CN103041030A - Pharmaceutical composition for treating fever with swollen head, as well as preparation method and application thereof - Google Patents
Pharmaceutical composition for treating fever with swollen head, as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a pharmaceutical composition for treating fever with swollen head. The pharmaceutical composition is a preparation which is prepared from the following active pharmaceutical ingredients in parts by weight: 17-31 parts of spica prunellae, 4-8 parts of thallus laminariae, 10-20 parts of radix scutellariae, 10-20 parts of coptis chinensis franch, 3-7 parts of radix et rhizoma rhei, 8-16 parts of folium isatidis, 13-23 parts of fructus forsythiae, 17-31 parts of radix isatidis, 8-16 parts of lasiosphaera seu calvatia, 17-31 parts of radix scrophulariae, 8-16 parts of fructus arctii, 4-8 parts of platycodon grandiflorus, 5-11 parts of herba menthae, 8-16 parts of bombyx batryticatus, 4-8 parts of rhizoma cimicifugae, 4-8 parts of bupleurum chinense, 8-16 parts of pericarpium citri reticulatae and 8-16 parts of radix glycyrrhizae. The invention further provides a preparation method and an application of the pharmaceutical composition. The pharmaceutical composition can effectively eliminate various symptoms of fever with swollen head and has good cure rate to fever with swollen head, and a new choice is provided for clinical pharmaceuticals.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of epidemic infection with swollen head and its production and use.
Background technology
Epidemic infection with swollen head is to be the warm malicious disease of principal character because of what experience that wind-heat evil toxin causes take red and swollen swollen, the heating of Tou Mian inflammation.Claim again that mumps, pig's head Fei, Chen ear are cold, big head, infection with swollen head etc., be equivalent to mumps (viral parotitis, infectious parotitis), the pyogenic parotitis (bacterial parotitis) of doctor trained in Western medicine.Be mainly in winter and spring, 5 years old to 10 years old child and teenager are the most common, and the adult is morbidity also.How not enough by the human righteousness, experience wind-heat evil toxin and due to, be to defend minute from the beginning of evil poison, the exterior syndromes such as visible heating, slight chill, soon pyretic toxicity is burnt bright lung stomach, on attack the face throat.Though its patient's condition is rapid, how without crisis, lessly see note of the ancient Chinese that heresy enters nutrient blood, the pathogen attacking the pericardium adversely.Belong to the sufferer of viral parotitis class in the epidemic infection with swollen head because having stronger infectiousness, therefore normal general and so on is attributed to the pestilence category again.Epidemic infection with swollen head has special clinical manifestation, and is more anxious except onset, outside the whole body loathing of cold, the heating, also has Head And Face to lift the red primary symptom that swells and ache.Pain is waited in some patients or companion pharynx, and the aversion to cold that continues then gradually stops and the calorific potential benefit increases, thirst and drinking, and dysphoria, Tou Mian burning swelling, the aggravation of having sore throat, but the less nutrient blood syndrome that occurs caving in, on the tongue arteries and veins, general red tongue with yellow fur, rapid and forceful pulse.
Epidemic infection with swollen head is brought very large misery to the patient, and cheek hurt like hell has a strong impact on studying and living.Some patient's pancreas, meninges, brain, liver and the heart all can be subject to infringement in various degree, and its serious harm to body is not limited in the parotid gland itself, but its hard to guard against complication, because its virus can be invaded various glandular tissues or nervous system and liver, kidney, the heart, the organ that joint etc. are nearly all, thereby often can cause meningoencephalitis, orchitis, pancreatitis, mastitis, the sufferers such as oophoritis, its pathogenic factor, for a kind of myxovirus causes viremia by entering blood after the epithelial tissue propagation after invading oral mucosa by droplet transmission, then be positioned the parotid gland or other organs, namely should virus at first invade oral mucosa and nasal mucosa, in epithelial tissue, enter blood circulation (for the first time viremia) after a large amount of propagation, involve the parotid gland and some tissues and propagation therein through blood flow, again enter blood circulation (for the second time viremia), invade some internal organs that involved last time.
In treatment, doctor trained in Western medicine there is no specific medicament at present, and general recommendations is treated with tcm methods, only is the pyogenic parotitis that directed toward bacteria causes, can use heavy dose of antibacterials to treat, but this also can cause causing at present extensive concern " abuse of antibiotics problem ".The traditional Chinese medical science then can adopt the method for cleansing pyretic toxicity, the loose heresy of dispelling wind, detumescence softening the hard mass according to this card according to the intrinsic treatment principle of being good at of the traditional Chinese medical science, and effect is extremely good good, stable, and has no side effect.Therefore, has suitable advantage with the Chinese medicine epidemic infection with swollen head at present.
Summary of the invention
The object of the present invention is to provide the pharmaceutical composition of the good treatment epidemic infection with swollen head of a kind of drug effect, and its production and use.
The invention provides a kind of pharmaceutical composition for the treatment of epidemic infection with swollen head, it is the preparation that the crude drug by following weight proportion is prepared from:
Spica Prunellae 17-31 part, Thallus Laminariae (Thallus Eckloniae) 4-8 part, Radix Scutellariae 10-20 part, Rhizoma Coptidis 10-20 part, Radix Et Rhizoma Rhei 3-7 part, Folium Isatidis 8-16 part, Fructus Forsythiae 13-23 part, Radix Isatidis 17-31 part, Lasiosphaera Seu Calvatia 8-16 part, Radix Scrophulariae 17-31 part, Fructus Arctii 8-16 part, Radix Platycodonis 4-8 part, Herba Menthae 5-11 part, Bombyx Batryticatus 8-16 part, Rhizoma Cimicifugae 4-8 part, Radix Bupleuri 4-8 part, Pericarpium Citri Reticulatae 8-16 part, Radix Glycyrrhizae 8-16 part.
Further, it is the preparation that the crude drug by following weight proportion is prepared from:
Spica Prunellae 22-26 part, Thallus Laminariae (Thallus Eckloniae) 5-7 part, Radix Scutellariae 13-17 part, Rhizoma Coptidis 13-17 part, Radix Et Rhizoma Rhei 4-6 part, Folium Isatidis 10-14 part, Fructus Forsythiae 16-20 part, Radix Isatidis 22-26 part, Lasiosphaera Seu Calvatia 10-14 part, Radix Scrophulariae 22-26 part, Fructus Arctii 10-14 part, Radix Platycodonis 5-7 part, Herba Menthae 7-9 part, Bombyx Batryticatus 10-14 part, Rhizoma Cimicifugae 5-7 part, Radix Bupleuri 5-7 part, Pericarpium Citri Reticulatae 10-14 part, Radix Glycyrrhizae 10-14 part.
Further preferably, it is the preparation that the crude drug by following weight proportion is prepared from:
24 parts of Spica Prunellaes, 6 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 5 parts of Radix Et Rhizoma Rhei, 12 parts of Folium Isatidiss, 18 parts of Fructus Forsythiaes, 24 parts of Radix Isatidis, 12 parts of Lasiosphaera Seu Calvatia, 24 parts of Radix Scrophulariaes, 12 parts of Fructus Arctiis, 6 parts of Radix Platycodoniss, 8 parts of Herba Menthaes, 12 parts of Bombyx Batryticatus, 6 parts of Rhizoma Cimicifugaes, 6 parts of Radix Bupleuri, 12 parts of Pericarpium Citri Reticulataes, 12 parts in Radix Glycyrrhizae.
Wherein, described pharmaceutical composition is to be active component by the water of the crude drug of described weight proportion or extractive with organic solvent, adds the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
Wherein, described preparation is oral Preparation.
Further, described oral Preparation is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises following operating procedure:
(1) by described weight proportion weighting raw materials;
(2) add be decocted first other each medicines except Herba Menthae, Radix Et Rhizoma Rhei of water, rear lower Herba Menthae, Radix Et Rhizoma Rhei merge decocting liquid, concentrated after, add that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment epidemic infection with swollen head.
Wherein, described medicine be treatment because of experience the evil poison of pathogenic wind-warm, heat very fire-transformation, hold back the few sun of resistance, Yangming Channel arteries and veins, strongly fragrantly do not fall apart, on attack the cheek, due to epidemic infection with swollen head or the medicine of its complication.
Wherein, described medicine is the medicine for the treatment of mumps or pyogenic parotitis.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " the compound compatibility medication is as using military forces " are the traditional Chinese medical science the most effective most scientific several large advantages, wherein " the compound compatibility medication is as using military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arraying troops for battle in the traditional Chinese medical science prescription is its effective means that is better than the Western medicine prescription.The tcm prescription theory is thought, each prescription, not only need to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, the basic structure that also should meet prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism of regulating, this illness of experiencing the evil poison of pathogenic wind-warm, excessive noxious heat of epidemic infection with swollen head is regulated and control, can obtain, the more green natural therapeutic effect that have no side effect better, more lasting than Western medicine, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, and prescription of the present invention is just being followed this principle.
In traditional Chinese medical science traditional theory, epidemic infection with swollen head is because experiencing the evil poison of pathogenic wind-warm, and heat is fire-transformation very, holds back the few sun of resistance, Yangming Channel arteries and veins, and is strongly fragrant and loose, on attack the cheek, and local overflow swollen, pain appear, even hyperpyrexia, irritated headache, the symptoms such as dysmasesis.Therefore, according to original theory and the rule of differentiation of tcm, the present invention uses the method for cleansing pyretic toxicity, the loose heresy of dispelling wind, detumescence softening the hard mass, the prescription of prescription such as pharmaceutical composition of the present invention.To usurp authority heat-clearing and toxic substances removing and can suppress viral Radix Isatidis as monarch drug, close ministerial drug Folium Isatidis, the Fructus Forsythiae heat-clearing and toxic substances removing in left hall in the side, Radix Scutellariae, Rhizoma Coptidis, Radix Et Rhizoma Rhei are cleansed pyretic toxicity; The ministerial drug Herba Menthae in right hall, Bombyx Batryticatus, Rhizoma Cimicifugae, the loose heresy of Radix Bupleuri dispelling wind.The auxiliary monarch drug of two hall ministerial drugs is intended to eliminate pathogenic main cause about above.Adjuvant drug then is divided into three the tunnel: left road adjuvant drug Radix Platycodonis, Fructus Arctii, Pericarpium Citri Reticulatae using pungent drugs for dispersion and bitter drugs for purgation lung qi, close Radix Glycyrrhizae with throat; Right wing adjuvant drug Lasiosphaera Seu Calvatia, Radix Scrophulariae be heat-clearing and toxic substances removing not only, also is longer than the sore-throat relieving mass dissipating and swelling eliminating; Mid-way adjuvant drug is then played the leading role in by the Spica Prunellae of being good at the few sun of removing summer-heat, pathogenic fire reducing eliminating stagnation and the Thallus Laminariae (Thallus Eckloniae) of attacking the knot softening the hard mass, to solve tumefaction of parotid, pain problem.Make the medicine Radix Glycyrrhizae, except the removing summer-heat relieving spasm to stop pain being arranged, brings up the effect of healthy energy persistent erection of the penis, but also coordinating the actions of various ingredients in a prescription for making.Below respectively organize the flavour of a drug post clearly demarcated, complement each other, given full play to the sexology research methodology marrow of analyzing mentally as the exclusive compound compatibility medication of Chinese medicine is structured the formation such as row army, therefore can obtain good efficacy.
Pharmaceutical composition of the present invention can effectively be eliminated all kinds of symptom of epidemic infection with swollen head, and is good to the cure rate of epidemic infection with swollen head, for clinical application provides a kind of new selection.
The specific embodiment
The preparation of embodiment 1 pharmaceutical composition of the present invention
Get Spica Prunellae 24 grams, Thallus Laminariae (Thallus Eckloniae) 6 grams, Radix Scutellariae 15 grams, Rhizoma Coptidis 15 grams, Radix Et Rhizoma Rhei 5 grams, Folium Isatidis 12 grams, Fructus Forsythiae 18 grams, Radix Isatidis 24 grams, Lasiosphaera Seu Calvatia 12 grams, Radix Scrophulariae 24 grams, Fructus Arctii 12 grams, Radix Platycodonis 6 grams, Herba Menthae 8 grams, Bombyx Batryticatus 12 grams, Rhizoma Cimicifugae 6 grams, Radix Bupleuri 6 grams, Pericarpium Citri Reticulatae 12 grams, Radix Glycyrrhizae 12 grams.Each flavour of a drug takes by weighing according to quantity, uses respectively clean gauze monolayer or double wrapped for subsequent use Herba Menthae and Radix Et Rhizoma Rhei.Mix the water purification with capacity, other each medicines except Herba Menthae, Radix Et Rhizoma Rhei of being decocted first, change 15 minutes to 20 minutes at a simmer after boiling after, add again Herba Menthae, Radix Et Rhizoma Rhei, after being fried boiling again 8～10 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, merge each time decocting liquid, namely get decoction.
The preparation of embodiment 2 pharmaceutical compositions of the present invention
Get Spica Prunellae 31 grams, Thallus Laminariae (Thallus Eckloniae) 4 grams, Radix Scutellariae 10 grams, Rhizoma Coptidis 10 grams, Radix Et Rhizoma Rhei 3 grams, Folium Isatidis 8 grams, Fructus Forsythiae 13 grams, Radix Isatidis 17 grams, Lasiosphaera Seu Calvatia 8 grams, Radix Scrophulariae 17 grams, Fructus Arctii 8 grams, Radix Platycodonis 4 grams, Herba Menthae 5 grams, Bombyx Batryticatus 8 grams, Rhizoma Cimicifugae 4 grams, Radix Bupleuri 4 grams, Pericarpium Citri Reticulatae 8 grams, Radix Glycyrrhizae 8 grams.Prepare decoction by embodiment 1 method, concentrated after, granulate after adding proper starch, dextrin mixing.
The preparation of embodiment 3 pharmaceutical compositions of the present invention
Get Spica Prunellae 17 grams, Thallus Laminariae (Thallus Eckloniae) 8 grams, Radix Scutellariae 20 grams, Rhizoma Coptidis 20 grams, Radix Et Rhizoma Rhei 7 grams, Folium Isatidis 16 grams, Fructus Forsythiae 23 grams, Radix Isatidis 31 grams, Lasiosphaera Seu Calvatia 16 grams, Radix Scrophulariae 31 grams, Fructus Arctii 16 grams, Radix Platycodonis 8 grams, Herba Menthae 11 grams, Bombyx Batryticatus 16 grams, Rhizoma Cimicifugae 8 grams, Radix Bupleuri 8 grams, Pericarpium Citri Reticulatae 16 grams, Radix Glycyrrhizae 16 grams.Prepare decoction by embodiment 1 method, concentrated after, drying adds after an amount of dextrin, soluble starch granulate, tabletting namely gets tablet.
The preparation of embodiment 4 pharmaceutical compositions of the present invention
Get Spica Prunellae 22 grams, Thallus Laminariae (Thallus Eckloniae) 7 grams, Radix Scutellariae 17 grams, Rhizoma Coptidis 17 grams, Radix Et Rhizoma Rhei 6 grams, Folium Isatidis 14 grams, Fructus Forsythiae 20 grams, Radix Isatidis 26 grams, Lasiosphaera Seu Calvatia 14 grams, Radix Scrophulariae 26 grams, Fructus Arctii 14 grams, Radix Platycodonis 7 grams, Herba Menthae 9 grams, Bombyx Batryticatus 14 grams, Rhizoma Cimicifugae 7 grams, Radix Bupleuri 7 grams, Pericarpium Citri Reticulatae 14 grams, Radix Glycyrrhizae 14 grams.Prepare decoction by embodiment 1 method, merging filtrate after concentrated, the drying, adds an amount of microcrystalline Cellulose, and is encapsulated behind the mixing, namely gets capsule.
The preparation of embodiment 5 pharmaceutical compositions of the present invention
Get Spica Prunellae 26 grams, Thallus Laminariae (Thallus Eckloniae) 5 grams, Radix Scutellariae 13 grams, Rhizoma Coptidis 13 grams, Radix Et Rhizoma Rhei 4 grams, Folium Isatidis 10 grams, Fructus Forsythiae 16 grams, Radix Isatidis 22 grams, Lasiosphaera Seu Calvatia 10 grams, Radix Scrophulariae 22 grams, Fructus Arctii 10 grams, Radix Platycodonis 5 grams, Herba Menthae 7 grams, Bombyx Batryticatus 10 grams, Rhizoma Cimicifugae 5 grams, Radix Bupleuri 5 grams, Pericarpium Citri Reticulatae 10 grams, Radix Glycyrrhizae 10 grams.With the 70%v/v ethanol extraction, merge ethanol extract first, behind the Recycled ethanol, the gained alcohol-extracted extract is for subsequent use; Medicinal residues decoct with water 2 times again, merge decocting liquid, and after concentrating, the gained the water extracted immersing paste is for subsequent use; Alcohol-extracted extract, the water extracted immersing paste are merged, after the drying, pulverize, cross 80 mesh sieves, each composition mix homogeneously is for subsequent use;
Get an amount of Macrogol 4000, after the melting, in the medicine adding melting substrate with above-mentioned mix homogeneously, 75-85 ℃ of lower insulation; Adopt pill dripping machine, it is splashed in the dimethicone, collect drop pill, namely get drop pill.
Below specify beneficial effect of the present invention by test example.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accepts patient's situation for medical treatment
Patient age and sex scope: mainly in the majority with child and teenager, but the adult is also arranged, there are men and women for sex, possesses following symptom feature (possess part and get final product, needn't also can not fully all possess), accepts altogether 21 examples for medical treatment.
Symptom feature:
Be generally: more anxious except onset, outside the whole body loathing of cold, the heating, also have Head And Face to lift the red primary symptom that swells and ache.Some patients or companion have sore throat, and the aversion to cold that continues then gradually stops and the calorific potential benefit increases, thirst and drinking, dysphoria, Tou Mian burning swelling, the aggravation of having sore throat, but the less nutrient blood syndrome that occurs caving in.On the tongue arteries and veins, general red tongue with yellow fur, rapid and forceful pulse.In a word, enlargement and pain are symptom the earliest under the ear, small number of patients is before 1 to 2 day of parotid gland enlargement, the general malaise symptom such as fever (body temperature can reach 39～40 ℃) occurs, have a headache, vomit, be off one's feed, then just occur on one side or the pain under the ear of both sides, the parotid gland is swollen with and, and surface skin is nervous, shinny, not red, heating, pain are obvious, dehisces or increases the weight of when eating sour thing.Usually then a before this side parotid gland enlargement develops into bilateral, but also can see bilateral parotid simultaneously enlargement.On the mucosa of the other buccal of upper jaw second molar, can see the orifice of parotid duct of enlargement, discharge without purulent secretion.
Or: the performances such as the body temperature moderate increases, headache, muscular soreness are arranged, but parotid gland enlargement still is first sign, continue about 7 days to 10 days, a normal side parotid gland is swollen first, enlargement also appears in the offside parotid gland after 2 days to 3 days, sometimes swelling only is one-sided, the characteristics of parotid gland enlargement are centered by ear-lobe, to forward and backward, lower expansion, blur margin, the flexible sense of touching, pain and tenderness are arranged, and surface skin is not red, and hotness can be arranged, dehisce, chew that the pain increased when particularly eating acidic food, common orifice of parotid duct is red and swollen.Swell and ache and peaked in the time of 3 days to 5 days, the pharyngeal and soft palate of homonymy can have swelling, and tonsil is shifted to the midline, and the laryngeal edema also can occur, and chest also edema can occur, the accidental red grouper pimple of trunk or urticaria.
Or: patient's pancreas, meninges, brain, liver and the heart that has all can be subject to infringement in various degree, and its serious harm to body is not limited in the parotid gland itself, cause complication but can invade nearly all organs such as various glandular tissues or nervous system and liver, kidney, the heart, joint because of its virus, common person has meningoencephalitis, orchitis, oophoritis, pancreatitis, mastitis etc.
Usually all because experience the evil poison of pathogenic wind-warm in positive QI-insufficiency, heat is fire-transformation very for above-mentioned symptom and sufferer, holds back few positive, the Yangming Channel arteries and veins of resistance, and is strongly fragrant and do not fall apart, on attack due to the cheek.
(2) treatment standard
Recovery from illness: the complete obiteration of above-mentioned symptom characteristics, it is unusual that check has no index of correlation.
Evident in efficacy: above-mentioned symptom obviously alleviates, and test rating has certain degree to improve simultaneously.
Certain effect is arranged: patient's symptom alleviates to some extent, or index slightly is improved.
Invalid: symptom remains unchanged, and index not to be improved.
(3) Therapeutic Method
1, embodiment 1 made decoction, each serving with 200 to 400ml, or daily 1 bowl in the used rice bowl of having a meal (child dose by age cuts down according to the circumstance, take medicine by the preceding method dosing of cutting down according to the circumstance, but need to drink to add and day take number of times), the first day took once every 3 hours to 4 hours, took once every 4 hours to 6 hours from next day, took according to quantity on time.
2, note also science conditioning daily life, observe some necessary points for attention, as:
⑴ for the infectious parotitis in the epidemic infection with swollen head, and at first should pay attention to prevention and stop infecting: epidemic period is not participated in large-scale collective activity, avoids the many places of people as far as possible; The patient will separate isolation with Healthy People, should be partitioned to swelling of parotid gland and disappear just can start going to a nursery or go to school afterwards fully, in order to avoid infect to other people; Patient's food service items will with other people separate, and scalding regularly; The article such as its clothes, bedding can place outdoor tanning by the sun; The things such as washbowl, towel, handkerchief need to scald 1 to 2 time with boiled water every day.
⑵ will regulate diet: because parotid gland enlargement, therefore the feed difficulty will eat half liquid food or soft diet being rich in nutrition, that be easy to digest, such as gruel, dough sheet soup, egg custard etc.Do not eat vinegar-pepper, sweet taste and stiff food (particularly acidic food), in order to avoid the saliva stimulating glandular secretion increases the weight of swelling and ache of the parotid gland.Want suitably to keep the skin wet more, be beneficial to the discharge of vivotoxin.Do not drink, smoke (especially adult patient), do not eat the food of " the Sheng Resheng expectorant of getting angry " such as pungent frying, delicious food savoury and cattle and sheep Carnis Canitis, eat fresh, light and more nutritious food more.
⑶ will note abundant rest, regularity living.
⑷ shelter is wanted circulation of air, the timing ventilation ventilation, keeps air fresh.
⑸ will stress health: note keeping oral hygiene, gargle through warm saline commonly used or compound recipe borax solution, to remove intraoral food debris, prevent the Secondary cases antibacterial and infect.Family is available 0.2% peracetic acid disinfectant then.
⑹ apply a hot compress to the affected part with the hot water bag of the clean towel of outsourcing, can assist to alleviate affected part pain.
⑺ Timing measurement body temperature, in case of necessity (above 39 ℃) can adopt the head cold compress, with physical method auxiliary temperature-reducings such as warm water or alcohol baths.
⑻ want close observation to have or not complication to occur, as: if acute high fever companion severe headache, vomiting, drowsiness or disturbance of consciousness appear in the patient, the meningeal irritation sign positive etc. should be watched out for meningitis or meningoencephalitis, must in time go to a doctor and check treatment.The virus of mumps is invaded well ripe reproduction body of gland, thus after 13～14 years old and postpubescence and adult patient danger can increase.Orchitis was common in behind the mumps about a week, was generally the high heat of burst, shiver with cold, painful and swollen testis, companion and acutely touched a tender spot, and the severe one skin of scrotum is remarkable edema now, and yellow hydrops is arranged in the cavity of tunica vaginalis, and pathological changes is only invaded a side mostly.If the male patient finds testicular pain, the binder of available cleaning or T-shaped strap hold up scrotum, to ease the pain; If there is swollen testis, during with the tenderness sense, the clean towel cold compress that available cold water soaked is local, then testis is held up, to improve local symptom.The concurrent general symptom of oophoritis of female patient is lighter, does not affect and becomes pregnant, and main manifestations is rapid rise fear of cold, heating, hypogastric region or waist and sacrum pain, and vaginal secretions increases, the menstrual cycle imbalance, severe patient can touch the ovary of enlargement, with tenderness.
(4) therapeutic outcome
In medicine composite for curing primary disease men and women patient 21 examples of the present invention (mainly in the majority with child and teenager), obtained good curative effect between many decades.Treatment time, difference according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and slightly to some extent, generally can obviously alleviate 2 days～4 days left and right sides symptoms, the various symptoms in the left and right sides then can disappear entirely in 10 days to 15 days, by above-mentioned science conditioning daily life, sincerely abide by points for attention, can more thoroughly cure and seldom develop complications.
By the aforementioned therapies standard, 21 routine patients fully recover totally, and cure rate reaches 100%, and is respond well.
Model case
The patient, the woman, 11 years old, the student, infant is felt dizzy pain, nausea, uncomfortable, its body temperature is 38.5 ℃.Next day, enlargement under the ear of infant left side, conscious pain.See the swelling of the infant cheek, blur margin, skin is shinny, heating and not rubescent, the flexible and tension of touching.Pain under its readme ear, dehisce and when taking food more very, aversion to cold, vexed, pharyngalgia, thirsty, loss of appetite, yellow urine, 39 ℃ of body temperature are examined its arteries and veins, several, real slightly stringy pulse, red tongue with thin and yellow fur is epidemic infection with swollen head.Bestow pharmaceutical composition of the present invention (embodiment 1 preparation), and sternly abide by the method for administration of above-mentioned " Therapeutic Method " it " 1 " and science conditioning and the points for attention of " 2 ".After infant was taken medicine 2, pain obviously alleviated, and other symptoms are also extenuated to some extent, and tongue is still red, but yellow fur seldom, and pulse condition is counted in fact.Advise it to continue to take, the conditioning as before.Pain and each symptom alleviate gradually, after 1 week, only take medicine its every day 2 times, to being permitted in two weeks, swell and ache and entirely remove, and all the other all symptoms are also lost to the greatest extent, more occur without any complication.By health check-up no abnormality seen index, follow up a case by regular visits to also not recurrence.
Brief summary:
(1) pharmaceutical composition of the present invention can effectively be eliminated because experiencing the evil poison of pathogenic wind-warm, and heat is fire-transformation very, holds back the few sun of resistance, Yangming Channel arteries and veins, strongly fragrant and loose, on attack the cheek, cause local overflow swollen, pain, even hyperpyrexia, irritated headache, the epidemic infection with swollen head of dysmasesis and similar TCM Syndrome Type and symptom.
(2) the former side's treatment of the clinical use of inventor pharmaceutical composition of the present invention and puji xiaodu drink primary disease many decades finds that the effect of pharmaceutical composition of the present invention is obviously better than the former side of puji xiaodu drink, is mainly manifested in following aspect:
1. within identical treatment time, use pharmaceutical composition of the present invention can reach 100% recovery from illness, use the former side of puji xiaodu drink then approximately to have 10% patient to fail to fully recover.
2. after the patient's administration to close body constitution, find that the former side's of puji xiaodu drink treatment time is longer 5～7 days than the present invention pharmaceutical composition, this just shows that pharmaceutical composition healing time of the present invention is shorter.
In sum, pharmaceutical composition of the present invention can effectively be eliminated all kinds of symptom of epidemic infection with swollen head, and is good to the cure rate of epidemic infection with swollen head, for clinical application provides a kind of new selection.
Claims (10)
1. pharmaceutical composition for the treatment of epidemic infection with swollen head is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:
Spica Prunellae 17-31 part, Thallus Laminariae (Thallus Eckloniae) 4-8 part, Radix Scutellariae 10-20 part, Rhizoma Coptidis 10-20 part, Radix Et Rhizoma Rhei 3-7 part, Folium Isatidis 8-16 part, Fructus Forsythiae 13-23 part, Radix Isatidis 17-31 part, Lasiosphaera Seu Calvatia 8-16 part, Radix Scrophulariae 17-31 part, Fructus Arctii 8-16 part, Radix Platycodonis 4-8 part, Herba Menthae 5-11 part, Bombyx Batryticatus 8-16 part, Rhizoma Cimicifugae 4-8 part, Radix Bupleuri 4-8 part, Pericarpium Citri Reticulatae 8-16 part, Radix Glycyrrhizae 8-16 part.
2. pharmaceutical composition according to claim 1 is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:
Spica Prunellae 22-26 part, Thallus Laminariae (Thallus Eckloniae) 5-7 part, Radix Scutellariae 13-17 part, Rhizoma Coptidis 13-17 part, Radix Et Rhizoma Rhei 4-6 part, Folium Isatidis 10-14 part, Fructus Forsythiae 16-20 part, Radix Isatidis 22-26 part, Lasiosphaera Seu Calvatia 10-14 part, Radix Scrophulariae 22-26 part, Fructus Arctii 10-14 part, Radix Platycodonis 5-7 part, Herba Menthae 7-9 part, Bombyx Batryticatus 10-14 part, Rhizoma Cimicifugae 5-7 part, Radix Bupleuri 5-7 part, Pericarpium Citri Reticulatae 10-14 part, Radix Glycyrrhizae 10-14 part.
3. pharmaceutical composition according to claim 2 is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:
24 parts of Spica Prunellaes, 6 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 5 parts of Radix Et Rhizoma Rhei, 12 parts of Folium Isatidiss, 18 parts of Fructus Forsythiaes, 24 parts of Radix Isatidis, 12 parts of Lasiosphaera Seu Calvatia, 24 parts of Radix Scrophulariaes, 12 parts of Fructus Arctiis, 6 parts of Radix Platycodoniss, 8 parts of Herba Menthaes, 12 parts of Bombyx Batryticatus, 6 parts of Rhizoma Cimicifugaes, 6 parts of Radix Bupleuri, 12 parts of Pericarpium Citri Reticulataes, 12 parts in Radix Glycyrrhizae.
4. the described pharmaceutical composition of any one according to claim 1～3, it is characterized in that: described pharmaceutical composition is to be active component by the water of the crude drug of described weight proportion or extractive with organic solvent, adds the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
5. the described pharmaceutical composition of any one according to claim 1-4, it is characterized in that: described preparation is oral Preparation.
6. pharmaceutical composition according to claim 5, it is characterized in that: described oral Preparation is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
7. the preparation method of the described pharmaceutical composition of claim 1～6 any one, it is characterized in that: it comprises following operating procedure:
(1) by described weight proportion weighting raw materials;
(2) add be decocted first other each medicines except Herba Menthae, Radix Et Rhizoma Rhei of water, rear lower Herba Menthae, Radix Et Rhizoma Rhei merge decocting liquid, concentrated after, add that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
8. the purposes of the described pharmaceutical composition of claim 1～6 any one in the medicine of preparation treatment epidemic infection with swollen head.
9. described purposes according to claim 8 is characterized in that: described medicine be treatment because of experience the evil poison of pathogenic wind-warm, heat very fire-transformation, hold back the few sun of resistance, Yangming Channel arteries and veins, strongly fragrantly do not fall apart, on attack the cheek, due to epidemic infection with swollen head or the medicine of its complication.
10. described purposes according to claim 8, it is characterized in that: described medicine is the medicine for the treatment of mumps or pyogenic parotitis.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623195A (en) * | 2013-11-28 | 2014-03-12 | 黄立新 | Medicine for treating epidemic parotitis |
| CN103656148A (en) * | 2013-12-27 | 2014-03-26 | 丁丽 | Traditional Chinese medicine formula for treating mumps |
| CN104189244A (en) * | 2014-08-19 | 2014-12-10 | 李新民 | Formula for treating epidemic parotitis |
| CN105168554A (en) * | 2015-09-10 | 2015-12-23 | 宋克垣 | Medicine for treating mumps and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389517A (en) * | 2011-11-26 | 2012-03-28 | 周秀玲 | Traditional Chinese medicine for treating fever with swollen head |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389517A (en) * | 2011-11-26 | 2012-03-28 | 周秀玲 | Traditional Chinese medicine for treating fever with swollen head |
Non-Patent Citations (1)
| Title |
|---|
| 苑述刚: "阮时宝教授应用普济消毒饮的经验介绍", 《陕西中医学院学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623195A (en) * | 2013-11-28 | 2014-03-12 | 黄立新 | Medicine for treating epidemic parotitis |
| CN103656148A (en) * | 2013-12-27 | 2014-03-26 | 丁丽 | Traditional Chinese medicine formula for treating mumps |
| CN104189244A (en) * | 2014-08-19 | 2014-12-10 | 李新民 | Formula for treating epidemic parotitis |
| CN105168554A (en) * | 2015-09-10 | 2015-12-23 | 宋克垣 | Medicine for treating mumps and preparation method thereof |
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| CN103041030B (en) | 2014-05-14 |
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