CN103013736A - Herba siegesbeckiae-harlequin glorybower leaf wine and method for producing same - Google Patents

Abstract

The invention discloses a herba siegesbeckiae-harlequin glorybower leaf wine, made from coix seeds, sticky rice, saccharifying enzyme, wine making high-activity dried yeast, herba siegesbeckiae and harlequin glorybower leaves as the raw materials through solid fermentation. The method for producing the herba siegesbeckiae-harlequin glorybower leaf wine is scientific in compatibility, simple in process and easy to operate; and the herba siegesbeckiae-harlequin glorybower leaf wine disclosed by the invention is colorless and transparent, sweet and delicious, and has special fresh scent of Chinese medicinal herbs. Besides, the herba siegesbeckiae-harlequin glorybower leaf wine has special functions of warding off diseases and preventing diseases.

Description

Yi Zhong pig paulownia wine and production method thereof

Technical field the invention belongs to health promoting wine manufacturing technology field, relate to a kind of take with the Dietotherapy double-purpose cereal seed of jog's tears, glutinous rice as main raw material and Zhong Cao Yao pig Xian, Harlequin Glorybower Leaf and Twig compatibility, with a kind of health-care white spirit and the production method thereof of special process brew.

Background technology health preserving wine in the market mostly is and is immersed in the liquor with herbal medicine and makes, and function is very few, and suitable crowd is restricted.

Pig paulownia good wine is to be main raw material and Tian Jia pig Xian, Harlequin Glorybower Leaf and Twig with the Dietotherapy double-purpose cereal seed of jog's tears and glutinous rice, with a kind of health care liquor of special process brew.

The seed of jog's tears: have another name called Semen Coicis, jobstears, Mi Ren, the seed of jog's tears, jobstears, bodhi pearl, maize rice.Seed of jog's tears chemical ingredients: kind benevolence contains coixenolide about 0.2% and Semen Coicis element, suitable octadecylene-8-is sour, steroidal compounds; Fatty oil about 7.2% main brown eleostearic acid, tetradecanoic acid, Brassicasterin, Stigmasterol etc.; Carbohydrate 79.17%; Protein 16.2%; The amino acid such as leucine, arginine, Methionin, tyrosine and vitamins B, triterpene compound etc.Nearly report also contains the brown eleostearic acid fat of asafoetide acyl Stigmasterol, asafoetide acyl campesterol, Stigmasterol and stearate, coixan.

The Semen Coicis drug effect: antitumor, immunizing power strengthens, always Skeletal Muscle Contraction, calmness, throe, quiet heat, suppress polysynaptic reflex, antimicrobial antiphlogistic, hypoglycemic, atherosclerosis, step-down, excited adrenal cortex function.

Seed of jog's tears health care function:

1, the seed of jog's tears is being rich in nutrition, can strengthen the spleen and stomach, again can promoting diuresis to eliminate damp pathogen.Be usually used in weakness of the spleen and the stomach, the few just sugar of food, the symptoms such as edema of lower limbs.

2, tonifying lung and Gu Wei, invigorating the spleen and dampness removing, nourishing the liver and Shujin are so have the sharp joint of curing rheumatism, the effect of strengthening the bones and muscles.

3, modern pharmacological research proves: the seed of jog's tears has good antitumous effect.Seed of jog's tears extract can make the sex change of cancer cells magma, and make cell nuclear fission stop at mid-term, the clinical treatment that can be used for Several Kinds of Malignancy, to cancer postoperative body void or radiotherapy, leukopenia due to the chemotherapy and poor appetite, the digestion reactions such as abdominal distension diarrhoea, or cancer ascites, four limbs edema etc. also has the good curative effect of seeing.

Glutinous rice: also claim rice, sweet, warm, nontoxic, can make people's qi and blood sufficient, unobstructed, but the poison of Xie Guanqing, spot chela, the function of useful gas antidiarrheal.

， pig Xian Fu Han pig Xian bitter taste glucoside, multiple sesquiterpene lactones, the flavones etc. such as pig Xian: You Ming Herba Siegesbeckiae, rheumatism grass, its chemical ingredients is as follows:

1; contain the fragrant alkene lactone of 9 β-isobutyl acyl-oxygen sill (9 β-hydroxy-8 β-isobutyryloxycostunolide) in the pig Xian stem, the fragrant alkene lactone (9 β-hydroxy-8-methacryloyloxycos-tunol ide) of 9 beta-hydroxies-8 β-iso-butylene acyl-oxygen sill, 8 β-isobutyryl Oxy-1 4-Tibet base-costunolide (8 β-isobuTCMLIByloxy-14-al-costunolide), the fragrant alkene lactone of 14-hydroxyl-8 β-isobutyl acyl-oxygen sill (14-hy-droxy-8 β-isobutyryloxycostunolide), 9 β, the fragrant alkene lactone of 14-dihydroxyl-8 β-isobutyl acyl-oxygen sill (9 β, 14-dihydroxy-8 β-isobutyryloxycostunolide), 8 β, 9 beta-dihydroxyies-1 β, 10 α-epoxy-11 β, 13-dihydro costunolide (8 β, 9 β-dihy-droxy-1 β, 10 α-epoxy-11 β, 13-dihydrocostunolide), 14-hydroxyl-8 β-isobutyryl Oxy-1 β, 10 α-epoxy costunolide (14-hydroxy-8 β-i sobutyryloxy-1 β, 10 α-epoxycostunolids), 15-hydroxyl-9 α-acetoxyl group-8 β isobutyryl Oxy-1 4-oxo is bought blue sloping careless lactone, and (hydroxyl-8 β-isobutyryl Oxy-1 4-oxo of 15-hydroxy-8 β-isobutyryloxy-14-oxo-melam)-15 is bought blue sloping careless lactone (15-hy-droxy-8 β-isobutyryloxy-14-oxo-melampolide), 19-acetoxyl group-12-oxo-10,11-dihydro geranyl vernol (19-acetoxy-12-oxo-10,11-dihy-drogeranylnerol), 19-acetoxyl group-15-hydrogen peroxide-12-oxo-13,14E-dehydrogenation-10,11,14,15,-tetrahydrochysene geranyl vernol (19-acetoxy-15-hydroperoxy-12-oxo-13,14E-dehydro-l0,1l, 14,15-teTCMLIBahydrogeranylnerol), 19-acetoxyl group-15-hydroxyl-12-oxo-13,14E-dehydrogenation-10,11,14,15-tetrahydrochysene geranyl vernol (19-acetoxy-15-hydroxy-12-oxo-13,14E-dehydro-10,11,14,15,-teTCMLIBahydrogeranylnerol), 2 β, 15,16-trihydroxy--mapping-8 (14)-pimanthrene-[2 β, 15,16,-TCMLIBihydroxy-ent-pimar-8 (14)-ene], 15,16-dihydroxyl-2-oxo-mapping-8 (14)-pimanthrene [15,16-dihydroxy-2-oxo-ent-pimar-8 (14)-ene], 15,16,18-trihydroxy--2-oxo-mapping-8 (14)-pimanthrene [15,16,18-TCMLIBihydroxy-2-oxo-ent-pimar-8 (14)-ene], l α-acetoxyl group-2 α, 3 α-epoxy isoalantolactone (1 α-acetoxy-2 α, 3 α-epoxyisoalan-tolactone).

2 Herba Siegesbeckiae herbs contain Herba Siegesbeckiae glucoside (siegesbeckioside) Herba Siegesbeckiae alcohol (siegesbeckiol) Herba Siegesbeckiae acid (siegesbeckic8cid), mapping-16 β, 17, the 18-Kauranetriol (ent-kauran-16 β, 17,18-TCMLIBiol), mapping-16 β, 17-dihydroxyl-19 kaurinic acid (ent-16 β, 17,18-TCMLIBiol) 17-hydroxyl-19-shell pine acid (ent-16 α H, 17-hydroxy-kauran-19-oicacid), the blue acid in Da Hua natural pond (grandifloricacid), kirenol (kirenol), Sitosterol (sitosterol), daucosterol (daucosterol), 16 α H-16,19-shell pine diacid (16 α, 19-kaurandioicacid).

3, siegesbeckia glabrescens Makino herb Han darutigene (contains kirenol in the darutigenol) ， pig, 16-ethanoyl kirenol (16-acetylkirenol), isopropylidene kirenol (isopropylideneki-renol).

Nature and flavor: cold in nature, flavor is hot, bitter.Gui Jing: return Liver Channel, kidney channel.Function: wind-damp dispelling, sharp joint, detoxifcation.Cure mainly: be used for that rheumatic arthralgia, muscles and bones are unable, soreness of the waist and knees, tetraplegia, hemiplegia, the wet sore of rubella.Mainly have following effects:

1, anti-inflammatory action: Xian bitter taste alkyd, every day, 50mg/kg po10 days, had anti-inflammatory action with albumen Heat probe coagulation and the swollen method proof of rat pin.

2, hypotensive effect and vasorelaxation action: cat butter proves that Xian grass decoction ip has hypotensive effect, and sustainable about 1.5 hours, its ethanol one infusion was also effective.Xian grass extracting solution can make and keep neural rabbit ear vasodilation, and blocks the contracting vascular reaction of exciting nerve and causing, to the then adiastole effect of rabbit ear blood vessel of exsomatizing.Think that thus its vasorelaxation action is to produce by the inhibition to sympathetic vasoconstrictor nerve, Xian grass extracting solution can not resist the contracting blood vessel function of norepinephrine, so it is not the adrenergic receptor of vasoactive unstriated muscle.

3, on the impact of small white mouse immunologic function: Xian grass decocting 3 hours, totally three times, collecting decoction is concentrated into 1ml and contains the 1g crude drug, and small white mouse is divided into three batches each two groups at random, and 10 every group, experimental group all gives Xian grass decoction 0.2mlip administration, once a day.Control group gives the equivalent stroke-physiological saline solution with method.First mouse is total to administration 6 days, the 6% starch meat soup 1.0ml that annotates in 4 days abdominal cavities, and detected in 7 days: peritoneal macrophage is engulfed percentage and the phagocytic index of chicken red blood cell; Serum lysozyme activities reached; Pluck eyeball and get blood counting lymphocyte absolute value.Second batch mouse administration 7 days, 20% sheep red blood cell (SRBC) 0.2ml annotates in 2 days abdominal cavities of administration.D8 detects: serum antibody titer; DNA and RNA pyridine orange fluorescent dye in the blood smear cell.The 3rd batch of mouse administration 7 days detected: Ea and Et garland rate of formation in 8 days; Thymus and spleen is weighed.The results are shown in Table 1 and table 2, show that the Xian grass has restraining effect to cellular immunization and humoral immunization, also has certain restraining effect to non-specific immunity.

4, on the thrombotic impact of rabbit: choose 10 of rabbit, Xian grass (I) group and the troxerutin group that are divided at random the iv administration, wet weight of thrombus before the as a result I group administration (38.28 ± 16.16mg) with administration after wet weight of thrombus (18.60 ± 5.34mg) significant differences (and P＜0.05, n=5).Wet weight of thrombus before the administration of troxerutin group (45.25 ± 13.91mg) with administration after (22.98 ± 8.94mg) difference highly significant (P＜0.01, n=5=, the two all has restraining effect to thrombosis, and the former inhibiting rate is 51.41%, and the latter is 49.22%.

5, on the impact of mouse Mesentery microcirculation: Xian grass injection liquid (I) and compound injection of red sage root (II) to mouse Mesentery microcirculation obstacle after restoration of blood flow, remarkable promotion use (P＜0.01) is arranged; 0.6g/ml the II of the I solution of (crude drug) and 0.3mg/ml (crude drug) is suitable to the effect of restoration of blood flow.

6, antibiotic and Antimalarial: prove with the flat board method of burrowing, the Xian grass is extremely sensitive to streptococcus aureus, to intestinal bacteria, Pseudomonas aeruginosa, Song's Shigella flexneri, Corynebacterium diphtheriae slight sensitive, Staphylococcus albus, micrococcus catarrhalis, bacillus enteritidis, hog cholera bacillus there is restraining effect.Xian grass decoction reaches 90% to the mouse gavage to mouse plasmodium inhibiting rate by 100g/kg.

7, other effect: Xian contains a-tocopherol tool antioxygenation.Xian grass 90% methanol extract suppresses activity to ACE (Angrotensis-convertinenzyme, angiotonin conversion factor enzyme) and reaches 30-40%, and the Xian glucoside has obvious antiearly pregnancy effect to rat when 20-40mg/kg dosage.

Harlequin Glorybower Leaf and Twig: nature and flavor: hot, bitter, sweet, cold.Gui Jing: enter Liver Channel, gallbladder channel, the spleen channel.Function: wind-damp dispelling.Cure mainly: dispelling the wind and dampness pathogens numbness pain, hemiplegia, essential hypertension, migraine; Malaria, dysentery, hemorrhoid, ulcer sore scabies.Leaf contain overseas dichrin (Clerodendrin), meso-inositol (Meso-inositol), alkaloid, robinin-7-glucosulfone aldehydic acid glucoside [Aeaeetin-7-glueurono-(1-2)-glueuronide).And isolate two kinds of molecular formula respectively for C24H3409 or C24H36010, the bitter-taste components of C23H3209 or C25H34010.These product still contain clerodendronin A (Clerodendronin A), clerodendronin B, clerodendrin A (Clerodendrin A) and clerodendrin B.Leaf contains clerodendroside first (clerodendrin A), clerodendroside second (clerodendrin B, acacetin-7-diglucuronide), clerodendron trichotomum bitter principle first (clerodendrin) and isomer second, and other amaroid and meso-inositol (mesoinsitol), other contains the husky glucoside (kusaginin) in storehouse, still contains clerodendroside (cleroden-droside).1. " Bencao Tujing ": " preventing and curing malaria." 2. " detailed outline is picked up any lost article from the road ": " washes the tinea unguium, all sore scabies, fries in shallow oil soup and washes sweat stain.The swollen person of not healing for a long time of wet ham takes with rose Yan word infusing drugs in wine.And can control all rheumatism, and end hemorrhoid and swell, fry in shallow oil the wine clothes.Control ulcer on the shank, mash and make cake, add tung oil and paste." 3. " south of the Five Ridges come medicine record ": " controls all ulcer, mash net for catching birds or fish it." 4. " modern Practical Chinese medicinal ": " controls a kind of malaria, and phlegm is tied in the heart, and all rheumatism, four limbs train of thought are jammed and are not relaxed, and the distension that disappears ends dysentery." 5. " herbal medicine is commonly used in Shanghai ": wind-damp dispelling, pain relieving, hypotensive.

Summary of the invention the purpose of this invention is to provide and a kind ofly utilizes the seed of jog's tears, glutinous rice, pig Xian, Harlequin Glorybower Leaf and Twig for raw material production De pig paulownia good wine and production method thereof, to overcome the deficiencies in the prior art.

Pig paulownia good wine of the present invention, its main points are to be formed through fermented soy by weight ratio by following raw material:

Seed of jog's tears 500g, glutinous rice 500g, saccharifying enzyme 2g, highly active dry yeast 1g, pig Xian 150g, Harlequin Glorybower Leaf and Twig 150g;

The production method of pig paulownia good wine of the present invention, concrete steps are as follows:

1, first seed of jog's tears, pig Xian, Harlequin Glorybower Leaf and Twig are ground into respectively meal;

2, seed of jog's tears powder and glutinous rice are put into large basin and mix an amount of water soaking of rear usefulness thoroughly after 1 hour, pull out and put into steamer and cook, cook rear truce, when treating that temperature is down to 35-40 ℃, put into the fermenting container of getting ready with who knows, add again saccharifying enzyme and highly active dry yeast that water is melted into liquid, after stirring that vessel port is tight-closed, fermented 7, and can steam wine;

The wine material that 3, will ferment complete takes out in the container and is separated into liquid and slag, and liquid is put into Liquor distillation pot, and slag is placed on the clean water mud ground plate, adds into pig Xian powder and Harlequin Glorybower Leaf and Twig powder to stir, and mixes rear accumulation thoroughly and covers plastics film and moistened 30 minutes;

4, will put double-edged fine-toothed comb above the Liquor distillation pot liquid, put gauze at double-edged fine-toothed comb, getting step 3 mixes thoroughly and moistens 30 cm thicks on the gauze that good material is put into double-edged fine-toothed comb, want when add high flame steam to be had spill this moment in time step 3 is mixed thoroughly and moisten good residue material gas is covered, with leaking with lid, until material is completed;

5, build the Liquor distillation pot lid, water is sealed lid again, and gas wine flows out through condenser, has first foreshot's gas to eject, and has flowed steaming wine process need 3 hours with regard to there being limpid liquor to flow out until fill a wine cup for after foreshot's gas is drained.

Approximately need 4 hours from the dosing spice to having steamed wine, the chemical ingredients in the Chinese medicinal materials is dissolved in the wine substantially, can blend by the number of degrees of demand when drinking.The medicinal liquor of the present invention preparation is named and is: pig paulownia good wine.

Pig paulownia good wine of the present invention, water white transparency, sweet good to eat, have the distinctive blue or green fragrance of herbal medicine.Have illly get rid of illness, the specific function of anosis diseases prevention.

Clinical trial certificate: often drink have antitumor, strengthening immunity, the inhibition bone shrinks, analgesia, calm, antibiotic, anti-inflammatory, reducing blood-fat, hypoglycemic, antithrombotic, improve the functions such as microcirculation, antiviral, anti-disease, wind-damp dispelling, expansion blood vessel, relieving rigidity of muscles and joints, dispelling the wind and dampness pathogens numbness pain, numbness of the limbs, hemiplegia; External application: control rubella, wet sore, killing parasites to relieve itching, the tinea manuum, wound etc.

Embodiment

1, batching: seed of jog's tears 500g, glutinous rice 500g, saccharifying enzyme 2g, highly active dry yeast 1g, pig Xian 150g, Harlequin Glorybower Leaf and Twig 150g;

2, first seed of jog's tears, pig Xian, Harlequin Glorybower Leaf and Twig are ground into respectively meal;

3, seed of jog's tears powder and glutinous rice are put into large basin and mix an amount of water soaking of rear usefulness thoroughly after 1 hour, pull out and put into steamer and cook, cook rear truce, when treating that temperature is down to 35 ℃, put into the fermenting container of getting ready with who knows, add again saccharifying enzyme and highly active dry yeast that water is melted into liquid, after stirring that vessel port is tight-closed, fermented 7, and can steam wine;

The wine material that 4, will ferment complete takes out in the container and is separated into liquid and slag, and liquid is put into Liquor distillation pot, and slag is placed on the clean water mud ground plate, adds into pig Xian powder and Harlequin Glorybower Leaf and Twig powder to stir, and mixes rear accumulation thoroughly and covers plastics film and moistened 30 minutes;

5, will put double-edged fine-toothed comb above the Liquor distillation pot liquid, put gauze at double-edged fine-toothed comb, getting step 3 mixes thoroughly and moistens 30 cm thicks on the gauze that good material is put into double-edged fine-toothed comb, want when add high flame steam to be had spill this moment in time step 3 is mixed thoroughly and moisten good residue material gas is covered, with leaking with lid, until material is completed;

6, build the Liquor distillation pot lid, water is sealed lid again, and gas wine flows out through condenser, has first foreshot's gas to eject, and has flowed steaming wine process need 3 hours with regard to there being limpid liquor to flow out until fill a wine cup for after foreshot's gas is drained.

An amount of normal this wine of drink can prolong life, and day takes 2 times, and each consumption is the 20-30 gram.

The present invention is the patients with diabetes mellitus of mM/l (160 milligrams/deciliter) through 100 blood plasma blood sugar 〉=8.9, drinks continuously 3 months, and blood sugar obviously reduction person rechecked afterwards on an empty stomach in 100%, one year that whole blood blood sugar is 3.9～6.1 mM/ls.

The present invention drank 3 months continuously through 100 leg joint pain patients, and the person of being clearly better rechecked in 100%, one year afterwards: 80 of painless painful persons normally walk; 20 of the obvious alleviators of pain.

Model case:

1, Wang, the man, 60 years old, suffer from more than the hemiplegia year of left side, obstinate, after drink pig paulownia good wine of the present invention, can walk after half a year, took continuously physical rehabilitation 1 year.

2, Lee, man 65 years old suffered from more than the hemiplegia year of left side, obstinate, after drink pig paulownia good wine of the present invention, can walk after eight months, took continuously physical rehabilitation 18 months.

3, revive certain, the woman, 70 years old, the headache symptom often appears, and night, pain had difficulty in going to sleep sometimes, drank and external application pig paulownia of the present invention good wine, and dip in pig paulownia good wine of the present invention and embrocate 10 minutes, and oral 20g, transference cure after 10 days at head night just before going to bed.

4, grandson, the woman, 72 years old, the numb pain symptom of knee joint often occurs, night, pain had difficulty in going to sleep sometimes, drank and external application pig paulownia of the present invention good wine, dipping in pig paulownia good wine of the present invention embrocates by 30 minutes at the pain position, and take 2 times day, each consumption is 20-30 Ke Benfaming pig paulownia good wine, transference cure after 30 days.

5, Lee, the man, 10 years old, by the mosquito bite shank, ulcer appears, and sufferings are hard to bear, smear pig paulownia good wine of the present invention, can walk after eight months, take continuously physical rehabilitation 18 months.

6, Liu, the man 12 years old, by the knee wound, smears pig paulownia good wine of the present invention, i.e. recovery from illness after 3 days.

7, Zhang, the man, 74 years old, after testing: blood plasma blood sugar 〉=8.9 mM/l (160 milligrams/deciliter) were typical patients with diabetes mellitus, drink continuously 3 months, and blood sugar obviously reduces, 1 year rechecks empty stomach whole blood blood sugar afterwards is 5.9 mM/ls.

8, the village, the man, 70 years old, the leg joint pain was drunk 3 months for many years continuously, and pain alleviates, and continues to drink pain disappearance half a year, rechecks afterwards in 1 year: it is painless painful normally to walk.

Pig paulownia good wine of the present invention, drink in right amount and can improve the health, the curative effect that gets rid of illness that it is special is and seed of jog's tears pig Xian, the contained chemical ingredients of Harlequin Glorybower Leaf and Twig is inseparable, especially seed of jog's tears pig Xian, the effect of the new material that the ethanol generation chemical reaction that produces with fermentation between the chemical ingredients of each material of Harlequin Glorybower Leaf and Twig produces, can't learn, in a word, the wine liquid that the used raw material of pig paulownia good wine of the present invention generates through rationally compatibility and its unique preparation method contains certain for the medicable material of human body, and these materials have played ill getting rid of illness, effect without treating diseases and making health-care.

Claims (1)

1. Yi Zhong pig paulownia good wine is characterized in that being formed through fermented soy by weight ratio by following raw material:

Seed of jog's tears 500g, glutinous rice 500g, saccharifying enzyme 2g, highly active dry yeast 1g, pig Xian 150g, Harlequin Glorybower Leaf and Twig 150g;

Its production method concrete steps are as follows:

1), first seed of jog's tears, pig Xian, Harlequin Glorybower Leaf and Twig are ground into respectively meal;

2) seed of jog's tears powder and glutinous rice are put into large basin and mix an amount of water soaking of rear usefulness thoroughly after 1 hour, pull out and put into steamer and cook, cook rear truce, when treating that temperature is down to 35-40 ℃, put into the fermenting container of getting ready with who knows, add again saccharifying enzyme and highly active dry yeast that water is melted into liquid, after stirring that vessel port is tight-closed, fermented 7, and can steam wine;

The wine material that 3) will ferment complete takes out in the container and is separated into liquid and slag, and liquid is put into Liquor distillation pot, and slag is placed on the clean water mud ground plate, adds into pig Xian powder and Harlequin Glorybower Leaf and Twig powder to stir, and mixes rear accumulation thoroughly and covers plastics film and moistened 30 minutes;

4) will put double-edged fine-toothed comb above the Liquor distillation pot liquid, put gauze at double-edged fine-toothed comb, getting step 3 mixes thoroughly and moistens 30 cm thicks on the gauze that good material is put into double-edged fine-toothed comb, want when add high flame steam to be had spill this moment in time step 3 is mixed thoroughly and moisten good residue material gas is covered, with leaking with lid, until material is completed;

5) build the Liquor distillation pot lid, water is sealed lid again, and gas wine flows out through condenser, has first foreshot's gas to eject, and has flowed steaming wine process need 3 hours with regard to there being limpid liquor to flow out until fill a wine cup for after foreshot's gas is drained.