CN102988578A - Medicinal composition for tonifying kidney, strengthening bone and preventing osteoporosis - Google Patents
Medicinal composition for tonifying kidney, strengthening bone and preventing osteoporosis Download PDFInfo
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- CN102988578A CN102988578A CN2012103911337A CN201210391133A CN102988578A CN 102988578 A CN102988578 A CN 102988578A CN 2012103911337 A CN2012103911337 A CN 2012103911337A CN 201210391133 A CN201210391133 A CN 201210391133A CN 102988578 A CN102988578 A CN 102988578A
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Abstract
The invention provides a medicinal composition for tonifying kidney, strengthening bone and preventing osteoporosis, which comprises the following components in parts by weight: 10 to 30 parts of chondroitin sulfate, 1 to 5 parts of twotooth achyranthes root, 1 to 5 parts of red-rooted salvia root, and 4 to 6 parts of rehmannia. The product has good effect for preventing and treating osteoporosis.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of invigorating the kidney and strengthening the bones and prevent and treat osteoporotic pharmaceutical composition.
Background technology
Osteoporosis (osteoporosis) is a kind of systemic osteopathia, it is characterized in that
The bone amountDescend and the fine structure of bone destroys, the fragility that shows as bone increases, thereby the danger of fracturing greatly increases, even slight
WoundOr also fracture easily in the atraumatic situation.
OsteoporosisDisease is a kind of chronic disease due to multifactor.Before fracture occurs, usually without Special Clinical Manifestation.The women is more than the male for this disease, is common in postmenopausal women and old people.Along with China
Aging populationIncrease, the osteoporosis sickness rate is in ascendant trend, all is a health problem that merits attention in China and even the whole world.
Motherland's medical science think primary disease generation, the development and " kidney qi " closely related, " the contrary opinion of transferring of Plain Questions " said: " kidney is not given birth to; then marrow can not be expired ", " Plain Questions six joints are hidden and resembled opinion " said: " kidney person, the master stings the dominator of storing essence; smart part is also; its Hua Zaifa, and it fills at bone " ", therefore its employing invigorating the kidney and strengthening the bones, invigorating the spleen and benefiting QI, promoting blood circulation to remove obstruction in the collateral are all obtained preferably effect.
The traditional Chinese medical science adopts differentiation of symptoms and signs for classification of syndrome, for different types, adopts the prescription of suiting the medicine to the illness.As adopting the prescription of nourishing the liver and kidney, bone and muscle strengthening for deficiency of the liver and kidney, such as square medicine: chien pu hu chien wan: 2 parts of Colla Plastri Testudinis, 2 parts of Colla cornus cervis, 2 parts of Tigris shins (now use Os Canitis generation), 2 parts of Radix Polygoni Multiflori, 2 parts of Radix Cyathulaes, 2 parts of the Cortexs Eucommiae, 2 parts of Herba Cynomoriis, 2 parts of Radix Angelicae Sinensis, 2 parts of Radix Rehmanniae Preparata, 2 parts of Radix Clematidis, 1 part of Cortex Phellodendri, 1 part of Radix Ginseng, 1 part of Rhizoma Et Radix Notopterygii, 1 part of the Radix Paeoniae Alba, 1 part of the Rhizoma Atractylodis Macrocephalae, 1.5 parts of great river Radix Aconiti Lateralis Preparatas, Mel is an amount of.Grind and be smalls, refined honey ball such as Semen phaseoli radiati are large).Every 10 grams that take, light salt brine send down every day 2～3 times on an empty stomach.
Adopt the prescription of Yishen Jianpi for yang deficiency of spleen and stomache, such as square medicine: SHENLING BAISHU SAN is closed Yougui Yin, the kidney-Yang-Reinkforcing Decotion: Semen Nelumbinis (peeling) 500 grams, and Semen Coicis 50 restrains, contracting Fructus Amomi 50 grams, Radix Platycodonis (stir-fry makes buff) 50 grams, (Sucus Zingberis soaks Semen Lablab Album, peeling, little stir-fry) 75 grams, Poria 100 grams, Radix Ginseng 100 grams, Radix Glycyrrhizae (stir-fry) 100 grams, the Rhizoma Atractylodis Macrocephalae 100 grams, Rhizoma Dioscoreae 100 grams.Grind and be smalls, each serving 6 grams, Fructus Jujubae is fried in shallow oil soup and is taken.
Adopt the prescription of blood-activating and qi-promoting, removing obstruction in the collateral to relieve pain for qi stagnation and blood stasis type, such as square medicine: Traditional Chinese medicine decoction for treating-ache and expelling atagnate: Radix Gentianae Macrophyllae 3 grams, Rhizoma Chuanxiong 6 grams, Semen Persicae 9 grams, Flos Carthami 9 grams, Radix Glycyrrhizae 6 grams, Rhizoma Et Radix Notopterygii 3 grams, Myrrha 6 grams, Radix Angelicae Sinensis 9 grams, Oletum Trogopterori (stir-fry) 6 grams, Rhizoma Cyperi 3 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 6 grams.Be decocted in water for oral dose, it is greasy to avoid cold and uncooked food, and is not taken by pregnant women.
Chondroitin sulfate (Chondroitin sulfate) is present in the animal cartilage in a large number, is the acid mucopolysaccharide that extracts preparation from animal tissue.Chondroitin sulfate is a kind of of glycosaminoglycans, by D-glucuronic acid and N-acetylamino galactosamine with β-1, the polysaccharide that the repetition disaccharide unit that the 4-glycosidic bond is formed by connecting forms, and at C-4 position or the C-6 position hydroxyl of N-acetylamino galactosamine Sulfation occurs, be mainly used in arthritis, eye drop etc., studies show that chondroitin sulfate can promote osteoblast hypertrophy and new bone formation." the sulfated compound chrondroitin is to the therapeutical effect of rats with osteoporosis for scientific and technical literature
" (Liu Xiuju, Zhang Jixian, Mu Zhongxiang etc., " food and pharmaceutical " 05 phase in 2008) study the effect that the sulfated compound chrondroitin is treated the rats with osteoporosis of Induced by Retinoic Acid, the result shows, compare with model group, the sulfated compound chrondroitin is high, middle dosage group can significantly increase rat body weight, improves bone mineral content and bone density, reduces serum alkaline phosphatase (ALP) level, and can significantly improve the biomechanical parameter of femur, rats with osteoporosis there is therapeutical effect.
There is no at present the drug regimen of Chinese medicine and chondroitin sulfate is studied.
Summary of the invention
The invention provides a kind of invigorating the kidney and strengthening the bones and prevent and treat osteoporotic pharmaceutical composition, adopt Chinese medicine and the chondroitin sulfate combined treatment osteoporosis of nourishing the liver and kidney, bone and muscle strengthening for deficiency of the liver and kidney.
The concrete technical scheme of the present invention is as follows:
A kind of invigorating the kidney and strengthening the bones prevents and treats osteoporotic pharmaceutical composition, comprises following weight portion:
Chondroitin sulfate 10-30 part
Radix Achyranthis Bidentatae 1-5 part
Radix Salviae Miltiorrhizae 1-5 part
Radix Rehmanniae 4-6 part.
Aforementioned pharmaceutical compositions preferably includes following weight portion:
30 parts of chondroitin sulfate
5 parts of Radix Achyranthis Bidentataes
5 parts of Radix Salviae Miltiorrhizaes
6 parts of Radix Rehmanniae.
Above-mentioned Chinese medicine composition can be got crude drug, and technique adds conventional adjuvant and is prepared into powder, capsule, tablet, granule, injection, oral liquid or drop pill routinely.
The specific embodiment
Below in conjunction with instantiation technical scheme of the present invention is described further, helps to understand the present invention, but do not limit content of the present invention.
Embodiment 1
Take by weighing Radix Achyranthis Bidentatae 10g, Radix Salviae Miltiorrhizae 10g, Radix Rehmanniae 40g, pulverize, decoct with water 2 times, each 500ml decocted 1 hour, and medicinal liquid merges, filter, it is 1.05-1.15(50-60 ℃ that filtrate is concentrated into relative density), add ethanol to the 50%-80% precipitate with ethanol, left standstill 24 hours, filter, filtrate decompression Distillation recovery ethanol, being concentrated into relative density is 1.10-1.25(50-60 ℃), spray drying obtains Chinese medicinal powder, adds 100g chondroitin sulfate mix homogeneously.
Embodiment 2
Take by weighing Radix Achyranthis Bidentatae 50g, Radix Salviae Miltiorrhizae 50g, Radix Rehmanniae 60g, pulverize, decoct with water 2 times, each 1600ml decocted 1 hour, and medicinal liquid merges, filter, it is 1.05-1.15(50-60 ℃ that filtrate is concentrated into relative density), add ethanol to the 50%-80% precipitate with ethanol, left standstill 24 hours, filter, filtrate decompression Distillation recovery ethanol, being concentrated into relative density is 1.10-1.25(50-60 ℃), spray drying obtains Chinese medicinal powder, adds 300g chondroitin sulfate mix homogeneously.
Embodiment 3
Take by weighing Radix Achyranthis Bidentatae 30g, Radix Salviae Miltiorrhizae 30g, Radix Rehmanniae 50g, pulverize, decoct with water 2 times, each 1100ml decocted 1 hour, and medicinal liquid merges, filter, it is 1.05-1.15(50-60 ℃ that filtrate is concentrated into relative density), add ethanol to the 50%-80% precipitate with ethanol, left standstill 24 hours, filter, filtrate decompression Distillation recovery ethanol, being concentrated into relative density is 1.10-1.25(50-60 ℃), spray drying obtains Chinese medicinal powder, adds 200g chondroitin sulfate mix homogeneously.
Claims (2)
1. an invigorating the kidney and strengthening the bones is prevented and treated osteoporotic pharmaceutical composition, it is characterized in that comprising following weight portion:
Chondroitin sulfate 10-30 part
Radix Achyranthis Bidentatae 1-5 part
Radix Salviae Miltiorrhizae 1-5 part
Radix Rehmanniae 4-6 part.
2. pharmaceutical composition as claimed in claim 1 is characterized in that comprising following weight portion:
30 parts of chondroitin sulfate
5 parts of Radix Achyranthis Bidentataes
5 parts of Radix Salviae Miltiorrhizaes
6 parts of Radix Rehmanniae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103911337A CN102988578A (en) | 2012-10-16 | 2012-10-16 | Medicinal composition for tonifying kidney, strengthening bone and preventing osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103911337A CN102988578A (en) | 2012-10-16 | 2012-10-16 | Medicinal composition for tonifying kidney, strengthening bone and preventing osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102988578A true CN102988578A (en) | 2013-03-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012103911337A Pending CN102988578A (en) | 2012-10-16 | 2012-10-16 | Medicinal composition for tonifying kidney, strengthening bone and preventing osteoporosis |
Country Status (1)
| Country | Link |
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| CN (1) | CN102988578A (en) |
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2012
- 2012-10-16 CN CN2012103911337A patent/CN102988578A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 刘秀菊等: "复方硫酸软骨素对大鼠骨质疏松症的治疗作用", 《食品与药品》 * |
| 崔燎等: "丹参水提物和丹参素促进成骨细胞活性和防治泼尼松所致大鼠骨质疏松", 《中国药理学通报》 * |
| 彭怀仁: "《中医方剂大辞典 第二册》", 28 February 1994, 人民卫生出版社 * |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130327 |