CN103025927B - 精确地比对与配准用于dna测序的阵列的方法及系统 - Google Patents

精确地比对与配准用于dna测序的阵列的方法及系统 Download PDF

Info

Publication number
CN103025927B
CN103025927B CN201180021839.8A CN201180021839A CN103025927B CN 103025927 B CN103025927 B CN 103025927B CN 201180021839 A CN201180021839 A CN 201180021839A CN 103025927 B CN103025927 B CN 103025927B
Authority
CN
China
Prior art keywords
domain
points
grid
biochemical
sites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180021839.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN103025927A (zh
Inventor
布赖恩·P·斯泰克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Complete Genomics Inc
Original Assignee
Callida Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Callida Genomics Inc filed Critical Callida Genomics Inc
Publication of CN103025927A publication Critical patent/CN103025927A/zh
Application granted granted Critical
Publication of CN103025927B publication Critical patent/CN103025927B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/24—Aligning, centring, orientation detection or correction of the image
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/32—Determination of transform parameters for the alignment of images, i.e. image registration using correlation-based methods
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G06T7/337—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods involving reference images or patches
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G06T7/73—Determining position or orientation of objects or cameras using feature-based methods
    • G06T7/74—Determining position or orientation of objects or cameras using feature-based methods involving reference images or patches
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/32—Normalisation of the pattern dimensions
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/04—Recognition of patterns in DNA microarrays

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Multimedia (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201180021839.8A 2010-04-30 2011-04-27 精确地比对与配准用于dna测序的阵列的方法及系统 Active CN103025927B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33013010P 2010-04-30 2010-04-30
US61/330,130 2010-04-30
US13/092,618 US8774494B2 (en) 2010-04-30 2011-04-22 Method and system for accurate alignment and registration of array for DNA sequencing
US13/092,618 2011-04-22
PCT/US2011/034178 WO2011137183A1 (en) 2010-04-30 2011-04-27 Method and system for accurate alignment and registration of array for dna sequencing

Publications (2)

Publication Number Publication Date
CN103025927A CN103025927A (zh) 2013-04-03
CN103025927B true CN103025927B (zh) 2015-12-16

Family

ID=44858300

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180021839.8A Active CN103025927B (zh) 2010-04-30 2011-04-27 精确地比对与配准用于dna测序的阵列的方法及系统

Country Status (6)

Country Link
US (2) US8774494B2 (enExample)
EP (2) EP2563953A4 (enExample)
JP (2) JP5654668B2 (enExample)
CN (1) CN103025927B (enExample)
SG (1) SG184963A1 (enExample)
WO (1) WO2011137183A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9382585B2 (en) 2007-10-30 2016-07-05 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US9880089B2 (en) 2010-08-31 2018-01-30 Complete Genomics, Inc. High-density devices with synchronous tracks for quad-cell based alignment correction
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
EP2732423A4 (en) 2011-07-13 2014-11-26 Multiple Myeloma Res Foundation Inc METHOD FOR DETECTING AND DISTRIBUTING DATA
EP2807272A1 (en) 2012-01-27 2014-12-03 Ventana Medical Systems, Inc. Devices and methods for detecting bio-analytes using optically decipherable patterns
US9135497B2 (en) * 2012-01-27 2015-09-15 National Instruments Corporation Identifying randomly distributed microparticles in images to sequence a polynucleotide
EP2920725B1 (en) 2012-11-19 2021-11-10 Apton Biosystems, Inc. Digital analysis of molecular analytes using single molecule detection
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US10088658B2 (en) * 2013-03-18 2018-10-02 General Electric Company Referencing in multi-acquisition slide imaging
WO2014153369A1 (en) * 2013-03-18 2014-09-25 Life Technologies Corporation Methods and systems for analyzing biological reaction systems
EP3036358B8 (en) 2013-08-22 2023-11-22 Pacific Biosciences of California, Inc. Digital analysis of molecular analytes using electrical methods
US9953417B2 (en) 2013-10-04 2018-04-24 The University Of Manchester Biomarker method
US9519823B2 (en) * 2013-10-04 2016-12-13 The University Of Manchester Biomarker method
WO2016103473A1 (ja) * 2014-12-26 2016-06-30 株式会社日立ハイテクノロジーズ 核酸分析用基板、核酸分析用フローセルおよび核酸分析装置
JP2016174578A (ja) * 2015-03-20 2016-10-06 東ソー株式会社 微小粒子選別装置および前記装置を備えた微小粒子回収装置
US9330932B1 (en) * 2015-03-31 2016-05-03 Micron Technology, Inc. Methods of fabricating features associated with semiconductor substrates
WO2017098013A1 (en) * 2015-12-10 2017-06-15 Qiagen Gmbh Method for determining the overall brightness of at least one object in a digital image
JP6672938B2 (ja) * 2016-03-25 2020-03-25 横浜ゴム株式会社 周波数選択板の設計方法および周波数選択板設計プログラム
US10467749B2 (en) * 2016-10-10 2019-11-05 Genemind Biosciences Company Limited Method and system for processing an image comprising spots in nucleic acid sequencing
JP2020514746A (ja) * 2016-12-01 2020-05-21 ノーティラス バイオテクノロジー インコーポレイテッド タンパク質をアッセイする方法
CA3056765C (en) 2017-03-17 2024-04-02 Apton Biosystems, Inc. Sequencing and high resolution imaging
MX389484B (es) 2017-11-13 2025-03-20 The Multiple Myeloma Res Foundation Inc Base de datos, de datos moleculares, omicos, de inmunoterapia, metabolicos, epigeneticos y clinicos, integrados
JP7062926B2 (ja) * 2017-11-24 2022-05-09 凸版印刷株式会社 呈色反応検出システム、呈色反応検出方法及びプログラム
EP3735259A4 (en) 2017-12-29 2021-09-08 Nautilus Biotechnology, Inc. DECODING PROTEIN IDENTIFICATION METHOD
EP3779868B1 (en) * 2018-04-10 2024-05-08 MGI Tech Co., Ltd. Fluorescence image registration method, gene sequencing instrument and system, and storage medium
US11435283B2 (en) 2018-04-17 2022-09-06 Sharif University Of Technology Optically detecting mutations in a sequence of DNA
CN109035164B (zh) * 2018-07-13 2022-03-04 北京控制工程研究所 一种快速鲁棒图像杂光抑制的方法及系统
WO2020037570A1 (zh) * 2018-08-22 2020-02-27 深圳市真迈生物科技有限公司 图像配准方法、装置和计算机程序产品
JP2022501026A (ja) 2018-09-19 2022-01-06 アプトン バイオシステムズ インコーポレイテッド 高密度に詰め込まれた分析物の層および検出方法
CN113227342A (zh) * 2019-01-09 2021-08-06 株式会社日立高新技术 核酸分析用基板、核酸分析用流动池以及图像分析方法
WO2020155043A1 (zh) * 2019-01-31 2020-08-06 深圳华大生命科学研究院 荧光图像配准方法、基因测序仪及系统、存储介质
EP4038546B1 (en) * 2019-10-01 2024-08-21 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
US12154266B2 (en) 2019-11-18 2024-11-26 10X Genomics, Inc. Systems and methods for binary tissue classification
EP4435718A3 (en) 2019-11-22 2024-12-18 10X Genomics, Inc. Systems and methods for spatial analysis of analytes using fiducial alignment
CN115428088A (zh) 2020-02-13 2022-12-02 10X基因组学有限公司 用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法
CN111407222B (zh) * 2020-04-27 2024-11-29 重庆金山医疗技术研究院有限公司 一种电子内窥镜传像组件景深调试装置及调试方法
EP4053794A1 (en) * 2021-03-05 2022-09-07 Leica Microsystems CMS GmbH Multispectral microscope system and method for registering first and second images by means thereof
EP4181077A1 (en) * 2021-11-11 2023-05-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method of evaluating at least one image of at least one micro-array
FR3133474B1 (fr) * 2022-03-11 2024-03-22 Aryballe Dispositif et procédé de caractérisation d’un alignement de caméra dans un capteur à puce photonique
EP4435717A1 (en) * 2023-03-24 2024-09-25 QIAGEN GmbH Method for providing an analysis of partition image data
CN119913026B (zh) * 2023-10-30 2025-12-02 迈克医疗电子有限公司 数字pcr仪及其通道微滴对齐方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6349144B1 (en) * 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
WO2009059022A1 (en) * 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
US20090250615A1 (en) * 2008-04-04 2009-10-08 Life Technologies Corporation Scanning system and method for imaging and sequencing

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US6610256B2 (en) 1989-04-05 2003-08-26 Wisconsin Alumni Research Foundation Image processing and analysis of individual nucleic acid molecules
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6401267B1 (en) 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
DK1179600T3 (da) 1996-06-04 2005-09-05 Univ Utah Res Found Overvågning af hybridisering under PCR
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6309824B1 (en) 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
AU737174B2 (en) 1997-10-10 2001-08-09 President & Fellows Of Harvard College Replica amplification of nucleic acid arrays
CA2342838A1 (en) 1998-09-15 2000-03-23 Yale University Molecular cloning using rolling circle amplification
ATE440148T1 (de) 1999-01-06 2009-09-15 Callida Genomics Inc Verbesserte sequenzierung mittels hybridisierung durch verwendung von sondengemischen
GB9901475D0 (en) 1999-01-22 1999-03-17 Pyrosequencing Ab A method of DNA sequencing
US20020150909A1 (en) * 1999-02-09 2002-10-17 Stuelpnagel John R. Automated information processing in randomly ordered arrays
US6272207B1 (en) 1999-02-18 2001-08-07 Creatv Microtech, Inc. Method and apparatus for obtaining high-resolution digital X-ray and gamma ray images
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
AU779835B2 (en) 1999-05-20 2005-02-10 Illumina, Inc. Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6754375B1 (en) 1999-07-16 2004-06-22 Packard Bioscience Company Method and system for interactively developing at least one grid pattern and computer-readable storage medium having a program for executing the method
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
DE60117930T2 (de) * 2000-06-06 2006-10-05 Agilent Technologies Inc., A Delaware Corp., Palo Alto Verfahren und System zur automatischen Extraktion von Daten aus einem Molekülarray
US6591196B1 (en) 2000-06-06 2003-07-08 Agilent Technologies Inc. Method and system for extracting data from surface array deposited features
US7440637B2 (en) * 2000-07-21 2008-10-21 The Trustees Of Columbia University In The City Of New York Method and apparatus for image mosaicing
AU3511802A (en) * 2000-08-22 2002-05-06 Affymetrix, Inc. System method, and computer software product for controlling biological microarray scanner
US6873422B2 (en) * 2000-12-08 2005-03-29 Mitutoyo Corporation Systems and methods for high-accuracy displacement determination in a correlation based position transducer
US20020192650A1 (en) * 2001-05-30 2002-12-19 Amorese Douglas A. Composite arrays
US7157229B2 (en) * 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
US6982793B1 (en) 2002-04-04 2006-01-03 Nanometrics Incorporated Method and apparatus for using an alignment target with designed in offset
US6980677B2 (en) * 2002-05-24 2005-12-27 Niles Scientific, Inc. Method, system, and computer code for finding spots defined in biological microarrays
US20050049797A1 (en) 2003-08-27 2005-03-03 Srinka Ghosh Method and system for displacement-vector-based detection of zone misalignment in microarray data
US7323681B1 (en) * 2003-09-11 2008-01-29 Applera Corporation Image enhancement by sub-pixel imaging
EP1718769A4 (en) 2004-02-27 2008-05-14 Harvard College Polonie FLUORESCENCE IN SITU SEQUENZIERKÜGELCHEN
US7072500B2 (en) 2004-05-07 2006-07-04 Wisconsin Alumni Research Foundation Image locking system for DNA micro-array synthesis
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
US7283677B2 (en) * 2004-08-31 2007-10-16 Hewlett-Packard Development Company, L.P. Measuring sub-wavelength displacements
EP1907571B1 (en) 2005-06-15 2017-04-26 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US20090264299A1 (en) 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
US20090111706A1 (en) * 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by amplification
ES2628973T3 (es) * 2007-05-31 2017-08-04 University Of Washington Mutagénesis inducible de genes diana
US8298768B2 (en) 2007-11-29 2012-10-30 Complete Genomics, Inc. Efficient shotgun sequencing methods
JP5835680B2 (ja) * 2007-11-05 2015-12-24 株式会社東芝 画像位置合わせ装置
WO2009097368A2 (en) * 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
AU2009270534B2 (en) * 2008-07-15 2015-09-17 Institut Pasteur Korea Method and apparatus for imaging of features on a substrate
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US9671344B2 (en) * 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
US9880089B2 (en) 2010-08-31 2018-01-30 Complete Genomics, Inc. High-density devices with synchronous tracks for quad-cell based alignment correction
US8175452B1 (en) 2010-10-26 2012-05-08 Complete Genomics, Inc. Method and system for imaging high density biochemical arrays with sub-pixel alignment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6349144B1 (en) * 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
WO2009059022A1 (en) * 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
US20090250615A1 (en) * 2008-04-04 2009-10-08 Life Technologies Corporation Scanning system and method for imaging and sequencing

Also Published As

Publication number Publication date
SG184963A1 (en) 2012-11-29
US8774494B2 (en) 2014-07-08
EP3043319A1 (en) 2016-07-13
JP2013527848A (ja) 2013-07-04
JP2015042185A (ja) 2015-03-05
JP6042859B2 (ja) 2016-12-14
WO2011137183A1 (en) 2011-11-03
US20150080231A1 (en) 2015-03-19
EP2563953A1 (en) 2013-03-06
JP5654668B2 (ja) 2015-01-14
CN103025927A (zh) 2013-04-03
US20110268347A1 (en) 2011-11-03
EP2563953A4 (en) 2015-06-03
US9359641B2 (en) 2016-06-07

Similar Documents

Publication Publication Date Title
CN103025927B (zh) 精确地比对与配准用于dna测序的阵列的方法及系统
US11308640B2 (en) Image analysis useful for patterned objects
EP2611954B1 (en) High-density biochemical array chips and method
US6980677B2 (en) Method, system, and computer code for finding spots defined in biological microarrays
CN115461778A (zh) 基于均衡的图像处理和空间串扰衰减器
US11989265B2 (en) Intensity extraction from oligonucleotide clusters for base calling
TW202307790A (zh) 線性傅立葉基準
HK1225487A1 (en) Method and system for accurate alignment and registration of array for dna sequencing
US12367263B2 (en) Intensity extraction for feature values in base calling
US20220414853A1 (en) Fiducials for use in registration of a patterned surface
KR20250137503A (ko) 지터 보정 이미지 분석
CN117545555A (zh) 线性傅里叶基准
HK1187384A (en) High-density biochemical array chips and method
HK1187384B (en) High-density biochemical array chips and method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP01 Change in the name or title of a patent holder

Address after: California, USA

Patentee after: COMPLETE GENOMICS Inc.

Address before: California, USA

Patentee before: Complete Genomics, Inc.

CP01 Change in the name or title of a patent holder