CN103006701A - 预防或治疗牙本质相关症状或疾病的组合物及方法 - Google Patents
预防或治疗牙本质相关症状或疾病的组合物及方法 Download PDFInfo
- Publication number
- CN103006701A CN103006701A CN2012102665405A CN201210266540A CN103006701A CN 103006701 A CN103006701 A CN 103006701A CN 2012102665405 A CN2012102665405 A CN 2012102665405A CN 201210266540 A CN201210266540 A CN 201210266540A CN 103006701 A CN103006701 A CN 103006701A
- Authority
- CN
- China
- Prior art keywords
- calcium
- preparation
- particle
- dentin
- tooth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 81
- 210000004268 dentin Anatomy 0.000 title claims abstract description 80
- 238000000034 method Methods 0.000 title claims abstract description 60
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 30
- 201000010099 disease Diseases 0.000 title claims abstract description 29
- 208000024891 symptom Diseases 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 claims abstract description 105
- 239000011575 calcium Substances 0.000 claims abstract description 46
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 43
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 42
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims description 52
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 50
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 46
- 239000004531 microgranule Substances 0.000 claims description 37
- 239000000243 solution Substances 0.000 claims description 34
- 239000002253 acid Substances 0.000 claims description 32
- 210000000214 mouth Anatomy 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 239000011737 fluorine Substances 0.000 claims description 27
- 229910052731 fluorine Inorganic materials 0.000 claims description 27
- 239000011574 phosphorus Substances 0.000 claims description 27
- 229910052698 phosphorus Inorganic materials 0.000 claims description 27
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 26
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 25
- 239000003710 calcium ionophore Substances 0.000 claims description 25
- CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical compound CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 claims description 25
- 239000000377 silicon dioxide Substances 0.000 claims description 24
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 18
- 235000012239 silicon dioxide Nutrition 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 14
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 14
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 14
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- 239000000126 substance Substances 0.000 claims description 11
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- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000001506 calcium phosphate Substances 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 9
- KLZUFWVZNOTSEM-UHFFFAOYSA-K Aluminium flouride Chemical compound F[Al](F)F KLZUFWVZNOTSEM-UHFFFAOYSA-K 0.000 claims description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 8
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 8
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 8
- 229910019142 PO4 Inorganic materials 0.000 claims description 7
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- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 6
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 6
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- 239000010452 phosphate Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 239000011775 sodium fluoride Substances 0.000 claims description 6
- 235000013024 sodium fluoride Nutrition 0.000 claims description 6
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 6
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 6
- 208000004188 Tooth Wear Diseases 0.000 claims description 5
- -1 acryl Chemical group 0.000 claims description 5
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- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
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- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 238000005299 abrasion Methods 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 229910000323 aluminium silicate Inorganic materials 0.000 claims description 4
- 229910052586 apatite Inorganic materials 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 4
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 4
- 229910001634 calcium fluoride Inorganic materials 0.000 claims description 4
- 239000000920 calcium hydroxide Substances 0.000 claims description 4
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- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 4
- 159000000007 calcium salts Chemical class 0.000 claims description 4
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 4
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- 235000011837 pasties Nutrition 0.000 claims description 4
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 4
- 239000011698 potassium fluoride Substances 0.000 claims description 4
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- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 4
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- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
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Abstract
Description
Claims (65)
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US13/242,866 US9901755B2 (en) | 2011-09-23 | 2011-09-23 | Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same |
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WO (1) | WO2013040952A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103876945A (zh) * | 2014-04-17 | 2014-06-25 | 厦门大学 | 一种牙本质小管封闭剂及其制备方法 |
CN104906137A (zh) * | 2015-06-01 | 2015-09-16 | 张亚南 | 一种牙科手术后的恢复药剂及包含所述药剂的膏体剂 |
CN105232575A (zh) * | 2015-10-22 | 2016-01-13 | 常州陀谱生物医学技术有限公司 | 牙齿脱敏剂、制备方法及其使用方法 |
CN106132421A (zh) * | 2014-03-21 | 2016-11-16 | 欧米亚国际集团 | 用于牙齿脱敏的经表面反应的碳酸钙 |
CN109953896A (zh) * | 2017-12-26 | 2019-07-02 | 苏州口腔医院有限公司 | 一种牙本质小管封闭剂及其制备方法 |
CN110974452A (zh) * | 2019-12-20 | 2020-04-10 | 上海交通大学医学院附属第九人民医院 | 表面修饰的钛及钛合金用于牙髓冠方封闭的应用 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9901755B2 (en) | 2011-09-23 | 2018-02-27 | Sancastle Worldwide Corporation | Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same |
NO2926797T3 (zh) * | 2014-03-31 | 2018-02-03 | ||
EP2997833B1 (en) * | 2014-09-22 | 2018-01-31 | Omya International AG | Surface-reacted calcium carbonate for use as anti-caking agent |
EP3175835A1 (en) * | 2015-12-04 | 2017-06-07 | Omya International AG | Oral care composition for remineralisation and whitening of teeth |
EP3509607A1 (en) * | 2016-09-08 | 2019-07-17 | Sancastle Worldwide Corporation | Formulation for preventing or treating dentin-associated symptoms or diseases, and method using the same |
CN109528498B (zh) * | 2018-12-30 | 2021-05-18 | 美釉(西安)生物技术有限公司 | 一种用于深入封闭牙小管并防止生物膜形成的牙齿脱敏剂 |
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CN1213355A (zh) * | 1996-01-29 | 1999-04-07 | 巴尔的摩的马里兰大学 | 生物活性玻璃组合物以及使用生物活性玻璃的治疗方法 |
CN1554607A (zh) * | 2003-12-22 | 2004-12-15 | 复旦大学 | 纳米介孔以及介孔-大孔复合生物玻璃及其制备方法 |
CN101528279A (zh) * | 2006-08-01 | 2009-09-09 | 荷兰联合利华有限公司 | 生物材料、其制备和用途 |
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GB136442A (en) | 1919-04-15 | 1919-12-18 | Viggo Valdemar Julius Andresen | Improvements in or relating to Dentifrices. |
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US5215740A (en) * | 1991-10-25 | 1993-06-01 | Church & Dwight Co., Inc. | Buffering system for anticalculus dentifrices |
CA2087911C (en) | 1992-01-24 | 1999-06-29 | Kiyoshi Abe | Spherical granules of porous silica or silicate, process for the production thereof, and applications thereof |
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US9901755B2 (en) | 2011-09-23 | 2018-02-27 | Sancastle Worldwide Corporation | Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same |
TWI483740B (zh) | 2011-09-23 | 2015-05-11 | Sancastle Worldwide Corp | 預防或治療牙本質相關症狀或疾病之組成物及方法 |
-
2011
- 2011-09-23 US US13/242,866 patent/US9901755B2/en not_active Expired - Fee Related
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2012
- 2012-07-30 WO PCT/CN2012/079345 patent/WO2013040952A1/zh active Application Filing
- 2012-07-30 CN CN201210266540.5A patent/CN103006701B/zh not_active Expired - Fee Related
- 2012-07-31 EP EP12178746.9A patent/EP2578272B1/en not_active Not-in-force
- 2012-09-21 JP JP2012207966A patent/JP5731459B2/ja not_active Expired - Fee Related
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2018
- 2018-01-11 US US15/868,559 patent/US10279203B2/en active Active
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CN1213355A (zh) * | 1996-01-29 | 1999-04-07 | 巴尔的摩的马里兰大学 | 生物活性玻璃组合物以及使用生物活性玻璃的治疗方法 |
CN1554607A (zh) * | 2003-12-22 | 2004-12-15 | 复旦大学 | 纳米介孔以及介孔-大孔复合生物玻璃及其制备方法 |
CN101528279A (zh) * | 2006-08-01 | 2009-09-09 | 荷兰联合利华有限公司 | 生物材料、其制备和用途 |
Cited By (7)
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CN106132421A (zh) * | 2014-03-21 | 2016-11-16 | 欧米亚国际集团 | 用于牙齿脱敏的经表面反应的碳酸钙 |
CN106132421B (zh) * | 2014-03-21 | 2021-01-29 | 欧米亚国际集团 | 用于牙齿脱敏的经表面反应的碳酸钙 |
CN103876945A (zh) * | 2014-04-17 | 2014-06-25 | 厦门大学 | 一种牙本质小管封闭剂及其制备方法 |
CN104906137A (zh) * | 2015-06-01 | 2015-09-16 | 张亚南 | 一种牙科手术后的恢复药剂及包含所述药剂的膏体剂 |
CN105232575A (zh) * | 2015-10-22 | 2016-01-13 | 常州陀谱生物医学技术有限公司 | 牙齿脱敏剂、制备方法及其使用方法 |
CN109953896A (zh) * | 2017-12-26 | 2019-07-02 | 苏州口腔医院有限公司 | 一种牙本质小管封闭剂及其制备方法 |
CN110974452A (zh) * | 2019-12-20 | 2020-04-10 | 上海交通大学医学院附属第九人民医院 | 表面修饰的钛及钛合金用于牙髓冠方封闭的应用 |
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CN103006701B (zh) | 2017-09-26 |
US10279203B2 (en) | 2019-05-07 |
US9901755B2 (en) | 2018-02-27 |
US20130078292A1 (en) | 2013-03-28 |
JP5731459B2 (ja) | 2015-06-10 |
US20180140873A1 (en) | 2018-05-24 |
JP2013067615A (ja) | 2013-04-18 |
WO2013040952A1 (zh) | 2013-03-28 |
EP2578272A1 (en) | 2013-04-10 |
EP2578272B1 (en) | 2018-11-14 |
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