CN103007208A - Traditional Chinese medicine formula for preventing fatty liver hemorrhagic syndrome of broiler chickens - Google Patents
Traditional Chinese medicine formula for preventing fatty liver hemorrhagic syndrome of broiler chickens Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine formula for preventing fatty liver hemorrhagic syndrome of broiler chickens. The formula comprises, by weight, 900 parts of penthorum Chinense pursh, 900 parts of salvia miltiorrhiza, 800 parts of stringy stonecrop, 800 parts of hawthorn, 750 parts of giant knotweed, 650 parts of curcuma and 500 parts of liquorice. The formula is good in treatment effect, obvious in treatment effect on the fatty liver hemorrhagic syndrome of the broiler chickens, superior to choline and free of tolerance and noxious substance residual by the aid of a pure traditional Chinese medicine preparation.
Description
Technical field
The present invention relates to the Chinese veterinarian field, in particular the syndromic Chinese prescription of a kind of control meat kind chicken fatty liver hemorrhagic.
Background technology
Meat kind chicken is the chicken of cultivating specially the offspring, and together copulation of the opposite sex, hatches the broiler Seedling after being mainly used to produce hatching egg.Traditional kind fowl raising teacher supports or the flat mode of supporting of rack by ground is flat, and the present meat kind chicken patterns of raising in cages that adopt more.Raising in cages of meat kind chicken although save bedding and padding, improved stocking density, saved feedstuff, and the most incidental disease infects and propagation in the production of kind chicken but also reduced, and also exists a lot of weak points.Because the build of meat kind chicken own is large, it is few to raise activity in cage, thereby causes body constitution to descend, and the resistance of disease is weakened, and the chicken overfertilization occurs and causes fatty liver hemorrhagic syndrome.At present sickness rate is generally chicken group's 1%-2%, have up to 5%-7%, even more than 15%; Mortality rate generally is lower than 5%, sometimes up to 20%-60%, can also cause the egg production of meat breeder flock to descend, and affects the appearance of egg-laying peak, and what affect hatching egg enters to incubate rate, and oneself becomes the commonly encountered diseases of many national aquacultures at present.
A large amount of research datas show, cause the syndromic generation principal element of meat kind chicken fat liver to comprise: edible high energy Low protein diet; Fat (animal oil, the dregs of fat) content is too much in the feedstuff; The nutrients such as some lipophilic fat sex factor such as methionine, choline, biotin, vitamin lack; The imbalance of body internal hormone is on the low side such as levels such as catecholamines in the blood; The hen house temperature is too high, subimbition, illumination are very few, change feedstuff, improper ventilation, the stressors such as frightened; The mould mycotoxin (aflatoxin, rubratoxin etc.) that loses generation of feedstuff also can cause liver function damage and cause that lipidosis falls ill in liver; The meat kind of raising in cages chicken is large because of feed intake, and activity space lacks, hypomotility, the fatty over-deposit of the easier generation of consuming little energy.
Its feature pathological changes is liver enlargement, and liver is yellow greasy shape, and there are petechia and white necrosis region in the surface, and matter is crisp frangible, when cutting with cutter, has fat to drip on the surface of cutter and adheres to; The chicken Glisson's capsule of sudden death breaks, and surface and intraperitoneal have clot; Subcutaneous, abdominal viscera is surperficial, a large amount of fat is all arranged around pelvic cavity and the fallopian tube.Suffer from the general overfertilization of this sick chicken, it is normal 25%～30% that body weight generally exceeds, and laying rate descends, and mortality rate increases, and this disease of high temperature season is particularly evident.The syndromic effective ways of prevention meat kind chicken fatty liver hemorrhagic are at present: the limit of strict implement finishing period hen is raised program, to keep suitable standard body weight; Should note guaranteeing nutritional labeling enough in the daily ration, can in every 1000kg feedstuff, add choline chloride 500g, methionine 500g, multivitamin 50g to morbidity chicken group, use continuously l0d; Also can in feedstuff per ton, add copper sulfate 63g, choline 550g, vitamin B
233mg, vitamin E 5500IU, methionine 550g, simultaneously crude protein in the daily ration is improved 1%-2%, energy level suitably reduces, morbidity chicken group there is preferably curative effect, but the raiser has any problem to the mixing homogeneity of medicine, and the simultaneously bad on the contrary impact of choline dosage control can cause untoward reaction.Also have the scholar to use some Chinese medicine formulas to prevent to obtain certain curative effect, but use the Chinese medicine component many, prescription is complicated, and mechanism is unclear, and cost is high; The modes that adopt mix fodder more, the chicken group absorbs difficulty, and onset is slow.For effectively treating meat kind chicken fatty liver hemorrhagic syndrome, it is theoretical that Chinese veterinarian is used in this test, use Chinese herbal medicine Penthorum chinense, Radix Salviae Miltiorrhizae, Herba Sedi, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Radix Curcumae, Radix Glycyrrhizae reasonable formula, it is main reaching blood circulation promoting and blood stasis dispelling, dispersing the stagnated live-QI to relieve the stagnation of QI, spleen invigorating intestinal stasis relieving, be aided with simultaneously heat-clearing and toxic substances removing, the function of gallbladder promoting removing dampness, the fat liver heat removing disappears, add in the ill chicken group drinking-water, observe it to the syndromic impact of meat kind chicken fatty liver hemorrhagic, for diagnosis and the Chinese herbal treatment of this disease provides theoretical foundation, be that meat kind chicken produces service better.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of control meat kind chicken fatty liver hemorrhagic syndromic Chinese prescription for the deficiencies in the prior art.
Technical scheme of the present invention is as follows:
The syndromic Chinese prescription of a kind of control meat kind chicken fatty liver hemorrhagic, prescription is: Penthorum chinense 900 weight portions, Radix Salviae Miltiorrhizae 900 weight portions, Herba Sedi 800 weight portions, Fructus Crataegi 800 weight portions, Rhizoma Polygoni Cuspidati 750 weight portions, Radix Curcumae 650 weight portions, Radix Glycyrrhizae 500 weight portions.
The present invention has following beneficial effect:
1 has selected the less Chinese herbal medicine such as Penthorum chinense, Herba Sedi, Rhizoma Polygoni Cuspidati, Radix Curcumae of usefulness of veterinary clinic, the medicine of the inside has hepatoprotective effect preferably, can also be antibacterial, antiviral, blood fat reducing, blood glucose, and adopt Chinese veterinarian's abstract science according to monarch, minister, help, make and carry out prescription, have no at present identical prescription report.
2 use modern preparation technique, use the liposoluble constituent in the modern Chinese medicine preparation technique ethanol refluxing process extraction medicine, and utilize decocting method to extract water soluble ingredient, and the fully extraction that reaches effective ingredient is prepared into oral liquid, has reduced the using dosage of medicine.Changed the method for spice after using crude drug directly to pulverize in the bibliographical information, and direct drinking-water, has absorbed sooner, it is short to have solved the Intestinum Gallus domesticus road, the difficult characteristics of Chinese herbal medicine powder absorption.
3 curative effects are high, and are obvious to the syndromic therapeutic effect of meat kind chicken fatty liver hemorrhagic, are better than choline, and pure Chinese medicinal preparation does not have toleration and nuisance residual simultaneously.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
1 test material and method
1.1 trial drug
Chinese medicine Penthorum chinense 900g is available from Gulin Penthorum chinense cooperative society, and Radix Salviae Miltiorrhizae 900g, Herba Sedi 800g, Fructus Crataegi 800g, Rhizoma Polygoni Cuspidati 750g, Radix Curcumae 650g, Radix Glycyrrhizae 500g are available from Yaan Huimin hall pharmacy, and 60 orders are pulverized respectively after being accredited as the certified products medical material, pack for subsequent use.
Get above 7 flavors, wherein Penthorum chinense adds 6 times of amounts (ml/g, lower with) 65%(V/V) alcohol reflux 2 times, each 1.5 hours, merge extractive liquid, filtered, and filtrate recycling ethanol is concentrated into and distinguishes the flavor of for subsequent use without ethanol; The 70%(V/V of 6 times of amounts of Radix Salviae Miltiorrhizae adding) alcohol reflux is 2 times, and each 2 hours, filter, filtrate recycling ethanol is concentrated into without ethanol and distinguishes the flavor of; The 80%(V/V of Fructus Crataegi, 6 times of amounts of Rhizoma Polygoni Cuspidati adding) alcohol reflux is 2 times, and each 1.5 hours, filter, filtrate recycling ethanol is concentrated into without ethanol and distinguishes the flavor of; All the other Herba Sedis, Radix Curcumae, Radix Glycyrrhizae, add 6 times of water gagings decoctions 2 times with Penthorum chinense, Radix Salviae Miltiorrhizae, Fructus Crataegi, Rhizoma Polygoni Cuspidati medicinal residues behind the ethanol extraction, each 1.5 hours, collecting decoction, and add above-mentioned Penthorum chinense, Radix Salviae Miltiorrhizae, Fructus Crataegi, Rhizoma Polygoni Cuspidati extract, thin up is to about 5300mL, be equivalent to every mL medicinal liquid and contain crude drug 1g, stirring and dissolving left standstill 12 hours, namely got (called after Plumbum preparatium liver protection decoction) for 2 times with 747 filter-cloth filterings.
1.2 experimental animal
Select the meat kind chicken of laying eggs of doubtful chicken fatty liver hemorrhagic syndrome natural occurrence in the Sichuan Agricultural University poultry breeding field, be no less than 700.
1.3 equipment and instrument
Electronic balance; The freezing desk centrifuge of high speed; Cryogenic refrigerator; Optical microscope; Photographing unit; Baking oven.
1.4 test method
1.4.1 the diagnosis of case and inclusive criteria
Carry out analysis-by-synthesis according to chicken group's kind, feed nutrition, age of onset, chicken group situation and clinical symptoms and make tentative diagnosis.Be diagnosed as chicken fatty liver hemorrhagic syndrome in conjunction with the eliminating of cuing open inspection pathological change, Serum Indexes detection, liver coefficient, liver fat rate, abdomen fat rate, laboratory diagnosis result and other case again.The fatty liver hemorrhagic syndrome sickness rate reaches 5% in the chicken group, judges that then this chicken group got fatty liver hemorrhagic syndrome.
The ill chicken of clinical symptoms is too obese, and what have surpasses 25% of normal type, and egg production reduces, and laying rate descends, and usually is reduced to 35%-55% by 75%-85%, can touch abundant fatty tissue at hypogastric region.Chicken is sudden onset often, and sick chicken spirit is depressed, poor appetite, and wattle, cockscomb fade and even are pale, and happiness is sleeping, is reluctant to walk about, and the abdominal part softness is sagging.Serious somnolence, paralysis, body temperature arrive 41.5-42.8 ℃, and then cockscomb, wattle and foot turn cold, can be dead within a few hours.
Pathological change is cutd open and is examined the chicken that dies of illness, and main manifestations is that intra abdominal fat deposits in a large number, and the periphery of particularly abdominal part, and muscular stomach and glandular stomach has the thick fat of one deck to exist.In addition, heart, mesentery etc. locate also to have the Fat Distribution of volume.The obvious enlargement of liver is light brown to yellow, and matter is crisp frangible and greasy feeling is arranged, and liver surface often has hemorrhage speckle, and a large amount of blood clots is arranged on every side.The liver disruption that has has large go out clot or blood clot in liver surface and the body cavity.Gallbladder enlargement or dwindle, cyst wall is because of the lipidosis thickening.Spleen matter is soft, generally loses enlargement.Muscular stomach is because the fat that is deposited wraps up, and its volume only is normal l/2-1/3, and the muscular stomach content is few, and Endothelium Corneum Gigeriae Galli is thin and easily peel off the attenuation of flesh layer.Kidney is enlargement slightly, and matter is crisp.Some cases also has one piece of normal hard shelled egg that forms in fallopian tube.
The Preliminary Determination of the detection of physiological and biochemical index Serum Indexes, liver coefficient, liver fat rate, abdomen fat rate is compared with normal kind chicken, and difference should be all remarkable.
Liver contact microscopy is got disease chicken liver contact microscopy, is full of fat vacuole in the visible hepatocyte, have in the endochylema a large amount of lipidosiss and differ in size hemorrhage; The visible local hepatic necrosis that has, fat are filled the air the whole lobules of liver that distributes, and make lobules of liver lose normal structure, and be similar to general fatty tissue.
1.4.2 test grouping
To make a definite diagnosis and suffer from 672 of the syndromic laying hens of chicken fatty liver hemorrhagic, be divided at random 3 groups, every group of 4 repetitions, each repeats each 56.The 1st group is the morbidity matched group, and the 2nd group of positive medicine matched group, choline chloride are pressed the dosed administration of 1g/kg feedstuff; The 3rd group is Plumbum preparatium liver protection decoction group, concentrates drinking-water by the concentration of 0.3mL/L, every day 1 time; Two test group observed first for 1 week, again successive administration treatment all drug withdrawals after 21 days, and the whole test period was 4 weeks.
1.5 General observation
4 weeks of experimental period, observe chicken group situation, search for food, drink water.
1.6 detection index
4 weeks of experimental period, respectively weigh 1 time (on an empty stomach 12h) when on-test in front 1 week and off-test, record the average weight of every group of chicken, the laying rate of every day, enter to incubate rate, mortality rate, cure rate after the end, and carry out 1 Serum Indexes and detect, liver coefficient, liver fat rate, abdomen fat rate measured.
1.6.1 sample collecting
Each each repeat to randomly draw 3 chickens and carry out following processing: every chicken body weight of weighing, wing venous blood collection (12h fasting before the blood sampling), preparation serum.Cut open after the blood sampling and kill, observe and record the naked eyes of respectively organizing the chicken viscera tissue and change, the complete liver of cutting of cutting open the belly takes by weighing liver weight; Peel off abdomen fat (fat around stomach fat and the muscular stomach), abdomen fat is weighed.
1.6.2 sample determination
After mensuration liver coefficient cutd open and kills chicken, the liver coefficient was calculated in the taking-up that liver is complete.Liver coefficient=liver weight (g)/body weight (g) * l00.
The mensuration of Biochemical Indices In Serum with disposable syringe on an empty stomach wing venous blood collection 2～5ml in centrifuge tube, slant setting 30min at room temperature, the centrifugal 10min of 3500r/min, serum are placed on-20 ℃ of preservations.Measure the content of T-CHOL (TC), triglyceride (TG), glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) in the serum according to the explanation of diagnostic test box.
The mensuration of liver fat rate
(1) liver of preserving under the low temperature is thawed under room temperature.
(2) liver being put into 105 ℃ baking oven dries to constant weight; Simultaneously fat-free filter paper is dried to constant weight in 105 ℃ of baking ovens, weigh up its weight (over dry filter paper is heavy) with electronic balance.
(3) sample is taken out from baking oven grind after, get 2g and wrap in the filter paper, labelling is good, again puts into baking oven and dries to constant weight, and weighs up the accurate weight (sample Bao Chong before the defat) of each filter paper packet at electronic balance.
(4) filter paper packet is put into exsiccator and be cooled to room temperature, with long forceps filter paper packet is put into the apparatus,Soxhlet's extracting barrel, inject l.67 doubly the absolute ether of primary rainbow pipette, the sample bag is immersed in the ether fully.Connect the extractor each several part, connect the condensed water current, in water bath with thermostatic control, carry out extracting, regulate water temperature between 70 ℃～80 ℃, make the ether of lower of condensation become beaded (120～150/min or reflux 7 times/more than the h), extracting (needs 6～12h) to extracting till a ether in the cylinder checks oil stains-less with the filter paper drop approximately.
(5) extracting complete after, take out filter paper packet with long forceps, make the ether volatilization in the ventilation.Ether in the extraction flask reclaims separately.Treat after the ether volatilization filter paper packet to be placed the l05 ℃ of dry 2h of baking oven, put into exsiccator and be cooled to till the constant weight, (sample Bao Chong after the defat) at last weighs.
(6) calculate liver fat rate liver fat rate (%)=(sample Bao Chong after the front sample Bao Chong-defat of defat) (g)/(sample Bao Chong before the defat-over dry filter paper is heavy) (g) * 100.
The mensuration of abdomen fat rate
The electronic balance that is placed with large plate is returned to zero; The chicken of slaughtering after weighing is cut open the chest from abdominal part, peel off first stomach fat, again the fat around the muscular stomach is peeled off out, be put in the large plate; It is heavy to weigh up and count record abdomen fat, calculates abdomen fat rate.Fat around the abdomen fat weight=stomach fat weight+muscular stomach is heavy; Heavy (g) * 100 of heavy (the g)/live body of abdomen fat rate (%)=abdomen fat.
1.7 the statistical disposition of test data
Test data carries out statistical analysis all by the statistics requirement with SPSS software, and all data are carried out significance test of difference with meansigma methods X ± standard deviation (SD) expression with variance analysis.
2 results and analysis
2.1 the selection of case
Be selected from Sichuan Agricultural University poultry breeding field 350 age in days meat kind chickens, laying rate drops to present 43% by early stage 75%, and sick chicken spirit is depressed, poor appetite, and wattle, cockscomb fade and even are pale, and happiness is sleeping, is reluctant to walk about, and the abdominal part softness is sagging.Find that after dissecting intra abdominal fat deposits in a large number, the periphery of particularly abdominal part, and muscular stomach and glandular stomach has the thick fat of one deck to exist.In addition, heart, mesentery etc. locate also to have the Fat Distribution of volume.The obvious enlargement of liver is light brown to yellow, and matter is crisp frangible and greasy feeling is arranged, and liver surface often has hemorrhage speckle, and a large amount of blood clots is arranged on every side.The liver disruption that has has large go out clot or blood clot in liver surface and the body cavity.Gallbladder enlargement or dwindle, cyst wall is because of the lipidosis thickening.Spleen matter is soft, generally loses enlargement.Muscular stomach is because the fat that is deposited wraps up, and its volume only is normal l/2～1/3, and the muscular stomach content is few, and Endothelium Corneum Gigeriae Galli is thin and easily peel off the attenuation of flesh layer.Kidney is enlargement slightly, and matter is crisp.Serum Indexes detection, liver coefficient, liver fat rate, abdomen fat rate are compared with normal kind chicken, and difference should be all remarkable; Get disease chicken liver contact microscopy, be full of fat vacuole in the visible hepatocyte, a large amount of lipidosiss is arranged in the endochylema.This chicken group of preliminary judgement suffers from fatty liver hemorrhagic syndrome, can be used as experimental animal.
2.2 overview
Respectively organizing main manifestations before the test is that appetite descends, astasia, and happiness is sleeping, and the enlarged abdomen softness is sagging, and severe patient is drowsiness, paralysis, one-sided sleeping ground, body temperature rises to 42 ℃; Minority case cockscomb, wattle are pale, and accidental cockscomb increases.During off-test, matched group still keeps weak state, without taking a turn for the better; Choline group and Plumbum preparatium liver protection decoction group mortality rate after medication 10 days reduces gradually, and cockscomb begins to redden, and the chicken group substantially recovers normal drinking-water and searches for food during off-test, laying rate and enter the rate of incubating certain rising is arranged.
2.3 fertility performance situation
As can be seen from Table 1, respectively organize indices before the test without significant difference (P＞0.05).3 weeks, as seen from Table 2, matched group increased by 13.88%, 13.25% difference extremely significantly (P＜0.01) than choline group, Plumbum preparatium liver protection decoction group body weight respectively when finishing.Laying rate comparative control group difference choline group and Plumbum preparatium liver protection decoction group reduce by 46.70%, 67.11% difference extremely significantly (P＜0.01); The choline group reduces by 13.91% significant difference (P＜0.05) than Plumbum preparatium liver protection decoction group.Enter to incubate rate relatively, matched group difference choline group and Plumbum preparatium liver protection decoction group reduce by 32.84%, 38.92% difference extremely significantly (P＜0.01).Mortality rate compares, and matched group difference choline group and Plumbum preparatium liver protection decoction group increase by 48.99%, 68.59% difference extremely significantly (P＜0.01); The choline group increases by 38.42% difference extremely significantly (P＜0.01) than Plumbum preparatium liver protection decoction group.Cure rate compares, and matched group difference choline group and Plumbum preparatium liver protection decoction group reduce by 79.64%, 98.05% difference extremely significantly (P＜0.01).After medication, choline group and Plumbum preparatium liver protection decoction group chicken group recover gradually, it is normal that body weight is tending towards, laying rate, enter to incubate rate and rise, mortality rate reduces, and the higher state of an illness of cure rate is effectively controlled, and matched group production achievement continues to descend, showing as body weight increases, and laying rate, enters to incubate rate and descends, and mortality rate rises.
Chicken public sentiment condition in front 1 week of table 1 administration
Chicken public sentiment condition in 3 weeks after table 2 administration
Represent difference extremely significantly (p＜0.01) with the different capitalizations of column data, different lowercase alphabet differentials different significantly (p＜0.05), same letter or without letter representation without significant difference (P＞0.05).
2.4 liver index variation
After cuing open extremely chicken, the liver coefficient is calculated in the taking-up that liver is complete.Liver coefficient=liver weight (g)/body weight (g) * l00.The result is as follows:
Table 3 liver index variation situation n=12
Find out that from upper table before the test, each organizes difference not remarkable (p＞0.05).When administration finishes, Plumbum preparatium liver protection decoction group and choline group all with matched group significant difference (p＜0.05), reduce respectively 12.65%, 13.71%.Can reduce the liver coefficient after the use medicine is described, eliminate the swelling of liver.
2.5 the mensuration of Biochemical Indices In Serum
With disposable syringe on an empty stomach wing venous blood collection 2～5mL in centrifuge tube, slant setting 30min at room temperature, the centrifugal 10min of 3500r/min, serum are placed on-20 ℃ of preservations.Measure the content of T-CHOL (TC), triglyceride (TG), glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) in the serum with automatic blood analyzer.As seen from Table 4, during on-test, each organizes difference not remarkable (P＞0.05).In 3 whens week after the administration, Plumbum preparatium liver protection decoction group and matched group glutamate pyruvate transaminase difference difference is (P＜0.05) extremely significantly, reduces by 25.00%, and choline group and matched group glutamate pyruvate transaminase difference is remarkable (P＜0.01) extremely, reduction by 29.17%; Glutamic oxaloacetic transaminase, GOT relatively Plumbum preparatium liver protection decoction group, choline group respectively with matched group difference extremely significantly (P＜0.01), reduce by 21.26%, 23.21%; T-CHOL is respectively organized difference not remarkable (P＞0.05), and the medicine group is lower than matched group; Triglyceride Plumbum preparatium liver protection decoction group, choline group respectively with matched group difference extremely significantly (P＜0.01), reduce by 48.35%, 57.46%.
Table 4 administration is the biochemical indicator situation during front 1 week
After table 5 administration 3 when week the biochemical indicator situation
2.6 the mensuration of liver fat rate
Adopt method noted earlier to record liver fat rate, as seen from Table 6, liver fat rate 1 week after medication is respectively organized and is not had significant difference (P＞0.05), but all is lower than matched group.2 whens week, Plumbum preparatium liver protection decoction group and choline group all with matched group difference difference extremely significantly (P＜0.01), reduce respectively 14.82%, 23.04%.2 whens week, Plumbum preparatium liver protection decoction group and choline group all with matched group difference significant difference (P＜0.05), reduce respectively 27.66%, 23.17%.
Table 6 liver fat rate measurement result
2.7 the mensuration of abdomen fat rate
Find out that from following table 7 before the test, it is not remarkable that each organizes difference.When administration finished, Plumbum preparatium liver protection decoction group and matched group difference is (P＜0.01) extremely significantly, reduced by 23.99%, and choline group and matched group difference significant difference (P＜0.05) reduce by 18.87%.
Table 7 abdomen fat rate measurement result
3 discuss
3.1 overview
By after using choline and Plumbum preparatium liver protection decoction, chicken group's outward appearance be improved significantly, searching for food drinking-water obtains replying successful.
3.2 fertility performance situation
Matched group fertility performance continuous decrease, and the body weight of medicine group is alleviated, enters to incubate rate and rises gradually at laying rate, and wherein Plumbum preparatium liver protection decoction group effect is better than matched group and choline group.
3.3 liver coefficient
After the medication, the liver coefficient decreases, and the medicine group is obvious, with improve liver circulation, certain relation diminishes inflammation.The prescription Chinese medicine can improve microcirculation disturbance, but also can improve because of the dysbolismus due to the cell hypoxic-ischemic, can be external the metabolite Accelerating Removal in the liver, improve simultaneously hepatocellular fibrosis, diminish inflammation, this also is the reason that affects fertility performance, liver index variation.
3.4 biochemical indicator
T-CHOL (TC), triglyceride (TG), glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) in the index serum of reflection liver health, be improved significantly.Hepatocyte be protected and be repaired to Chinese drug-treated group can, keeps hepatocellular normal function, and the permeability of liver plasma membrane is reduced, and the transaminase discharges reduction in the cell.Li Kunwu etc. (2003) reported ' ' JD-three levies liver Thailand " the chicken FLS that is caused by high lipid food is had remarkable therapeutical effect; can significantly reduce TG in hepatic fat content and the serum, TC resultant; alleviate hepatocyte edema, downright bad lesion degree, it is active to reduce serum GPT, GOT.
3.5 liver fat rate and abdomen fat rate
After using medicine, the blood circulation of liver part improves, and nutrition supply is obviously supplied with, and the hepatocyte metabolism is restored and strengthens, and can promote the outward transport of liver fat, accelerates the beta oxidation in hepatocyte, so liver fat rate is reduced; Abdomen fat rate is also obviously improved Plumbum preparatium liver protection decoction successful simultaneously.
3.6 about medicament composing prescription
Penthorum chinense is monarch drug in the side, Ming Dynasty's herbal for Relief of Famines begins to be stated from, warm in nature, sweet in the mouth, nontoxic, tool heat clearing away, diuresis elimination of urine, detoxify, invigorate blood circulation, the effect such as suppressing the hyperactive liver, spleen invigorating, the jaundice of dispelling, be Miao ethnic group's treatment hepatopathy among the people through proved recipe, be called " Radix Rhodiolae ", cure mainly jaundice, edema, amenorrhea, metrorrhagia, leukorrhagia, traumatic injury, and various hepatitis, cholecystitis, fatty liver etc.But modern study shows the spleen invigorating soothing liver-QI, protects the liver to treat liver, and collateral dredging is invigorated blood circulation, transaminase lowering, and for fatty liver, alcoholic liver, the medicine liver, hepatic injury, hepatic fibrosis, liver cirrhosis and metabolic gout etc. has prevention and repairs blocking effect.Radix Salviae Miltiorrhizae is ministerial drug, can invigorate blood circulation and transfer liver, stasis-dispelling and pain-killing, the removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind, the modern study proof can suppress and hepatocellular degeneration when alleviating acute and chronic liver injury, necrosis and inflammatory reaction, accelerating fibers is organized heavily and is absorbed, and has anti-hepatic fibrosis, improves the effect that liver blood circulates, prevents liver cirrhosis.Herba Sedi is adjuvant drug, is extremely wide medicinal herbs commonly used of folklore simply, and all herbal medicine has the effect of heat-clearing and toxic substances removing, swelling diuretic, evacuation of pus granulation promoting etc.; Sarmentosin has the effect of obvious reduction serum glutamic pyruvic transminase, and effect also is the active drug for the treatment of hepatitis rapidly and lastingly.Fructus Crataegi is adjuvant drug, can appetite-stimulating indigestion-relieving, change stagnate removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm; Be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.; Studies confirm that Fructus Crataegi can significantly reduce serum cholesterol and triglyceride, effectively prevents and treats atherosclerosis; Fructus Crataegi can also be by strengthening myocardial contraction, increasing cardiac output.Rhizoma Polygoni Cuspidati is adjuvant drug, the hemostasis of Huoxue San " expectorant, the detoxifcation of dispeling the wind, anti-inflammatory analgetic, remuval of damp and hot jaundice arranged, control chronic tracheitis, antibiotic, antiviral, protect the liver, the effect such as blood fat reducing, blood glucose.Radix Curcumae is for making medicine, can promoting QI circulation for relieving depression, and removing heat from blood removing blood stasis with potent drugs, soothing the liver strongly fragrant all medicine people Liver Channel that draws.The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, modern pharmacology proof have the effect of adrenocortical hormone sample, arrhythmia have protect the liver, the effects such as analgesia, analgesic, sedation, blood fat reducing, cholesterol reducing, resisting pathogenic microbes.All medicines share the more aobvious magical effect, are total to long memorial liver spleen dampness removing, repercussive intestinal stasis relieving, the merit of disappear fat liver heat removing, heat-clearing and toxic substances removing.
4 conclusions
By this test as can be known, the Plumbum preparatium liver protection decoction has preferably therapeutical effect to the fatty liver that meat kind chicken occurs, and can obviously play under doses and improve fertility performance, reduces mortality rate, improves cure rate; The liver protecting; reduce the liver coefficient; reduce glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, cholesterol, triglyceride; can also reduce the effect of liver fat rate, abdomen fat rate; the Plumbum preparatium liver protection decoction has had the soothing liver and strengthening spleen of moving back dampness removing by reasonable formula; the repercussive intestinal stasis relieving, the merit of disappear fat liver heat removing, heat-clearing and toxic substances removing can be used for the treatment of clinical meat kind chicken fatty liver.
Should be understood that, for those of ordinary skills, can be improved according to the above description or conversion, and all these improvement and conversion all should belong to the protection domain of claims of the present invention.
Claims (1)
1. prevent and treat the syndromic Chinese prescription of meat kind chicken fatty liver hemorrhagic for one kind, it is characterized in that, prescription is: Penthorum chinense 900 weight portions, Radix Salviae Miltiorrhizae 900 weight portions, Herba Sedi 800 weight portions, Fructus Crataegi 800 weight portions, Rhizoma Polygoni Cuspidati 750 weight portions, Radix Curcumae 650 weight portions, Radix Glycyrrhizae 500 weight portions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310018500.3A CN103007208B (en) | 2013-01-18 | 2013-01-18 | Traditional Chinese medicine formula for preventing fatty liver hemorrhagic syndrome of broiler chickens |
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| CN103446440A (en) * | 2013-08-29 | 2013-12-18 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treating poultry fatty liver hemorrhagic syndrome and preparation method thereof |
| CN105250913A (en) * | 2015-11-03 | 2016-01-20 | 吉林农业大学 | Medicinal composition for treating fatty liver syndrome of laying hen |
| CN108042596A (en) * | 2017-12-15 | 2018-05-18 | 中南民族大学 | Stringy stonecrop is preparing the application in resisting the drug of hyperlipidemia and fatty liver caused by alcohol |
| CN110680902A (en) * | 2019-11-22 | 2020-01-14 | 沈阳伟嘉牧业技术有限公司 | Traditional Chinese medicine composition for treating laying hen fatty liver |
| CN112353854A (en) * | 2020-11-24 | 2021-02-12 | 四川农业大学 | Traditional Chinese medicine composition for preventing and treating laying hen fatty liver syndrome and preparation method thereof |
| CN112425699A (en) * | 2020-11-24 | 2021-03-02 | 四川丰岩牧野农业发展有限公司 | Traditional Chinese medicine composition and feed for improving growth performance and immune function of black-bone hen chicks and preparation method of traditional Chinese medicine composition and feed |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446440A (en) * | 2013-08-29 | 2013-12-18 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treating poultry fatty liver hemorrhagic syndrome and preparation method thereof |
| CN103446440B (en) * | 2013-08-29 | 2015-11-25 | 青岛绿曼生物工程有限公司 | Syndromic pure Chinese medicine composition for the treatment of poultry fatty liver hemorrhagic and preparation method thereof |
| CN105250913A (en) * | 2015-11-03 | 2016-01-20 | 吉林农业大学 | Medicinal composition for treating fatty liver syndrome of laying hen |
| CN105250913B (en) * | 2015-11-03 | 2019-11-12 | 吉林农业大学 | A kind of pharmaceutical composition for treating laying hen fatty liver syndrome |
| CN108042596A (en) * | 2017-12-15 | 2018-05-18 | 中南民族大学 | Stringy stonecrop is preparing the application in resisting the drug of hyperlipidemia and fatty liver caused by alcohol |
| CN110680902A (en) * | 2019-11-22 | 2020-01-14 | 沈阳伟嘉牧业技术有限公司 | Traditional Chinese medicine composition for treating laying hen fatty liver |
| CN112353854A (en) * | 2020-11-24 | 2021-02-12 | 四川农业大学 | Traditional Chinese medicine composition for preventing and treating laying hen fatty liver syndrome and preparation method thereof |
| CN112425699A (en) * | 2020-11-24 | 2021-03-02 | 四川丰岩牧野农业发展有限公司 | Traditional Chinese medicine composition and feed for improving growth performance and immune function of black-bone hen chicks and preparation method of traditional Chinese medicine composition and feed |
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