CN102988809B - 一种治疗尿路感染的中药 - Google Patents
一种治疗尿路感染的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗尿路感染的中药，它是由以下重量配比的药材制备而成：白花草200、茜草50份、黄柏15份、甘草10份、石韦25份、车前草15份、金银花藤25份、五味子15份、知母10份、女贞子10份、旱莲花10份、茯苓皮20份、陈皮5份、赤小豆15份、益母草15份、酸枣仁20份、小麦秸秆20份。实验证明，本发明能够安全有效治疗尿路感染。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗尿路感染的中药
背景技术
尿路感染是口咽和喉咽部病变的主要症状，以咽喉部红肿疼痛、吞咽不适为特征，又称喉痹。属于一种多发常见病症，见于西医学的急性扁桃体炎、急性咽炎和单纯性喉炎和扁桃体脓肿等。
目前的治疗药物主要是消炎药和抗生素，消炎治标不治本，抗生素又是国家限制使用的药品。因此研究开发一种安全有效治疗尿路感染的中药非常有实用价值。
本发明中药所涉及药材的研究现状如下：
白花草【来源】药材基源：为兰科植物鹅毛玉凤花的茎叶。拉丁植物动物矿物名：Habenaria dentata (Sw.)Schltr.[Orchis dentata Sw.; Platanthera dentata (Sw.)Lindl.]。【性味】味甘；微苦；性平。【功能主治】清热利湿。主热淋。【用法用量】内服：煎汤，9-15g。
茜草【来源】本品为茜草科植物茜草Rubia cordifolia L. 的干燥根及根茎。春、秋二季采挖，除去泥沙，干燥。【性味】苦，寒。【归经】归肝经。【功能主治】凉血，止血，祛瘀，通经。用于吐血，衄血，崩漏，外伤出血，经闭瘀阻，关节痹痛，跌扑肿痛。【用法用量】 6～9g。
黄柏【来源】本品为芸香科植物黄皮树Phellodendron chinense Schneid.或黄檗Phellodendron amurense Rupr.的干燥树皮。前者习称“川黄柏”，后者习称“关黄柏”。剥取树皮后，除去粗皮，晒干。【性味】苦，寒。【归经】归肾、膀胱经。【功能主治】清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，痿{辟}，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。【用法用量】 3～12g；外用适量。
甘草【来源】本品为豆科植物甘草 Glycyrrhiza uralensis Fisch.、胀果甘草 Glycyrrhiza inflata Bat. 或光果甘草 Glycyrrhiza glabra L. 的干燥根。春、秋二季采挖，除去须根，晒干。【性味】甘，平。【归经】归心、肺、脾、胃经 。【功能主治】补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。【用法用量】 1.5～9g。
石韦【来源】本品为水龙骨科植物庐山石韦Pyrrosia sheareri （Bak.）Ching、石韦Pyrrosia lingua （Thunb.）Farwell 或有柄石韦Pyrrosia petiolosa （Christ）Ching 的干燥叶。全年均可采收，除去根茎及根，晒干或阴干。【炮制】除去杂质，洗净，切段，晒干，筛去细屑。【性味】甘、苦，微寒。【归经】归肺、膀胱经。【功能主治】利尿通淋，清热止血。用于热淋，血淋，石淋，小便不通，淋沥涩痛，吐血，衄血，尿血，崩漏，肺热喘咳。【用法用量】 6～12g。
车前草【来源】本品为车前科植物车前Plantago asiatica L.或平车前Plantago depressa Willd.的干燥全草。夏季采挖，除去泥沙，晒干。【炮制】除去杂质，洗净，切段，晒干。【性味】甘，寒。【归经】归肝、肾、肺、小肠经。【功能主治】清热利尿，祛痰，凉血，解毒。用于水肿尿少，热淋涩痛，暑湿泻痢，痰热咳嗽，吐血衄血，痈肿疮毒。【用法用量】 9～30g；鲜品30～60g，煎服或捣汁服。外用鲜品适量，捣敷患处。
金银花藤【来源】本品为忍冬科植物忍冬Lonicera japonica Thunb.、红腺忍冬Lonicera hypoglauca Miq.、山银花（毛萼忍冬）Lonicera confusa DC. 或毛花柱忍冬Lonicera dasystyla Rehd.的干燥藤茎。
五味子【来源】本品为木兰科植物五味子Schisandra chinensis （Turcz.）Baill.或华中五味子Schisandra sphenanthera Rehd. et Wils.的干燥成熟果实。前者习称“北五味子”，后者习称“南五味子”。秋季果实成熟时采摘，晒干或蒸后晒干，除去果梗及杂质。【性味】酸、甘，温。【归经】归肺，心、肾经。【功能主治】收敛固涩，益气生津，补肾宁心。用于久嗽虚喘，梦遗滑精，遗尿尿频，久泻不止，自汗，盗汗，津伤口渴，短气脉虚，内热消渴，心悸失眠。【用法用量】 1.5～6g。
知母【来源】本品为百合科植物知母Anemarrhena asphodeloides Bunge.的干燥根茎。春、秋二季采挖，除去须根及泥沙，晒干，习称“毛知母”；或除去外皮，晒干。【性味】苦、甘，寒。【归经】归肺、胃、肾经。【功能主治】清热泻火，生津润燥。用于外感热病，高热烦渴，肺热燥咳，骨蒸潮热，内热消渴，肠燥便秘。【用法用量】 6～12g。【注意】脾虚便溏者不宜。
女贞子【来源】本品为木犀科植物女贞Ligustrum lucidum Ait. 的干燥成熟果实。冬季果实成熟时采收，除去枝叶，稍蒸或置沸水中略烫后，干燥；或直接干燥。【性味】甘、苦，凉。【归经】归肝、肾经。【功能主治】滋补肝肾，明目乌发。用于眩晕耳鸣，腰膝酸软，须发早白，目暗不明。【用法用量】 6～12g。
旱莲花【来源】为旱金莲科植物旱金莲的全草。秋、冬采全草。【性味】味辛；酸；性凉。【归经】心；肾经。【功能主治】清热解毒；凉血止血。主目赤肿痛；疮疖；吐血；咯血。【用法用量】内服：煎汤，鲜品15-30g。外用：适量，捣烂敷；或煎水洗。
茯苓皮【来源】为多孔菌科植物茯苓菌核的外皮。【性味】甘；淡；性平。【归经】肾；膀胱经。【功能主治】利水消肿。主水温肿满；小便不利。【用法用量】内服：煎汤，3-5g。
陈皮【来源】本品为芸香科植物橘Citrus reticulata Blanco 及其栽培变种的干燥成熟果皮。药材分为“陈皮”和“广陈皮”。采摘成熟果实，剥取果皮，晒干或低温干燥。【性味】苦、辛，温。【归经】归肺、脾经。【功能主治】理气健脾，燥湿化痰。用于胸脘胀满，食少吐泻，咳嗽痰多。【用法用量】 3～9g。
赤小豆【来源】本品为豆科植物赤小豆Phaseolus calcaratus Roxb. 或赤豆Phaseolus angularis Wight的干燥成熟种子。秋季果实成熟而未开裂时拔取全株，晒干，打下种子，除去杂质， 再晒干。【性味】甘、酸，平。【归经】归心、小肠经。【功能主治】利水消肿，解毒排脓。用于水肿胀满，脚气肢肿，黄疸尿赤，风湿热痹，痈肿疮毒，肠痈腹痛。【用法用量】 9～30g。外用适量，研末调敷。
益母草【来源】本品为唇形科植物益母草Leonurus japonicus Houtt. 的新鲜或干燥地上部分。鲜品春季幼苗期至初夏花前期采割；干品夏季茎叶茂盛、花未开或初开时采割，晒干，或切段晒干。【性味】苦、辛，微寒。【归经】归肝、心包经。【功能主治】活血调经，利尿消肿。用于月经不调，痛经，经闭，恶露不尽，水肿尿少；急性肾炎水肿。【用法用量】 9～30g；鲜品12～40g。
酸枣仁【来源】本品为鼠李科植物酸枣Ziziphus jujuba Mill. var. spinosa （Bunge）Hu ex H.F.Chou的干燥成熟种子。秋末冬初采收成熟果实，除去果肉及核壳，收集种子，晒干。【性味】甘、酸，平。【归经】归肝、胆、心经。【功能主治】补肝，宁心，敛汗，生津。用于虚烦不眠，惊悸多梦，体虚多汗，津伤口渴。【用法用量】 9～15g。
小麦秸秆【来源】本品为禾本科植物小麦的干燥秸秆。
发明内容
本发明旨在提供一种治疗尿路感染的中药，通过选择合适的药材及其配比，达到安全有效治愈尿路感染的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗尿路感染的中药，其特征在于，它是由以下重量配比的药材制备而成：白花草200、茜草50份、黄柏15份、甘草10份、石韦25份、车前草15份、金银花藤25份、五味子15份、知母10份、女贞子10份、旱莲花10份、茯苓皮20份、陈皮5份、赤小豆15份、益母草15份、酸枣仁20份、小麦秸秆20份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人于2009年10月-2010年4月间共收集75例尿路感染的门诊患者，其中男35例，女40例，年龄23-65岁，病程2-15天。随机分为：治疗组50例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
对照口服尿路康胶囊，按照说明书服用。疗程1周。
治疗组口服本发明按照具体实施例1制得的胶囊，每日2次。疗程1周。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 50 | 42 | 6 | 2 | 0（0%） | 96% |
| 对照组 | 25 | 10 | 13 | 2 | 2（8%） | 92% |
可见，本发明优选实施方式制得的药物能够安全有效治疗尿路感染。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：白花草200克、茜草50克、黄柏15克、甘草10克、石韦25克、车前草15克、金银花藤25克、五味子15克、知母10克、女贞子10克、旱莲花10克、茯苓皮20克、陈皮5克、赤小豆15克、益母草15克、酸枣仁20克、小麦秸秆20克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗尿路感染。口服，每日分早晚两次服用。
具体实施例2
称取：白花草200克、茜草50克、黄柏15克、甘草10克、石韦25克、车前草15克、金银花藤25克、五味子15克、知母10克、女贞子10克、旱莲花10克、茯苓皮20克、陈皮5克、赤小豆15克、益母草15克、酸枣仁20克、小麦秸秆20克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗尿路感染。口服，每日一次。
具体实施例3
称取：白花草200克、茜草50克、黄柏15克、甘草10克、石韦25克、车前草15克、金银花藤25克、五味子15克、知母10克、女贞子10克、旱莲花10克、茯苓皮20克、陈皮5克、赤小豆15克、益母草15克、酸枣仁20克、小麦秸秆20克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗尿路感染。口服，每日分早中晚三次服用。
Claims (1)
1.一种治疗尿路感染的中药，其特征在于，它是由以下重量配比的药材制备而成：白花草200、茜草50份、黄柏15份、甘草10份、石韦25份、车前草15份、金银花藤25份、五味子15份、知母10份、女贞子10份、旱莲花10份、茯苓皮20份、陈皮5份、赤小豆15份、益母草15份、酸枣仁20份、小麦秸秆20份。
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| CN101085264A (zh) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | 一种治疗尿路感染的中药制剂 |
| CN101104044A (zh) * | 2007-06-14 | 2008-01-16 | 张红梅 | 治疗尿泌系感染的中药方剂 |
| CN101129734A (zh) * | 2007-08-29 | 2008-02-27 | 北京艺信堂医药研究所 | 一种治疗糖尿病尿路感染的中药制剂 |
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| CN101085264A (zh) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | 一种治疗尿路感染的中药制剂 |
| CN101129734A (zh) * | 2007-08-29 | 2008-02-27 | 北京艺信堂医药研究所 | 一种治疗糖尿病尿路感染的中药制剂 |
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| 《孙伟治疗慢性泌尿系统感染经验举隅》;陈继红等;《中国中医药信息杂志》;20070531;第14卷(第5期);82-83 * |
| 邢儒伶等.《吕仁和六对论治再发性尿路感染的经验》.《辽宁中医杂志》.2002,第29卷(第6期),317-318. |
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