CN103028046B - 用于治疗萎缩性鼻炎的中药组合物及其制备方法 - Google Patents
用于治疗萎缩性鼻炎的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN103028046B CN103028046B CN201210594232.5A CN201210594232A CN103028046B CN 103028046 B CN103028046 B CN 103028046B CN 201210594232 A CN201210594232 A CN 201210594232A CN 103028046 B CN103028046 B CN 103028046B
- Authority
- CN
- China
- Prior art keywords
- radix
- weight portions
- weight portion
- weight
- volatile oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 191
- 239000000203 mixture Substances 0.000 title claims abstract description 107
- 201000008283 Atrophic Rhinitis Diseases 0.000 title claims abstract description 38
- 206010039088 Rhinitis atrophic Diseases 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims description 23
- 210000000582 semen Anatomy 0.000 claims abstract description 66
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241001438943 Callicarpa kwangtungensis Species 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 140
- 239000000341 volatile oil Substances 0.000 claims description 90
- 239000000706 filtrate Substances 0.000 claims description 79
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 74
- 239000012153 distilled water Substances 0.000 claims description 67
- 229940079593 drug Drugs 0.000 claims description 65
- 238000003756 stirring Methods 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 34
- 241000628997 Flos Species 0.000 claims description 33
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 33
- 239000007923 nasal drop Substances 0.000 claims description 33
- 239000000843 powder Substances 0.000 claims description 27
- 238000001914 filtration Methods 0.000 claims description 25
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 22
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 22
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 21
- 230000001105 regulatory effect Effects 0.000 claims description 21
- 238000004821 distillation Methods 0.000 claims description 17
- -1 filter Substances 0.000 claims description 17
- 239000002244 precipitate Substances 0.000 claims description 17
- 241000959626 Calvatia Species 0.000 claims description 16
- 239000009670 cang er zi wan Substances 0.000 claims description 15
- 239000002552 dosage form Substances 0.000 claims description 15
- 239000008517 radix Trichosanthis Substances 0.000 claims description 15
- 241001299553 Ilex chinensis Species 0.000 claims description 14
- 241001100935 Ilex purpurea Species 0.000 claims description 14
- 235000003366 Ilex purpurea Nutrition 0.000 claims description 14
- 238000003809 water extraction Methods 0.000 claims description 14
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 11
- 229930006000 Sucrose Natural products 0.000 claims description 11
- 239000005720 sucrose Substances 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 4
- 230000006837 decompression Effects 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 52
- 208000002193 Pain Diseases 0.000 abstract description 29
- 230000036407 pain Effects 0.000 abstract description 26
- 238000000034 method Methods 0.000 abstract description 24
- 208000027418 Wounds and injury Diseases 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 7
- 208000014674 injury Diseases 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 240000005373 Panax quinquefolius Species 0.000 abstract description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract 2
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 2
- 235000011477 liquorice Nutrition 0.000 abstract 2
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 241000928504 Centipeda minima Species 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 241000935235 Fritillaria meleagris Species 0.000 abstract 1
- 235000002710 Ilex cornuta Nutrition 0.000 abstract 1
- 241001310146 Ilex cornuta Species 0.000 abstract 1
- 241000234435 Lilium Species 0.000 abstract 1
- 241001071917 Lithospermum Species 0.000 abstract 1
- 241000218378 Magnolia Species 0.000 abstract 1
- 241000133231 Marshallia caespitosa Species 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 240000005790 Oroxylum indicum Species 0.000 abstract 1
- 235000012920 Oroxylum indicum Nutrition 0.000 abstract 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 244000292697 Polygonum aviculare Species 0.000 abstract 1
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 1
- 241000534017 Saururus chinensis Species 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- 244000067505 Xanthium strumarium Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000012907 honey Nutrition 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 70
- 210000004072 lung Anatomy 0.000 description 70
- 239000008280 blood Substances 0.000 description 69
- 230000001737 promoting effect Effects 0.000 description 36
- 210000001331 nose Anatomy 0.000 description 33
- 210000000952 spleen Anatomy 0.000 description 32
- 206010011224 Cough Diseases 0.000 description 26
- 210000004185 liver Anatomy 0.000 description 26
- 230000017531 blood circulation Effects 0.000 description 24
- 230000007812 deficiency Effects 0.000 description 24
- 241001465754 Metazoa Species 0.000 description 22
- 210000003734 kidney Anatomy 0.000 description 21
- 210000003928 nasal cavity Anatomy 0.000 description 21
- 210000002784 stomach Anatomy 0.000 description 19
- 241000699670 Mus sp. Species 0.000 description 18
- 235000009508 confectionery Nutrition 0.000 description 17
- 239000000284 extract Substances 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 210000002850 nasal mucosa Anatomy 0.000 description 15
- 208000033809 Suppuration Diseases 0.000 description 14
- 206010039509 Scab Diseases 0.000 description 13
- 201000010099 disease Diseases 0.000 description 13
- 230000003203 everyday effect Effects 0.000 description 13
- 230000008569 process Effects 0.000 description 13
- 239000007789 gas Substances 0.000 description 12
- 210000002216 heart Anatomy 0.000 description 12
- 231100000614 poison Toxicity 0.000 description 12
- 230000008961 swelling Effects 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 11
- 206010062717 Increased upper airway secretion Diseases 0.000 description 10
- 210000001015 abdomen Anatomy 0.000 description 10
- 210000004877 mucosa Anatomy 0.000 description 10
- 208000026435 phlegm Diseases 0.000 description 10
- 208000006820 Arthralgia Diseases 0.000 description 9
- 206010028748 Nasal obstruction Diseases 0.000 description 9
- 238000010171 animal model Methods 0.000 description 9
- 239000003440 toxic substance Substances 0.000 description 9
- 241000158526 Nasalis Species 0.000 description 8
- 206010030113 Oedema Diseases 0.000 description 8
- 238000003304 gavage Methods 0.000 description 8
- 238000005469 granulation Methods 0.000 description 8
- 230000003179 granulation Effects 0.000 description 8
- 230000001717 pathogenic effect Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 230000028327 secretion Effects 0.000 description 8
- 206010007247 Carbuncle Diseases 0.000 description 7
- 206010068319 Oropharyngeal pain Diseases 0.000 description 7
- 201000007100 Pharyngitis Diseases 0.000 description 7
- 206010000087 Abdominal pain upper Diseases 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 6
- 231100000111 LD50 Toxicity 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 6
- 208000031971 Yin Deficiency Diseases 0.000 description 6
- 230000002159 abnormal effect Effects 0.000 description 6
- 208000006673 asthma Diseases 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 208000001848 dysentery Diseases 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 210000003800 pharynx Anatomy 0.000 description 6
- 206010040872 skin infection Diseases 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 206010003694 Atrophy Diseases 0.000 description 5
- 208000025747 Rheumatic disease Diseases 0.000 description 5
- 230000037444 atrophy Effects 0.000 description 5
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 230000004087 circulation Effects 0.000 description 5
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- 210000003097 mucus Anatomy 0.000 description 5
- 230000001575 pathological effect Effects 0.000 description 5
- 230000001047 pyretic effect Effects 0.000 description 5
- 230000000552 rheumatic effect Effects 0.000 description 5
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 201000000736 Amenorrhea Diseases 0.000 description 4
- 206010001928 Amenorrhoea Diseases 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 208000019255 Menstrual disease Diseases 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 4
- 206010036790 Productive cough Diseases 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 231100000540 amenorrhea Toxicity 0.000 description 4
- 206010003549 asthenia Diseases 0.000 description 4
- 208000010668 atopic eczema Diseases 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 210000004081 cilia Anatomy 0.000 description 4
- 230000035619 diuresis Effects 0.000 description 4
- 208000001780 epistaxis Diseases 0.000 description 4
- 239000003172 expectorant agent Substances 0.000 description 4
- 230000003419 expectorant effect Effects 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 206010022437 insomnia Diseases 0.000 description 4
- 230000002175 menstrual effect Effects 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 235000019615 sensations Nutrition 0.000 description 4
- 201000009890 sinusitis Diseases 0.000 description 4
- 230000035943 smell Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 230000017423 tissue regeneration Effects 0.000 description 4
- 210000003932 urinary bladder Anatomy 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 3
- 206010013954 Dysphoria Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 3
- 206010039101 Rhinorrhoea Diseases 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 208000006750 hematuria Diseases 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 208000013403 hyperactivity Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 201000003453 lung abscess Diseases 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 230000010355 oscillation Effects 0.000 description 3
- 230000003119 painkilling effect Effects 0.000 description 3
- 230000008506 pathogenesis Effects 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 210000003802 sputum Anatomy 0.000 description 3
- 208000024794 sputum Diseases 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 206010002653 Anosmia Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010726 Conjunctival oedema Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010013952 Dysphonia Diseases 0.000 description 2
- 208000034507 Haematemesis Diseases 0.000 description 2
- 208000000616 Hemoptysis Diseases 0.000 description 2
- 208000010473 Hoarseness Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 238000011887 Necropsy Methods 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 241000447727 Scabies Species 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 2
- 206010043458 Thirst Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 206010048245 Yellow skin Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000002547 anomalous effect Effects 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000000680 avirulence Effects 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 208000017574 dry cough Diseases 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 239000003337 fertilizer Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 description 2
- 238000003958 fumigation Methods 0.000 description 2
- 230000000762 glandular Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000007952 growth promoter Substances 0.000 description 2
- 206010019847 hepatosplenomegaly Diseases 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 231100001252 long-term toxicity Toxicity 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 229940002297 nasacort Drugs 0.000 description 2
- 208000010753 nasal discharge Diseases 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 208000005687 scabies Diseases 0.000 description 2
- 108010048734 sclerotin Proteins 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 231100000041 toxicology testing Toxicity 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 239000002435 venom Substances 0.000 description 2
- 210000001048 venom Anatomy 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 241000707825 Argyrosomus regius Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 206010010970 Cor pulmonale chronic Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 206010050515 Hyposmia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 241000237955 Nassarius Species 0.000 description 1
- 239000008896 Opium Substances 0.000 description 1
- 208000004224 Opium Dependence Diseases 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 206010037596 Pyelonephritis Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 206010040849 Skin fissures Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 235000019558 anosmia Nutrition 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002973 anti-dopamine Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000026636 chronic pulmonary heart disease Diseases 0.000 description 1
- 230000002595 cold damage Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000007937 eating Effects 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 230000008472 epithelial growth Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 235000019559 hyposmia Nutrition 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000011309 nasal bleeding Diseases 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000007436 olfactory function Effects 0.000 description 1
- 229960001027 opium Drugs 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000001944 turbinate Anatomy 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
组别 | 例数 | 鼻黏液纤毛摆动时间(min) | MTR(mm/min) |
治疗组 | 105 | 9.17±0.31 | 9.67±0.82 |
对照组 | 85 | 24.29±1.95 | 3.49±0.17 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210594232.5A CN103028046B (zh) | 2012-12-29 | 2012-12-29 | 用于治疗萎缩性鼻炎的中药组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210594232.5A CN103028046B (zh) | 2012-12-29 | 2012-12-29 | 用于治疗萎缩性鼻炎的中药组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103028046A CN103028046A (zh) | 2013-04-10 |
CN103028046B true CN103028046B (zh) | 2014-06-18 |
Family
ID=48015775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210594232.5A Expired - Fee Related CN103028046B (zh) | 2012-12-29 | 2012-12-29 | 用于治疗萎缩性鼻炎的中药组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103028046B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105079579A (zh) * | 2015-09-25 | 2015-11-25 | 王动力 | 一种治疗萎缩性鼻炎的中药组合物 |
CN105079462A (zh) * | 2015-09-25 | 2015-11-25 | 王动力 | 一种治疗萎缩性鼻炎的中药组合物 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1149469A (zh) * | 1995-11-09 | 1997-05-14 | 阳灵广 | 鼻炎内服剂 |
CN1559578A (zh) * | 2004-02-17 | 2005-01-05 | 李爱英 | 一种治疗鼻炎的中药 |
CN101987190A (zh) * | 2009-07-31 | 2011-03-23 | 王晓锐 | 一种高效治疗鼻炎的中药 |
-
2012
- 2012-12-29 CN CN201210594232.5A patent/CN103028046B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1149469A (zh) * | 1995-11-09 | 1997-05-14 | 阳灵广 | 鼻炎内服剂 |
CN1559578A (zh) * | 2004-02-17 | 2005-01-05 | 李爱英 | 一种治疗鼻炎的中药 |
CN101987190A (zh) * | 2009-07-31 | 2011-03-23 | 王晓锐 | 一种高效治疗鼻炎的中药 |
Also Published As
Publication number | Publication date |
---|---|
CN103028046A (zh) | 2013-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103520694B (zh) | 治疗慢性阻塞性肺病稳定期的中药组合物及其制备方法 | |
CN103432475B (zh) | 一种治疗过敏性鼻炎的中药组合物及其制备方法 | |
CN104367879A (zh) | 一种用于治疗鸡劳伤的药物组合物及其制备方法 | |
CN102488847B (zh) | 治疗鸡传染性法氏囊病的中药组合物、制备方法和应用 | |
CN103611004A (zh) | 一种治疗尿毒症的中药汤剂 | |
CN103432559A (zh) | 一种治疗血滞型月经减少及痛经的中药组合物及其制备方法和用途 | |
CN103120760B (zh) | 用于治疗急性鼻窦炎的中药组合物及其制备方法 | |
CN102846824B (zh) | 一种治疗寒湿血瘀阻络型糖尿病足的中药组合物及其制备方法 | |
CN103028046B (zh) | 用于治疗萎缩性鼻炎的中药组合物及其制备方法 | |
CN104001045A (zh) | 一种用于治疗犬肺炎的药物及其制备方法 | |
CN103212031A (zh) | 用于治疗原发性肾病综合征的中药组合物及其制备方法 | |
CN102727738B (zh) | 用于治疗慢性阻塞性肺疾病的中药组合物及其制备方法 | |
CN102579818B (zh) | 一种藏药组合物及其制备方法与应用 | |
CN104771578A (zh) | 用于治疗变应性鼻炎的中药 | |
CN103356870B (zh) | 一种治疗产后缺乳的中药制剂及制备方法 | |
CN103028040B (zh) | 用于治疗小儿慢性鼻窦炎的中药组合物及其制备方法 | |
CN102895519B (zh) | 用于治疗过敏性鼻炎的中药及其制备方法 | |
CN104398789A (zh) | 一种治疗缺铁性贫血的中药汤剂 | |
CN103041172B (zh) | 用于治疗慢性鼻窦炎的中药组合物及其制备方法 | |
CN103705639A (zh) | 一种治疗脑积水的中药制剂 | |
CN102908575B (zh) | 用于治疗慢性单纯性鼻炎的内用中药及其制备方法 | |
CN107137689A (zh) | 一种治疗更年期综合征的中药组合物 | |
CN106177736A (zh) | 一种缓解肠胃不适引起便秘的艾叶保健茶及其制备方法 | |
CN105267815A (zh) | 一种治疗小儿肺肾两虚型哮喘的喷雾剂及其制备方法 | |
CN105169089A (zh) | 一种用于治疗经行头痛的中药丸剂及制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Sun Xiangye Inventor after: Ding Hongju Inventor before: The inventor has waived the right to be mentioned |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: REQUEST NOT TO RELEASE THE NAME TO: SUN XIANGYE DING HONGJU |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171024 Address after: Lang Jun Center No. 28 road 401120 Chongqing city Yubei District Huanglong longta Street Building 3 2-1 Patentee after: Chongqing AOPO Ruisen Technology Co. Ltd. Address before: 266071 Shandong province Qingdao City Road No. 19 east red room unit 7 Patentee before: Qingdao Hengbo Instrument Co., Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180327 Address after: 401120 Chongqing Yubei District Hui Xing Street Xingke Road No. 293 with mountain name 7 9 Patentee after: CHONGQING XUANNU BIOTECHNOLOGY CO., LTD. Address before: Lang Jun Center No. 28 road 401120 Chongqing city Yubei District Huanglong longta Street Building 3 2-1 Patentee before: Chongqing AOPO Ruisen Technology Co. Ltd. |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140618 Termination date: 20181229 |
|
CF01 | Termination of patent right due to non-payment of annual fee |