CN103083344A - Compound praziquantel parasite repellent tablet for pets and preparation method thereof - Google Patents
Compound praziquantel parasite repellent tablet for pets and preparation method thereof Download PDFInfo
- Publication number
- CN103083344A CN103083344A CN 201110342869 CN201110342869A CN103083344A CN 103083344 A CN103083344 A CN 103083344A CN 201110342869 CN201110342869 CN 201110342869 CN 201110342869 A CN201110342869 A CN 201110342869A CN 103083344 A CN103083344 A CN 103083344A
- Authority
- CN
- China
- Prior art keywords
- praziquantel
- starch
- preparation
- tablet
- ivermectin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a compound praziquantel parasite repellent tablet for pets. The tablet is characterized by comprising the following components by mass percent: 68-80 of praziquantel, 3-5 of ivermectin, 13-20 of starch, 1-10 of 10% starch slurry for soft material preparation, 3-6 of sodium carboxymethyl starch, and 0.5-1 of magnesium stearate. The preparation method consists of: weighing the praziquantel and the ivermectin, adding the starch, mixing them, conducting crushing and sieving to obtain a mixture; and adding the starch slurry to make a soft material, carrying out granulation with a sieve, performing drying at 50DEG C-70DEG C, subjecting the obtained dry granules to grain straightening through the sieve, adding the magnesium stearate and the sodium carboxymethyl starch, mixing them uniformly, and conducting tabletting, thus obtaining the product. With a smooth and clean appearance, the tablet provided in the invention can disintegrate rapidly, has all indicators optimized, and can achieve a good parasite repellent effect after oral administration. And the preparation method has a simple and feasible process and a low cost, thus being suitable for industrial production.
Description
Technical field
The present invention relates to a kind of house pet compound praziquantel expelling tablet and preparation method thereof.
Background technology
The primary need of veterinary's parasitic disease is the anti-parasite medicine that exploitation makes new advances.But new drug development need to expend huge fund, each new drug from set about studying last registration, listing will be experienced for a long time.On the basis of original medicine, develop various preparation formulations, utilize existing medicine and new technique to prepare the research direction that compound preparation is the development new drug.The clinical research result proves, compound preparation and single-dose have same high curative effect, adverse effect few, and the advantages such as taking convenience in daily preventing and controlling, are more easily avoided missing, and ensures the reasonability of medication.House pet can not utilize the reason of oneself to go to take medicine as the people due to himself characteristic, and therefore suitable dosage form seems particularly important.Tablet is the oral formulations that is fit to house pet of generally acknowledging.In China, ivermectin and praziquantel are all 2005 editions kinds of recording of Chinese veterinary pharmacopoeia, and its single preparations of ephedrine can be produced in enormous quantities, and compound preparation there is not yet report and sells.
Summary of the invention
The object of the present invention is to provide a kind of feasible process, throwing to take convenient, that anthelminthic effect is good house pet compound praziquantel expelling tablet and preparation method thereof, it can satisfy current day by day complicated pet body entozoa infection and reach more and more serious Drug resistance to the demand of new veterinary drug.
A kind of house pet compound praziquantel expelling tablet is characterized in that its component and mass percent are respectively praziquantel 68～80, ivermectin 3～5, starch 13～20,10% starch slurry 1～10, carboxymethyl starch sodium 3～6, magnesium stearate 0.5～1.
Above-mentioned house pet is characterized in that taking praziquantel, ivermectin with the preparation method of compound praziquantel expelling tablet, adds the starch co-grinding to cross 60～100 mesh sieves, makes homogeneous mixture; Add starch slurry, make soft material, granulate with 14～20 mesh sieves, dry under 50 ℃～70 ℃, the dried granule of gained adds magnesium stearate and carboxymethyl starch sodium with 14～20 mesh sieve granulate, mix homogeneously, and tabletting namely gets product.
Tablet appearance of the present invention is bright and clean, and disintegrate is rapid, and the tablet indices has all reached optimization, and oral rear anthelmintic is effective, and technique is simple, feasible, cost is low, is fit to commercial production.
The specific embodiment
Component of the present invention and mass percent are respectively praziquantel 68～80, ivermectin 3～5, starch 13～20,10% starch slurry 1～10, carboxymethyl starch sodium 3～6, magnesium stearate 0.5～1.Take praziquantel, ivermectin during preparation, add the starch co-grinding to cross 60～100 mesh sieves, make homogeneous mixture; Add starch slurry to make soft material, granulate with 14～20 mesh sieves, dry under 50 ℃～70 ℃, the dried granule of gained adds magnesium stearate and carboxymethyl starch sodium with 14～20 mesh sieve granulate, mix homogeneously, and tabletting namely gets product.
It is lubricant that the present invention adopts magnesium stearate, and carboxymethyl starch sodium is disintegrating agent, take 10% starch slurry as adhesive.The present invention is take praziquantel as principal agent, and take ivermectin as accessory drugs, ivermectin cures mainly nematicide, and praziquantel all has good curative effect to cestode and front and back dish trematodiasis, and two medicines are without incompatibility, and the pest-resistant spectrum of the compound recipe of composition is wide, cost is low, clinical effectiveness good.
The present invention has take starch as diluent the effect that helps the principal agent praziquantel to pulverize and sieve concurrently simultaneously.Praziquantel, when ivermectin pulverizes and sieves, first add starch to mix and make mixture, cross 60～100 mesh sieves, assemble voluntarily agglomeratingly thereby overcome because of the principal agent electrostatic interaction, be difficult for sieving, be difficult to the shortcoming of mix homogeneously.
Embodiment
Get praziquantel 750g, ivermectin 15g, add starch 150g co-grinding, cross 100 mesh sieves, make homogeneous mixture; Add 10% starch slurry 88g, make soft material, granulate with 20 mesh sieves, dry under 50 ℃～70 ℃, the dried granule of gained adds 5.5g magnesium stearate and 55g carboxymethyl starch sodium, mix homogeneously with 20 mesh sieve granulate after granulate, tabletting makes that to make tablet bright and clean attractive in appearance, and sheet heavily is controlled at 245mg～280mg.
Claims (2)
1. house pet compound praziquantel expelling tablet, it is characterized in that its component and mass percent be respectively praziquantel 68～80, ivermectin 3～5, starch 13～20, for the preparation of 10% starch slurry 1～10, carboxymethyl starch sodium 3～6, the magnesium stearate 0.5～1 of soft material.
2. house pet claimed in claim 1 with the preparation method of compound praziquantel expelling tablet, is characterized in that taking praziquantel, ivermectin, adds the starch co-grinding to cross 60～100 mesh sieves, makes homogeneous mixture; Add 10% starch slurry, make soft material, granulate with 14～20 mesh sieves, dry under 50 ℃～70 ℃, the dried granule of gained adds magnesium stearate and carboxymethyl starch sodium with 14～20 mesh sieve granulate, mix homogeneously, and tabletting namely gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110342869 CN103083344A (en) | 2011-11-03 | 2011-11-03 | Compound praziquantel parasite repellent tablet for pets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110342869 CN103083344A (en) | 2011-11-03 | 2011-11-03 | Compound praziquantel parasite repellent tablet for pets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103083344A true CN103083344A (en) | 2013-05-08 |
Family
ID=48196825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110342869 Pending CN103083344A (en) | 2011-11-03 | 2011-11-03 | Compound praziquantel parasite repellent tablet for pets and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103083344A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751201A (en) * | 2014-01-03 | 2014-04-30 | 聊城大学 | Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof |
| CN104586801A (en) * | 2015-01-29 | 2015-05-06 | 沈阳伟嘉牧业技术有限公司 | Veterinary parasite expelling orally disintegrating tablet |
| CN107669646A (en) * | 2017-10-31 | 2018-02-09 | 佛山市南海东方澳龙制药有限公司 | Ivermectin tablet and preparation method thereof |
| CN107837238A (en) * | 2017-10-31 | 2018-03-27 | 佛山市南海东方澳龙制药有限公司 | The preparation method and ivermectin tablet of ivermectin tablet |
| CN108670974A (en) * | 2018-06-13 | 2018-10-19 | 四川农业大学 | A kind of broad-spectrum anti-parasite chewable tablets and preparation method thereof |
| CN109846842A (en) * | 2019-01-31 | 2019-06-07 | 四川省泰信动物药业有限公司 | A kind of pet composite tablet and preparation method thereof |
| CN110721167A (en) * | 2018-12-26 | 2020-01-24 | 瑞普（天津）生物药业有限公司 | Compound insect-expelling flavor tablet formula for pets and preparation method thereof |
| CN113134008A (en) * | 2020-01-17 | 2021-07-20 | 中国农业大学 | Ivermectin praziquantel chewable tablet for pets and preparation method thereof |
| CN115813872A (en) * | 2022-12-27 | 2023-03-21 | 佛山市南海东方澳龙制药有限公司 | Compound ivermectin insect repellent tablet for animals and preparation method thereof |
| CN115844843A (en) * | 2022-12-27 | 2023-03-28 | 佛山市南海东方澳龙制药有限公司 | Multi-unit dispersed insect-repellent sheet and method for producing the same |
| CN115869275A (en) * | 2022-12-27 | 2023-03-31 | 佛山市南海东方澳龙制药有限公司 | Insect expelling tablet for animals and preparation method thereof |
-
2011
- 2011-11-03 CN CN 201110342869 patent/CN103083344A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751201A (en) * | 2014-01-03 | 2014-04-30 | 聊城大学 | Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof |
| CN104586801A (en) * | 2015-01-29 | 2015-05-06 | 沈阳伟嘉牧业技术有限公司 | Veterinary parasite expelling orally disintegrating tablet |
| CN107669646A (en) * | 2017-10-31 | 2018-02-09 | 佛山市南海东方澳龙制药有限公司 | Ivermectin tablet and preparation method thereof |
| CN107837238A (en) * | 2017-10-31 | 2018-03-27 | 佛山市南海东方澳龙制药有限公司 | The preparation method and ivermectin tablet of ivermectin tablet |
| CN108670974A (en) * | 2018-06-13 | 2018-10-19 | 四川农业大学 | A kind of broad-spectrum anti-parasite chewable tablets and preparation method thereof |
| CN110721167A (en) * | 2018-12-26 | 2020-01-24 | 瑞普（天津）生物药业有限公司 | Compound insect-expelling flavor tablet formula for pets and preparation method thereof |
| CN109846842A (en) * | 2019-01-31 | 2019-06-07 | 四川省泰信动物药业有限公司 | A kind of pet composite tablet and preparation method thereof |
| CN113134008A (en) * | 2020-01-17 | 2021-07-20 | 中国农业大学 | Ivermectin praziquantel chewable tablet for pets and preparation method thereof |
| CN113134008B (en) * | 2020-01-17 | 2022-08-30 | 中国农业大学 | Ivermectin praziquantel chewable tablet for pets and preparation method thereof |
| CN115813872A (en) * | 2022-12-27 | 2023-03-21 | 佛山市南海东方澳龙制药有限公司 | Compound ivermectin insect repellent tablet for animals and preparation method thereof |
| CN115844843A (en) * | 2022-12-27 | 2023-03-28 | 佛山市南海东方澳龙制药有限公司 | Multi-unit dispersed insect-repellent sheet and method for producing the same |
| CN115869275A (en) * | 2022-12-27 | 2023-03-31 | 佛山市南海东方澳龙制药有限公司 | Insect expelling tablet for animals and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103083344A (en) | Compound praziquantel parasite repellent tablet for pets and preparation method thereof | |
| CN102488753B (en) | Fishing Chinese medicinal composition with antibacterial and antibiotic functions and preparation method thereof | |
| CN101601670B (en) | Compound niclosamide parasite-expelling tablet used for pet and preparation method thereof | |
| CN102935084A (en) | Compound ivermectin sustained release tablet and preparation method thereof | |
| CN101239168A (en) | Composition with ease pain anti-inflammatory action | |
| CN105582008A (en) | Composition containing vildagliptin and metformin and preparation method of composition | |
| CN103751201A (en) | Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof | |
| CN102846569A (en) | Drug composition containing pirfenidone, and preparation method thereof | |
| Zhou et al. | Effects of dietary supplementations with the fibrous root of Rhizoma Coptidis and its main alkaloids on non-specific immunity and disease resistance of common carp | |
| CN102160855B (en) | Dex-ibuprofen sustained release tablets and preparation method thereof | |
| CN102048704A (en) | Levofloxacin lactate dispersible tablet and preparation method thereof | |
| CN107753498A (en) | Compound ivermectin tablet and preparation method thereof | |
| EP4014999B1 (en) | Combination product containing limonin compound and sulfonylurea drug | |
| CN107595871A (en) | Compound preparation containing ivermectin and preparation method thereof | |
| CN107693532A (en) | Compound anti-parasitic preparation and preparation method thereof | |
| CN101947233A (en) | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof | |
| CN102370091B (en) | Feed for preventing nematode diseases of flocks and herds | |
| CN201426858Y (en) | Clopidogrel hydrogen shlfate and aspirin double-layer tablet | |
| CN110327356A (en) | Combination product comprising limonoid and alpha-glucosidase inhibitor | |
| CN104127389A (en) | Praziquantel chewing tablet for pets and preparation method thereof | |
| CN105284907B (en) | A kind of granular formulation for killing nematode containing AVM and trichoderma harzianum | |
| CN100382836C (en) | External use traditional Chinese medicinal preparation for treating ringworm of the nails | |
| JP2007031302A (en) | Adiponectin production accelerator and metabolic syndrome preventive | |
| CN102247390B (en) | Medicine for treating bacterial air sacculitis in livestock and preparation method thereof | |
| CN103083345A (en) | Broad-spectrum anti-parasitic compound ivermectin tablet for pets |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130508 |