CN103025319B - 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂 - Google Patents

用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂 Download PDF

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Publication number
CN103025319B
CN103025319B CN201080066694.9A CN201080066694A CN103025319B CN 103025319 B CN103025319 B CN 103025319B CN 201080066694 A CN201080066694 A CN 201080066694A CN 103025319 B CN103025319 B CN 103025319B
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formulation
capsule
therapeutic agent
delivery
lumen
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CN103025319A (zh
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米尔·A·伊姆兰
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Draw Buddhist Nun's Medical Treatment Co Ltd
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Incube Laboratories LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

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  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN201080066694.9A 2010-03-10 2010-12-23 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂 Active CN103025319B (zh)

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CN201510345861.8A CN105168174B (zh) 2010-03-10 2010-12-23 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂

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US33994110P 2010-03-10 2010-03-10
US61/339,941 2010-03-10
PCT/US2010/062073 WO2011112229A2 (en) 2010-03-10 2010-12-23 Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

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CN103025319A CN103025319A (zh) 2013-04-03
CN103025319B true CN103025319B (zh) 2015-07-01

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CN201510345861.8A Active CN105168174B (zh) 2010-03-10 2010-12-23 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂

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EP (2) EP3603624A1 (enExample)
JP (4) JP5931757B2 (enExample)
CN (2) CN103025319B (enExample)
AU (3) AU2010347732A1 (enExample)
CA (1) CA2792862C (enExample)
WO (1) WO2011112229A2 (enExample)

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CN105168174A (zh) * 2010-03-10 2015-12-23 因卡伯实验室有限责任公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂
US10179228B2 (en) 2009-12-24 2019-01-15 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10300010B2 (en) 2010-12-23 2019-05-28 Rani Therapeutics, Llc Methods for delivering entanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10307579B2 (en) 2010-12-23 2019-06-04 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10314891B2 (en) 2010-12-23 2019-06-11 Rani Therapeutics, Llc Method for delivering pramlintide into a lumen of the intestinal tract using a swallowable drug delivery device
US10314892B2 (en) 2010-12-23 2019-06-11 Rani Therapeutics, Llc Method of delivering a somatostatin compound into a lumen of the intestinal tract using a swallowable drug delivery device
US10322167B2 (en) 2010-12-23 2019-06-18 Rani Therapeutics, Llc Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device
US10335463B2 (en) 2010-12-23 2019-07-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10350163B2 (en) 2010-12-23 2019-07-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10478396B2 (en) 2010-12-23 2019-11-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10487145B2 (en) 2010-12-23 2019-11-26 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10548850B2 (en) 2010-12-23 2020-02-04 Rani Therapeutics, Llc Therapeutic composition comprising insulin prepared for delivery into an intestinal tract
US10632251B2 (en) 2010-12-23 2020-04-28 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10752681B2 (en) 2010-12-23 2020-08-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10874840B2 (en) 2010-12-23 2020-12-29 Rani Therapeutics, Llc Preparation comprising exanatide for delivery into a lumen of the intestinal tract
US11439817B2 (en) 2009-08-03 2022-09-13 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract

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JP6226862B2 (ja) * 2012-04-05 2017-11-08 久光製薬株式会社 穿刺装置及びその製造方法
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US11833319B2 (en) * 2019-03-01 2023-12-05 Rani Therapeutics, Llc Propulsive drug delivery from a swallowable device into a patients intestinal tract
KR102068616B1 (ko) * 2019-03-15 2020-01-21 (주)한국원자력 엔지니어링 장내 체류를 위한 내용물 운반체
EP3962516A4 (en) * 2019-05-03 2023-01-04 Rani Therapeutics, LLC COAGAGING FACTOR PREPARATIONS FOR ADMINISTRATION INTO TISSUES OF THE INTESTINAL TRACT USING AN INGESTIONABLE DRUG DELIVERY DEVICE
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CN112717265B (zh) * 2020-12-27 2023-04-07 河北医科大学第二医院 一种胃肠道肿瘤的靶点追踪装置及方法
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CN113769249B (zh) * 2021-09-10 2023-08-04 安翰科技(武汉)股份有限公司 一种给药胶囊

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Cited By (46)

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Publication number Priority date Publication date Assignee Title
US11439817B2 (en) 2009-08-03 2022-09-13 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US12403308B2 (en) 2009-08-03 2025-09-02 Alva Therapeutics, Inc. Swallowable capsule and method for stimulating incretin production within the intestinal tract
US11872396B2 (en) 2009-08-03 2024-01-16 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US10493253B2 (en) 2009-12-24 2019-12-03 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US12268831B2 (en) 2009-12-24 2025-04-08 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10252039B2 (en) 2009-12-24 2019-04-09 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US11338118B2 (en) 2009-12-24 2022-05-24 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10596359B2 (en) 2009-12-24 2020-03-24 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10179228B2 (en) 2009-12-24 2019-01-15 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US11253686B2 (en) 2009-12-24 2022-02-22 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
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