CN103083515A - Traditional Chinese medicine preparation used for treating arthralgia, and preparation method thereof - Google Patents
Traditional Chinese medicine preparation used for treating arthralgia, and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation used for treating arthralgia. The preparation is prepared from, by weight, 40-60% of a traditional Chinese medicine thick paste and 60-40% of auxiliary materials. The traditional Chinese medicine thick paste is obtained by water extraction and concentration of the raw medicine materials of, by weight, 550-650 parts of Japanese ampelopsis root tuber, 150-250 parts of glabrous scrcandra herb, 150-250 parts of kleincinquefoil herb, 150-250 parts of narrowleaf loosestrife herb, 550-650 parts of ovientvine stem, 95-105 parts of common anemarrhena, 95-105 parts of salvia miltiorrhiza, 20-30 parts of prepared common monkshood daughter root, 15-20 parts of common monkshood mother-root, 30-40 parts of kusnezoff monkshood mother-root, 25-35 parts of cassiabarktree twig, 20-30 parts of musk, 20-30 parts of dragon's blood, 20-25 parts of fourstamen stephania root, 15-18 parts of swordlike atractylodes rhizome, 18-22 parts of seven-lobed yam rhizome, 15-18 parts of silkworm faeces, 20-25 parts of Chinese quince, 20-25 parts of Mongolian milkvetch root, 20-25 parts of Szechwan lovage rhizome, 18-20 parts of largeleaf gentian root, and 25-30 parts of leopard bone. The traditional Chinese medicine preparation has a good arthralgia treatment effect. When the preparation is produced, production period is shortened, disintegration speed is improved, bioavailability is improved, and treatment effect is improved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of arthromyodynia and preparation method thereof.
Background technology
Arthromyodynia be by wind, cold, wet, hot etc. cause with limbs joint and muscular soreness, numbness, weighing, joint stuffiness, even the scorching hot grade of arthroncus is a class disease of primary symptom, the concept of arthromyodynia is extensive, comprise internal organs numbness and limbs numbness, the arthromyodynia of limbs comprises rheumatic fever (rheumatic arthritis), rheumatoid arthritis, osteoarthritis of western medicine etc.
The Chinese Herbs of existing treatment arthromyodynia is not fine, and preparation technology exists the production cycle long, is mainly in this operation of cold drying, needs 3-5 days; The finished product disintegration time is slow, and generally just disintegrate is complete about 40 minutes, has greatly reduced bioavailability.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of arthromyodynia and preparation method thereof, Chinese medicine preparation of the present invention treatment arthromyodynia good effect, and shorten the production cycle when producing, and accelerate disintegration rate, increase bioavailability, improved curative effect.
The technical scheme of employing of the present invention is:
A kind of arthromyodynia Chinese medicine preparation for the treatment of is made by Chinese medicine thick paste and adjuvant, it is characterized in that, the percentage by weight of its component is:
Chinese medicine thick paste 40%-60%, adjuvant 60-40%,
described Chinese medicine thick paste is carried and is got by following raw materials in part by weight liquid medicine: Radix Ampelopsis 550-650, Herba Sarcandrae 150-250, five wind 150-250, Lysimachia trientaloides Hemsl. 150-250, Caulis Sinomenii 550-650, Rhizoma Anemarrhenae 95-105, Radix Salviae Miltiorrhizae 95-105, Radix Aconiti Lateralis Preparata 20-30, Radix Aconiti 15-20, Radix Aconiti Kusnezoffii 30-40, Ramulus Cinnamomi 25-35, Moschus 20-30, Sanguis Draxonis 20-30, Radix Stephaniae Tetrandrae 20-25, Rhizoma Atractylodis 15-18, Rhizoma Dioscoreae Septemlobae 18-22, Bombyx mori L. 15-18, Fructus Chaenomelis 20-25, Radix Astragali 20-25, Rhizoma Chuanxiong 20-25, Radix Gentianae Macrophyllae 18-20, Os pardi 25-30
Described adjuvant comprises the filler of 35-50%, the disintegrating agent of 5%-10%,
The described percentage ratio shared mass percent that is each composition when granulating.
Described treatment arthromyodynia Chinese medicine preparation, made by Chinese medicine thick paste and adjuvant, it is characterized in that: described filler is one or more in mannitol, sorbitol, xylitol, lactose, sucrose, glucose, starch, dextrin, pregelatinized Starch and microcrystalline Cellulose; Described disintegrating agent is one or more in carboxymethyl starch sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, low-substituted hydroxypropyl cellulose, silicon dioxide.
described treatment arthromyodynia Chinese medicine preparation, made by Chinese medicine thick paste and adjuvant, it is characterized in that: described Chinese medicine thick paste is carried and is got by following raw materials in part by weight liquid medicine: Radix Ampelopsis 550-650, Herba Sarcandrae 150-250, five wind 150-250, Lysimachia trientaloides Hemsl. 150-250, Caulis Sinomenii 550-650, Rhizoma Anemarrhenae 95-105, Radix Salviae Miltiorrhizae 95-105, Radix Aconiti Lateralis Preparata 20-30, Radix Aconiti 15-20, Radix Aconiti Kusnezoffii 30-40, Ramulus Cinnamomi 25-35, Moschus 20-30, Sanguis Draxonis 20-30, Radix Stephaniae Tetrandrae 20-25, Rhizoma Atractylodis 15-18, Rhizoma Dioscoreae Septemlobae 18-22, Bombyx mori L. 15-18, Fructus Chaenomelis 20-25, Radix Astragali 20-25, Rhizoma Chuanxiong 20-25, Radix Gentianae Macrophyllae 18-20, Os pardi 25-30,
The preparation method of described treatment arthromyodynia Chinese medicine preparation is characterized in that, comprises the following steps:
A, the at first preparation of Chinese medicine thick paste
Take the crude drug such as Radix Ampelopsis, Herba Sarcandrae, five wind, Lysimachia trientaloides Hemsl., Caulis Sinomenii, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae by formula ratio, decoct with water three times, adding for the first time 10 times of water gagings (weight ratio) decocted 2 hours, adding for the second time 8 times of water gagings decocted 2 hours, adding for the third time 8 times of water gagings decocted 1 hour, collecting decoction, filter, it is 1.20(50 ℃ that filtrate is concentrated into relative density) clear paste, add 4 times of water gagings (weight ratio), stir evenly, standing 12 hours, filter, filtrate is condensed into relative density to 1.30-1.35(50 ℃) thick paste, and get final product;
B, take filler, 1/2nd disintegrating agent sets high in fast wet mixing pelletizer; after opening stirring arm, shears; then the Chinese medicine thick paste that slowly adds step (a) to make adds appropriate 75% ethanol adjusting viscosity, and 18 orders are granulated; 80 ℃ of dryings; 20 order granulate, then add remaining disintegrating agent to mix, be pressed into tablet; film coating gets final product.
In the present invention, described filler is better is one or more of starch, pregelatinized Starch, microcrystalline Cellulose.That the content of described filler is better is 40%-50%, the described percentage ratio shared mass percent that is each composition when granulating.
In the present invention, what described disintegrating agent was better is carboxymethyl starch sodium and/or polyvinylpolypyrrolidone, and better is carboxymethyl starch sodium.That the content of described disintegrating agent is better is 5%-7%.
In the present invention, in pelletization, according to practical situation, need add ethanol and regulate viscosity; The concentration of ethanol is 50-95%, preferred 75%.
In the present invention, in the end in the tabletting process, add the moderate lubrication agent, lubricant is the conventional lubricant that uses in this area, is one or more in Pulvis Talci, micropowder silica gel and magnesium stearate, and better is magnesium stearate.The content of described lubricant is the conventional use in this area, and that better is 0.5%-2%, and described percentage ratio accounts for the mass percent of the front granule total amount of last tabletting for each composition.
In the present invention, the tablet of finally making, every contains the raw medicinal herbs amount and is equivalent to 2.2g.
On the basis that meets this area general knowledge, in the present invention, the optimum condition of each above-mentioned technical characterictic can combination in any obtain preferred embodiments of the present invention.
Positive progressive effect of the present invention is: the Chinese medicine thick paste of extraction, do not need cold drying, and simplified production stage, shortened the production cycle; In pelletization, the Chinese medicine thick paste has played again the effect of binding agent, has saved cost; Disintegration time (disintegration time in 20 minutes, was 40 minutes originally) has been accelerated in the adjustment that adds in disintegrating agent, adds, and is conducive to absorption of human body, has increased bioavailability.Tablet formulation of the present invention is scientific and reasonable, and the treatment arthromyodynia is effective.
The specific embodiment
Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.
Equal commercially available the getting of each component in following embodiment.
Embodiment 1
| Component | Gram |
| The Chinese medicine thick paste | 40 |
| Carboxymethyl starch sodium | 10 |
| Starch | 50 |
| Magnesium stearate | 0.4 |
| Grain amount | 80.7 |
Preparation method:
A, the at first preparation of Chinese medicine thick paste
take (g) Radix Ampelopsis 550, Herba Sarcandrae 150, five wind 150, Lysimachia trientaloides Hemsl. 150, Caulis Sinomenii 550, the Rhizoma Anemarrhenae 95, Radix Salviae Miltiorrhizae 95, Radix Aconiti Lateralis Preparata 20, Radix Aconiti 15, Radix Aconiti Kusnezoffii 30, Ramulus Cinnamomi 25, Moschus 20, Sanguis Draxonis 20, Radix Stephaniae Tetrandrae 20, Rhizoma Atractylodis 15, Rhizoma Dioscoreae Septemlobae 18, Bombyx mori L. 15, Fructus Chaenomelis 20, the Radix Astragali 20, Rhizoma Chuanxiong 20, Radix Gentianae Macrophyllae 18, Os pardi 25 crude drug such as grade, decoct with water three times, adding for the first time 10 times of water gagings (weight ratio) decocted 2 hours, adding for the second time 8 times of water gagings decocted 2 hours, adding for the third time 8 times of water gagings decocted 1 hour, collecting decoction, filter, it is 1.20(50 ℃ that filtrate is concentrated into relative density) clear paste, add 4 times of water gagings (weight ratio), stir evenly, standing 12 hours, filter, filtrate is condensed into relative density to 1.30-1.35(50 ℃) the Chinese medicine thick paste, get final product,
B, get starch, half carboxymethyl starch sodium sets high in fast wet mixing pelletizer, after opening stirring arm, shears, slowly adds the Chinese medicine thick paste, adds appropriate 75% ethanol and regulates viscosity, glutinous net when being beneficial to granulate.Granulate, drying, granulate adds second half carboxymethyl starch sodium, magnesium stearate mix homogeneously, tabletting, coating gets final product.
Recording disintegration time is: 18 minutes.
Embodiment 2
| Component | Gram |
| The Chinese medicine thick paste | 60 |
| Carboxymethyl starch sodium | 5 |
| Pregelatinized Starch | 35 |
| Magnesium stearate | 0.35 |
| Grain amount | 70.2 |
Preparation method:
A, the at first preparation of Chinese medicine thick paste
take (g) Radix Ampelopsis 600, Herba Sarcandrae 180, five wind 180, Lysimachia trientaloides Hemsl. 180, Caulis Sinomenii 600, the Rhizoma Anemarrhenae 100, Radix Salviae Miltiorrhizae 100, Radix Aconiti Lateralis Preparata 25, Radix Aconiti 20, Radix Aconiti Kusnezoffii 33, Ramulus Cinnamomi 26, Moschus 22, Sanguis Draxonis 23, Radix Stephaniae Tetrandrae 24, Rhizoma Atractylodis 16, Rhizoma Dioscoreae Septemlobae 19, Bombyx mori L. 16, Fructus Chaenomelis 21, the Radix Astragali 22, Rhizoma Chuanxiong 22, Radix Gentianae Macrophyllae 19, Os pardi 26 crude drug such as grade, decoct with water three times, adding for the first time 10 times of water gagings (weight ratio) decocted 2 hours, adding for the second time 8 times of water gagings decocted 2 hours, adding for the third time 8 times of water gagings decocted 1 hour, collecting decoction, filter, it is 1.20(50 ℃ that filtrate is concentrated into relative density) clear paste, add 4 times of water gagings (weight ratio), stir evenly, standing 12 hours, filter, filtrate is condensed into relative density to 1.30-1.35(50 ℃) the Chinese medicine thick paste, get final product,
B, get pregelatinized Starch, half carboxymethyl starch sodium sets high in fast wet mixing pelletizer, after opening stirring arm, shears, slowly adds numbness gram sheet to transfer cream, adds appropriate 95% ethanol and regulates viscosity, glutinous net when being beneficial to granulate.Granulate, drying, granulate adds second half carboxymethyl starch sodium, magnesium stearate mix homogeneously, tabletting, coating, and get final product.
Recording disintegration time is: 19 minutes.
Embodiment 3
| Component | Gram |
| The Chinese medicine thick paste | 50 |
| Polyvinylpolypyrrolidone | 5 |
| Lactose | 25 |
| Microcrystalline Cellulose | 20 |
| Magnesium stearate | 0.38 |
| Grain amount | 76.5 |
Preparation method:
A, the at first preparation of Chinese medicine thick paste
take (g) Radix Ampelopsis 650, Herba Sarcandrae 200, five wind 190, Lysimachia trientaloides Hemsl. 200, Caulis Sinomenii 640, the Rhizoma Anemarrhenae 100, Radix Salviae Miltiorrhizae 100, Radix Aconiti Lateralis Preparata 25, Radix Aconiti 20, Radix Aconiti Kusnezoffii 33, Ramulus Cinnamomi 26, Moschus 22, Sanguis Draxonis 25, Radix Stephaniae Tetrandrae 25, Rhizoma Atractylodis 16, Rhizoma Dioscoreae Septemlobae 19, Bombyx mori L. 16, Fructus Chaenomelis 21, the Radix Astragali 25, Rhizoma Chuanxiong 22, Radix Gentianae Macrophyllae 19, Os pardi 26 crude drug such as grade, decoct with water three times, adding for the first time 10 times of water gagings (weight ratio) decocted 2 hours, adding for the second time 8 times of water gagings decocted 2 hours, adding for the third time 8 times of water gagings decocted 1 hour, collecting decoction, filter, it is 1.20(50 ℃ that filtrate is concentrated into relative density) clear paste, add 4 times of water gagings (weight ratio), stir evenly, standing 12 hours, filter, filtrate is condensed into relative density to 1.30-1.35(50 ℃) the Chinese medicine thick paste, get final product,
B, get lactose, microcrystalline Cellulose, half polyvinylpolypyrrolidone sets high in fast wet mixing pelletizer, after opening stirring arm, shears, slowly adds numbness gram sheet to transfer cream, adds appropriate 80% ethanol and regulates viscosity, glutinous net when being beneficial to granulate.Granulate, drying, granulate adds second half polyvinylpolypyrrolidone, magnesium stearate mix homogeneously, tabletting, coating, and get final product.
Recording disintegration time is: 13 minutes.
Embodiment 4
| Component | Gram |
| The Chinese medicine thick paste | 50 |
| Polyvinylpolypyrrolidone | 5 |
| Mannitol | 10 |
| Pregelatinized Starch | 35 |
| Magnesium stearate | 0.38 |
| Grain amount | 76.1 |
Preparation method:
A, the at first preparation of Chinese medicine thick paste
take (g) Radix Ampelopsis 620, Herba Sarcandrae 220, five wind 220, Lysimachia trientaloides Hemsl. 190, Caulis Sinomenii 650, the Rhizoma Anemarrhenae 105, Radix Salviae Miltiorrhizae 105, Radix Aconiti Lateralis Preparata 25, Radix Aconiti 20, Radix Aconiti Kusnezoffii 33, Ramulus Cinnamomi 26, Moschus 22, Sanguis Draxonis 25, Radix Stephaniae Tetrandrae 25, Rhizoma Atractylodis 16, Rhizoma Dioscoreae Septemlobae 19, Bombyx mori L. 16, Fructus Chaenomelis 21, the Radix Astragali 25, Rhizoma Chuanxiong 25, Radix Gentianae Macrophyllae 20, Os pardi 30 crude drug such as grade, decoct with water three times, adding for the first time 10 times of water gagings (weight ratio) decocted 2 hours, adding for the second time 8 times of water gagings decocted 2 hours, adding for the third time 8 times of water gagings decocted 1 hour, collecting decoction, filter, it is 1.20(50 ℃ that filtrate is concentrated into relative density) clear paste, add 4 times of water gagings (weight ratio), stir evenly, standing 12 hours, filter, filtrate is condensed into relative density to 1.30-1.35(50 ℃) the Chinese medicine thick paste, get final product,
B, get mannitol, pregelatinized Starch, half polyvinylpolypyrrolidone sets high in fast wet mixing pelletizer, after opening stirring arm, shears, slowly adds numbness gram sheet to transfer cream, adds appropriate 75% ethanol and regulates viscosity, glutinous net when being beneficial to granulate.Granulate, drying, granulate adds second half polyvinylpolypyrrolidone, magnesium stearate mix homogeneously, tabletting, coating, and get final product.
Recording disintegration time is: 14 minutes.
Model case
Case 1Zhang, 40 years old, the driver came institute medical on May 8th, 2004.
The main suit: back, extremities joint pain are violent, can not be upright 20 days.
Medical history: one month in and month out before, because helper people freights to car, perspire more, rub one's body with a towel with cold water again subsequently, then feel coldness of the body, can not be upright, the back and have a pain in the leg the pain unbearably.Though through multi-treatment, DeGrain.The state of an illness day by day increased the weight of, and recommends through the people, came institute's diagnosis and treatment on May 8th, 2004.
Check: lumbar and back pain is violent, and the health rickets is met cold rnning and weighed, and logical warm pain slightly subtracts.Pale tongue, tongue are white, tense pulse.
Diagnosis: arthromyodynia
Treatment: take Chinese medicine preparation of the present invention, every day 3 times, each 5-8 sheet serve on 20 days, and back, extremities joint pain alleviate, can be upright, continued to take 30 days, and all pain are uncomfortable to disappear, then takes consolidation in 10 days, so far not recurrence.
Case 2Mrs Li, 65 years old, the peasant suffered from arthromyodynia for many years, and both hands refer to, double-legged toe, wrist, the little ankylosis such as ankle, it is heavier that ankylosis appears in daystart, and have uncomfortable from head to foot.Taken Western medicine for many years, poor effect, the Chinese medicinal tablet for the treatment of arthromyodynia of the present invention was taken by my institute afterwards, every day 3 times, each 5-8 sheet is after serveing on 30 days, wrist, the little ankylosis phenomenon such as ankle is alleviated to some extent, continues to take tablet of the present invention, 40 days afterwards, both hands refer to, the both feet toe, wrist, the little ankylosis phenomenon such as ankle thoroughly disappears.Need take and consolidate curative effect in 20 days, so far not recurrence.
Case 3Week certain, the man, 50 years old, the peasant suffered from arthromyodynia for many years, felt that both hands refer to every morning, double-legged toe, wrist, the little ankylosis such as ankle, weather when cooling, and have uncomfortable from head to foot.Taken Western medicine for many years, poor effect, the Chinese medicinal tablet for the treatment of arthromyodynia of the present invention was taken by my institute afterwards, every day 3 times, each 5-8 sheet is after serveing on 60 days, wrist, the little ankylosis phenomenon such as ankle is alleviated to some extent, continues to take tablet of the present invention, 40 days afterwards, both hands refer to, the both feet toe, wrist, the little ankylosis phenomenon such as ankle thoroughly disappears.Need take and consolidate curative effect in 30 days, so far not recurrence.
Claims (3)
1. a Chinese medicine preparation for the treatment of arthromyodynia, made by Chinese medicine thick paste and adjuvant, it is characterized in that, the percentage by weight of its component is:
Chinese medicine thick paste 40%-60%, adjuvant 60-40%,
described Chinese medicine thick paste is carried and is got by following raw materials in part by weight liquid medicine: Radix Ampelopsis 550-650, Herba Sarcandrae 150-250, five wind 150-250, Lysimachia trientaloides Hemsl. 150-250, Caulis Sinomenii 550-650, Rhizoma Anemarrhenae 95-105, Radix Salviae Miltiorrhizae 95-105, Radix Aconiti Lateralis Preparata 20-30, Radix Aconiti 15-20, Radix Aconiti Kusnezoffii 30-40, Ramulus Cinnamomi 25-35, Moschus 20-30, Sanguis Draxonis 20-30, Radix Stephaniae Tetrandrae 20-25, Rhizoma Atractylodis 15-18, Rhizoma Dioscoreae Septemlobae 18-22, Bombyx mori L. 15-18, Fructus Chaenomelis 20-25, Radix Astragali 20-25, Rhizoma Chuanxiong 20-25, Radix Gentianae Macrophyllae 18-20, Os pardi 25-30
Described adjuvant comprises the filler of 35-50%, the disintegrating agent of 5%-10%,
The described percentage ratio shared mass percent that is each composition when granulating.
2. treatment arthromyodynia Chinese medicine preparation according to claim 1, made by Chinese medicine thick paste and adjuvant, it is characterized in that: described filler is one or more in mannitol, sorbitol, xylitol, lactose, sucrose, glucose, starch, dextrin, pregelatinized Starch and microcrystalline Cellulose; Described disintegrating agent is one or more in carboxymethyl starch sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, low-substituted hydroxypropyl cellulose, silicon dioxide.
3. the preparation method for the treatment of arthromyodynia Chinese medicine preparation as claimed in claim 1, is characterized in that, comprises the following steps:
A, the at first preparation of Chinese medicine thick paste
take Radix Ampelopsis by formula ratio, Herba Sarcandrae, five wind, Lysimachia trientaloides Hemsl., Caulis Sinomenii, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Aconiti Lateralis Preparata, Radix Aconiti, Radix Aconiti Kusnezoffii, Ramulus Cinnamomi, Moschus moschiferous is fragrant, Sanguis Draxonis, Radix Stephaniae Tetrandrae, Rhizoma Atractylodis, Rhizoma Dioscoreae Septemlobae, Bombyx mori L., Fructus Chaenomelis, the Radix Astragali, Rhizoma Chuanxiong, Radix Gentianae Macrophyllae, the crude drug such as Os pardi, decoct with water three times, adding for the first time 10 times of water gagings (weight ratio) decocted 2 hours, adding for the second time 8 times of water gagings decocted 2 hours, adding for the third time 8 times of water gagings decocted 1 hour, collecting decoction, filter, it is 1.20(50 ℃ that filtrate is concentrated into relative density) clear paste, add 4 times of water gagings (weight ratio), stir evenly, standing 12 hours, filter, filtrate is condensed into relative density to 1.30-1.35(50 ℃) thick paste, and get final product,
B, take filler, 1/2nd disintegrating agent sets high in fast wet mixing pelletizer; after opening stirring arm, shears; then the Chinese medicine thick paste that slowly adds step (a) to make adds appropriate 75% ethanol adjusting viscosity, and 18 orders are granulated; 80 ℃ of dryings; 20 order granulate, then add remaining disintegrating agent to mix, be pressed into tablet; film coating gets final product.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316298A (en) * | 2013-06-26 | 2013-09-25 | 柳晖 | Traditional Chinese composition for treating arthralgia |
| CN103585536A (en) * | 2013-12-04 | 2014-02-19 | 刘奕平 | Preparation method of medicine for treating puerperal arthralgia |
| CN104524220A (en) * | 2015-01-09 | 2015-04-22 | 杨茹芹 | Traditional Chinese medicine composition for treating qi depression blood stagnation type scleroderma |
| CN115414436A (en) * | 2022-10-20 | 2022-12-02 | 合肥今越制药有限公司 | A BIKE tablet for treating hyperuricemia, and its preparation method |
| CN115590930A (en) * | 2022-11-10 | 2023-01-13 | 合肥今越制药有限公司（Cn） | Traditional Chinese medicine tablet for treating gout and preparation method thereof |
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| CN1554369A (en) * | 2003-12-23 | 2004-12-15 | 贵阳中医学院药厂 | Medicine for treating rheumatoid arthritis and its preparing method |
| CN1660246A (en) * | 2004-12-07 | 2005-08-31 | 叶耀良 | Compound preparation of Chinese traditional medicine regulating menstruation and nourishing the blood |
| CN101439173A (en) * | 2008-11-20 | 2009-05-27 | 郭传法 | Chinese medicine prescription for treating rheumatic arthritis |
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| CN1350852A (en) * | 2000-10-30 | 2002-05-29 | 兰州三极生物资源技术公司 | Medicine for treating rheumatic or rheumatoid arthritis, osteoarthropathy and gout |
| CN1554369A (en) * | 2003-12-23 | 2004-12-15 | 贵阳中医学院药厂 | Medicine for treating rheumatoid arthritis and its preparing method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103316298A (en) * | 2013-06-26 | 2013-09-25 | 柳晖 | Traditional Chinese composition for treating arthralgia |
| CN103316298B (en) * | 2013-06-26 | 2014-12-10 | 威海高科医疗设备有限公司 | Traditional Chinese composition for treating arthralgia |
| CN103585536A (en) * | 2013-12-04 | 2014-02-19 | 刘奕平 | Preparation method of medicine for treating puerperal arthralgia |
| CN103585536B (en) * | 2013-12-04 | 2015-05-13 | 刘奕平 | Preparation method of medicine for treating puerperal arthralgia |
| CN104524220A (en) * | 2015-01-09 | 2015-04-22 | 杨茹芹 | Traditional Chinese medicine composition for treating qi depression blood stagnation type scleroderma |
| CN115414436A (en) * | 2022-10-20 | 2022-12-02 | 合肥今越制药有限公司 | A BIKE tablet for treating hyperuricemia, and its preparation method |
| CN115590930A (en) * | 2022-11-10 | 2023-01-13 | 合肥今越制药有限公司（Cn） | Traditional Chinese medicine tablet for treating gout and preparation method thereof |
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Application publication date: 20130508 |