CN100396311C - Medicine for treating recurrent peptic ulcer - Google Patents

Abstract

The present invention discloses a medicine for treating relapsing peptic ulcer, which is prepared from raw materials of the following portions by weight: 80 to 90 portions of airbladder, 60 to 80 portions of thunberg fritillary bulb, 85 to 100 portions of cuttlefish bone, 90 to 100 portions of calcined oyster shell, 55 to 75 portions of bletilla tuber, 60 to 80 portions of stalactite, 75 to 90 portions of chicken's egg membrane carbon, 30 to 50 portions of notoginseng, 75 to 90 portions of rhubarb, 60 to 86 portions of pinellia tuber, 35 to 50 portions of chicken's gizzard-membrane, 35 to 50 portions of corydalis tuber, 85 to 100 portions of milkvetch root, 55 to 80 portions of ginseng and 28 to 50 portions of sliced antler. The total effective rate of the medicine is 100%; the medicine has the advantages of high pain alleviating and ulcer healing speed, no toxic or side effect, convenient administration and portability; combined with the existing western medicines, the cure rate of the present invention is obviously enhanced, and the relapse rate is low; the relapse rate of the medicine group of the present invention is obvious lower than that of the control group.

Description

A kind of medicine for the treatment of recurrent peptic ulcer

Technical field

The present invention relates to a kind of Chinese medicine for the treatment of peptic ulcer, is a kind of medicine for the treatment of recurrent peptic ulcer specifically.

Background technology

Peptic ulcer mainly refers to occur in the duodenal ulcer of harmonization of the stomach, treatment Chinese and western medicine to peptic ulcer all can obtain gratifying clinical efficacy at present, especially Western medicine antacid, receptor antagonist, proton pump inhibitor, bismuth etc. continue to bring out, the clinical cure rate of peptic ulcer obviously improves, but relapse rate was still up to more than 80% in 1 year, cause the great attention of medical circles, so the treatment of anti-peptic ulcer recurrence, the radical cure peptic ulcer becomes the research focus.

Scientist finds that gastric ulcer is by due to the helicobacter pylori, is generally proved now, and it all is microbial by helicobacter pylorus surpassing 90% duodenal ulcer and surpassing 80% gastric ulcer.

Say that from the traditional Chinese medical science angle peptic ulcer belongs to disease categories such as " stomach infections ", " gastric abscess ", " stomachache ", " epigastric pain ", " pantothenic acid ", it is unsuccessful more than this is sick because of feelings will, eating and drinking without temperance, the overstrain internal injury, weakness of the spleen and stomach, or because of exopathogen invasion and attack, medicine irritation etc., make taste lose key, the stomach network is impaired and ulcer occurs.

Peptic ulcer is a cardinal symptom with epigastrium pain in often, has chronicity, rhythmicity, repetitious dull pain, burning pain, dull pain, severe pain or with belch, pantothenic acid, feel sick, symptom such as vomiting.

Summary of the invention

The object of the present invention is to provide a kind of medicine for the treatment of recurrent peptic ulcer, make this disease relapse rate low, alleviate the patient suffering.

The traditional Chinese medical science thinks that spleen is that soil is dirty, irrigates four and is close to, and it is the source of QI and blood that temper, taste are all arranged in the five internal organs, and so the root of the five internal organs is the appellation the foundation of acquired constitution.Point out among the Li Dongyuan " Treatise on the spleen and stomach ": " the vigour abundance, all because of QI of the spleen and stomach do not have hinder, then can nourish vigour.Gastric qi is a little less than this, eating twice as usual, then QI of the spleen and stomach is promptly hindered, vigour can not be filled, and all causes of disease and give birth to also." modern pharmacological research shows that the medical instrument of invigorating the spleen and benefiting QI has the treatment gastric mucosa injury, increases the effect that mucosal blood flow promotes ulcer healing.

Verify through clinical treatment decades routine peptic ulcers up to ten thousand: it is basic that temper is good for fortune, the key that deficiency of spleen-QI is not only the ulcer morbidity and is lapsed to, and the key of recurrence after Peptic Ulcers heals especially, this point has become the common recognition of Most scholars.Primary disease is a deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, and cold and heat are staggered, wet stasis of blood cross-reference.In treatment, must whole develop simultaneously with the part, invigorating the spleen and benefiting QI, deficiency and excess is taken into account, cold Wen Xiangshi, the wet stasis of blood in like manner, lifting and accent can guarantee just that in the hope of reaching " the prosperous four seasons of spleen are not subjected to heresy " peptic ulcer for the treatment of recovery from illness no longer recurs.

Medicine of the present invention is made by the raw material of following parts by weight:

Air Bladder pseudosciaenae seu Acipenser 80--90 part, Bulbus Fritillariae Thunbergii 60--80 part, Endoconcha Sepiae 85--100 part, Concha Ostreae (calcined) 90--100 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 55--75 part, Stalactitum 60--80 part, Membrana Follicularis ovi charcoal 75--90 part, Radix Notoginseng 30--50 part, Radix Et Rhizoma Rhei 75--90 part, Rhizoma Pinelliae 60--86 part, Endothelium Corneum Gigeriae Galli 35--50 part, Rhizoma Corydalis 35--50 part, Radix Astragali 85--100 part, Radix Ginseng 55--80 part, Cornu Cervi tablet 28--50 part.

The said medicine Air Bladder pseudosciaenae seu Acipenser is fried into pearl with breathing out powder, removes Pulvis concha Mactrae, and Membrana Follicularis ovi is sprinkled upon the Membrana Follicularis ovi surface with 95% ethanol, light with fire, burn till carbon, other medicines dry naturally or dry, pulverized the 80-100 mesh sieve, encapsulated, every heavy 0.5 gram, each clothes 5--6 grain, every day three times, or make every clothes 3 grams of the watered pill, every day three times, or make every ball 12 grams of honeyed pill, obey a ball at every turn, every day three times, obeying 30 is a course of treatment.

The further scheme of above-mentioned medicine is:

80 parts in Air Bladder pseudosciaenae seu Acipenser, 65 parts of Bulbus Fritillariae Thunbergii, 85 parts of Endoconcha Sepiaes, 90 parts of Concha Ostreae (calcined)s, 55 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 60 parts of Stalactitums, 75 parts of Membrana Follicularis ovi charcoals, 30 parts of Radix Notoginseng, 75 parts of Radix Et Rhizoma Rhei, 60 parts of the Rhizoma Pinelliaes, 40 parts of Endothelium Corneum Gigeriae Galli, 45 parts of Rhizoma Corydalis, 90 parts of the Radixs Astragali, 55 parts of Radix Ginsengs, 30 parts of Cornu Cervi tablets.

The effect of every flavor medicine in this prescription:

Air Bladder pseudosciaenae seu Acipenser: strengthening by means of tonics, strongly invigorating QI and blood, contained colloid protection ulcer surface is with the merit that strengthens detumescence and promoting granulation, pain relieving behind the stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE.

Endoconcha Sepiae: contain in the calcium salt energy and gastric acid, alleviate pantothenic acid,, can promote the ulcer surface antiinflammatory simultaneously, quicken ulcer healing, so the effect of antacid, pain relieving, hemostasis, removing dampness, granulation promoting is arranged to the burning sensation good effect of stomach.

Bulbus Fritillariae Thunbergii: removing heat-phlegm, mass dissipating and swelling eliminating, peimine have spasmolytic, dissipating depression of QI sending down the abnormal ascending QI, astringing to arrest bleeding, the deacidification effect helps digestion.

Concha Ostreae (calcined): antiacid pain relieving, calm antiinflammatory, raise immunity, the fine and close blood capillary of energy is to reduce the permeability of blood vessel.

The Pseudobulbus Bletillae (Rhizoma Bletillae): matter is sticking and puckery, contains Rhizoma Bletillae gel, can form one deck coverlay at mucomembranous surface, prevents the erosion to mucosa of gastric acid and pepsin, protection ulcer surface, analgesic hemostatic, putrefaction-removing granulation-promoting, subduing swelling and detoxicating.

Stalactitum: chemical constituent mainly is a calcium carbonate, and the antacid effect is stronger, and the merit of benefiting qi and supporting yang is arranged.

The Membrana Follicularis ovi charcoal: astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, granulation promoting is dried, invigorating the spleen and replenishing QI, invigorating the stomach and promoting digestion.

Radix Notoginseng: can stop blooding, again can blood circulation promoting and blood stasis dispelling, shabby tissue regeneration promoting, putrefaction-removing granulation-promoting can promote gastric mucosa blood circulation and gastric mucosa reparation, again helicobacter pylori is had inhibitory action.

Radix Et Rhizoma Rhei: clear. Tang Rong river cloud: " Radix Et Rhizoma Rhei is the gas medicine simply, is again the blood medicine, and the stasis of blood, particularly panacea are not stayed in hemostasis ".The Radix Et Rhizoma Rhei hemostatic function is not second to Radix Notoginseng, and especially to upper gastrointestinal hemorrhage, function is distinguished.10 people opinions such as " Journal of Traditional Chinese Medicine " (1991 5 phase 25 pages) Ning Xihong: point out in " the rhubarb treatment campylobacter pyloridis positive is to the peptic ulcer clinical observation " literary composition that Radix Et Rhizoma Rhei has 5 kinds of effects, 1, antibiotic, remove campylobacter pyloridis, help ulcer healing.2, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling can suppress allergy and the microcirculation that strengthens diseased region, and degree reduces inflammation.3, promote the gastric mucosa PGE2 to generate, this material can promote gastric mucosal blood flow, promotes mucous secretion, the gastric acid inhibitory secretion, and class matter fat is accumulated, and strengthens gastric mucosal barrier, and plays the effect of protection mucosa.4, the effect that reduces stomach free acid and pepsin activity is arranged, help the gastric duodenal ulcer healing.5, the effect of the vegetative nerve of adjusting is arranged, make disorderly stomach functional rehabilitation normal, also help ulcer healing.

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, dissolving lump and resolving mass, stopping nausea and vomiting by lowering the adverse flow of QI.3 people such as " Liaoning Journal of Traditional Chinese Medicine " (1992 10 phase 42 pages) Liu Shouyi: " Rhizoma Pinelliae antiulcer action Experimental Study of Mechanism " literary composition is pointed out: the Rhizoma Pinelliae has four kinds of effects, 1, gastric acid inhibitory secretion, 2, reduce the free acidity of gastric juice, 3, reduce the total acidity of gastric acid.4, suppress pepsin activity.

Endothelium Corneum Gigeriae Galli: stomach function regulating is aid digestion, contains gastric hormone, increases gastric motility.

Rhizoma Corydalis: collateral dredging, soothing the liver, circulation of qi promoting, pain relieving, promote local organization vasodilation, blood flow quickens, and helps the edema extinction of ulcer surrounding tissue, can reduce stomachial secretion gastric acid and pepsin, accelerates healing time.

The Radix Astragali: replenishing QI to invigorate the spleen, mend the foundation of acquired constitution, strengthen body immunity, improve the activity of gastric mucosa superoxide dismutase, eliminate free radical, play the effect of protection gastric mucosa.

Radix Ginseng: element culturing fixed folder, invigorating the spleen and benefiting QI increases the defence capability of human body to destructive stimulus, improves the human body stress ability, the regulating muscle body immunity function.

Cornu Cervi tablet: strong effect is arranged, and the warming YANG benefit is smart, reaches the purpose of temperature compensation expelling the toxic substance from the body with tonic.Dissipating blood stasis for subsidence of swelling has its regenerated effect of enhancing to long-term ulcer and for the moment newborn bad ulcer that is difficult for healing.

Integral formulation treatment of the present invention combines with topical therapeutic, all medicines share, complement each other, element culturing fixed folder, invigorating the spleen and benefiting QI, dispersing the stagnated liver-QI for regulating the stomach, the removing dampness dissipating blood stasis, pain relieving antacid, granulation promoting the hit main idea of treatment ulcer of infections that heals, reach that vigour is filled, temper is good for, protect the stomach film, hold back ulcer, tissue regeneration promoting flesh, healing soon, do not recur.

The invention has the advantages that: 1 total effective rate is 100%, and the rapid ulcer healing of pain relieving is fast, and there were significant differences with existing Western medicine contrast cure rate, sees Table 2.2, relapse rate is low, is starkly lower than matched group with medicine group relapse rate of the present invention, sees Table 3.3, have no side effect.4, take easy to carry.

Clinical experiment

Time: in January, 2002-2004 year December.

Patient's choice criteria: select outpatient's 400 examples, gastroscopy meets " internal medicine " (People's Health Publisher the 5th edition) peptic ulcer diagnostic criteria; The patient is divided at random with Drug therapy 200 examples of the present invention western medicine group 200 examples; Two groups of patient's sex ages, the course of disease, ulcer kind, ulcer area are all similar, difference with insignificance between group, and (P＞0.05) has comparability.

Table 1 patient situation

Therapeutic Method: with medicine group of the present invention, obey 6 at every turn, every day 3 times, obey 3 courses of treatment, 30 days per courses of treatment.Matched group adopts Western medicine omeprazole sheet 20mg, and 1 time/day, morning is oral on an empty stomach; The each 100mg of bismuth pectin 3 times/day, serve on 3 courses of treatment, 30 days per courses of treatment.Use other drug during the treatment, finish gastroscopy the course of treatment, judge curative effect.

Curative effect determinate standard

Short term effect criterion

Cure: clinical symptoms, sign disappear, the healing of gastroscope check ulcer surface; Produce effects: clinical symptoms, sign disappear substantially, and gastroscope check ulcer surface heals substantially or dwindles more than 2/3; Take a turn for the better: clinical symptoms, sign have improvement, and gastroscope check ulcer surface dwindles 1/2; Invalid: clinical symptoms, sign do not have obvious improvement, and gastroscope check ulcer surface dwindles less than 1/2, or no change.

Late result criterion

Two groups of gastroscopys are judged the patient who cures: drug withdrawal was followed up a case by regular visits to after 1 year, and no ulcer clinical symptoms recidivist is not for recurring, if symptoms such as stomachache, belch, pantothenic acid occur between withdrawal time, the check gastroscope finds that focus person is a ulcer recurrence.

The result

1, clinical general curative effect relatively

Table 2 curative effect of medication synopsis of the present invention

Two groups of contrasts, clinical effective rate difference are remarkable (P＞0.05) not, and there were significant differences for cure rate (P＜0.05).

2, ulcer recurrence situation contrast

Two groups of drug withdrawals that heal the sick were followed up a case by regular visits to after 1 year, and the result is starkly lower than matched group with medicine group relapse rate of the present invention.

Table 3 ulcer recurrence situation contrast table

The contrast of two groups of recurrence situations, there were significant differences (P＜0.05), medicine of the present invention obviously low with in matched group.

Medical record is given an example:

What XX, man 54 years old, cadre, first visit in July, 2002.Patient's stomachache has 20 years, recently aggravation.Gastroscopy, there is the protrusion alcove in lesser gastric curvature portion, diameter 4.5CM, dark 0.5CM, the tenderness scope is wide, diagnosis: extensive inflammation and adhesion are arranged around the vertical huge ulcer of lesser gastric curvature, ulcer, the existing huge pain of epigastrium, anorexia, idol has pantothenic acid, constipation, the tongue tire is thick greasy, thready and rolling pulse, take 3 courses of treatment of this medicine, gastroscope is rechecked, and alcove disappears, local no tenderness, no gastropathy symptom, all are normal.

Open XX, man 53 years old, peasant, first visit in October, 2003.Patient's stomachache has 15 years, and be everlasting ante cibum and midnight occur, and often wake up because of stomachache night, and it is surplus February to separate melena, inappetence, and pale complexion, companion's acid regurgitation, noisy borborygmus, shortness of breath and fatigue, body of the tongue is red partially.Recently stomachache is violent, gastroscopy, pyloric cap antetheca diameter 1.2CM, roun ulcer, rear wall has a gingival pocket to form, diagnosis: duodenal ulcer, take 3 courses of treatment of this medicine, and all diseases disappear, the work of going to the field, gastroscope is rechecked, and front and back walls ulcer all heals.

Lee XX, man 46 years old, builder, first visit in February, 2004.Have a stomachache pantothenic acid 12 years of patient, stomach is noisy, the pantothenic acid stomachache, stomach has the underwater sound of shaking, the pain pain relieved by pressing, the hard earlier back of abdominal distention, stool is half congealed, and every autumn and winter increase the weight of, recently because of the food cold drink, the stomachache grand mal, gastroscopy, gastric antrum portion is the hyperemia of speckle sample, and one of diameter 1.4CM ulcer is arranged.Descendant duodenum mucous hyperemia edema, the portion antetheca of falling are seen diameter 1.0CM arranged side by side of two places and diameter 1.2CM ulcer, are diagnosed as plyability ulcer, take 3 courses of treatment of this medicine, and gastroscope is rechecked, and ulcer all heals.

Specific embodiment embodiment 1: 90 parts in Air Bladder pseudosciaenae seu Acipenser, 60 parts of Bulbus Fritillariae Thunbergii, 90 parts of Endoconcha Sepiaes, 100 parts of Concha Ostreae (calcined)s, 60 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 70 parts of Stalactitums, 75 parts of Membrana Follicularis ovi charcoals, 38 parts of Radix Notoginseng, 75 parts of Radix Et Rhizoma Rhei, 60 parts of the Rhizoma Pinelliaes, 35 parts of Endothelium Corneum Gigeriae Galli, 36 parts of Rhizoma Corydalis, 90 parts of the Radixs Astragali, 60 parts of Radix Ginsengs, 28 parts of Cornu Cervi tablets.

Embodiment 2: 83 parts in Air Bladder pseudosciaenae seu Acipenser, 65 parts of Bulbus Fritillariae Thunbergii, 98 parts of Endoconcha Sepiaes, 95 parts of Concha Ostreae (calcined)s, 73 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 67 parts of Stalactitums, 88 parts of Membrana Follicularis ovi charcoals, 35 parts of Radix Notoginseng, 85 parts of Radix Et Rhizoma Rhei, 86 parts of the Rhizoma Pinelliaes, 42 parts of Endothelium Corneum Gigeriae Galli, 40 parts of Rhizoma Corydalis, 85 parts of the Radixs Astragali, 65 parts of Radix Ginsengs, 30 parts of Cornu Cervi tablets.

Embodiment 3: 80 parts in Air Bladder pseudosciaenae seu Acipenser, 65 parts of Bulbus Fritillariae Thunbergii, 85 parts of Endoconcha Sepiaes, 90 parts of Concha Ostreae (calcined)s, 55 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 60 parts of Stalactitums, 75 parts of Membrana Follicularis ovi charcoals, 30 parts of Radix Notoginseng, 75 parts of Radix Et Rhizoma Rhei, 60 parts of the Rhizoma Pinelliaes, 40 parts of Endothelium Corneum Gigeriae Galli, 45 parts of Rhizoma Corydalis, 90 parts of the Radixs Astragali, 55 parts of Radix Ginsengs, 30 parts of Cornu Cervi tablets.

Embodiment 4: 85 parts in Air Bladder pseudosciaenae seu Acipenser, 70 parts of Bulbus Fritillariae Thunbergii, 100 parts of Endoconcha Sepiaes, 100 parts of Concha Ostreae (calcined)s, 70 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 65 parts of Stalactitums, 80 parts of Membrana Follicularis ovi charcoals, 40 parts of Radix Notoginseng, 80 parts of Radix Et Rhizoma Rhei, 80 parts of the Rhizoma Pinelliaes, 40 parts of Endothelium Corneum Gigeriae Galli, 38 parts of Rhizoma Corydalis, 100 parts of the Radixs Astragali, 70 parts of Radix Ginsengs, 35 parts of Cornu Cervi tablets.

Claims (2)

1. medicine for the treatment of recurrent peptic ulcer, it is characterized in that: this medicine is made by the crude drug of following parts by weight:

Air Bladder pseudosciaenae seu Acipenser 80--90 part, Bulbus Fritillariae Thunbergii 60--80 part, Endoconcha Sepiae 85--100 part, Concha Ostreae (calcined) 90--100 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 55--75 part, Stalactitum 60--80 part, membrana follicularis ovi charcoal 75--90 part, Radix Notoginseng 30--50 part, Radix Et Rhizoma Rhei 75--90 part, Rhizoma Pinelliae 60--86 part, Endothelium Corneum Gigeriae Galli 35--50 part, Rhizoma Corydalis 35--50 part, Radix Astragali 85--100 part, Radix Ginseng 55--80 part, Cornu Cervi tablet 28--50 part.

2. a kind of medicine for the treatment of recurrent peptic ulcer according to claim 1, it is characterized in that: this medicine is made by the crude drug of following parts by weight:

80 parts in Air Bladder pseudosciaenae seu Acipenser, 65 parts of Bulbus Fritillariae Thunbergii, 85 parts of Endoconcha Sepiaes, 90 parts of Concha Ostreae (calcined)s, 55 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 60 parts of Stalactitums, 75 parts of Membrana Follicularis ovi charcoals, 30 parts of Radix Notoginseng, 75 parts of Radix Et Rhizoma Rhei, 60 parts of the Rhizoma Pinelliaes, 40 parts of Endothelium Corneum Gigeriae Galli, 45 parts of Rhizoma Corydalis, 90 parts of the Radixs Astragali, 55 parts of Radix Ginsengs, 30 parts of Cornu Cervi tablets.