CN103028066B

CN103028066B - Traditional Chinese medicine composition for treating ankylosing spondylitis

Info

Publication number: CN103028066B
Application number: CN201210558828.XA
Authority: CN
Inventors: 余兰; 周瑾
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-12-20
Filing date: 2012-12-20
Publication date: 2014-04-23
Anticipated expiration: 2032-12-20
Also published as: CN103028066A

Abstract

The invention discloses a traditional Chinese medicine composition for treating ankylosing spondylitis, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition for treating the ankylosing spondylitis comprises the following medicinal raw materials in part by weight: 10 parts of mulberry twig, 6 parts of radix aconiti, 8 parts of erycibe obtusifolia, 10 parts of tortoise shell, 8 parts of herba epimedii, 9 parts of achyranthes bidentata, 9 parts of notopterygium root, 12 parts of rhizoma smilacis glabrae, 12 parts of lycopodium clavatum, 8 parts of cistanche deserticola, 9 parts of pyrola, 12 parts of pseudoginseng, 10 parts of cortex lycii radicis, 6 parts of little multibanded krait and 8 parts of processed rehmannia. The traditional Chinese medicine composition uses natural Chinese herbs as the raw materials, is accurate in therapeutic effect and free of toxic side effect, can effectively cure the ankylosing spondylitis with difficulty in relapse, and the effective rate of 96%.

Description

A kind of Chinese medicine composition for the treatment of ankylosing spondylitis

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of ankylosing spondylitis, belong to the field of Chinese medicines.

Background technology

Ankylosing spondylitis (ankylosing spondylitis, AS) is a kind of chronic inflammatory disease, mainly invades sacroiliac joint, spinal column apophysis, the other soft tissue of spinal column and periphery joint, and the extra-articular manifestation that can occur together.Clinical main manifestations is waist, the back of the body, neck, buttocks, hip pain and arthralgia, and deformity of spine and ankylosis can occur severe patient.The common morbidity crowd age, average age of onset was 25 years old between 10～40 years old, and women's sickness rate is low compared with male, and the ratio of men and women's sickness rate is (2-3): 1.

AS insidious onset, patient engenders buttocks hip or low-back pain and/or sends out stiffly, especially, to crouch for a long time (night) or to sit when of a specified duration obviously, stands up difficulty, rises morning or sitting plays immediately waist and sends out obviously stiffly, but alleviates after activity.Some patients feel buttocks hip severe pain, radiate once in a while to periphery.Disease early pain is many is discontinuity in a side, and after the several months, pain is many is persistence at bilateral.With disease progression pathological changes, by sacroiliac joint, to lumbar vertebra, breast cervical vertebra, developed, occur corresponding site pain, limitation of activity or deformity of spine.

At present, AS there is no radical cure method.Patient is by Comprehensive Treatments such as non-medicine, medicine and operations, and alleviating pain and a deadlock, control or reduce inflammation, keep at ordinary times good posture, prevent spinal column or joint deformity, and correction deformity joint if desired, to reach the object of improving patients ' life quality.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine composition that can effectively treat ankylosing spondylitis, this Chinese medicine preparation can effectively be treated ankylosing spondylitis, determined curative effect and difficult recurrence.

Technical scheme of the present invention is:

Treating a Chinese medicine composition for ankylosing spondylitis, is to be made by the crude drug of following weight parts: Ramulus Mori 10, Radix Aconiti 6, Caulis Erycibes 8, Carapax Et Plastrum Testudinis 10, Herba Epimedii 8, Radix Achyranthis Bidentatae 9, Rhizoma Et Radix Notopterygii 9, Rhizoma Smilacis Glabrae 12, Herba Lycopodii 12, Herba Cistanches 8, Herba Pyrolae 9, Radix Notoginseng 12, Cortex Lycii 10, Bungarus Parvus 6, Radix Rehmanniae Preparata 8.

Single dose dose (unit: gram): Ramulus Mori 10, Radix Aconiti 6, Caulis Erycibes 8, Carapax Et Plastrum Testudinis 10, Herba Epimedii 8, Radix Achyranthis Bidentatae 9, Rhizoma Et Radix Notopterygii 9, Rhizoma Smilacis Glabrae 12, Herba Lycopodii 12, Herba Cistanches 8, Herba Pyrolae 9, Radix Notoginseng 12, Cortex Lycii 10, Bungarus Parvus 6, Radix Rehmanniae Preparata 8.

Preparation and instructions of taking: be decocted in water for oral dose, every day, potion, divided twice one after each meal sooner or later.

The pharmacological action of each Chinese medicine:

Ramulus Mori: micro-hardship, flat.Return Liver Channel.Effect with cure mainly: wind-damp dispelling, sharp joint.Be used for takeing on arm, joint aches numbness.

Radix Aconiti: pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Effect with cure mainly: expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.

Caulis Erycibes: pungent, temperature; Slightly poisonous.Return liver, spleen, stomach warp.Effect with cure mainly: expelling wind and removing dampness, reducing swelling and alleviating pain.For rheumatic arthralgia, hemiplegia, tumbling and swelling.

Carapax Et Plastrum Testudinis: salty, sweet, be slightly cold.Return liver, kidney, heart channel.Effect with cure mainly: nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.

Herba Epimedii: acrid, sweet, warm.Return liver, kidney channel.Effect with cure mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.

Radix Achyranthis Bidentatae: bitter, sour, flat.Return liver, kidney channel.Effect with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea and mass in the abdomen, dizziness due to hyperactivity of liver-YANG.

Rhizoma Et Radix Notopterygii: pungent, bitter, temperature.Return bladder, kidney channel.Effect with cure mainly: cold expelling, dispel the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.

Rhizoma Smilacis Glabrae: sweet, light, flat.Return liver, stomach warp.Effect with cure mainly: dehumidifying, removing toxic substances, easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula disease, scabies, the limbs contracture due to syphilis and mercurialism, bones and muscles pain.

Herba Lycopodii: micro-hardship, pungent, temperature.Return liver,spleen,kidney warp.Effect with cure mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.

Herba Cistanches: sweet, salty, temperature.Return kidney, large intestine channel.Effect with cure mainly: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.

Herba Pyrolae: sweet, bitter, temperature.Return liver, kidney channel.Effect with cure mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.

Radix Notoginseng: sweet, micro-hardship, temperature.Return liver, stomach warp.Effect with cure mainly: dissipating blood stasis hemostasis, subduing swelling and relieving pain.For spitting of blood, to spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.

Cortex Lycii: sweet, cold.Return lung, liver, kidney channel.Effect with cure mainly: removing heat from blood except steam, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.

Bungarus Parvus: sweet, salty, temperature; Poisonous.Return Liver Channel.Effect with cure mainly: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Effect with cure mainly: nourishing YIN and supplementing blood, beneficial essence is filled out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.

The invention has the beneficial effects as follows: it is raw material that the present invention adopts natural Chinese medicine, determined curative effect and having no side effect, can effectively cure ankylosing spondylitis and be difficult for recurrence, and effective percentage reaches 96%.

Below in conjunction with clinical trial and model case, the present invention is further described.

One, clinical trial

1, clinical data: in 2010, between December to 2011 year December, choose at random patients with ankylosing spondylitis 100 examples of 15～56 years old, be divided at random two groups for the treatment of group and matched groups, wherein, and treatment group 50 examples, male's 32 examples, women's 18 examples, the mean age is 25.4 years old; Matched group 50 examples, male's 34 examples, women's 16 examples, the mean age is 25.8 years old.

2, diagnostic criteria:

(1), symptom: take both sides sacroiliac joint, lower back repeatedly pain as main;

(2), sign.Early, patient's spinal column activity in mid-term is limited in various degree, patients with terminal spinal column occurs that tetanic property is bow-backed fixing, thorax mobility reduces or disappears;

(3), lab testing.Erythrocyte sedimentation rate speeds more, rheumatoid factor negative, the HLA-B27 positive;

(4), x-ray inspection has typical case's change of ankylosing spondylitis and sacroiliitis.Early stage: sacroiliac joint gap is fuzzy, and slightly fine and close, joint space broadening.Mid-term: joint space is narrow, edge, joint hypertrophy with corrode staggered, indentation, the broadening of ilium side seam compact zone, the widelyst reaches 3 centimetres.In late period: joint space disappears, bone compact zone disappears, and bone trabecula passes through, and has been bony ankylosis.

3, Therapeutic Method: treatment group is taken medicine of the present invention, and every day is oral meal at twice; Matched group is taken sulfasalazine and methotrexate, each 0.5g, and every day is oral meal at twice.

4, efficacy assessment standard:

Cure: heavy stiff transference cure, sacroiliac joint and each arthralgia symptom disappear, and arthroncus disappears, and joint motion is freely; Each joint positive sign disappears, and it is normal that each joint physiological function is recovered.

Effective: heavy stiff symptom is clearly better, and sacroiliac joint and each arthralgia symptom are clearly better, and arthroncus is clearly better, and joint motion obviously improves; Each joint positive sign is clearly better, and each function of joint is obviously recovered.

Effective: heavy stiff symptom takes a turn for the better, and sacroiliac joint and each arthralgia symptom take a turn for the better, and arthroncus takes a turn for the better, and joint motion improves; Each joint positive sign alleviates, and each function of joint is improved.

Invalid: heavy stiff symptom is without improvement, and sacroiliac joint and each arthralgia symptom are without improvement, and arthroncus is unchanged; Each joint positive sign is without improvement, and each function of joint is unchanged.

5, therapeutic outcome:

?	Cure	Effective	Effectively	Invalid	Total effective rate %
						Treatment group	29	13	6	2	96%
Matched group	6	10	16	18	64%

The specific embodiment

Embodiment

Proportioning (unit: gram): Ramulus Mori 10, Radix Aconiti 6, Caulis Erycibes 8, Carapax Et Plastrum Testudinis 10, Herba Epimedii 8, Radix Achyranthis Bidentatae 9, Rhizoma Et Radix Notopterygii 9, Rhizoma Smilacis Glabrae 12, Herba Lycopodii 12, Herba Cistanches 8, Herba Pyrolae 9, Radix Notoginseng 12, Cortex Lycii 10, Bungarus Parvus 6, Radix Rehmanniae Preparata 8.

Claims

1. treat a Chinese medicine composition for ankylosing spondylitis, it is characterized in that being made by the crude drug of following weight parts: Ramulus Mori 10, Radix Aconiti 6, Caulis Erycibes 8, Carapax Et Plastrum Testudinis 10, Herba Epimedii 8, Radix Achyranthis Bidentatae 9, Rhizoma Et Radix Notopterygii 9, Rhizoma Smilacis Glabrae 12, Herba Lycopodii 12, Herba Cistanches 8, Herba Pyrolae 9, Radix Notoginseng 12, Cortex Lycii 10, Bungarus Parvus 6, Radix Rehmanniae Preparata 8.