CN103052627B - 作为fak抑制剂的嘧啶衍生物 - Google Patents

作为fak抑制剂的嘧啶衍生物 Download PDF

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Publication number
CN103052627B
CN103052627B CN201180039922.8A CN201180039922A CN103052627B CN 103052627 B CN103052627 B CN 103052627B CN 201180039922 A CN201180039922 A CN 201180039922A CN 103052627 B CN103052627 B CN 103052627B
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CN103052627A (zh
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T.海因里希
C.埃斯达尔
H.格赖纳
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Merck Patent GmbH
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
CN201180039922.8A 2010-08-18 2011-07-19 作为fak抑制剂的嘧啶衍生物 Expired - Fee Related CN103052627B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010034699.3 2010-08-18
DE102010034699A DE102010034699A1 (de) 2010-08-18 2010-08-18 Pyrimidinderivate
PCT/EP2011/003597 WO2012022408A1 (de) 2010-08-18 2011-07-19 Pyrimidinderivate als fak inhibitoren

Publications (2)

Publication Number Publication Date
CN103052627A CN103052627A (zh) 2013-04-17
CN103052627B true CN103052627B (zh) 2015-08-19

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Country Link
US (1) US8906916B2 (https=)
EP (1) EP2606034B1 (https=)
JP (2) JP6049617B2 (https=)
CN (1) CN103052627B (https=)
AR (1) AR082722A1 (https=)
AU (1) AU2011291110B2 (https=)
CA (1) CA2808540C (https=)
DE (1) DE102010034699A1 (https=)
DK (1) DK2606034T3 (https=)
ES (1) ES2572740T3 (https=)
HR (1) HRP20160562T1 (https=)
HU (1) HUE027846T2 (https=)
IL (1) IL224751A (https=)
PL (1) PL2606034T3 (https=)
RS (1) RS54882B1 (https=)
SI (1) SI2606034T1 (https=)
WO (1) WO2012022408A1 (https=)

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DE102010034699A1 (de) * 2010-08-18 2012-02-23 Merck Patent Gmbh Pyrimidinderivate
JP5937112B2 (ja) * 2011-02-17 2016-06-22 カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドＣａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｒｃ Ｐｔｙ Ｌｉｍｉｔｅｄ 選択的ｆａｋ阻害剤
EP2675793B1 (en) 2011-02-17 2018-08-08 Cancer Therapeutics Crc Pty Limited Fak inhibitors
US9013997B2 (en) * 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
WO2014027199A1 (en) * 2012-08-14 2014-02-20 Cancer Therapeutics Crc Pty Ltd Fak and flt3 inhibitors
WO2014026242A1 (en) * 2012-08-17 2014-02-20 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
CA2882158A1 (en) * 2012-08-17 2014-02-20 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
TW201412740A (zh) * 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
WO2014174745A1 (ja) * 2013-04-26 2014-10-30 国立大学法人京都大学 Ｅｇ５阻害剤
US10106834B2 (en) 2013-10-09 2018-10-23 The General Hospital Corporation Methods of diagnosing and treating B cell acute lymphoblastic leukemia
WO2015123722A1 (en) * 2014-02-19 2015-08-27 Bionomics Limited Inhibitors
DK3185868T3 (da) * 2014-08-25 2022-05-23 Salk Inst For Biological Studi Hidtil ukendte ULK1-inhibitorer og fremgangsmåder til anvendelse af samme
WO2019117813A1 (en) * 2017-12-15 2019-06-20 National University Of Singapore Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
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IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
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ES2572740T3 (es) 2016-06-02
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US20130158005A1 (en) 2013-06-20
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WO2012022408A1 (de) 2012-02-23
CA2808540C (en) 2018-09-11
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AR082722A1 (es) 2012-12-26
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