant. In the liquid agent for contact lens, the component (b) has a concentration of 0.005 to 1.0 w/v%, and (the component (b)):(the component (c)) is 1:0.05 to 1:200.

Description

  The present invention relates to a liquid agent for contact lenses and has a particularly excellent disinfecting effect, and at the same time, improves safety for eyes, and is suitable for cleaning, storing, disinfecting and the like of contact lenses (hereinafter simply referred to as “care”). The present invention relates to a liquid agent that can be used.

  Furthermore, the present invention relates to a liquid preparation that is expected to have an effect of preventing rough skin and improving rough skin during care.

  While contact lenses are superior to eyeglasses in terms of function and aesthetics, the burden on the cornea associated with wearing is great, so care is extremely important for continuous and safe use. Because this care is troublesome, contact lenses were used when you were young, but it is said that you may change to glasses when you get older.

  Also, in recent years, diseases such as dry eczema and atopic dermatitis, which are said to be caused by lifestyle changes and stress, are increasing, and even young people have the opportunity to use water with contact lens care. There is also a tendency to worry about hand irritation and eczema.

  The main care includes cleaning to remove dirt attached to the contact lens by wearing, storage to maintain the shape and standards of the contact lens when not worn, disinfection to suppress or sterilize the growth of microorganisms, etc. However, in addition to keeping the contact lens clean, there are important functional cares such as maintaining and enhancing the wettability of the surface and providing a cushioning action that reduces the uncomfortable feeling when worn. If you want to treat these cares for different purposes, you must understand that you must prepare liquids for them and use them each time. Therefore, today, multifunctional solutions capable of simultaneously performing some of these cares have been developed and used. For example, disinfecting essential for hydrous soft lenses, multi-purpose solution (hereinafter referred to as MPS) that can be stored and washed in one solution, and oxygen permeable hard lenses can be washed, stored, and protein removed in one solution. A type that can be performed (hereinafter referred to as a one-component type). In addition to MPS, in order to prevent microbial contamination within the period of use even with one liquid type, it contains an antibacterial agent (also called a disinfectant, bactericidal agent, etc., but will be called "antibacterial agent" in this specification). Is done.

  Patent documents and the like describe a wide variety of antibacterial agents. In particular, MPS is used as a safety and lens material in order to wear contact lenses taken from care solutions that are being stored in the eyes as they are. It is necessary to consider that the influence of As such a measure, it is generally known that a high molecular weight antibacterial agent can be used to prevent accumulation in the lens material (Patent Document 1), and other components (trometamol, nonionic isotonicity). In combination with an antibacterial agent or an amino acid, etc., even if the amount of the antibacterial agent used is reduced (Patent Documents 2 and 3), or a combination of two or more antibacterial agents (Patent Document 4) is there. The purpose of these documents is to achieve a balance between how to increase the safety and at the same time increase the disinfection effect. Currently, polyhexamethylene biguanide or polyquad (registered trademark) are mainly used as antibacterial agents for MPS in the market, and these are both cationic antibacterial agents.

  On the other hand, an anionic surfactant has been preferably used as a hard lens cleaning agent from the beginning of development (Patent Document 5). This is due to reasons such as excellent removal of dirt from the lens and excellent feeling of cleaning, but amphoteric surfactants, anionic surfactants, etc. are mainly used in the one-part liquid agents currently on the market. Yes.

  However, if it is attempted to remove contact lens dirt with a surfactant, it will also wash away lipids and proteins from the skin of the fingers. The skin is composed of proteins, lipids, natural moisturizing factors, etc. In order for the skin to be healthy and clean, it is necessary for the stratum corneum to retain appropriate moisture. Removal of surface lipids and the like reduces the water retention capacity. If the skin is deficient in moisture, voids between the stratum corneum on the skin surface increase and bacteria and chemical irritants are likely to invade. is there.

  In addition, it is known that when the cationic antibacterial agent coexists in a liquid agent containing such an anionic surfactant, the cationic antibacterial agent is deactivated by the ionic bond between the two ( Patent Document 6 and Patent Document 7). Therefore, sorbate is used for a one-component contact lens solution (Patent Document 8), a combination of a cationized polymer and an amphoteric surfactant (Patent Document 9), or a polyol. Proposals for use as an antibacterial agent (Patent Document 10) have been made.

  In addition, although there is a description in Patent Document 4 that an anionic surfactant can be included in a liquid agent containing a cationic antibacterial agent, only a word is described, and a preferable surfactant is amphoteric. Or it is specified that it is a nonionic surfactant. In addition, among proposals aimed at MPS, there is a description (Patent Document 11) that an anionic surfactant can be added to a liquid agent containing a polyquaternium-based sterilizing component, but this is also described in one word. However, it is clearly stated in the document that nonionic surfactants are preferred. In any case, a cationic antibacterial agent and an anionic surfactant are allowed to coexist positively by simply being listed as one of the surfactants conventionally used in contact lens care products. There is no document that suggests that.

JP-T63-500426 JP-A-6-67123 Japanese Patent Laid-Open No. 11-249087 JP 2001-522673 A JP-A-62-70812 Japanese Patent Laid-Open No. 2005-80818 Table 2001/020997 JP-A-4-51015 Japanese Patent Laid-Open No. 10-221654 JP 2004-77902 A JP 2002-136578 A

  The object of the present invention is to use a highly safe cationic antibacterial agent as a contact lens solution, and also to use an anionic surfactant that can maintain and enhance the cleaning effect. It is to propose a new solution that can be achieved.

  Furthermore, with regard to conventional contact lens-related products, eyesight and eye safety have been developed with the highest priority in relation to their application and field of use, whereas in the present invention, not only the above-mentioned priorities but also liquid agents are directly handled. Providing liquids that are gentle on the hand skin from a new perspective that it is also a product handled by the company was a solution issue.

  The contact lens solution of the present invention comprises (a) at least one cationic antibacterial agent selected from the group consisting of polyquaternium-4, polyquaternium-6, polyquaternium-11, polyquaternium-16, polyquaternium-22, and (b) ) Anionic surfactant and (c) nonionic surfactant, the component (b) is 0.005 to 1.0 w / v%, and (b) :( c) is 1: 0. 0.05 to 1: 200.

  The cationic antibacterial agent (a) is a polyquaternium antibacterial agent and has been studied as a liquid preparation for contact lenses in the past, and some safety is guaranteed. The polyquaternium-based antibacterial agent used in the present invention is limited to the specific compounds listed, and not all cationic antibacterial agents can be applied. Further, the nonionic surfactant (c) is allowed to coexist so that the disinfecting effect is not impaired even when used in combination with the anionic surfactant (b). is there.

  Further, it is preferable to use the component (a) in a concentration range of 0.0001 to 0.5 w / v%. Depending on the selected polyquaternium, there is a range in the optimum use concentration, but it has an excellent disinfecting effect even in a small amount from the beginning, and (c) component prevents the disinfection effect from being disinfected by (c) component, This is because a desired liquid preparation can be provided by adding a small amount.

  In the present invention, in addition to the components (a) to (c), as the component (d), at least one of a polyol having 5 to 6 carbon atoms or a humectant can be included. Of these components (d), polyol is considered to function in the same manner as component (c), and it can be expected to further enhance the disinfection effect. In addition, the moisturizing agent can be expected to have an effect of confining moisture in the stratum corneum of the finger, improving water absorption and moisture retention, improving the skin condition, and enhancing the moisture retention function.

  The addition amount of the polyol is suitably 0.1 to 5.0 w / v%, and the addition amount of the humectant is suitably 0.005 to 10.0 w / v%. Even if added in a smaller amount than these concentration ranges, the above-mentioned effects for addition of each component become difficult to be exhibited, and if added in a larger amount than the above range, there is a possibility of causing problems in the lens material and safety. Because there is.

  The moisturizer is preferably one or more selected from amino acids, lactic acid and salts thereof, pyrrolidonecarboxylic acid and salts thereof, polyvinylpyrrolidone and derivatives thereof. More specifically, the amino acid is an α-amino acid, and one or more selected from proline, serine, glycine, alanine, lysine, arginine, threonine, and salts thereof are preferable. These components are so-called natural moisturizing factors (NMF), which are present in the stratum corneum of the skin to prevent moisture absorption and water loss, and to keep the skin fresh, elastic and flexible. Contribute to maintenance.

  Further, in addition to or in addition to the component (d), 5,5-dimethylhydantoin-formaldehyde condensate, sorbic acid and its salt, benzoic acid and its salt, antibacterial polypeptide, chitosan as component (e) At least one selected from pectin can also be added. This is because, as described in the background art, these components (e) expand the antibacterial spectrum and maintain a more stable disinfecting effect by using components that are conventionally used as antibacterial agents.

  The contact lens solution of the present invention is a cation that is conventionally known by ionic bond between an anionic surfactant having a high cleaning effect and a cationic antibacterial agent having an excellent disinfection effect and safety. Since the active antibacterial agent is prevented from being deactivated, the advantages of both can be fully exploited even when both components are actively used.

  Further, by combining with other antibacterial agents, a wide antibacterial spectrum is expected, and the stable disinfecting / preserving effect of the contact lens solution can be exhibited.

  Furthermore, it can be expected to prevent / improve rough skin caused by so-called water work during contact lens care, which has tended to be overlooked so far.

FIG. 1 is a view showing the results of the moisturizing effect test of Example 52. In FIG. FIG. 2 is a view showing the results of the moisturizing effect test of Example 53.

  In general, the present invention dares to use a component that is said to impair the function of one or both when used in combination, and by adding a third component thereto, it is possible to unexpectedly prevent the deactivation, and more than expected This is based on the knowledge that the functions of

  As described above, the liquid preparation for contact lenses of the present invention has at least one cationic property selected from the group consisting of polyquaternium-4, polyquaternium-6, polyquaternium-11, polyquaternium-16, and polyquaternium-22 as component (a). The composition contains an antibacterial agent, an anionic surfactant as the component (b), and a nonionic surfactant as the third component, and the concentration of the component (b) in the liquid is 0.005 to 1.0 w. / V%, and the component (b) and the component (c) are contained in a ratio of 1: 0.05 to 1: 200.

  The component (a) imparts a disinfecting / preserving effect to the liquid agent as the name of the antibacterial agent indicates. Polyquaternium is an ingredient name based on INCI (International Nomenclature of Cosmetic Ingredients) and is published by CTFA (Cosmetic Toiletry and Fragrance Association, currently PCPC-Personal Care Products Council). It is an international labeling name for cosmetic ingredients, and this polyquaternium is labeled with a number, where polyquaternium-4 is a hydroxyethylcellulose dimethyl diallyl ammonium chloride copolymer, and polyquaternium-6 is a poly (diallyl). Dimethylammonium chloride), polyquaternium-11 is a copolymer of vinylpyrrolidone and quaternized dimethylaminoethyl methacrylate, polyquaternium-16 is a copolymer of vinylpyrrolidone and quaternized vinylimidazole, polyquaternium -22 represents a copolymer of acrylic acid and diallyldimethylammonium chloride, both of which have a quaternary ammonium group in the structural formula, and polyquaternium-4 is a trade name “Cell Coat L-200” (Akzo Nobel Co., Ltd.), Polyquaternium-6 is trade name “Marcote 100” (manufactured by Nalco Japan Co., Ltd.), and Polyquaternium-11 is trade name “Guffcut 734” “Guffcut 755” “Guffcut 755N” (both are ISP Japan ( Manufactured by Co., Ltd.), Polyquaternium-16 is trade names “Rubicut FC370” “Rubicut 550” “Rubicut Excellence” (both manufactured by BASF Japan), and Polyquaternium-22 is trade names “MARCOAT 280” “MARCOAT 295” (any Also made by Nalco Japan Co., Ltd.) Te, because they are commercially available, respectively, it is readily available.

  Since the quaternary ammonium group is positively charged, it is easily ionically bonded to the anionic surfactant, and therefore is not usually used together in the same solution. However, in the present invention, by using a nonionic surfactant as the third component, it is possible to use these in combination, and furthermore, they have succeeded in expressing excellent effects (such as disinfection, safety, and washing) of both. Is. It is not clear how the addition of the nonionic surfactant acts on this function expression, but it probably prevents or binds the cationic antibacterial agent and the anionic surfactant. However, it is thought to be caused by maintaining a uniformly dissolved state in the liquid agent.

  Note that component (a) is the specific compound. Cationic antibacterial agents are widely used, such as those provided with other polyquaternium numbers and biguanide antibacterial agents. However, as long as it is confirmed in the present invention, it is necessary to select from the group described above.

  The concentration of the component (a) used is in the range of 0.0001 to 0.5 w / v%, preferably 0.005 to 0.1 w / v%. If the concentration is lower than the above concentration, it is difficult to obtain a desired disinfecting or antiseptic effect. If the concentration exceeds the above concentration, the safety of the liquid may be lowered.

  The anionic surfactant of the component (b) used in the present invention is not particularly limited as long as it is highly safe for eyes. For example, α-olefin sulfonate, alkyl sulfonate, alkyl benzene sulfonic acid Salt, polyoxyethylene alkylphenol ether sulfate sulfate, alkyl phosphate, polyoxyethylene alkyl ether sulfate ester salt, alkyl sulfate ether, N-acyl taurine salt, N-acyl amino acid salt, hydrogenated coconut oil sodium glyceryl sulfate, etc. It is done. These may be used alone or in combination of two or more. Among these anionic surfactants, α-olefin sulfonate, hydrogenated coconut oil glyceryl sulfate, alkylbenzene sulfonate, and the like are particularly preferably used, and specifically, “Nikkor” manufactured by Nikko Chemicals Co., Ltd. OS-14 "," Nikkor SGC-80N "manufactured by Nikko Chemicals Co., Ltd.," Lypon LS-250 "manufactured by Lion Corporation, and the like.

  In general, anionic surfactants have a very good detergency against lipid stains, and not only stains derived from eye grease generated during wearing of contact lenses, but also stains from fingers during lens attachment / detachment. However, since the cleaning effect is high, it is not necessary to rub the lens when processing a normal lens, and a sufficient cleaning effect can be obtained only by dipping. The concentration of the component (b) used in the present invention is preferably in the range of 0.005 to 1.0 w / v%, more preferably 0.1 to 1.0 w / v%. When the concentration is lower than 0.005 w / v%, the desired cleaning effect cannot be exhibited. When the concentration is higher than 1.0 w / v%, the cleaning effect is sufficient, and an eye with an excessive surfactant is necessary. This is because irritation may occur.

  In the present invention, in addition to the components (a) and (b), a nonionic surfactant as the component (c) is blended. By the action of the component (c), a stable disinfection / preservation effect is exhibited without inhibiting the function of the component (a). In addition, when a thickener coexists in the liquid agent, the disinfection / preservation effect may be inhibited. Even in such a case, the component (c) can block the action. At the same time, the problems of precipitation of the conjugate and turbidity of the solution caused by the ionic bond between the component (a) and the component (b) are also solved. Actually, it is unclear whether (a) and (b) are dissolved in the solution in a combined state in the solution or whether they are present independently, but precipitation and cloudiness occur. Then, since each component in the liquid agent becomes non-uniform, it is considered that it is a great advantage in the present invention that it is effectively prevented. Furthermore, the component (c) also has the original effect of removing the dirt from the lens and the function of imparting appropriate wettability to the lens surface.

  About the manufacturing method of the liquid agent for contact lenses containing the said (a)-(c) component, it is better to pay attention to the order added to a liquid agent. That is, when the component (c) is added last, the ionic bond between the component (a) and the component (b) is allowed once, so that the production time is long in order to dissolve the white turbidity and precipitate generated. There is a risk. Therefore, it is preferable to mix | blend (a) component or (b) component last among three components. And it can obtain easily by adding each component in a predetermined amount of sterilized purified water or deionized water and then dissolving it uniformly, as in preparing an ordinary aqueous solution. The solution for contact lenses thus obtained is clear and can be sterilized by an autoclave or aseptic filtration, if necessary.

  Nonionic surfactants used in the present invention include polyoxyethylene glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbit fatty acid esters, polyoxyethylene Ethylene alkyl phenyl formaldehyde condensate, polyoxyethylene hydrogenated castor oil, polyoxyethylene sterols, polyethylene glycol fatty acid esters, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene alkyl ether , Polyoxyethylene lanolin alcohols, polyoxyethylene fatty acid amides, etc. Ku is polyoxyethylene those containing the ethylene chain structure or a polyoxyethylene polyoxypropylene block copolymer is employed. More specifically, “Nikkor BC-40TX”, “Nikkor HCO-60” manufactured by Nikko Chemicals Co., Ltd., BASF Co. There is “Root Roll F127” manufactured by the company.

  And it is preferable to add the compounding quantity of (c) component in contrast with the compounding quantity of the said (b) component. In general, component (a) can exhibit a disinfecting / preserving effect when added in a small amount, but in order to obtain a desired cleaning effect for component (b), a larger amount is used compared to component (a). In order to prevent deactivation due to the coexistence of the two, it is appropriate to consider the component (b) as a reference. In the present invention, (b) and (c) are contained in a ratio of 1: 0.05 to 1: 200, preferably 1: 0.5 to 1: 200. If the ratio of the component (c) is relatively low, the liquid agent is likely to be clouded or precipitated, and the component (a) may not be uniformly dispersed in the liquid agent, and there is a possibility that the disinfection / preservative effect cannot be exhibited. On the other hand, if the ratio of the component (c) is relatively large, the main component of the cleaning effect is the component (c), and the cleaning effect may not be improved for the added amount of the whole surfactant. .

  Further, the total addition amount of the surfactant, that is, the total concentration of the component (b) and the component (c) is 0.05 to 10 w / v%, preferably 0.1 to 5 w / v%. There is no need to increase the amount of addition beyond this concentration with respect to the target contact lens dirt, and if it is too low, the cleaning effect may be insufficient.

  In the present invention, as the component (d), at least one of a polyol having 5 to 6 carbon atoms or a humectant can be added. In addition to the same action as the component (c) that prevents the binding between the component (a) and the component (b) or assists the dissolution of the conjugate in water, the polyol gives further antiseptic and antiseptic effects to the solution. It becomes possible. This is because, unlike the component (a), the polyol is not influenced by the component (b), such as white turbidity and precipitation, so that the effect is not hindered. In addition, as described in Patent Document 10, when the solution contains a proteolytic enzyme, the enzyme is also stabilized in the liquid.

  Examples of the polyol having 5 to 6 carbon atoms include 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, cyclopentane1,2-diol, and 1,2 -Hexanediol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, cyclohexane-1,3-diol 1,2,6-hexanetriol, methylcyclohexane-1,2,4-triol, cyclohexane-1,2,4,5-tetrol and the like. Among these polyols, 1,2-pentanediol and 1,2-hexanediol are particularly preferable in terms of stability and raw material cost. In addition, since these polyols do not have an influence such as adsorption to the lens material, a liquid agent having excellent lens compatibility can be provided. In particular, 1,2-pentanediol having one hydroxyl group at each of the terminal carbon of pentane and the adjacent carbon is more glycerin than glycerin and propylene glycol generally used in conventional contact lens solutions. It is suitable as a substance having an excellent disinfection effect and higher safety than propylene glycol, and a substance having an excellent stabilization effect when a proteolytic enzyme coexists.

  The concentration of the polyol used is preferably in the range of 0.1 to 5.0 w / v%, more preferably 1.0 to 4.0 w / v%. When the concentration of the polyol is lower than 0.1 w / v%, the above effect due to the addition of the component (d) is insufficient and the meaning of adding is lost, and when it exceeds 5.0 w / v%, the osmotic pressure of the liquid becomes high. This is because there is a possibility of adversely affecting the lens specification and surface condition.

  On the other hand, examples of the humectant include hyaluronic acid, collagen, polyhydric alcohol, amino acid and lactic acid and salts thereof, pyrrolidone carboxylic acid and salts thereof, polyvinyl pyrrolidone and derivatives thereof (for example, copolymers of N vinyl pyrrolidone and other monomers) Etc.). Among them, amino acids, lactic acid and salts thereof, pyrrolidone carboxylic acid and salts thereof are called natural moisturizing factors, commonly called NMF (see Fragrance Journal October issue (2005), etc.) and are present in the outermost stratum corneum of the skin. It is a biological component that enhances the water retention function, and is a substance suitable as a moisturizing agent for component (d) in the present invention. NMF is a general term for water-soluble water-retaining components in the keratin, and the amount thereof is regarded as one of the skin condition evaluation indexes in the development of cosmetics.

  Of the humectants exemplified above, NMF and polyvinyl pyrrolidone are preferable because of their excellent usability as a contact lens solution, and amino acids of the NMF are preferably α-amino acids (particularly proline, serine, glycine, alanine, lysine). Arginine, threonine as well as their salts). In general, it is construed that inorganic salts are also included as NMF, but the moisturizing effect can be further improved by adding it as a tonicity agent or the like to the liquid agent of the present invention as described later. In addition, it seems to have secondary effects such as improved surface wettability for contact lens materials.

  The concentration of the humectant used is suitably 0.005 to 10.0 w / v%, and more preferably 0.01 to 5.0 w / v%. If the concentration of the humectant is lower than 0.005 w / v%, the desired moisturizing effect is difficult to obtain even if it is added. This is because it is difficult to expect further improvement of the moisturizing effect.

  The liquid preparation of the present invention further contains, as component (e), 5,5-dimethylhydantoin-formaldehyde condensate, sorbic acid and its salt, benzoic acid and its salt, antibacterial polypeptide, chitosan, pectin, piroctone olamine , At least one selected from. These components (e) are intended to provide a liquid agent having a more stable disinfecting / preserving effect at the same time as aiming to expand the so-called antibacterial spectrum.

  The amount of component (e) added varies depending on the compound selected, and thus cannot be determined unconditionally. For example, in the case of 5,5-dimethylhydantoin / formaldehyde condensate, 0.001 to 0.1 w / v%, In the case of sorbic acid and salts thereof, 0.05 to 0.5 w / v% is preferable, and in the case of benzoic acid and salts thereof, 0.05 to 0.5 w / v% is preferable. The amount of addition is low compared to the case where each of these is used alone as an antibacterial agent. Since the disinfecting / preserving effect can be obtained by the component (a) or the component (d), each component that acts as an antibacterial agent may be used at a lower concentration. Of these, 5,5-dimethylhydantoin / formaldehyde condensate can be preferably used in consideration of compatibility with components (a) to (c) in the presence of liquid.

  In addition to the above components (a) to (e), components having various functions used in general contact lens solutions can be added to the present invention. For example, when a metal ion sequestering agent is added, it is possible to remove dirt deposited as an insoluble salt by combining calcium ions in the tear fluid component with the lens material. The sequestering agent is not particularly limited as long as it is an ophthalmologically acceptable compound. For example, polyvalent carboxylic acids such as ethylenediaminetetraacetic acid, citric acid and tartaric acid, hydroxycarboxylic acids such as gluconic acid, and sodium salts thereof. And salts such as potassium salts. Among these, polyvalent carboxylic acids such as ethylenediaminetetraacetic acid, citric acid, and tartaric acid, and sodium salts and potassium salts thereof are preferable. The concentration of the sequestering agent is preferably in the range of 0.001 to 1.0 w / v%, more preferably 0.01 to 0.1 w / v%. When the concentration of the sequestering agent is less than 0.001 w / v%, the effect of removing the polyvalent metal ions is insufficient and the meaning of adding becomes dilute. Because.

  In the liquid preparation of the present invention, a proteolytic enzyme can be blended in order to effectively remove protein stains adhering to the contact lens. Examples of the proteolytic enzyme used in the present invention include proteases derived from plants such as papain, bromelain and ficin, proteases derived from animals such as trypsin, chymotrypsin and pancreatin, and microorganisms such as bacterial proteases produced by bacteria such as Bacillus. Any of the derived proteases can be used. Specifically, “Biolase” (manufactured by Nagase ChemteX Corporation), “Alcalase”, “Esperase”, “Sabinase”, “Durazyme”, “Subtilisin A” (manufactured by Novozymes Japan), “Protease” N “Amano”, “Protease S“ Amano ”” (manufactured by Amano Pharmaceutical Co., Ltd.), “Biosoak” (manufactured by Daiwa Kasei Co., Ltd.), and the like. The concentration of proteolytic enzyme in the case of mixing from the beginning as a liquid agent is appropriately determined according to the cleaning effect to be obtained and the use time, etc., but if it is too small, the cleaning effect becomes insufficient, and a certain degree due to long-term storage As a result, the enzyme activity decreases, and it makes no sense to add the enzyme. If the amount is too large, the amount of the enzyme that acts on the soil is limited, so that the amount exceeds the necessary and sufficient amount. Therefore, 0.01 to 5 w / v% is appropriate in the liquid. In particular, stabilization of the incorporated proteolytic enzyme is advantageously achieved by the presence of the component (d). The liquid preparation of the present invention is not only provided as one liquid type as described above, but also as a liquid enzyme dilution containing a large amount of polyhydric alcohol in which the proteolytic enzyme is maintained in a stable state, It can also be used as a solution for a solid proteolytic enzyme agent such as powder.

  Furthermore, the liquid agent of the present invention may contain a buffer conventionally used to maintain a stable pH. It is possible to suppress a change in pH due to contact with the outside air until it is used after it is manufactured or within a period of use. Specific examples of the buffer include borate buffer, phosphate buffer, Tris buffer, citrate buffer, etc. Among them, more effective disinfecting effect when used in combination with borate buffer. Is particularly preferable. The concentration of such a buffer is generally 0.05 to 3.0 w / v%, preferably 0.1 to 1.5 w / v%, particularly preferably 0.3 to 1.0 w / v%. Is done. When the concentration of the buffer is lower than 0.05 w / v%, the effect of keeping the pH of the contact lens solution constant becomes low, and the meaning of adding becomes dilute, and higher than 3.0 w / v%. However, this is because the stability of the pH cannot be further improved. The pH of the liquid is preferably close to that of tears, and therefore is preferably in the range of 5-9. This pH is easily maintained by the buffering agent, and can maintain a stable quality throughout the storage and use period.

  As other components, thickeners, tonicity agents and the like can also be added. The thickener adjusts the viscosity of the liquid so that the surface is not scratched when the lens is cared, and has a cushioning action with the cornea when the lens is worn. As the thickener used, polyvinyl alcohol, poly-N-vinylpyrrolidone, polyethylene glycol, polyacrylamide and its hydrolyzate, polyacrylic acid, polyacrylate, isobutylene-maleic anhydride copolymer, methyl vinyl ether- Maleic anhydride copolymer, ring-opened product of each of the above copolymers and salts thereof, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, gelatin, sodium alginate, sodium chondroitin sulfate, xanthan gum, gum arabic And viscous bases such as girl gum. In addition, it is desirable to use an isotonic agent in order to relieve irritation to the eye, and in general, the osmotic pressure is adjusted to about 150 to 650 mOsm, and preferably to about 200 to 350 mOsm when used for soft contact lenses such as MPS. As such an isotonic agent, sodium chloride, potassium chloride, sodium carbonate and the like can be used.

  The contact lens care method using the contact lens solution according to the present invention thus obtained is performed as follows as an example. First, a few drops of the contact lens solution according to the present invention are dropped on the contact lens removed from the eye, and the contact lens is held between the thumb and forefinger or on the palm of the hand for several seconds to several tens of seconds. Rub. At this time, if a moisturizing agent is included as the component (d), moisture is imparted to the fingers. Next, after rinsing with such a liquid for contact lens, storage and disinfection are performed by immersing in a case filled with the liquid for 10 minutes to 24 hours, preferably 30 minutes to 8 hours. This is merely an example, and the care method using the liquid preparation of the present invention is not limited to the above. For example, when proteolytic enzymes are used in combination, if the contact lenses after storage are rinsed with tap water etc. and then worn again, or if the contact lenses are very dirty, use a cleaning agent that contains a special oxidizing agent. After processing, the usage method according to need, such as storing in the liquid preparation of the present invention, is adopted.

  In order to clarify the present invention more specifically, several examples of the contact lens solution according to the present invention are shown below. In addition, each component shown to a table | surface is shown by (w / v%).

(Examples 1-3 and Comparative Examples 1-4)
-Antibacterial effect test-
Using S. aureus (Sa: Staphylococcus aureus ATCC6538), E. coli (Es: Escherichia coli ATCC8739), and Pseudomonas aeruginosa (Pa: Pseudomonas aeruginosa ATCC9027) as test bacteria Each of them was suspended in a sterilized darbecolic acid buffer (hereinafter referred to as DPBST) to prepare a test bacterial solution of 10 ⁷ to 10 ⁸ cfu / ml.

Meanwhile, various contact lens solutions of Examples 1 to 3 were prepared in the component composition shown in Table 1 below, and the pH thereof was adjusted. In addition,
(A) As a cationic antibacterial agent, polyquaternium-4 (trade name “CELLCOAT L-200” manufactured by Akzo Nobel Co., Ltd.), polyquaternium-6 (trade name “MARCOAT 100” manufactured by Nalco Japan Co., Ltd.), polyquaternium -16 (trade name “Ruby Cut Excellence” manufactured by BASF Japan Ltd.)
(B) α-olefin sulfonate sodium (trade name “Nikkor OS-14” manufactured by Nikko Chemicals Co., Ltd.) as an anionic surfactant,
(C) Polyoxyethylene alkyl ethers (trade name “Nikkor BC-40TX” manufactured by Nikko Chemicals Co., Ltd.) as a nonionic surfactant,
As other ingredients, an isotonic agent (NaCl) was added.

  Further, as Comparative Examples 1 to 3, when the component (c) in Examples 1 to 3 was not added, and as Comparative Example 4, the component (b) was added to Examples 1 to 3 in MPS containing commercially available polyquaternium-1. The liquid agent added so that it might become the same density | concentration was used.

  10 ml of the prepared various contact lens solutions were taken in separate sterilized test tubes, and 0.05 ml of various test bacteria solutions were added thereto. After that, these various test liquid mixture liquids are stored in a constant temperature bath at 23 ° C., and a certain amount of each liquid mixture is taken out after 4 hours and 24 hours from the preparation of the liquid mixture. The solution was diluted with sterilized DPBST, and the viable cell count was examined by the agar plate pour method. The culture in this agar plate pour method was performed using a SCDLP agar medium at 33 ° C. for 5 days.

By the above method, the number of viable bacteria immediately after inoculation and the number of viable bacteria after 4 hours and 24 hours from the preparation of the mixed solution are obtained, and from the number of viable bacteria obtained by such measurement, the following calculation formula is obtained. Thus, the amount of bacterial reduction converted to logarithm was determined.
Bacterial decrease amount [logarithmic conversion] = LOG (viable cell count in 1 ml of bacterial suspension immediately after preparation) −LOG (viable cell count in 1 ml of bacterial suspension after treatment)
The results are shown in Table 1.

  From the results in Table 1, regarding (1) Sa, the addition of an anionic surfactant except for polyquaternium-1 has almost no effect on the antibacterial effect. (2) Regarding E.c., as shown in Examples 1 to 3, the antibacterial effect is maintained by the addition of component (c). (3) Regarding P.a., polyquaternium-6 can maintain the antibacterial effect without adding the component (c). I understand. Therefore, it was shown that it is effective to combine the components (a) to (c) (examples of the present invention) in order to exhibit antibacterial effects against various bacteria.

(Examples 4 to 5)
With respect to the component of Example 2, 1,2-pentanediol (trade name “Hydrolite-5”: manufactured by Kosei Co., Ltd.), 1,2-hexanediol (trade name) as the polyol of component (d) The same antibacterial effect test was performed except that “KMO-6” (manufactured by Kogyo Co., Ltd.) was added. The results are shown in Table 2 below.

  From the results in Table 2, it can be seen that the antibacterial effect against E.c. is greatly improved as compared with Example 2. That is, in the present invention, it was shown that the antibacterial effect is increased by adding a polyol as the component (d) in addition to the components (a) to (c). In addition, from this test result, it turned out that the effect with respect to P.a. is enhanced more by 1,2-hexanediol than 1,2-pentanediol among (d) components.

(Transparency evaluation test of liquid agent-Ratio of (b) anionic surfactant and (c) nonionic surfactant-
(A) Polyquaternium-6 is changed from 0.0005 to 0.025 w / v% as the component, (b) “OS-14” as the component, (BC) “BC-40TX” as the component, (b ): An evaluation test was conducted on the transparency of the liquid preparation when the mixing ratio of (c) was variously changed. The results are shown in Table 3 below. In the table, ◯ indicates transparent, and X indicates cloudiness or precipitation.

  From the results shown in Table 3, it can be seen that when (b) :( c) is 1: 0.01, it becomes cloudy as the concentration of component (a) increases. On the other hand, when the ratio of the component (c) is higher than that of the component (b), it can be seen that the solution maintains transparency (that is, a uniform product can be provided as a contact lens solution).

(Examples 6 to 18 and Comparative Example 5)
In addition to the components described in Examples 1 to 5, hydrogenated coconut oil glyceryl sulfate (trade name “Nikkor SGC-80N” manufactured by Nikko Chemicals Co., Ltd.), which is an anionic surfactant, as a component (b), and linear Sodium alkylbenzene sulfonate (trade name “Lypon LS-250” manufactured by Lion Corporation),
(C) Nonionic surfactant polyoxyethylene (196) polyoxypropylene (67) alkyl ether (trade name “Rootroll F127” manufactured by BASF Co.) and polyoxyethylene (60) hydrogenated castor oil (c) Product name “Nikkor HCO-60” (manufactured by Nikko Chemicals)
(E) 5,5-dimethylhydantoin / formaldehyde condensate (trade name “Dantguard 2000”, Lonza Japan Co., Ltd.),
In addition, ethylenediaminetetraacetic acid disodium (trade name “Clewat N” manufactured by Nagase ChemteX Corporation) and borate buffer were added as sequestering agents.

  The composition of these components and the results of the antibacterial effect test are shown in Table 4 and Table 5. The target bacterial species for the antibacterial effect test is Escherichia coli, and the treatment method is the same as in Examples 1 to 5.

  As shown in Table 4, (b) :( c) are within various ranges within the scope of the present invention (Example 6 = 1: 200, Example 7 = 1: 0.5, Example 8 = 1: 10). In Example 9 = 1: 2), it was found that all exhibited a sufficient antibacterial effect. On the other hand, according to Comparative Example 5, it was found that the antibacterial effect was lowered in the system not containing the component (c) and that the liquid agent became cloudy and could not be provided as a product. Table 5 shows various (b) components (Examples 12 to 13), various (c) components (Examples 14 and 15), various (d) components (Example 16), and (e) component as an antibacterial agent. The results are shown for the case of adding (Example 17). All showed that the bactericidal effect was excellent.

  (D) As a moisturizing agent, DL-sodium lactate manufactured by Showa Kako Co., Ltd., sodium pyrrolidone carboxylate manufactured by Ajinomoto Healthy Supply Co., Ltd. (shown as PCA sodium in the table), L-proline, serine, glycine, DL-alanine, L-lysine hydrochloride, L-arginine, L-threonine, BASF Co. Polyvinylpyrrolidone (trade name Kollidon 30) manufactured by the company was used.

  The composition of these components and the results of the antibacterial effect test are shown in Tables 6 to 8. Although not described in the table, in each example, sodium chloride is 0.2 w / v%, crewat N is 0.02 w / v%, boric acid is 0.15 w / v%, Borax is contained at 0.2 w / v% and glycerin is contained at 2 w / v%. The antibacterial effect test method and the like are the same as those in Examples 1 to 5.

  Each Example shown in Table 6 to Table 8 shows the same antibacterial effect even when compared with Example 4 or Example 10 and the like, indicating that there is no adverse effect on the antibacterial effect due to the addition of a moisturizing agent. It was.

(Examples 38 to 51)
As an anionic surfactant of component (b), palm oil fatty acid methyl taurine sodium (trade name “Nikkor CMT-30” manufactured by Nikko Chemicals Co., Ltd.), polyoxyethylene (4.5) sodium alkyl ether acetate (product) The name “Nikkor AKYPO RLM45” (manufactured by Nikko Chemicals) and polyoxyethylene (10) sodium alkyl ether acetate (trade name “Nikkor AKYPO RLM100”: manufactured by Nikko Chemicals) were used.

  The composition of these components and the results of the antibacterial effect test are shown in Table 9 and Table 10. Although not described in the table, each example has 0.2% w / v sodium chloride, 0.02 w / v% crewat N, and 0% boric acid as optional components, as in the above examples. .15w / v%, borax 0.2w / v%, glycerin 2w / v%. The antibacterial effect test method is the same as in Examples 1 to 5.

  As shown in Tables 9 and 10, even when (a) component (antibacterial agent) is combined with other types of component (b) (anionic surfactant) that may diminish its efficacy, It can be seen that component c) (nonionic surfactant) suppresses the influence. The results also show that the antibacterial efficacy is not adversely affected even when other types of component (d) (humectant) are used in combination.

(Example 52)
-Moisturizing effect test-
(D) The moisturizing effect was evaluated by the following method using a liquid for contact lenses to which a moisturizing agent was added as a component.

  First, the test site (human forearm) was stabilized for 1 hour in an environment of room temperature of about 20 ° C. and humidity of about 66%. Next, the position where each test solution was applied to the forearm flexion side was determined, and the test range was marked at 2.5 × 2.5 cm. Each test solution was applied to the entire test area using a cotton swab and allowed to stand for 1 minute, and then the test solution was washed out with purified water for 30 seconds. Excess water outside the test range was wiped off and allowed to air dry for 2 minutes. Next, one drop of purified water was placed in the center of the test range, and 10 seconds later, the purified water was blotted with water absorbent paper. Skin hygrometer (SR-101 type; manufactured by Rozen Star Co., Ltd.) by the time the sensor is immediately pressed against the skin, and the moisture content of the skin. The water content (%) was measured using a measuring system. The average value of the measurement results was determined, and the amount of change (%) in water content was determined from the difference between the water content (%) at each measurement point and the water content before the start of the test.

  In the said test method, the result at the time of using each solution of purified water and Example 10, Example 38, Example 39, Example 40, and Example 41 as a test solution is shown in FIG.

  As shown in FIG. 1, compared with Example 10 of the present invention that does not contain purified water or a moisturizing agent, the liquid agents of Examples 38 to 41 to which a moisturizing agent is added give a moisture retention effect to the skin. You can see that

(Example 53)
-Moisturizing effect test 2-
The same test as in Example 52 was carried out using purified water, each solution of Examples 45 and 46, and (test solution 53; “DL-sodium lactate” in Example 18 instead of “serine” and “L-lysine hydrochloride”. (Test solution added with 0.05% w / v salt ”), (Test solution 54;“ L-arginine ”and“ L-threonine ”in place of“ DL-sodium lactate ”in Example 18) (Test solution added with 05 w / v%), (Test solution 55; test solution added with 0.11 w / v% of “glycine” and “DL-alanine” in place of “DL-sodium lactate” in Example 18) ), A total of 6 types of liquid agents. The result is shown in FIG.

  As shown in FIG. 2, it can be seen that any liquid agent has a moisture retention effect on the skin.

(Example 54)
-Cleaning effect test-
For the liquid preparations of Examples 1, 3, 4, 38, and 39, and the liquid preparation of Example 2 with 0.1% hydroxypropylmethylcellulose added as a thickener, the cleaning effect was as follows. A test was conducted. First, 0.1 g of beef tallow and 0.1 g of olive oil were weighed and added with 100 mL of physiological saline and dissolved by heating, and then auto homomixer (M type, manufactured by Tokushu Kika Kogyo Co., Ltd.). ) At 5000 rpm × 5 minutes to prepare an artificial lipid suspension.

  An oxygen-permeable hard contact lens (trade name “Menicon EX”: manufactured by Menicon Co., Ltd.) was prepared as a test lens, and after one test lens was immersed in 5 mL of the artificial lipid suspension for 10 minutes, it was taken out. And dried to obtain an artificial lipid-stained lens. Then, 1 piece of the obtained artificial lipid dirt adhesion lens was put into 2 mL of the contact lens solution of Examples 1 to 4, soaked for 4 hours, then taken out, and the same solution was dropped onto the 2 to 3 drop lens. The contact lens was cleaned by rubbing with a fingertip for 5 seconds.

  After the cleaning treatment, the appearance of the contact lens was observed. As a result, the artificial dirt adhering to the contact lens was completely removed regardless of which solution of the present invention was used. As is clear from this result, the contact lens solution according to the present invention has an excellent cleaning effect in addition to its excellent disinfecting effect.

(Example 55)
-Protein removal effect test-
The contact lens solutions of Examples 8 and 10 were subjected to the protein removal test of the solutions obtained by mixing the liquid enzymes with the solutions as follows. First, for use in the protein removal effect test, bovine albumin: 0.388 (w / v)%, bovine γ-globulin: 0.161 (w / v)%, egg white lysozyme: 0.12 (w / V)%, sodium chloride: 0.9 (w / v)%, calcium chloride dihydrate: 0.015 (w / v)%, sodium dihydrogen phosphate dihydrate: 0.104 (w / V)% was dissolved in water, and an artificial tear was adjusted to pH 7.0 using 1N sodium hydroxide.

  The test hard contact lens was prepared, heat-treated at 80 ° C. for 30 minutes while the contact lens was immersed in 10 ml of the artificial tears, and then washed with tap water. After repeating this operation five times, it was confirmed that the lens surface was completely clouded, and these artificial cloudy lenses were used as test lenses and used in the following experiments.

  The liquid agent containing the enzyme is 2.0 (w / w)% of proteolytic enzyme (trade name: Bioplase: manufactured by Nagase ChemteX Corp.), 10.0 (w / w)% of borax, and 60 of glycerin. 0.0 (w / w)% and water 38.0 (w / w)% mixed and prepared, and 0.3 mL was added to 10 mL of the contact lens solution. The artificial white turbid lens is immersed in this mixed solution and stored at room temperature for 4 hours. Then, the lens is taken out, washed with tap water, dried, and the degree of white turbid stain remaining on the lens is measured with a dark field stereomicroscope. As a result, it was confirmed that protein stains were completely removed.

(Example 56)
-Enzyme stability test-
In each contact lens solution of Examples 10, 38, 39, and 40, the enzyme was mixed at 0.12%, and the enzyme activity of the solution was measured according to the following method. Each enzyme activity was measured in the same manner after storage for 6 months or after storage for 6 months at 35 ° C., and the residual enzyme activity was calculated according to the following formula.

-Activity measurement of proteolytic enzyme (TNBS method)-
Add 0.9 ml of 1% sodium sulfite solution to 0.6 ml of each solution (sample) and leave at 50 ° C. for about 2 minutes. Thereafter, 0.4% DMC substrate solution (20 ml of purified water was put in a vial, heated to 80-100 ° C. with a hot plate, 0.20 g of dimethyl casein (manufactured by Novozymes Japan) was added, and 20 minutes. Stir with a stirrer and dissolve completely.After dissolution, add 20 ml of borate buffer solution (4.28 g of borax and 4.15 g of sodium dihydrogen phosphate dihydrate dissolved in 100 ml of purified water), Further, 0.6 ml of a solution made up to a total volume of 50 ml with purified water) was added, and after 1 minute at 50 ° C., 0.15 ml of a 0.1% sodium 2,4,6-trinitrobenzenesulfonate (TNBS) solution was added, and further 50 ° C. Put on for 25 minutes. After the reaction, add 1.5 ml of cold water, leave at room temperature for 25 minutes, and measure the absorbance at a wavelength of 425 nm (as a control, use 0.6 ml of 1% sodium sulfite solution instead of the sample). . A solution having a known enzyme concentration is measured in advance by the same method as described above to prepare a calibration curve, and the enzyme concentration of the sample is determined from the absorbance of the measurement result.
Residual enzyme activity (%) = (Proteolytic enzyme activity after storage / Proteolytic enzyme activity at the time of preparation) × 100

  In the liquid preparation of this example, the residual activity of the enzyme stored at 25 ° C. for 6 months was 100%, and the residual activity of the enzyme stored at 35 ° C. for 6 months was 85%. From this result, it can be seen that the liquid preparation of the present invention can be stored and used for a long period of time while maintaining a high enzyme activity.

(Example 57)
Regarding the contact lens solutions of Examples 1 to 3, 38, 39, and 40, the influence on the contact lens was confirmed by the following test.
-Lens compatibility test-
After immersing one oxygen-permeable hard contact lens (trade name “Menicon Z”: manufactured by Menicon Co., Ltd.) for 8 to 12 hours in 2 ml of each of the above solutions, the solution is taken out and dropped onto the 2 to 3 drop lens. Then, after scrubbing with a fingertip for 5 seconds, the cycle of rinsing with tap water for 5 seconds and dipping again in 2 mL of a new solution was repeated 30 cycles. After the treatment, the appearance, standard (base curve, power, size) and surface water wettability of the lens (n = 3) were measured and compared with the lens before the test. As a control, a commercially available contact lens cleaning stock solution (trade name “O-to-care” manufactured by Menicon Co., Ltd.) was used. As a result, there was no difference between the example of the present invention and the control in terms of appearance, specifications, and water wettability with those of the lens before the test. Therefore, it can be seen that the liquid preparation of the present invention example is not an object that adversely affects the lens but has good compatibility.

(Example 58)
The safety of the contact lens solutions of Example 3 and Example 4 was confirmed by the following test.
-Rabbit eyewear test of treated lens-
(Test Lens Treatment Method) One oxygen permeable hard contact lens (trade name “Menicon EX”: manufactured by Menicon Co., Ltd.) was immersed in 2 ml of the solutions of Examples 3 and 4 for 8 to 12 hours and then taken out. Then, the same solution was dropped onto a 2 to 3 drop lens, rubbed for 5 seconds with a fingertip, and then rinsed with tap water for 5 seconds to obtain a test lens.
As a control, a control lens was obtained by the same treatment with a commercially available contact lens cleaning and preservation solution (trade name “O2 Care Mill Fabreche” manufactured by Menicon Co., Ltd.).

(Wear test)
The lens was worn on one eye of the eyelid and the control lens was worn on the other eye. This wearing was carried out on a total of 5 kites. After wearing for 6 hours, the lens was removed, the state of the anterior segment was observed using the naked eye and a slit lamp, and the anterior segment findings were recorded according to the evaluation method of the Draize method.

  As a result of the test, there was no difference between the example of the present invention and the control, and no immediate irritation was observed in the wearing of the treated lens, and it was determined to be an “irritant” by evaluation by the Draize method. Therefore, it was proved that the safety of this solution was high.

  The present invention is a liquid agent used for care such as cleaning, storage, disinfection, and protein removal of contact lenses, and in particular, a nonionic surfactant coexisting even when a known polyquaterium antibacterial agent is used in combination with an anionic surfactant. Thus, the effects of both can be maximized. Therefore, since a high cleaning effect and disinfection / preservation effect can be exhibited, a contact lens solution that can be suitably used for contact lenses and has high safety can be provided. Moreover, since a moisture retention effect is imparted to the finger skin by adding a moisturizing agent, moist skin can be maintained.

Claims (9)

(A) at least one cationic antibacterial agent selected from the group consisting of polyquaternium-4, polyquaternium-6, polyquaternium-11, polyquaternium-16, and polyquaternium-22;
(B) an anionic surfactant;
(C) a nonionic surfactant,
The component (b) is 0.005 to 1.0 w / v%, and (b) :( c) is contained in a ratio of 1: 0.05 to 1: 200. . The contact lens solution according to claim 1, wherein the concentration of the component (a) is 0.0001 to 0.5 w / v%. The contact lens solution according to claim 1 or 2, wherein the solution further comprises (d) at least one of a polyol having 5 to 6 carbon atoms or a humectant. The contact lens solution according to claim 3, wherein the concentration of the polyol is 0.1 to 5.0 w / v%. The contact lens solution according to claim 3, wherein the concentration of the humectant is 0.005 to 10.0 w / v%. The contact according to claim 3 or 5, wherein the humectant is one or more selected from amino acids, lactic acid and salts thereof, pyrrolidonecarboxylic acid and salts thereof, polyvinylpyrrolidone and derivatives thereof. Lens solution. The contact lens solution according to claim 6, wherein the amino acid is an α-amino acid. The contact lens solution according to claim 7, wherein the α-amino acid is one or more selected from proline, serine, glycine, alanine, lysine, arginine, threonine, and salts thereof. The liquid solution further comprises at least one selected from (e) 5,5-dimethylhydantoin-formaldehyde condensate, sorbic acid and its salt, benzoic acid and its salt, antibacterial polypeptide, chitosan and pectin. The liquid agent for contact lenses in any one of thru | or 8.

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