CN103041241B - Compound psoriasis arthropathica removal decoction - Google Patents

Abstract

The invention relates to field of Chinese traditional medicine formulas, in particular to compound psoriasis arthropathica removal decoction. The compound psoriasis arthropathica removal decoction is characterized in that the compound psoriasis arthropathica removal decoction comprises the following raw materials by weight percentage: 10-19% of oldenlandia diffusa, 9-13% of fructus psoraleae, 7-9% of sweet wormwood, 2-5% of subprostrate sophora, 9-11% of radix astragali, 2-4% of spatholobus stem, 5-7% of radix arnebiae seu lithospermi, 3-5% of cyrtomium rhizome,4-6% of radix isatidis, 2-4% of rhizoma smilacis glabrae, 2-4% of cortex dictamni, 2-5% of tree peony bark, 2-6% of radix salviae miltiorrhizae, 1-3% of radix rehmanniae, 3-5% of lumbricus and 4-7% of liquorice. The 16 Chinese traditional medicines are soaked by water and decocted, and a filtrate is obtained by removing dregs. The compound psoriasis arthropathica removal decoction is low in cost, has no obvious toxic or side effects, and can treat psoriasis vulgaris effectively.

Description

Compound recipe Xiaoyin Yu Mange decoction

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of compound recipe Xiaoyin Yu Mange decoction that is used for the treatment of psoriasis vulgaris.

Background technology

As everyone knows, psoriasis is a kind of common proliferative, inflammatory dermatosis, modern medicine study, psoriatic generation and heredity, infect, dysbolismus, spirit, Factors Affecting Neuroendocrine Mechanisms, the too many levels such as nerve immunity are relevant, also find environment, the natural causes such as season also have impact to its morbidity, molecular biological research finds that again the hypertrophy of psoriasis epidermis is subject to the regulation and control of cytokine profiles, but at present the pathogenesis of this polygenes dermatoses is also lacked to definite understanding, mostly think that the pathology of psoriasis vulgaris is mainly the hyperplasia of angle unit, therefore blood vessel hyperplasia and inflammatory reaction, there is no the method for radical cure, and also without effect method, modern medicine mainly adopts immunomodulator, antiinflammatory, antiallergic, ultraviolet phototherapy, the methods such as hormone, but said medicine its can cause hepatorenal damage, gastrointestinal reaction, bone marrow depression and prolonged application hormone can cause osteoporosis, secondary hypertension is sick, diabetes, superinfection, spirit changes, many untoward reaction such as electrolyte disturbance, drug side effect is large, and the state of an illness easily recurs, and has a strong impact on patient's quality of life.Because its course of disease of psoriasis vulgaris is touching, easily outbreak repeatedly, and sickness rate has year by year the trend rising, and becomes a difficult problem of the current medical circle of puzzlement, and weather, environment, crowd are flowed, the factor of social pressure and marriage has become main risk factor.

Summary of the invention

Object of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, and a kind of determined curative effect is provided, with low cost, the compound recipe Xiaoyin Yu Mange decoction of the treatment psoriasis vulgaris having no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of compound recipe Xiaoyin Yu Mange decoction, it is characterized in that raw material composition is by weight percentage: Herba Hedyotidis Diffusae 10～19%, Fructus Psoraleae 9～13%, Herba Artemisiae Annuae 7～9%, Radix Sophorae Tonkinensis 2～5%, the Radix Astragali 9～11%, Caulis Spatholobi 2～4%, Radix Arnebiae (Radix Lithospermi) 5～7%, Rhizoma Osmundae 3～5%, Radix Isatidis 4～6%, Rhizoma Smilacis Glabrae 2～4%, Cortex Dictamni 2～4%, Cortex Moutan 2～5%, Radix Salviae Miltiorrhizae 2～6%, Radix Rehmanniae 1～3%, Pheretima 3～5%, Radix Glycyrrhizae 4～7%, above-mentioned 16 taste Chinese medicines are soaked in water, the filtrate of removing slag after decocting to obtain.

The invention has the beneficial effects as follows, cost is low, without obvious toxic-side effects, can effectively treat psoriasis vulgaris.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopt Herba Hedyotidis Diffusae, Fructus Psoraleae, Herba Artemisiae Annuae, Radix Sophorae Tonkinensis, the Radix Astragali, Caulis Spatholobi, Radix Arnebiae (Radix Lithospermi), Rhizoma Osmundae, Radix Isatidis, Rhizoma Smilacis Glabrae, Cortex Dictamni, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Pheretima, Radix Glycyrrhizae is that raw material is prepared from, its component (% by weight) is Herba Hedyotidis Diffusae 18%, Fructus Psoraleae 13%, Herba Artemisiae Annuae 8%, Radix Sophorae Tonkinensis 5%, the Radix Astragali 10%, Caulis Spatholobi 3%, Radix Arnebiae (Radix Lithospermi) 6%, Rhizoma Osmundae 4%, Radix Isatidis 5%, Rhizoma Smilacis Glabrae 3%, Cortex Dictamni 3%, Cortex Moutan 4%, Radix Salviae Miltiorrhizae 5%, Radix Rehmanniae 3%, Pheretima 4%, Radix Glycyrrhizae 6%, get 58 kilograms of above-mentioned 16 kinds of raw material gross weights, after selected cleaning, under greenhouse experiment, use 20000ml water soaking about 20 minutes, then decoct 60 minutes, the routine filtration of removing slag, high pressure, after sterilization process, gained filtrate is 9000ml altogether, bag subpackage, sealing, every bag of 150ml.Every bu 2 times is oral, each (medicine) being taken before meal 150ml sooner or later.

Therapeutic Principle of the present invention: psoriasis belongs to the traditional Chinese medical science " white Mange, psoriasis, psoriasis " category; its pathogenesis is not yet completely clear so far; motherland's medical science thinks that primary disease is relevant with heat in blood; heat in blood is these pathogenetic main intrinsic factor; the formation of heat in blood mostly is damaged by excess of seven emotions; mechanism of qi does not relax, strongly fragrant fire-transformation of a specified duration; Or surfeit greasy and surfeit flavour, impairing the spleen and stomach, lifting imbalance, functional activity of QI being not smooth, strongly fragrant fire-transformation of a specified duration; Affection due to external wind and heat pathogenic dryness, the bright skin of heat; Caused by liver and kidney deficiency in addition, disharmony of Chong and Conception Channels, disharmony of nutrient QI with defensive QI, internal organs imbalance of YIN and YANG etc. all can be sent out as primary disease.Primary disease pathogenesis is that heat in blood, blood are dry, blood stasis is strongly fragrant between skin, fur, space between skin and muscles and send out, sick easy impairment of YIN hematozemia for a long time, and internal organs imbalance of YIN and YANG, nutrient QI and blood being insufficient, raw dry humorously, hinder in skin and be chronic outbreak.Therefore drafted clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation to remove blood stasis, eliminating dampness and dredging channels, blood enriching and dryness moistening, the principle for the treatment of of skin moistening and itch stopping.The sweet micro-bitter cold of Herba Hedyotidis Diffusae nature and flavor in the present invention, return stomach, large intestine, small intestine meridian, there is heat clearing away, removing toxic substances, dampness removing, the merit of eliminating carbuncle, the existing stronger removing toxicity for eliminating carbuncles effect of this product, has again the merit of clearing away heat-damp and promoting diuresis, oral administration and external, modern pharmacological research Herba Hedyotidis Diffusae has remarkable inhibition cell propagation effect, suppresses the generation of epithelial cells, interleukin-6, tumor necrosis factor, reaches antiinflammatory, adjusts immunity function, Fructus Psoraleae enters kidney, spleen channel, the arduous large temperature of nature and flavor, there is the kidney warming promoting flow of QI and blood, disperse the merit of table, < < Compendium of Materia Medica > > thinks that Fructus Psoraleae can also control " wind cold caused by deficiency, by all cold numbness resistances ", Fructus Psoraleae passes through warming the kidney and strengthening the spleen, promoting flow of QI and blood, disperse table, skin QI and blood must be filled, human righteousness is sufficient simultaneously, heresy can not be invaded, be beneficial to the rehabilitation of disease, Fructus Psoraleae is used for the treatment of the research that the dermopathic curative effects such as psoriasis have obtained modern medicine, more and more studies have shown that the extract of Fructus Psoraleae, the significant curative effect of derivatives for treatment multiple dermatosis.The U.S. has extracted 8-methoxypsoralen (8-MOP) from Ammimaivs, and is applied to clinically, and it has similar structure and the effect of effective ingredient psoralen of extracting to the bone fat of therefrom building up one's health by taking tonic.Therefore, Fructus Psoraleae is the psoriatic a kind of more effective medicine for the treatment of; Both are monarch drug altogether.Herba Artemisiae Annuae nature and flavor are arduous cold, return liver, gallbladder, kidney channel, it is warm in nature and not dry, mend and not high, energy clearing away deficiency-heat, is the key medicine of removing heat from blood expelling summer-heat, < < herbal classic > >: " main scabies scabies crust is itched; malignant boil, kills louse, and Zhi Liure is between joint."; Radix Sophorae Tonkinensis is returned lung meridian, has heat-clearing and toxic substances removing, the effect of reducing swelling and alleviating pain, < < Kaibao Bencao > >: " pyogenic infections from tumour or sore disappears for all poison of drug of Radix Sophorae Tonkinensis solution, pain relieving."; The Radix Astragali is returned spleen lung meridian, has the effect of invigorating the spleen and benefiting QI poison holding, and the modern pharmacological research Radix Astragali strengthens the phagocytic function of reticuloendothelial cell, can adjust the immunne response of Serum of Patients With Autoimmune Diseases, makes damaged skin functional rehabilitation; Caulis Spatholobi can be enriched blood, and can invigorate blood circulation again; Radix Arnebiae (Radix Lithospermi) has clear and rich removing heat from blood and the effect of invigorating blood circulation, and has again the effect of separating noxious heat in the blood system; Rhizoma Osmundae has removing heat from blood, the merit of heat-clearing and toxic substances removing; Six is ministerial drug altogether.Radix Isatidis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Rhizoma Smilacis Glabrae, Cortex Dictamni clearing away heat-damp and promoting diuresis; Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Rehmanniae YIN nourishing, clearing away heat and cooling blood, promoting blood circulation to remove blood stasis; Pheretima heat clearing away eliminating stagnation, expel wind to dredge collateral; Be adjuvant drug, modern pharmacological research Cortex Moutan has certain antihistaminic, protection mastocyte.Radix Salviae Miltiorrhizae has the effect of antihistamine and exudation.Radix Glycyrrhizae nature and flavor are sweet flat, can relax medicine strong and alleviate poisonous side effect of medicine, again can the spleen and stomach regulating, invigorating the spleen and benefiting QI, with solid the foundation of acquired constitution, can the cold-proof medicine of a cold nature thing impairment of the spleen upset one's stomach, to alleviate its gastrointestinal reaction, and Radix Glycyrrhizae still has glucocorticoid sample antiinflammatory action, again can the multiple allergy of antagonism, there is stronger antiinflammatory and immunoregulation effect, for making medicine.All medicines share, and pyretic toxicity is clear, damp and hot dispelling, and QI and blood is contained, and blood is prosperous, skin profit.Prescription of the present invention, the whole reconditioner body immunity function of energy, the effects such as energy antiinflammatory, antiallergic, antiviral, Immunosuppression reaction simultaneously.There is clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation to remove blood stasis, eliminating dampness and dredging channels, blood enriching and dryness moistening, the merit of skin moistening and itch stopping, makes just arrogantly, and evil poison removes, and can effectively treat psoriasis.

The embodiment that each raw material of the present invention also can the listed ratio of according to the form below (percentage by weight) mixes realizes, and it decocts program, oral methods is identical with embodiment 1, and its content is as shown in the table.

Below in conjunction with my institute, the clinical preliminary test that Wendeng City, In Shandong Weihai central hospital carries out is done further, is described in detail the present invention:

1, case selection: the routine patient of clinical random selection 62, male 41 examples, female's 21 examples, age 17-64 year, average 48.2 ± 5.8 years old, course of disease two weeks-20 year, average 3.7 ± 8.4 years.

2, diagnostic criteria: the diagnostic criteria that all cases are all formulated with reference to < < clinical dermatology > > is drafted and < < new Chinese medicine guideline of clinical investigations > >.Clinical criteria 1. skin lesion is red pimple or speckle, clear border, and the visible semitransparent thin film of surface coverage multilamellar silvery white squama, strikes off the visible petechial hemorrhage of thin film; 2. can betide any position of health, be symmetry and distribute, be apt to occur in knee joint, elbow joint is stretched side and head, finger (toe) first of a few patients is point-like (thimble shape) depression; 3. subjective symptoms has pruritus in various degree; 4. the heavy summer in winter is light.1. Excluded cases merges serious cardiovascular and cerebrovascular vessel patient, 2. serious hepatic and kidney function obstacle person, 3. gestation or women breast-feeding their children person, 4. those who are allergic to this drug, 5. just long-term steroid or long-term steroid person once in February, 6. 7. medication or data are not congruent in accordance with regulations affects the treatment or safety judgement person for joint type, pustule type, erythrodermic psoriasis.

3, criterion of therapeutical effect: comprise clinical cure, effective, effective, invalid, treatment finishes to evaluate total effects.Criterion of therapeutical effect is drafted with reference to relevant criterion of therapeutical effect in < < new Chinese medicine guideline of clinical investigations > >.Clinical cure: skin lesion disappears completely or only stays filbert pigmentation spots, occurs without new erythra; Effective: the skin lesion > 80% that disappears, without new erythra, occur, gargalesthesia obviously alleviates: effectively: skin lesion disappears more than 30%, but < 80% occurs without new erythra, and gargalesthesia alleviates; Invalid: skin lesion disappears below 30%, or have new erythra to occur.Total effective rate is in cure rate+obvious effective rate+effective percentage.

4, Therapeutic Method: each serving using compound recipe Xiaoyin Yu Mange mixture 150ml, morning every day, late twice one after each meal, stop other dependencys treatments during treatment, and 1 14 days courses for the treatment of, every three days, take continuously the present invention and treat five courses for the treatment of each course for the treatment of.

5, therapeutic outcome: the present invention treats 62 examples, cures 7 examples (11.30%), effective 22 examples (35.4%), effective 28 examples (45.2%), invalid 5 examples (8.1%), total effective rate 91.9%.

Claims (1)

1. the compound recipe Xiaoyin Mange decoction of healing, it is characterized in that: raw material composition is by weight percentage, Herba Hedyotidis Diffusae 10～19%, Fructus Psoraleae 9～13%, Herba Artemisiae Annuae 7～9%, Radix Sophorae Tonkinensis 2～5%, the Radix Astragali 9～11%, Caulis Spatholobi 2～4%, Radix Arnebiae (Radix Lithospermi) 5～7%, Rhizoma Osmundae 3～5%, Radix Isatidis 4～6%, Rhizoma Smilacis Glabrae 2～4%, Cortex Dictamni 2～4%, Cortex Moutan 2～5%, Radix Salviae Miltiorrhizae 2～6%, Radix Rehmanniae 1～3%, Pheretima 3～5%, Radix Glycyrrhizae 4～7%, above-mentioned 16 taste Chinese medicines are soaked in water, the filtrate of removing slag to obtain after decocting.