CN103006530A - Bee venom compound with sun-proof effect - Google Patents
Bee venom compound with sun-proof effect Download PDFInfo
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- CN103006530A CN103006530A CN2012105629519A CN201210562951A CN103006530A CN 103006530 A CN103006530 A CN 103006530A CN 2012105629519 A CN2012105629519 A CN 2012105629519A CN 201210562951 A CN201210562951 A CN 201210562951A CN 103006530 A CN103006530 A CN 103006530A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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Abstract
The invention discloses a bee venom compound with a sun-proof effect. The bee venom compound comprises a sun-proof cosmetic substrate component and bee venom. According to the invention, the bee venom is applied to sun-proof cosmetics for the first time, can effectively prevent ultraviolet ray from hurting skin, relieve scytitis caused by sunburn, and meanwhile enable the skin to keep humidification, provide nutrient for the skin, prompt the rehabilitation of hurt skin, and improve the self-protecting ability of the skin. And in addition, according to the invention, the bee venom, algal polysaccharides and Vc phosphate magnesium are compounded, thus the effects (including sun resistance, diminish inflammation, repair after being exposed to the sun and the like) of the bee venom compound are enhanced. The bee venom compound with the sun-proof effect comprises cream, emulsion, water aqua, gelatum and jelly, and is suitable for crowd with various skin types.
Description
Technical field:
The invention belongs to cosmetic field, be specifically related to a kind of Venenum apis compositions with sun-proof function.
Background technology:
Aggravation along with environmental pollution and the destroyed degree of atmosphere shines ground ultraviolet also more and more stronger.Wherein, UVB(is ultraviolet B radiation) the strongest to the skin ability to function, can reach the corium surface, make corium vasodilation be nucleic acid or protein denaturation in red and swollen shape, the epidermis cell.After the permanent irradiation, edema, vesicle, erythema, decortication, aging appear in skin, even cause skin carcinoma.And UVA(is long wave ultraviolet) penetration power is stronger, can reach deep dermis, and effect has accumulation to skin.After the permanent irradiation, skin meeting brown, collagen fiber fracture, flexibility decrease, wrinkle generate.In addition, UVA causes that to UVB skin lesion also has synergism.Therefore, essential to the protection of UVB and UVA in the daily life.
In the sunscreen that China's " cosmetics health standard " (version in 2007) restriction is used, major part can only absorb UVB, and its sun-proof interval is single, light stability is poor, easy oxidized going bad, and skin is also had zest.A large amount of or life-time service can make skin produce and rely on, and easily cause Skin Cell and structural failure.And TiO
2Though can protect UVA with ZnO, when consumption was excessive, adsorptivity, the transparency and breathability were relatively poor, and skin is also had photocatalytic and zest, also easily stopped up pore.Although the kind of sun care preparations emerges in an endless stream on the market at present, sign has the potent sun care preparations of high spf value and PFA value to be subject to especially consumers in general's favor, but these cosmetics SPF (sun protection factor) are higher, the consumption of its sunscreen certainly will be just larger, and between the sunscreen, have mutual sensitization between sunscreen and solvent and the substrate.So, use the probability of these product skin allergy very large, sense of discomfort and insecurity also increase thereupon.
Summary of the invention:
The object of the invention is to for existing sun care preparations to skin have than strong and stimulating and phototoxicity, a large amount of use skin is produced rely on, skinfeel is greasy, breathability is poor, easily stop up the problem such as pore, provide a kind of safer, have a Venenum apis compositions of sun-proof function efficiently.
Venenum apis compositions with sun-proof function of the present invention comprises sun care preparations substrate composition, it is characterized in that, also contains Venenum apis.
Preferably, described Venenum apis prepares by the following method, gets thick Venenum apis water dissolution, and then after the ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
This Venenum apis purification process is being simplified the Venenum apis purifying process, provides cost savings simultaneously, can also to melittin, the effective enrichment of apamin isoreactivity material and concentrated with remarkable beautifying skin-protection function, remove hyaluronidase, phospholipase A
2Deng the material that easily causes skin allergy, inflammation and pain, guarantee safety, without skin irritation and irritated in, sun-proof function is significantly strengthened.This purification process has solved the not yet effective problem such as enrichment of active substance that has the beauty and skin care effect in the prior art in the Venenum apis, has filled up the blank that Venenum apis is used in sun care preparations, and has given full play to its sun-proof function.
Preferably, described Venenum apis, its content accounts for 0.00001% ~ 2% of Venenum apis compositions gross mass.
Described Venenum apis preferably prepares by the following method: get thick Venenum apis and add 10-30 times of volume water and fully dissolve, the centrifugal 10-30min of 5000-10000g, after the ultrafilter membrane of supernatant by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
The effect such as repair after, amelioration of inflammation sun-proof for strengthening, the solarization, the Venenum apis compositions with sun-proof function of the present invention preferably also contains Sargassum polysaccharides, and its content accounts for the 0.01%-5% of Venenum apis compositions gross mass.Further preferably also contain V
CMagnesium phosphorate, its content accounts for the 0.1%-5% of Venenum apis compositions gross mass.
Described Sargassum polysaccharides refers to one or more the combination in sodium alginate, Porphyra Polysaccharide, Thallus Laminariae polysaccharide, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma gelatinae polysaccharide, Hijiki polysaccharide, laminarin, Sargassum polysaccharide, spirulina polysaccharide, sargassan, Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) polysaccharide, fucoidin, angle fork polysaccharides, Zostera marina polysaccharide and the chlorella polysaccharide.Commercially available, also can be according to existing method preparation.
Described V
CMagnesium phosphorate can be from commercial.
Described thick Venenum apis can be the thick Venenum apis of wasp and/or the thick Venenum apis of Apis, can own use the collector of bee venom collection, also can be from commercial.
Also include sunscreen in the cosmetic base of the Venenum apis compositions with sun-proof function of the present invention, described sunscreen refers to UVA protective agent and/or UVB protective agent.
Described UVA protective agent is preferably 2,2 '-two-(1, the 4-phenylene) 1H-benzimidazole-4, the disodium salt of 6-disulfonic acid, MBBT, the Terephthalidene Dicamphor Sulfonic Acid, the combination of one or more in the BEMT, its consumption is, by the percentage ratio that accounts for Venenum apis compositions gross mass, 2,2 '-two-(1, the 4-phenylene) 1H-benzimidazole-4, the disodium salt 0.1% ~ 4.5% of 6-disulfonic acid, MBBT 0.1% ~ 3.5%, the Terephthalidene Dicamphor Sulfonic Acid 0.1% ~ 4.5%, BEMT 0.2% ~ 4.5%.
Described UVB protective agent is preferably Phenylbenzimidazolesulfonic acid and potassium, sodium and triethanolamine salt, ethylhexyl methoxy cinnamate, Ethylhexysalicylate, TiO
2In one or more combination, its consumption is, by the percentage ratio that accounts for Venenum apis compositions gross mass, Phenylbenzimidazolesulfonic acid and potassium thereof, sodium and triethanolamine salt 0.1%-3%, ethylhexyl methoxy cinnamate 0.02%-8%, Ethylhexysalicylate 0.2%-8%, TiO
20.5%-6%.
Above-mentioned UVA protective agent, UVB protective agent and cosmetic base all can be commercial.
Venenum apis compositions with sun-proof function of the present invention prepares by the following method, with Venenum apis take powdery form or be mixed with in advance mass fraction and be the 10%-50% aqueous solution, with other composition homogenizing or mix, can according to the technique preparation of the sun care preparations kind of preparing according to routine, can be made into the sun care preparationss such as cream frost, emulsion, water preparation, gel or gel.
Venenum apis composition stable with sun-proof function of the present invention is good, coating evenly, spreadability is good.Zoopery and human body are tried out the results show; Venenum apis compositions safety with sun-proof function of the present invention, to skin non-stimulated or photosensitization, can effectively prevent and reduce ultraviolet to the infringement of skin, and can improve the self-protection ability of skin comprehensively.
The function cosmetics that the Venenum apis compositions that the present invention has a sun-proof function can be used as ordinary cosmetics or has an anti-sunlight function use.
Solution of the present invention be based on the inventor to ultraviolet characteristic, skin by the light stability of the mechanism of action of ultraviolet injury, ultraviolet means of defence, sunscreen with to the sensitization of skin, and to the understanding of functional activity material beauty and skin care effect, in conjunction with modern sun care preparations and pharmacological research achievement, filter out in the multifunction activity material of comforming and have remarkable maintenance skin wetness, opposing ultraviolet injury, diminish inflammation, reduce Venenum apis, Sargassum polysaccharides and V that melanin formed, repaired the effect such as sunburn skin
CMagnesium phosphorate carries out scientific composition with sunscreen, gives full play to and the multi-efficiency such as repairs after sun-proof, antiinflammatory, the solarization.
Venenum apis with Venenum apis compositions of sun-proof function of the present invention contains abundant melittin, apamin, catecholamine, free amino acid, vitamin, trace element and glycerol isoreactivity composition.Its molecular weight is little, and immunogenicity is low, is difficult for producing anaphylaxis.Melittin has the effects such as obvious antioxidation, anti-ultraviolet radiation, can eliminate scytitis, suppress swelling.Apamin can improve microcirculation, promotes the epidermis cell metabolism, accelerates the old and new's Skin Cell and substitutes, and Skin Cell is rejuvenated again.Catecholamine has antiinflammation to the damaged skin that causes because of illumination etc., is beneficial to wound healing, reduces cicatrix.Free amino acid, vitamin and trace element isoreactivity substance assist to keep skin wetness, nutrition is provided; and it is active to have an antioxidation, restraint of tyrosinase; can protect skin to avoid ultraviolet injury, check melanin generation, and improve the natural cover for defense function of skin.Glycerol can absorb airborne moisture, prevents the moisture of skin evaporation, thereby reaches moistening effect, and can assist the ability that improves the skin self-regeneration.
The common outer gelatinised matrix of the born of the same parents that contain large quantity of moisture that forms of other polysaccharide components and fibrous proteins in Sargassum polysaccharides in the Venenum apis compositions with sun-proof function of the present invention and the skin; form one deck homogeneous film at skin surface; make moisture permeate into horny layer and induce its further aquation from substrate microstructure; when effectively replenishing moisture of skin, reducing the percutaneous moisture loss, strengthened the self-protection ability of skin.Sargassum polysaccharides can also promote horn cell and skin flbroblast growth, increases skin elasticity, remove UV-induced free radical, upgrades rapidly and repair sunburn skin.It effectively the absorption portion wave-length coverage ultraviolet, weaken and eliminate ultraviolet to skin sunburn, tanned effect, with Venenum apis, V
CAfter magnesium phosphorate and sunscreen are composite, skin is significantly improved to the protective capacities of UVA and UVB.
V in the Venenum apis compositions with sun-proof function of the present invention
CThe magnesium phosphorate stable chemical nature, be difficult for oxidized, be not subjected to the factor affecting such as alkali or metal ion, after skin absorbs by the rapid enzymolysis of the phosphate V that can dissociate
CV
CAs the endogenous antioxidant, have the restraint of tyrosinase activity, pigmentation is effectively desalinated and reduced to reducible UV-induced melanin, makes skin not by tanned.V
CCan also effectively remove free radical, reduce UV-induced inflammatory reaction, activate collagenic supersession, repair sunburn skin, thus the delaying skin photoaging.Simultaneously, V
CMagnesium phosphorate can also effectively increase chemical stability, effectiveness and the sun-proof property of the Venenum apis compositions with sun-proof function.
2,2 '-two-(1, the 4-phenylene) 1H-benzimidazole-4, the disodium salt of 6-disulfonic acid, MBBT, Terephthalidene Dicamphor Sulfonic Acid, BEMT can absorb the ultraviolet in UVA zone, can improve the PFA value of the Venenum apis compositions with sun-proof function.
Phenylbenzimidazolesulfonic acid and potassium thereof, sodium and triethanolamine salt, ethylhexyl methoxy cinnamate, Ethylhexysalicylate can absorb the ultraviolet in UVB zone, can improve the spf value of the Venenum apis compositions with sun-proof function.
TiO
2Can usable reflection and scatters ultraviolet, reduce itself and the contacting of skin, raising has spf value and the PFA value of the Venenum apis compositions of sun-proof function.
Compared with prior art, the present invention has following beneficial effect:
1, the present invention is directed to the special physiology of skin structure and to the sensitivity of the used composition of cosmetics, the Venenum apis with preferred pure natural of Venenum apis compositions of sun-proof function of the present invention is primary raw material.Although it is very rare to add at present the cosmetics of Venenum apis, Venenum apis is included already in " international cosmetic raw material standard Chinese catalogue (2010 editions) ", and it is safe, feasible that this explanation is applied to cosmetics with Venenum apis.In addition, in the Venenum apis compositions with sun-proof function of the present invention, employed Venenum apis is through purification process, the material that easily causes skin allergy, inflammation and pain in the thick Venenum apis is effectively removed, and the compositions such as melittin, apamin is highly enriched, thereby given play to more significant sun-proof function.Simultaneously, the Venenum apis among the present invention can be absorbed by the skin rapidly, does not cause skin allergy, also can not bring any burden to skin.
2, the Venenum apis compositions with sun-proof function of the present invention optimizes Venenum apis, Sargassum polysaccharides, the V of pure natural
CMagnesium phosphorate and sunscreen are collaborative composite, with skin the better compatibility are arranged, and can be absorbed by the skin rapidly, and be safe, gentle, do not cause the reactions such as stimulations, allergy, and skin is not born yet, and owing to Venenum apis and Sargassum polysaccharides, V
CThe forward synergism of magnesium phosphorate, sunscreen when reducing the sunscreen consumption, has significantly improved it to ultraviolet protective capacities, has effectively improved properties of product.
3, Venenum apis, Sargassum polysaccharides, the V in the Venenum apis compositions with sun-proof function of the present invention
CMagnesium phosphorate can absorption portion ultraviolet, and improve the self-protection ability of skin comprehensively.After reducing the use amount of sunscreen, not only do not weaken it to ultraviolet protective capacities, its properties of product and safety are significantly improved, and prevented from occuring because of untoward reaction such as the inflammation of using a large amount of sunscreen to cause, stimulations.
4, thereby the Venenum apis compositions with sun-proof function of the present invention can not only be by effectively absorption, shielding UVA and the UVB minimizing damage to skin, keep skin wetness, reduce melanin deposition, eliminate sun damage, diminish inflammation, alleviate sunscreen to skin irritation and photosensitization, can also promote the damaged skin reparation, mottle and tanned vestige are disappeared fast, improve skin natural cover for defense function comprehensively, have sun-proof, whitening, moisturizing, nutrition, antiinflammatory, releive, the multi-efficiency such as reparation.
5, the present invention preferably arrives several good light stability, water solublity, oil-soluble UVA protective agent and the UVB protective agent that little to skin irritation, synergism is good, and the Venenum apis composition quality with sun-proof function that preparation obtains is reliable, effect is remarkable.
The specific embodiment:
Following examples are that the invention will be further described, but embodiments of the present invention are not limited to following embodiment introduction, all variation that is equal to or flexible categories that all should be considered as the present invention's protection of doing according to method of the present invention.
Below raw materials used, except special indicating, be commercially available.
Embodiment 1
Adopt collector of bee venom to gather the thick Venenum apis of wasp, add 25 volume water and fully dissolve, the centrifugal 15min of 8000g, supernatant is by the ultrafilter membrane ultrafiltration of molecular cut off 10000Da, and the filtrate lyophilization makes Venenum apis.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
A phase: Terephthalidene Dicamphor Sulfonic Acid 1%, carbomer 0.1%, NaCl 0.8%, 1,3 butylene glycol 5%, propylene glycol 4%, EDTA-2Na0.1%, deionized water surplus.
B phase: BEMT 1.5%, ethylhexyl methoxy cinnamate 0.3%, Ethylhexysalicylate 1%, micron order diamond-type oiliness TiO
2Dispersion liquid 9%(contains TiO
21.5%), fatty alcohol-polyoxyethylene ether 3%, C
12-C
15Alkyl benzoate 9%, dicaprylyl carbonate 2%, microwax 0.8%, azone/Cremophor RH40 0.2%, HANSHENGJIAO 0.5%.
C phase: Venenum apis 0.5%(adds with the form that deionized water is mixed with mass fraction 50% Venenum apis solution in advance).
D phase: butoben 0.5%, green tea essence 0.2%.
Technical process: heat respectively the A phase with B to 80 ℃, stir lower slowly B is added to A mutually in.Stirring is cooled to 55 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix homogenizing and make the Venenum apis compositions with sun-proof function of the present embodiment-the contain ultra light sun block lotion of Venenum apis.
The emulsion feel of present embodiment preparation is fine and smooth, coating is even, profit does not separate, easily absorption.Be coated on face, neck neck and the arm, outdoor activities 12h, skin can blackening.
Embodiment 2
Adopt collector of bee venom to gather the thick Venenum apis of Apis, add 10 times of volume water and fully dissolve, after the centrifugal 30min of 5000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
The A phase: 2,2 '-two-(Isosorbide-5-Nitrae-phenylene) 1H-benzimidazole-4, the disodium salt 1.5% of 6-disulfonic acid, MBBT 1%, carbomer 0.2%, glycerol 4%, propylene glycol 3%, deionized water surplus.
B phase: BEMT 0.2%, ethylhexyl methoxy cinnamate 8%, TiO
2/ hydration Silicon stone/aluminium hydroxide/dimethyl siloxane/methylsiloxane copolymer 0.5%, ceteareth-2 1.5%, ceteareth-212%, Jojoba oil 3%, cetearyl alcohol 2%, glyceryl monostearate 1%, caprylic/capric triglyceride 4%, ethylhexyl palmitate 3%, polydimethylsiloxane 2%, isopropyl myristate 3%, ethyl hydroxybenzoate 0.1%.
C phase: Venenum apis 0.00001%(adds with the form of powder).
D phase: azone/Cremophor RH40 1%, triethanolamine 0.2%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: heat respectively the A phase with B to 80 ℃, stir lower with B be added to A mutually in.Stirring is cooled to 45 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix homogenizing and make the Venenum apis compositions with sun-proof function of the present embodiment-the contain suntan lotion frost of Venenum apis.
The cream frost of present embodiment preparation is glossy, exquisite quality, be evenly distributed, profit do not separate mutually.Be coated in face, outdoor activities 10h, skin can blackening.
Embodiment 3
Buy the thick Venenum apis of wasp from Wuhan benefit people bee product company limited, add 30 times of volume water and fully dissolve, after the centrifugal 10min of 10000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
Adopt collector of bee venom to gather the thick Venenum apis of Apis, add 30 times of volume water and fully dissolve, after the centrifugal 10min of 10000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
A phase: MBBT 0.1%, Terephthalidene Dicamphor Sulfonic Acid 4.5%, Phenylbenzimidazolesulfonic acid and potassium thereof, sodium and triethanolamine salt 1%, glycerol 5%, propylene glycol 3%, butanediol 2%, deionized water surplus.
The B phase: wasp aptoxin 1%, Apis Venenum apis 1%(Venenum apis are all added with the form of powder), deionized water 38%.
C phase: azone/Cremophor RH40 1%, triethanolamine 0.2%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: 30 ℃, mix first the A phase, again will be in advance the B of mixing be added to A mutually in, mix rear adding C phase component, mixing makes the Venenum apis compositions with sun-proof function of the present embodiment-the contain sun-proof water preparation of Venenum apis.
The water preparation of present embodiment preparation is without precipitation, high, the easy absorption of transparency, non-stimulated.Be sprayed on face and neck neck place, outdoor activities 9h, skin can blackening.
Embodiment 4
Buy the thick Venenum apis of Apis from the Shen Feng of Fujian Province scientific and technological development company limited, add 15 times of volume water and fully dissolve, after the centrifugal 20min of 6000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
The A phase: 2,2 '-two-(Isosorbide-5-Nitrae-phenylene) 1H-benzimidazole-4, disodium salt 4.5%, Phenylbenzimidazolesulfonic acid and the potassium thereof of 6-disulfonic acid, sodium and triethanolamine salt 3%, HANSHENGJIAO 0.4%, acrylate/C
10-30Alkyl acrylate cross-linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, propylene glycol 5%, butanediol 5%, deionized water surplus.
B phase: Venenum apis 0.5%(adds with the form that distilled water is mixed with mass fraction 10% Venenum apis solution in advance), sodium alginate 0.01%, deionized water 20%.
C phase: Cremophor RH40 ester 1%, triethanolamine 0.2%, essence 0.1%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: mix the A phase component and be heated to 80 ℃ stirring, add when being cooled to 40 ℃ and be pre-mixed uniform B phase, stir 10min to transparent, add and make Venenum apis compositions with sun-proof function-the contain sun protection gel of Venenum apis behind the C phase stirring and evenly mixing.
The gel of present embodiment preparation is transparent, tissue is fine and smooth, without caking, under-10 ℃ and 40 ℃ of conditions, without paste separation.Be coated in neck neck and arm place, outdoor activities 8h, skin can blackening.
Embodiment 5
Prepare the method for Venenum apis according to embodiment 1, make wasp aptoxin.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
The A phase: 2,2 '-two-(Isosorbide-5-Nitrae-phenylene) 1H-benzimidazole-4, the disodium salt 0.1% of 6-disulfonic acid, Terephthalidene Dicamphor Sulfonic Acid 1%, Phenylbenzimidazolesulfonic acid and potassium thereof, sodium and triethanolamine salt 1.5%, HANSHENGJIAO 0.2%, acrylate/C
10-30Alkyl acrylate cross-linked polymer 0.6%, glycerol 5%, propylene glycol 3%, deionized water surplus.
The B phase: wasp aptoxin 0.00001%(adds with the form that deionized water is mixed with mass fraction 10% Venenum apis solution in advance), Porphyra Polysaccharide 1%, Thallus Laminariae polysaccharide 2%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 2%, deionized water 30%.
C phase: azone/Cremophor RH40 1%, triethanolamine 0.3%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: mix the A phase component and be heated to 80 ℃ stirring, add when being cooled to 45 ℃ and be pre-mixed uniform B phase, stir homogenizing 3min, be sequentially added into mutually each component of C under the room temperature, the Venenum apis compositions with sun-proof function that makes the present embodiment of stirring-the contain sun-proof gel of Venenum apis.
The gel of preparing in the present embodiment, quality is slim and graceful, and sensation is nice and cool.Be coated in facial and arm place, outdoor activities 9h, skin can blackening.
Embodiment 6
The method for preparing Venenum apis according to embodiment 2 makes Apis Venenum apis.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
A phase: carbomer 0.2%, glycerol 4%, propylene glycol 3%, deionized water surplus.
B phase: BEMT 4.5%, Ethylhexysalicylate 0.2%, TiO
2/ hydration Silicon stone/aluminium hydroxide/dimethyl siloxane/methylsiloxane copolymer 6%, ceteareth-2 1.5%, ceteareth-212%, Jojoba oil 3%, cetearyl alcohol 2%, glyceryl monostearate 1%, caprylic/capric triglyceride 4%, ethylhexyl palmitate 3%, polydimethylsiloxane 2%, isopropyl myristate 3%, ethyl hydroxybenzoate 0.1%.
C phase: Venenum apis 2%(adds with the form that deionized water is mixed with mass fraction 50% Venenum apis solution in advance), Eucheuma gelatinosum polysaccharide 0.2%, Eucheuma gelatinae polysaccharide 0.3%, deionized water 15%.
D phase: azone/Cremophor RH40 1%, triethanolamine 0.2%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: heat respectively the A phase with B to 80 ℃, stir lower with B be added to A mutually in.Stirring is cooled to 45 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix homogenizing and make the Venenum apis compositions with sun-proof function of the present embodiment-the contain suntan lotion frost of Venenum apis.
The cream frost of present embodiment preparation is glossy, exquisite quality, be evenly distributed, profit do not separate mutually.Be coated in face, outdoor activities 10h, skin can blackening.
Embodiment 7
Prepare the method for Venenum apis according to embodiment 3, make wasp aptoxin.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
A phase: Terephthalidene Dicamphor Sulfonic Acid 0.1%, carbomer 0.1%, glycerol 5%, propylene glycol 3%, deionized water surplus.
B phase: BEMT 1%, Ethylhexysalicylate 8%, ceteareth-2 1.2%, ceteareth-21 1.5%, Parleam 3%, caprylic/capric triglyceride 3%, ethylhexyl palmitate 3%, polydimethylsiloxane 2%, ethyl hydroxybenzoate 0.1%.
The C phase: wasp aptoxin 0.5%(adds with the form that deionized water is mixed with mass fraction 50% Venenum apis solution in advance), Hijiki polysaccharide 0.01%, V
CMagnesium phosphorate 0.1%, deionized water 20%.
D phase: azone/Cremophor RH40 1%, triethanolamine 0.1%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: heat respectively the A phase with B to 80 ℃, stir lower slowly B is added to A mutually in.Stirring is cooled to 55 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix homogenizing and make the Venenum apis compositions with sun-proof function of the present embodiment-the contain ultra light sun block lotion of Venenum apis.
The emulsion feel of present embodiment preparation is fine and smooth, coating is even, profit does not separate, easily absorption.Be coated on face, neck neck and the arm, outdoor activities 12h, skin can blackening.
Embodiment 8
Prepare the method for Venenum apis according to embodiment 1, make wasp aptoxin.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
A phase: MBBT 3.5%, Phenylbenzimidazolesulfonic acid and potassium thereof, sodium and triethanolamine salt 0.1%, glycerol 5%, propylene glycol 3%, butanediol 2%, deionized water surplus.
The B phase: Venenum apis 0.00001%(Venenum apis is all added with the form of powder), laminarin 0.2%, Sargassum polysaccharide 0.2%, spirulina polysaccharide 0.4%, sargassan 0.2%, V
CMagnesium phosphorate 1%, deionized water 30%.
C phase: azone/Cremophor RH40 1%, triethanolamine 0.2%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: 35 ℃, mix first the A phase, again will be in advance the B of mixing be added to A mutually in, mix rear adding C phase component, mixing makes the Venenum apis compositions with sun-proof function of the present embodiment-the contain sun-proof water preparation of Venenum apis.
The water preparation of present embodiment preparation is without precipitation, high, the easy absorption of transparency, non-stimulated.Be sprayed on face and neck neck place, outdoor activities 8h, skin can blackening.
Embodiment 9
Prepare the method for Venenum apis according to embodiment 4, make Venenum apis.
The Venenum apis compositions with sun-proof function of the present embodiment by gross mass percent 100%, is comprised of following component:
The A phase: 2,2 '-two-(Isosorbide-5-Nitrae-phenylene) 1H-benzimidazole-4, the disodium salt 1% of 6-disulfonic acid, Terephthalidene Dicamphor Sulfonic Acid 2%, Phenylbenzimidazolesulfonic acid and potassium thereof, sodium and triethanolamine salt 1%, HANSHENGJIAO 0.4%, acrylate/C
10-30Alkyl acrylate cross-linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, propylene glycol 5%, butanediol 5%, deionized water surplus.
B phase: Venenum apis 2%(adds with the form that distilled water is mixed with mass fraction 10% Venenum apis solution in advance), Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) polysaccharide 1%, fucoidin 1%, angle fork polysaccharides 1%, Zostera marina polysaccharide 1%, chlorella polysaccharide 1%, V
CMagnesium phosphorate 5%, deionized water 20%.
C phase: ethylhexyl methoxy cinnamate 0.02%, Cremophor RH40 ester 1%, triethanolamine 0.2%, essence 0.1%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: mix the A phase component and be heated to 80 ℃ stirring, add when being cooled to 40 ℃ and be pre-mixed uniform B phase, stir 10min to transparent, add the Venenum apis compositions with sun-proof function that makes the present embodiment behind the C phase stirring and evenly mixing-the contain sun protection gel of Venenum apis.
The gel of present embodiment preparation is transparent, tissue is fine and smooth, without caking, under-10 ℃ and 40 ℃ of conditions, without paste separation.Be coated in neck neck and arm place, outdoor activities 9h, skin can blackening.
Embodiment 10
The Venenum apis compositions with sun-proof function of embodiment 1-9 preparation is carried out the test of mice opposing ultraviolet injury ability.
Tested object be sample 1(A, a), sample 2(B, b), sample 3(C, c), sample 4(D, d), sample 5(E, e), sample 6(F, f), sample 7(G, g), sample 8(H, h), sample 9(I, i).Sample A-I is the Venenum apis compositions with sun-proof function of embodiment 1-9 preparation successively, and sample a-i is that (sample a-i substitutes Venenum apis, Sargassum polysaccharides and V among the sample A-I with the deionized water of equivalent for the control sample of sample A-I successively
CThe quality percentage composition that magnesium phosphorate is shared does not namely all contain Venenum apis, Sargassum polysaccharides and V among the sample a-i
CMagnesium phosphorate, and among the sample a-i sunscreen other compositions, content respectively with sample A-I in sunscreen form, content is identical).
Get 54 of quality (20 ± 2) g Kunming healthy mices, male and female half and half are divided into 18 groups at random, 3 every group.Mice is prophylactically smeared sample (smear respectively an above-mentioned sample for every group, smear above-mentioned 18 samples for totally 18 groups), and every back is to 0.6mL, and every monaural 2 times/d, is smeared 4d altogether to 0.3mL.Be horizontally fixed on mice on the brandreth and place apart from uviol lamp vertical dimension 10cm place and shine 6h, cause the skin lesion mouse model.Take mouse skin keratinization and decortication degree as evaluation index, perusal mouse back change of skin situation, analytic sample is to the effect of mice opposing ultraviolet injury.
The skin lesion mouse model is continued to put to death with disconnected ridge behind the ultraviolet radiation 40h, weighing mice quality, get respectively more circular auricle and the skin graft of two ears and back 9mm diameter, its quality of accurate weighing, calculate ear index (ear index=auricle quality/mice quality) and skin index (skin index=skin graft quality/mice quality), analytic sample is shot the inhibitory action of mice edema wounded to ultraviolet.Get back portion skin and fixedly behind the 24h, make the sealing sample with 10% formaldehyde.The sealing sample is placed 10 times of Microscopic observation skin configurations, the skin of observing from the visual field under 40 times of mirrors again begins to clap the first pictures topmost, every mobile scale 2mm claps and gets one afterwards, bat is got after 5 with microimage analysing system and is chosen 5 points on every pictures, measure its epidermal thickness, every pictures is measured 25 points altogether, and averaging is designated as epidermal thickness, and analytic sample is to the cornified inhibitory action of mouse skin.Every pictures is got 6 visuals field, counts fibroblast number in each visual field, averages to be designated as each visual field dermal fibroblast number.Ultraviolet injury mouse ear index, skin index, epidermal thickness and fibroblast measurement result see Table 1.
Table 1: ultraviolet injury mouse ear index, skin index, epidermal thickness and fibroblast
Mice by ultraviolet radiation after, be coated with sample A-I(is the Venenum apis compositions with sun-proof function of embodiment of the invention 1-9 preparation) mouse ear index, skin index, epidermal thickness value be the control sample of sample A-I than being coated with sample a-i(all) low, fibroblastic number is than being coated with many with sample a-i in its dermal tissue.Experimental result shows; but the damage epidermis that Venenum apis compositions establishment of the present invention is caused by ultraviolet radiation thickens, suppresses the epidermis keratinization, reduces the inflammation generation, promotes fibroblast to generate; when protection skin is avoided ultraviolet injury; improve barrier function and the self-protection ability of skin, and had the effects such as sun-proof, antiinflammatory, reparation.
Embodiment 11
Following various sample sun-proof functions are estimated:
The percent of the present embodiment refers to mass percent.
The wasp aptoxin of the present embodiment and Apis Venenum apis are that the preparation method according to embodiment 3 prepares.
Sun care preparations substrate: BEMT 1.5%, ethylhexyl methoxy cinnamate 0.3%, Ethylhexysalicylate 1%, micron order diamond-type oiliness TiO
2Dispersion liquid 9%(contains TiO
21.5%), Terephthalidene Dicamphor Sulfonic Acid 1%, fatty alcohol-polyoxyethylene ether 3%, C
12-C
15Alkyl benzoate 9%, dicaprylyl carbonate 2%, microwax 0.8%, azone/Cremophor RH40 0.2%, HANSHENGJIAO 0.5%, NaCl0.8%, 1,3 butylene glycol 5%, propylene glycol 4%, EDTA-2Na0.1%, butoben 0.5%, green tea essence 0.2%, deionized water surplus.
Contain thick Venenum apis cosmetic composition (be sample A, thick Venenum apis content is mass fraction 2%):
A1: the thick Venenum apis 2% of wasp, sun care preparations substrate 98%;
A2: the thick Venenum apis 0.5% of wasp, the thick Venenum apis 1.5% of Apis, sun care preparations substrate 98%.
Contain Venenum apis cosmetic composition (be sample B, Venenum apis content is mass fraction 2%):
B1: wasp aptoxin 2%, sun care preparations substrate 98%;
B2: wasp aptoxin 0.5%, Apis Venenum apis 1.5%, sun care preparations substrate 98%.
Contain Sargassum polysaccharides cosmetic composition (be sample C, Sargassum polysaccharides content is mass fraction 2%):
C1: laminarin 2%, sun care preparations substrate 98%;
C2: Hijiki polysaccharide 1%, sodium alginate 1%, sun care preparations substrate 98%.
Contain Venenum apis and Sargassum polysaccharides cosmetic composition (be sample D, the total content of Venenum apis, Sargassum polysaccharides is mass fraction 2%):
D1: wasp aptoxin 1%, laminarin 1%, sun care preparations substrate 98%;
D2: Apis Venenum apis 0.5%, wasp aptoxin 0.5%, sodium alginate 0.5%, Hijiki polysaccharide 0.5%, sun care preparations substrate 98%.
Contain Sargassum polysaccharides and V
CThe magnesium phosphorate cosmetic composition (be sample E, Sargassum polysaccharides and V
CThe total content of magnesium phosphorate is mass fraction 2%):
E1: laminarin 1%, V
CMagnesium phosphorate 1%, sun care preparations substrate 98%;
E2: sodium alginate 0.5%, Hijiki polysaccharide 0.5%, V
CMagnesium phosphorate 1%, sun care preparations substrate 98%.
Contain Venenum apis, Sargassum polysaccharides and V
CThe magnesium phosphorate cosmetic composition (be sample F, Venenum apis, Sargassum polysaccharides and V
CThe total content of magnesium phosphorate is mass fraction 2%):
F1: wasp aptoxin 0.5%, laminarin 0.5%, V
CMagnesium phosphorate 1%, sun care preparations substrate 98%;
F2: Apis Venenum apis 0.4%, wasp aptoxin 0.4%, sodium alginate 0.4%, Hijiki polysaccharide 0.4%, V
CMagnesium phosphorate 0.4%, sun care preparations substrate 98%.
Choose 39 of healthy volunteers, wherein the male is 9,30 of women, age 25-32 year, average 27.7 years old, unglazed perceptual history of disease previously, do not use at no distant date the medicine that affects light sensation, without serious systemic disease, immunodeficiency or autoimmune disease, to cosmetics without allergy, facial NAI, do not use hormone medicine or immunosuppressant, do not participate in other clinical trials, do not smear external preparation.Be divided at random 13 groups, namely the sun care preparations matrix group, contain thick Venenum apis cosmetic composition group (sample A1-A2), contain Venenum apis cosmetic composition group (sample B1-B2), contain Sargassum polysaccharides cosmetic composition group (sample C1-C2), contain Venenum apis and Sargassum polysaccharides cosmetic composition group (sample D1-D2), contain Sargassum polysaccharides and V
CMagnesium phosphorate cosmetic composition group (sample E1-E2), contain Venenum apis, Sargassum polysaccharides and V
CMagnesium phosphorate cosmetic composition group (sample F 1-F2), 3 every group.
According to the assay method of " cosmetics health standard " (version in 2007) about sun care preparations SPF (sun protection factor) (spf value) and long wave ultraviolet protection index (PFA value), record sample spf value and PFA value, the results are shown in Table 2.Wherein, sample A is the meansigma methods of sample A1, A2 group, and sample B is the meansigma methods of sample B1, B2 group, sample C is the meansigma methods of sample C1, C2 group, sample D is the meansigma methods of sample D1, D2 group, and sample E is the meansigma methods of sample E1, E2 group, and sample F is the meansigma methods of sample F 1, F2 group.
Table 2: each sample spf value and PFA value
As can be seen from Table 2, compare with sun care preparations substrate, the spf value of sample A-F and PFA value are relatively high.This illustrates Venenum apis, Sargassum polysaccharides and V
CMagnesium phosphorate has synergism to sunscreen in the cosmetic base, can strengthen its sun-proof ability.
Because removed the sensitization source in the thick Venenum apis, so compare with containing thick Venenum apis cosmetic composition (being sample A), containing Venenum apis cosmetic composition (being sample B) does not only have obvious irritation to skin, can also alleviate sunscreen to the sensitization of skin.Since enrichment the effective ingredient in the Venenum apis, contain the spf value of Venenum apis cosmetic composition and PFA value obviously than containing thick Venenum apis cosmetic combinations object height.
With contain Venenum apis cosmetic composition (being sample B), contain Sargassum polysaccharides cosmetic composition (being sample C) and compare, contain Venenum apis and Sargassum polysaccharides cosmetic composition (being sample D) when effectively alleviating the sensitization of sunscreen to skin, spf value and PFA value are significantly improved.Sargassum polysaccharides and Venenum apis have the forward synergism among this explanation the present invention, and the sun-proof ability of Venenum apis compositions is significantly improved.
With contain Venenum apis cosmetic composition (being sample B), contain Sargassum polysaccharides and V
CMagnesium phosphorate cosmetic composition (being sample E) is compared, and contains Venenum apis, Sargassum polysaccharides and V
CMagnesium phosphorate cosmetic composition (being sample F) is when effectively alleviating the sensitization of sunscreen to skin, and spf value and PFA value are significantly improved.Sargassum polysaccharides, V among this explanation the present invention
CMagnesium phosphorate and Venenum apis have the forward synergism, and the sun-proof ability of Venenum apis compositions is significantly improved.
In sum; the Venenum apis compositions with sun-proof function among the present invention can not only effectively absorb and shield UVA and UVB to reduce itself and the contacting and infringement of skin; can also fundamentally improve the self-protection ability of skin comprehensively, have the multi-efficiencies such as sun-proof, whitening, moisturizing, nutrition, antiinflammatory, reparation.
Above-described embodiment is the better embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included in protection scope of the present invention.
Claims (10)
1. the Venenum apis compositions with sun-proof function comprises sun care preparations substrate composition, it is characterized in that, also contains Venenum apis.
2. Venenum apis compositions according to claim 1, it is characterized in that, described Venenum apis prepares by the following method, gets thick Venenum apis water dissolution, and then after the ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
3. Venenum apis compositions according to claim 2, it is characterized in that, described Venenum apis prepares by the following method: get thick Venenum apis and add 10-30 times of volume water and fully dissolve, the centrifugal 10-30min of 5000-10000g, after the ultrafilter membrane of supernatant by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis, and described thick Venenum apis is the thick Venenum apis of wasp and/or the thick Venenum apis of Apis.
4. according to claim 1 and 2 or 3 described Venenum apis compositionss, it is characterized in that, described Venenum apis, its content accounts for 0.00001% ~ 2% of Venenum apis compositions gross mass.
5. Venenum apis compositions according to claim 1 is characterized in that, also includes sunscreen in the cosmetic base of described Venenum apis compositions with sun-proof function, and described sunscreen is UVA protective agent and/or UVB protective agent.
6. Venenum apis compositions according to claim 5, it is characterized in that, described UVA protective agent is 2,2 '-two-(1, the 4-phenylene) 1H-benzimidazole-4, the disodium salt of 6-disulfonic acid, MBBT, the Terephthalidene Dicamphor Sulfonic Acid, the combination of one or more in the BEMT, its consumption is, by the percentage ratio that accounts for Venenum apis compositions gross mass, 2,2 '-two-(1, the 4-phenylene) 1H-benzimidazole-4, the disodium salt 0.1% ~ 4.5% of 6-disulfonic acid, MBBT 0.1% ~ 3.5%, the Terephthalidene Dicamphor Sulfonic Acid 0.1% ~ 4.5%, BEMT 0.2% ~ 4.5%; Described UVB protective agent is Phenylbenzimidazolesulfonic acid and potassium, sodium and triethanolamine salt, ethylhexyl methoxy cinnamate, Ethylhexysalicylate, TiO
2In one or more combination, its consumption is, by the percentage ratio that accounts for Venenum apis compositions gross mass, Phenylbenzimidazolesulfonic acid and potassium thereof, sodium and triethanolamine salt 0.1%-3%, ethylhexyl methoxy cinnamate 0.02%-8%, Ethylhexysalicylate 0.2%-8%, TiO
20.5%-6%.
7. according to claim 4 or 5 or 6 described Venenum apis compositionss, it is characterized in that, described Venenum apis compositions with sun-proof function also contains Sargassum polysaccharides, and its content accounts for the 0.01%-5% of Venenum apis compositions gross mass.
8. Venenum apis compositions according to claim 7, it is characterized in that, described Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Thallus Laminariae polysaccharide, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma gelatinae polysaccharide, Hijiki polysaccharide, laminarin, Sargassum polysaccharide, spirulina polysaccharide, sargassan, Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) polysaccharide, fucoidin, angle fork polysaccharides, Zostera marina polysaccharide and the chlorella polysaccharide.
9. Venenum apis compositions according to claim 7 is characterized in that, described Venenum apis compositions with sun-proof function also contains VC phosphate magnesium, and its content accounts for the 0.1%-5% of Venenum apis compositions gross mass.
10. Venenum apis compositions according to claim 1, it is characterized in that, described Venenum apis compositions with sun-proof function is cream frost, emulsion, water preparation, gel or Gel mile, and described Venenum apis compositions with sun-proof function can or have the function cosmetics of anti-sunlight function as ordinary cosmetics.
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| CN103371949A (en) * | 2013-06-29 | 2013-10-30 | 安徽榄菊日用制品有限公司 | Multi-effect sunscreen and wrinkle reduction hand cream and preparation method thereof |
| CN107998027A (en) * | 2017-12-24 | 2018-05-08 | 姚佑灿 | A kind of antiradiation injury repairs breast |
| CN109890835A (en) * | 2016-06-24 | 2019-06-14 | 金容隨 | The purification bee venom of the method for the purification bee venom of preparation removal allergic component and the removal allergic component prepared by the method |
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| CN103263361A (en) * | 2013-06-08 | 2013-08-28 | 广州暨南生物医药研究开发基地有限公司 | Application of porphyra polysaccharide to preparation of ultraviolet ray injury resistant skin care product |
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| CN103371949B (en) * | 2013-06-29 | 2015-08-12 | 安徽榄菊日用制品有限公司 | A kind of Multi-effect sunscreen wrinkle reduction hand cream and preparation method thereof |
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| CN109890835B (en) * | 2016-06-24 | 2022-05-17 | 金容隨 | Method for preparing refined bee venom with removed allergic components and refined bee venom with removed allergic components prepared by the method |
| CN107998027A (en) * | 2017-12-24 | 2018-05-08 | 姚佑灿 | A kind of antiradiation injury repairs breast |
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| CN103006530B (en) | 2014-10-29 |
| WO2014094380A1 (en) | 2014-06-26 |
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