CN102988446A - Medicinal composition for promoting blood circulation to remove meridian obstruction and preventing and treating osteoporosis - Google Patents
Medicinal composition for promoting blood circulation to remove meridian obstruction and preventing and treating osteoporosis Download PDFInfo
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- CN102988446A CN102988446A CN2012103911801A CN201210391180A CN102988446A CN 102988446 A CN102988446 A CN 102988446A CN 2012103911801 A CN2012103911801 A CN 2012103911801A CN 201210391180 A CN201210391180 A CN 201210391180A CN 102988446 A CN102988446 A CN 102988446A
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Abstract
The invention provides a medicinal composition for promoting blood circulation to remove meridian obstruction and preventing and treating osteoporosis, which comprises the following components in parts by weight: 4 to 6 parts of hemlock parsley, 8 to 12 parts of safflower, 2 to 4 parts of notopterygium root, 8 to 12 parts of Chinese angelica, and 10 to 30 parts of chondroitin sulfate. The product has good effect of preventing and treating osteoporosis.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of promoting blood circulation to remove obstruction in the collateral control osteoporosis drug compositions.
Background technology
Osteoporosis (osteoporosis) is a kind of systemic osteopathia, it is characterized in that the bone amount descends and the fine structure of bone destroys, the fragility that shows as bone increases, thereby the danger of fracture greatly increases, even also fracture easily in slight wound or the atraumatic situation.Osteoporosis is a kind of chronic disease due to multifactor.Before fracture occurs, usually without Special Clinical Manifestation.The women is more than the male for this disease, is common in postmenopausal women and old people.Along with the increase of China's aging population, the osteoporosis sickness rate is in ascendant trend, all is a health problem that merits attention in China and even the whole world.
Motherland's medical science think primary disease generation, the development and " kidney qi " closely related, " the contrary opinion of transferring of Plain Questions " said: " kidney is not given birth to; then marrow can not be expired ", " Plain Questions six joints are hidden and resembled opinion " said: " kidney person, the master stings the dominator of storing essence; smart part is also; its Hua Zaifa, and it fills at bone " ", therefore its employing invigorating the kidney and strengthening the bones, invigorating the spleen and benefiting QI, promoting blood circulation to remove obstruction in the collateral are all obtained preferably effect.
The traditional Chinese medical science adopts differentiation of symptoms and signs for classification of syndrome, for different types, adopts the prescription of suiting the medicine to the illness.As adopting the prescription of nourishing the liver and kidney, bone and muscle strengthening for deficiency of the liver and kidney, such as square medicine: chien pu hu chien wan: 2 parts of Colla Plastri Testudinis, 2 parts of Colla cornus cervis, 2 parts of Tigris shins (now use Os Canitis generation), 2 parts of Radix Polygoni Multiflori, 2 parts of Radix Cyathulaes, 2 parts of the Cortexs Eucommiae, 2 parts of Herba Cynomoriis, 2 parts of Radix Angelicae Sinensis, 2 parts of Radix Rehmanniae Preparata, 2 parts of Radix Clematidis, 1 part of Cortex Phellodendri, 1 part of Radix Ginseng, 1 part of Rhizoma Et Radix Notopterygii, 1 part of the Radix Paeoniae Alba, 1 part of the Rhizoma Atractylodis Macrocephalae, 1.5 parts of great river Radix Aconiti Lateralis Preparatas, Mel is an amount of.Grind and be smalls, refined honey ball such as Semen phaseoli radiati are large).Every 10 grams that take, light salt brine send down every day 2～3 times on an empty stomach.
Adopt the prescription of Yishen Jianpi for yang deficiency of spleen and stomache, such as square medicine: SHENLING BAISHU SAN is closed Yougui Yin, the kidney-Yang-Reinkforcing Decotion: Semen Nelumbinis (peeling) 500 grams, and Semen Coicis 50 restrains, contracting Fructus Amomi 50 grams, Radix Platycodonis (stir-fry makes buff) 50 grams, (Sucus Zingberis soaks Semen Lablab Album, peeling, little stir-fry) 75 grams, Poria 100 grams, Radix Ginseng 100 grams, Radix Glycyrrhizae (stir-fry) 100 grams, the Rhizoma Atractylodis Macrocephalae 100 grams, Rhizoma Dioscoreae 100 grams.Grind and be smalls, each serving 6 grams, Fructus Jujubae is fried in shallow oil soup and is taken.
Adopt the prescription of blood-activating and qi-promoting, removing obstruction in the collateral to relieve pain for qi stagnation and blood stasis type, such as square medicine: Traditional Chinese medicine decoction for treating-ache and expelling atagnate: Radix Gentianae Macrophyllae 3 grams, Rhizoma Chuanxiong 6 grams, Semen Persicae 9 grams, Flos Carthami 9 grams, Radix Glycyrrhizae 6 grams, Rhizoma Et Radix Notopterygii 3 grams, Myrrha 6 grams, Radix Angelicae Sinensis 9 grams, Oletum Trogopterori (stir-fry) 6 grams, Rhizoma Cyperi 3 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 6 grams.Be decocted in water for oral dose, it is greasy to avoid cold and uncooked food, and is not taken by pregnant women.
Chondroitin sulfate (Chondroitin sulfate) is present in the animal cartilage in a large number, is the acid mucopolysaccharide that extracts preparation from animal tissue.Chondroitin sulfate is a kind of of glycosaminoglycans, by D-glucuronic acid and N-acetylamino galactosamine with β-1, the polysaccharide that the repetition disaccharide unit that the 4-glycosidic bond is formed by connecting forms, and at C-4 position or the C-6 position hydroxyl of N-acetylamino galactosamine Sulfation occurs, be mainly used in arthritis, eye drop etc., studies show that chondroitin sulfate can promote osteoblast hypertrophy and new bone formation." the sulfated compound chrondroitin is to the therapeutical effect of rats with osteoporosis for scientific and technical literature
" (Liu Xiuju, Zhang Jixian, Mu Zhongxiang etc., " food and pharmaceutical " 05 phase in 2008) study the effect that the sulfated compound chrondroitin is treated the rats with osteoporosis of Induced by Retinoic Acid, the result shows, compare with model group, the sulfated compound chrondroitin is high, middle dosage group can significantly increase rat body weight, improves bone mineral content and bone density, reduces serum alkaline phosphatase (ALP) level, and can significantly improve the biomechanical parameter of femur, rats with osteoporosis there is therapeutical effect.
There is no at present the drug regimen of Chinese medicine and chondroitin sulfate is studied.
Summary of the invention
The invention provides a kind of promoting blood circulation to remove obstruction in the collateral control osteoporosis drug compositions, adopt Chinese medicine and the chondroitin sulfate combined treatment osteoporosis of blood-activating and qi-promoting, removing obstruction in the collateral to relieve pain for qi stagnation and blood stasis type.
The concrete technical scheme of the present invention is as follows:
A kind of promoting blood circulation to remove obstruction in the collateral control osteoporosis drug compositions comprises following weight portion:
Rhizoma Chuanxiong 4-6 part
Flos Carthami 8-12 part
Rhizoma Et Radix Notopterygii 2-4 part
Radix Angelicae Sinensis 8-12 part
Chondroitin sulfate 10-30 part.
Above-mentioned pharmaceutical composition preferably includes following weight portion:
6 parts of Rhizoma Chuanxiongs
12 parts on Flos Carthami
4 parts of Rhizoma Et Radix Notopterygiis
12 parts of Radix Angelicae Sinensis
30 parts of chondroitin sulfate.
Above-mentioned Chinese medicine composition can be got crude drug, and technique adds conventional adjuvant and is prepared into powder, capsule, tablet, granule, injection, oral liquid or drop pill routinely.
The specific embodiment
Below in conjunction with instantiation technical scheme of the present invention is described further, helps to understand the present invention, but do not limit content of the present invention.
Embodiment 1
Take by weighing Rhizoma Chuanxiong 4g, Flos Carthami 8g, Rhizoma Et Radix Notopterygii 2g, Radix Angelicae Sinensis 8g pulverizes, and decocts with water 2 times, each 220ml decocted 1 hour, and medicinal liquid merges, filter, it is 1.05-1.15(50-60 ℃ that filtrate is concentrated into relative density), add ethanol to the 50%-80% precipitate with ethanol, left standstill 24 hours, and filtered filtrate decompression Distillation recovery ethanol, being concentrated into relative density is 1.10-1.25(50-60 ℃), spray drying obtains Chinese medicinal powder, adds 10g chondroitin sulfate mix homogeneously.
Embodiment 2
Take by weighing Rhizoma Chuanxiong 5g, Flos Carthami 10g, Rhizoma Et Radix Notopterygii 3g, Radix Angelicae Sinensis 10g pulverizes, and decocts with water 2 times, each 260ml decocted 1 hour, and medicinal liquid merges, filter, it is 1.05-1.15(50-60 ℃ that filtrate is concentrated into relative density), add ethanol to the 50%-80% precipitate with ethanol, left standstill 24 hours, and filtered filtrate decompression Distillation recovery ethanol, being concentrated into relative density is 1.10-1.25(50-60 ℃), spray drying obtains Chinese medicinal powder, adds 20g chondroitin sulfate mix homogeneously.
Embodiment 3
Take by weighing Rhizoma Chuanxiong 6g, Flos Carthami 12g, Rhizoma Et Radix Notopterygii 4g, Radix Angelicae Sinensis 12g pulverizes, and decocts with water 2 times, each 340ml decocted 1 hour, and medicinal liquid merges, filter, it is 1.05-1.15(50-60 ℃ that filtrate is concentrated into relative density), add ethanol to the 50%-80% precipitate with ethanol, left standstill 24 hours, and filtered filtrate decompression Distillation recovery ethanol, being concentrated into relative density is 1.10-1.25(50-60 ℃), spray drying obtains Chinese medicinal powder, adds 30g chondroitin sulfate mix homogeneously.
Claims (2)
1. promoting blood circulation to remove obstruction in the collateral control osteoporosis drug compositions is characterized in that comprising following weight portion:
Rhizoma Chuanxiong 4-6 part
Flos Carthami 8-12 part
Rhizoma Et Radix Notopterygii 2-4 part
Radix Angelicae Sinensis 8-12 part
Chondroitin sulfate 10-30 part.
2. pharmaceutical composition as claimed in claim 1 is characterized in that comprising following weight portion:
6 parts of Rhizoma Chuanxiongs
12 parts on Flos Carthami
4 parts of Rhizoma Et Radix Notopterygiis
12 parts of Radix Angelicae Sinensis
30 parts of chondroitin sulfate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103911801A CN102988446A (en) | 2012-10-16 | 2012-10-16 | Medicinal composition for promoting blood circulation to remove meridian obstruction and preventing and treating osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103911801A CN102988446A (en) | 2012-10-16 | 2012-10-16 | Medicinal composition for promoting blood circulation to remove meridian obstruction and preventing and treating osteoporosis |
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| CN102988446A true CN102988446A (en) | 2013-03-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012103911801A Pending CN102988446A (en) | 2012-10-16 | 2012-10-16 | Medicinal composition for promoting blood circulation to remove meridian obstruction and preventing and treating osteoporosis |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742876A (en) * | 2005-09-29 | 2006-03-08 | 沈阳中药制药有限公司 | Chinese medicine for treating tractures and preparation for making plaster thereof |
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2012
- 2012-10-16 CN CN2012103911801A patent/CN102988446A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742876A (en) * | 2005-09-29 | 2006-03-08 | 沈阳中药制药有限公司 | Chinese medicine for treating tractures and preparation for making plaster thereof |
Non-Patent Citations (2)
| Title |
|---|
| 曹译等: "《鹿茸硫酸软骨素蛋白聚糖的分离纯化研究》", 《生物学杂志》 * |
| 齐尚锋等: "《中医药防治骨质疏松症的研究概况》", 《中国骨质疏松杂志》 * |
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| PB01 | Publication | ||
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Application publication date: 20130327 |