CN103007042B - Traditional Chinese medicine composition for treating gastric ulcer - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating gastric ulcer, wherein Fructus Polygoni Orientalis and cuttlebone are used as a monarch drug for replenishing qi to invigorate spleen, clearing away heat and promoting dieresis, and dispersing blood stasis and relieving pain; and costustoot, radix angelicae, rhizoma atractylodis macrocephalae and cortex moutan are used as a ministerial drug for enhancing effects. Meanwhile, the costustoot further enables qi of tri-jiao to be ventilated, so as to recover the function of middle burner spleen and stomach lowering; the spleen prefers moisture to dryness and the rhizoma atractylodis macrocephalae can eliminate dampness and realize diuresis, so as to further enhance spleen and stomach functions, and keep healthy and do not be evil; and the function of removing blood stasis and producing new blood of the radix angelicae and the cortex moutan are adopted. Rhizoma bletillae and roasted concha arcae are used as adjuvant drugs to enhance hyperacidity relieving and skin generating functions. When the spleen and the stomach are healthy, qi is promoted and the blood stasis is removed and wetting heat is removed; and all the medicines are combined so as to replenish qi to invigorate the spleen, clear away heat and promote diuresis, remove blood stasis and relieve pain, and relieve hyperacidity and generate skin. The clinical utilization shows that the traditional Chinese medicine composition has the reliable curative effect on treating the gastric ulcer and has no untoward effects; and the traditional Chinese medicine composition can be accepted by vast gastric ulcer patients and is worthy of being popularized. The total effective rate is 90.5% and the traditional Chinese medicine composition is an effective drug for treating the gastric ulcer.

Description

A kind of Chinese medicine composition for the treatment of gastric ulcer

Technical field

The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of gastric ulcer.

Background technology

Gastric ulcer be due to gastric mucosa is had detrimental effect invasion and attack factor and mucosa self-defense/reparation factor between unbalanced result.Gastric mucosa is except the gastric acid of frequent contact high concentration, also be subject to the invasion and attack of pepsin, microorganism, cholate, ethanol, medicine and other harmful substances, under normal circumstances, gastric mucosa can be resisted the detrimental effect of these invasion and attack factors, maintain the integrity of mucosa, but strengthen in invasion and attack factor, or in the time that defence/reparation factor weakens, or both are while existing simultaneously, can cause the generation of gastric ulcer.Clinical manifestation is: upper abdomen middle part, rhythmicity pain to the right or to the left, and acid regurgitation, belch, heartburn, Abdeminal pain, feels sick, vomiting, loss of appetite etc.

Gastric ulcer belongs to the categories such as the traditional Chinese medical science " gastric abscess ", " acid regurgitation ", and sick position is at stomach, closely related with liver, spleen.Stomach is burnt between two parties, the main digesting food of being received, with reduce to suitable.Stomach is connected with film with spleen, the exterior and the interior each other, and The spleen has the function to transport and transform nutrients, rises and be good for, and the two one rise and one drop, is the important department of ascending or descending movement of vital Qi, and liver controlling conveyance and dispersion helps the fluent middle burnt mechanism of qi of taste.Improper diet and overtiredness, spleen and stomach function is impaired, transformation failure of spleen, functional activity of QI being not smooth; Liver-QI transversely invading the stomach, the liver failing to dredge the spleen, dysfunction of the spleen in transportation, stomach-QI being unable to descend normally, depression and stagnation of QI, stomach network is obstructed, stagnation of QI and blood may bring about pain; The delicious food of being addicted to drink, retention of damp-heat in the interior, stomach loses and makes moist; It is sick that the blood stasis of blood is stagnant for a long time; Do not allow pain.Meanwhile, hyperactive liver-QI attacking the stomach, in retention of damp-heat in the interior, Jiao also can cause acid regurgitation, and the disease of clinical findings is often complicated and changeable, simulataneous insufficiency and excessive.Chinese medicine improving symptom, improve aspect ulcer healing quality and there is larger advantage,, few side effects low than western medical treatment relapse rate.(Wang Yu, Xie Peilin, the progress [J] of Chinese medicine gastric ulcer, Hubei Journal of Traditional Chinese Medicine, 2012,34(10): 77-79.)

Summary of the invention

The traditional Chinese medical science is thought the generation of gastric ulcer, is mainly because eating and drinking without temperance, feelings will are smooth, overstrain internal injury etc. causes spleen and stomach function weakness, transformation failure of spleen, and ascending or descending movement of vital Qi is not normal; Or depression and stagnation of QI, with the passing of time hematogenous blockage, stasis blocking stomach network; Or due to retention of damp-heat in the interior etc.

For the Chinese medicine of abundant treatment gastric ulcer, the invention provides a kind of Chinese medicine composition for the treatment of gastric ulcer.

The invention provides a kind of Chinese medicine composition for the treatment of gastric ulcer, composition and the mass ratio of its formula are as follows: the mass ratio of Fructus Polygoni Orientalis, Endoconcha Sepiae, the Radix Aucklandiae, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Cortex Moutan, Pseudobulbus Bletillae (Rhizoma Bletillae) and Concha Arcae (calcined) is 2:3:1:2:3:2:2:2.

Fructus Polygoni Orientalis, enters liver, stomach, spleen three warps.There is repercussive eliminating stagnation, invigorating spleen to remove dampness, effect of clearing away heat to alleviate pain.The effect of " not Lu " Yan Qiyou " QI invigorating "." Chinese herbal medicine is commonly used in Shanghai " says its " loose blood, removing food stagnancy, pain relieving ".Modern study, it can be used for the treatment of gastric ulcer.Endoconcha Sepiae, " book on Chinese herbal medicine is new again " Yan Qike enters spleen channel.There is dehumidifying, effect of astringing to arrest bleeding, antacid sore." modern Practical Chinese medicinal " claims it: " for antacid, effective to hyperchlorhydria, gastric ulcer ".Modern pharmacological research shows that it contains calcium carbonate, can do antacid agent.The two is monarch drug.

The Radix Aucklandiae, can enter spleen, stomach, Liver Channel, and the stagnant gas of kind current taste, is the key medicine of promoting the circulation of QI to relieve pain.Compendium of Material Medica speech: " Radix Aucklandiae, is the medicine of three warmers edema caused by disorder of QI, all gas of energy lifting ".The Radix Angelicae Dahuricae, returns stomach warp, has dampness, an evacuation of pus of invigorating blood circulation, effect of granulation promoting pain relieving, and it is kind in Yangming Channel damp.Compendium of Material Medica speech: " row hands sun is bright for the Radix Angelicae Dahuricae, the white acrid in the mouth of color; Gas warm in nature is thick, and row foot sun is bright; For the bright principal agent of sun, thus disorders of blood can be controlled again, and the pain relieving of evacuation of pus granulation promoting ".Therefore, and the use Radix Angelicae Dahuricae " broken stagnated blood, mends fresh blood ... pain relieving granulation promoting " (" Japan hanako materia medica ").The Rhizoma Atractylodis Macrocephalae, returns spleen, stomach warp, has invigorating the spleen and benefiting QI, the effect of dampness diuretic." Rhizoma Atractylodis Macrocephalae, is to foster taste ... help digestion except the key medicine of painful abdominal mass also.Insufficiency of the spleen strong, art can be mended it, and insufficiency of stomach is not received, and art can help it " (" book on Chinese herbal medicine converges and says "), modern pharmacological research shows: the card Rhizoma Atractylodis Macrocephalae of ulcer, and can pus expelling by strengthening vital QI.Cortex Moutan, clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.It can " control the intestines and stomach hematocele, epistaxis, haematemesis ... " (" pearl sac "), " settling five organs is treated carbuncle skin ulcer " (Shennong's Herbal).Modern pharmacological research shows, its contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; Paeonol has the effect such as analgesia, antiulcer simultaneously.Four is ministerial drug.

" Pseudobulbus Bletillae (Rhizoma Bletillae), astringing QI ooze expectorant, hemostasis, the medicine of eliminating carbuncle is also " (" book on Chinese herbal medicine converges and says "), enter liver, stomach warp with it, hemostasis, detumescence, granulation promoting, sore.Modern pharmacological research shows, 1% Pseudobulbus Bletillae (Rhizoma Bletillae) decoct gavage, and the rat pipe film injury that hydrochloric acid is caused has protective effect; To anesthetized dog, experimental Stomach duodenum perforation has therapeutical effect.Concha Arcae (calcined), can enter stomach, Liver Channel, has effect of relieving gastric hyperacidity to alleviate stomachache." Peptic Ulcers is controlled in relieving gastric hyperacidity to alleviate stomachache " (" Shandong Chinese herbal medicine handbook ".Modern pharmacological research shows, this product master is containing calcium carbonate, in energy and gastric acid, alleviates the pain of gastric ulcer.The two is adjuvant drug.

Fructus Polygoni Orientalis, Endoconcha Sepiae are monarch drug, replenishing QI to invigorate the spleen, clearing away heat-damp and promoting diuresis, blood-activating analgetic.The Radix Aucklandiae, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Cortex Moutan are ministerial drug, and principal drug assistance is strengthened effect.Meanwhile, also can the pass through gas of three warmers of the Radix Aucklandiae, in recovery, burnt spleen rises the merit that stomach falls; " spleen preferring dryness to dampness ", the Rhizoma Atractylodis Macrocephalae also can the further strong spleen and stomach function of dampness diuretic, reaches " healthy energy deposit in, heresy can not be done "; Separately get the merit of the Radix Angelicae Dahuricae, Cortex Moutan eliminating blood stasis to promote regeneration of blood.Taking Pseudobulbus Bletillae (Rhizoma Bletillae) and Concha Arcae (calcined) the two as adjuvant drug, to strengthen the effect of antacid, granulation promoting.

The invention provides a kind of Chinese medicine composition for the treatment of gastric ulcer, prescription is scientific and reasonable.Both logical traditional Chinese medical science pharmacology, has again modern medicine technology for evidence.The strong gas clots absorbing of taste is dispelled, and heat of wetting removes, and all medicines share, replenishing QI to invigorate the spleen, clearing away heat-damp and promoting diuresis, stasis-dispelling and pain-killing, antacid granulation promoting.

A kind of Chinese medicine composition for the treatment of gastric ulcer provided by the invention, adopts the agent of prior art granulation.

Instructions of taking is as follows: by the granules medicine of above-mentioned 1 dosage, pour in container, add warm water 300mL, stir and make it abundant mixing, day 2 times, early sub-service in 1 hour after ante cibum, supper, 1 dose of every day.1 dosage is as embodiment 1.Treatment time is totally 28 days 1 course for the treatment of.

Taboo: this Chinese medicine composition allergy sufferers is forbidden. criterion of therapeutical effect and therapeutic outcome:" new Chinese medicine guideline of clinical investigations (trying) ", Beijing, Chinese Medicine science and technology publishing house, 2002:151-155.), determine criterion of therapeutical effect as follows: fully recover: ulcer and around inflammation all disappear.Effective: ulcer disappears, and still has inflammation.Effective: ulcer area is dwindled more than 50%.Invalid: ulcer area is dwindled not as good as 50%. treatment case and therapeutic effect statistics:according to mentioned above principle and criterion of therapeutical effect, use Drug therapy patients w ith peptic ulcer disease 126 examples of the present invention, wherein, male 70 examples, female's 56 examples; 30～66 years old age.Take medicine 1 course for the treatment of by instructions of taking, recovery from illness 33 examples, effective 36 examples, totally 69 examples, male 36 examples, female's 33 examples, cure-remarkable-effectiveness rate 54.8%.Effective 45 examples, male 27 examples, female's 18 examples, effective percentage is 35.7%.Invalid totally 12 examples, male 7 examples, female's 5 examples; Be 9.5%.Total effective rate is cure-remarkable-effectiveness rate+effective percentage, and total effective rate is 90.5%.Treatment time is totally 28 days 1 course for the treatment of. beneficial effect:a kind of Chinese medicine composition for the treatment of gastric ulcer provided by the invention, Fructus Polygoni Orientalis, Endoconcha Sepiae are monarch drug, replenishing QI to invigorate the spleen, clearing away heat-damp and promoting diuresis, blood-activating analgetic.The Radix Aucklandiae, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Cortex Moutan are ministerial drug, and principal drug assistance is strengthened effect.The simultaneously Radix Aucklandiae gas of three warmers that also can pass through, in recovery, burnt spleen rises the merit that stomach falls; " spleen preferring dryness to dampness ", the Rhizoma Atractylodis Macrocephalae also can dampness diuretic, and further strong spleen and stomach function reaches " healthy energy deposit in, heresy can not be done "; Separately get the merit of the Radix Angelicae Dahuricae, Cortex Moutan eliminating blood stasis to promote regeneration of blood.Taking Pseudobulbus Bletillae (Rhizoma Bletillae) and Concha Arcae (calcined) the two as adjuvant drug, to strengthen the effect of antacid, granulation promoting.The strong gas clots absorbing of taste is dispelled, and heat of wetting removes, and all medicines share, replenishing QI to invigorate the spleen, clearing away heat-damp and promoting diuresis, stasis-dispelling and pain-killing, antacid granulation promoting.Clinical showing, a kind of Chinese medicine composition for the treatment of gastric ulcer provided by the invention, treatment gastric ulcer curative effect is reliable, and has no adverse reaction, and can be accepted by vast patients w ith peptic ulcer disease, and clinic is promoted.Its total effective rate is 90.5%, is a kind of active drug that is used for the treatment of gastric ulcer. detailed description of the invention embodiment 1treat a Chinese medicine composition for gastric ulcer, composition and the mass ratio of its formula are as follows: Fructus Polygoni Orientalis 10g, Endoconcha Sepiae 15g, Radix Aucklandiae 5g, Radix Angelicae Dahuricae 10g, Rhizoma Atractylodis Macrocephalae 15g, Cortex Moutan 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g and Concha Arcae (calcined) 10g.A kind of Chinese medicine composition for the treatment of gastric ulcer provided by the invention, adopts the agent of prior art granulation.Instructions of taking is as follows: by the granules medicine of above-mentioned 1 dosage, pour in container, add warm water 300mL, stir and make it abundant mixing, day 2 times, early sub-service in 1 hour after ante cibum, supper, 1 dose of every day.Treatment time is totally 28 days 1 course for the treatment of.Taboo: this Chinese medicine composition allergy sufferers is forbidden. criterion of therapeutical effect and therapeutic outcome:" new Chinese medicine guideline of clinical investigations (trying) ", Beijing, Chinese Medicine science and technology publishing house, 2002:151-155.), determine criterion of therapeutical effect as follows: fully recover: ulcer and around inflammation all disappear.Effective: ulcer disappears, and still has inflammation.Effective: ulcer area is dwindled more than 50%.Invalid: ulcer area is dwindled not as good as 50%.

Claims (2)

1. a Chinese medicine composition for the treatment of gastric ulcer, is characterized in that, composition and the mass ratio of its formula are as follows: the mass ratio of Fructus Polygoni Orientalis, Endoconcha Sepiae, the Radix Aucklandiae, the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Cortex Moutan, Pseudobulbus Bletillae (Rhizoma Bletillae) and Concha Arcae (calcined) is 2:3:1:2:3:2:2:2.

2. the Chinese medicine composition for the treatment of gastric ulcer as claimed in claim 1, it is characterized in that, composition and the quality of its formula are as follows: Fructus Polygoni Orientalis 10g, Endoconcha Sepiae 15g, Radix Aucklandiae 5g, Radix Angelicae Dahuricae 10g, Rhizoma Atractylodis Macrocephalae 15g, Cortex Moutan 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g and Concha Arcae (calcined) 10g.

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