CN102988404B - Astragalus polysaccharide injection and preparation method thereof - Google Patents
Astragalus polysaccharide injection and preparation method thereof Download PDFInfo
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- CN102988404B CN102988404B CN201210540730.1A CN201210540730A CN102988404B CN 102988404 B CN102988404 B CN 102988404B CN 201210540730 A CN201210540730 A CN 201210540730A CN 102988404 B CN102988404 B CN 102988404B
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Abstract
The purpose of the invention is to disclose an astragalus polysaccharide injection and a preparation method thereof. The astragalus polysaccharide injection comprises following components by weight per 100 mL: 1 to 3 g of astragalus polysaccharide, 0.01 to 0.10 g of dexamethasone sodium phosphate, 0.5 to 1.5 g of barbital, 1 to 5 g of antipyrine. 3 to 8 g of aminopyrine, 0.01 to 0.03 g of EDTA-2Na (Ethylenediamine Teraacetic Acid Disodium Salt), and the balance of water for injection; in comparison with the prior art, barbital, aminopyrine and antipyrine are added, thereby increasing the efficacy, widening the antimicrobial spectrum, reducing the drug resistance, and being quick to take effect; furthermore, the process of the preparation method is simple and easy to realize to achieve the purpose of the invention.
Description
Technical field
The present invention relates to a kind of injection and preparation method thereof, particularly a kind of astragalin injection for animals and preparation method thereof.
Background technology
Astragalus polysaccharides is that the dry root of leguminous plant Radix Astagali or Radix Astragali is through the water solublity heteropolysaccharide extracting, concentrated, purification forms.Faint yellow, powder exquisiteness, evenly free from admixture, tool draws moist.Astragalus polysaccharides is made up of hexuronic acid, glucose, fructose, rhamnose, arabinose, galacturonic acid and glucuronic acid etc., can be used as immunopotentiating agent or regulator, there is the effects such as antiviral, antitumor, defying age, radioprotective, anti-stress, antioxidation simultaneously.Astragalus polysaccharides is one of main active of the Radix Astragali, extracts, is isolated through high-tech.In recent years, due to the raising of the understanding of people to chemical synthetic drug toxic and side effects, the world of medicine starts to pay attention to exploitation natural plant medicament both at home and abroad.Little, evident in efficacy, the double Drug of exploitation toxic and side effects and trophism are more and more urgent in the demand of the Chinese herbal medicine additive of one, and the Radix Astragali is produced as holding up this solid positive class Chinese herbal feed additive to start to be used to animal husbandry.
Astragalus polysaccharides has the utilization that improves nutrient substance, promotes the function of growth of animal, and astragalus polysaccharides includes aminoacid, vitamin, the multiple nutrients materials such as trace element; Have containing UGF (UGF).Can significantly improve the speed of growth of poultry as feed additive, promote Abwehrkraft des Koepers, improve meat, eggs and milk quality and output.Astragalus polysaccharides is a kind of interferon inducers, its antiviral principle: the function of stimulating expression of macrophage and T cell, making E ring form cell number increases, Cytokines Production, promotes that interleukin induces, and makes animal body produce endogenous interferon, thereby reach antiviral object, be used for the treatment of piglet circovirus disease, infectious bursal disease, influenza Chinese mugwort viral infectious.The Radix Astragali can reduce sickness rate more than 50% by preventing cold, and the Radix Astragali and interferon use in conjunction can reduce sickness rate more than 70%.
Dexamethasone sodium phosphate belongs to Aeroseb-Dex, has antiinflammatory, antiallergic, and effect such as antitoxin grade, can be used for infectious serious adrenocortical insufficiency, connective tissue disease, the allergy such as serious bronchitis asthma.
But the antimicrobial spectrum of existing product is narrower, drug resistance is larger, takes effect slow.
Therefore, need especially a kind of astragalin injection and preparation method thereof, solved the problem of above-mentioned existing existence.
Summary of the invention
The object of the present invention is to provide a kind of astragalin injection and preparation method thereof, for the deficiencies in the prior art, added barbital, aminophenazone and phenazone, increased drug effect, expanded antimicrobial spectrum, reduced drug resistance, instant effect.
Technical problem solved by the invention can realize by the following technical solutions:
On the one hand, the invention provides a kind of astragalin injection, it is characterized in that, it comprises the following components by weight percent of every 100ml: astragalus polysaccharides 1-3g, dexamethasone sodium phosphate 0.01-0.10g, barbital 0.5-1.5g, phenazone 1g-5g, aminophenazone 3g-8g, EDTA-2Na 0.01-0.03g, surplus is water for injection.
In one embodiment of the invention, preferably, described astragalin injection comprises the following components by weight percent of every 100ml: astragalus polysaccharides 1.6g, dexamethasone sodium phosphate 0.05g, barbital 0.9g, phenazone 2g, aminophenazone 5g, EDTA-2Na 0.015g, surplus is water for injection.
On the other hand, the preparation method that the invention provides a kind of astragalin injection, is characterized in that, gets appropriate water, in the water-bath of 40-50 degree Celsius, heat, in constantly stirring, add aminophenazone, phenazone, keep temperature lasting stirring, make solution become clarification, then in constantly stirring, add barbital, EDTA-2Na, dexamethasone sodium phosphate, stirring makes its clarification, adds astragalus polysaccharides, stirs and obtains tan supernatant liquid.Be cooled to after room temperature, regulating pH value with sodium hydroxide solution is 6.5-7.0, then adds the water of surplus, to obtain final product.
Astragalin injection of the present invention and preparation method thereof, compared with prior art, has added barbital, aminophenazone and phenazone, has increased drug effect, has expanded antimicrobial spectrum, has reduced drug resistance, instant effect; And preparation method technique is simple, easily realize, realize object of the present invention.
Feature of the present invention can be consulted the detailed description of the better embodiment of this case and obtain and is well understood to.
Detailed description of the invention
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, further set forth the present invention below in conjunction with concrete.
Astragalin injection of the present invention, it comprises the following components by weight percent of every 100ml: astragalus polysaccharides 1-3g, dexamethasone sodium phosphate 0.001-0.10g, barbital 0.5-1.5g, phenazone 1g-5g, aminophenazone 3g-8g, EDTA-2Na 0.01-0.03g, surplus is water for injection.
In the present invention, preferably, described astragalin injection comprises the following components by weight percent of every 100ml: astragalus polysaccharides 1.6g, dexamethasone sodium phosphate 0.05g, barbital 0.9g, phenazone 2g, aminophenazone 5g, EDTA-2Na 0.015g, surplus is water for injection.
The preparation method of astragalin injection of the present invention, get appropriate water, in the water-bath of 40-50 degree Celsius, heat, in constantly stirring, add aminophenazone, phenazone, keep temperature lasting stirring, make solution become clarification, then in constantly stirring, add barbital, EDTA-2Na, dexamethasone sodium phosphate, stirring makes its clarification, adds astragalus polysaccharides, stirs and obtains tan supernatant liquid.Be cooled to after room temperature, regulating pH value with sodium hydroxide solution is 6.5-7.0, then adds the water of surplus, to obtain final product.
By the astragalin injection fill making, in ampoule bottle, cillin bottle, vial or plastic bottle, the capacity of fill can be 10ml, 20ml, 50ml, 100m, 200ml and 250ml etc.
Embodiment 1:
Get appropriate water, in the water-bath of 40-50 degree Celsius, heat, in constantly stirring, add aminophenazone 3g, phenazone 1g, keep temperature lasting stirring, make solution become clarification, then in constantly stirring, add barbital 0.5g, EDTA-2Na0.01g, dexamethasone sodium phosphate 0.001g, stir and make its clarification, add astragalus polysaccharides 1.0g, stir and obtain tan supernatant liquid.Be cooled to after room temperature, regulating pH value with sodium hydroxide solution is 6.5-7.0, then adds the water for injection of surplus, makes into 100ml, to obtain final product.
Embodiment 2:
Get appropriate water, in the water-bath of 40-50 degree Celsius, heat, in constantly stirring, add aminophenazone 4.5g, phenazone 2g, keep temperature lasting stirring, make solution become clarification, then in constantly stirring, add barbital 0.9g, EDTA-2Na0.025g, dexamethasone sodium phosphate 0.005g, stir and make its clarification, add astragalus polysaccharides 2g, stir and obtain tan supernatant liquid.Be cooled to after room temperature, regulating pH value with sodium hydroxide solution is 6.5-7.0, then adds the water for injection of surplus, makes into 100ml, to obtain final product.
Embodiment 3:
Get appropriate water, in the water-bath of 40-50 degree Celsius, heat, in constantly stirring, add aminophenazone 5g, phenazone 2g, keep temperature lasting stirring, make solution become clarification, then in constantly stirring, add barbital 0.9g, EDTA-2Na0.015g, dexamethasone sodium phosphate 0.05g, stir and make its clarification, add astragalus polysaccharides 1.6g, stir and obtain tan supernatant liquid.Be cooled to after room temperature, regulating pH value with sodium hydroxide solution is 6.5-7.0, then adds the water for injection of surplus, makes into 100ml, to obtain final product.
Embodiment 4:
Get appropriate water, in the water-bath of 40-50 degree Celsius, heat, in constantly stirring, add aminophenazone 8g, phenazone 5g, keep temperature lasting stirring, make solution become clarification, then in constantly stirring, add barbital 1.5g, EDTA-2Na0.03g, dexamethasone sodium phosphate 0.1g, stir and make its clarification, add astragalus polysaccharides 3.0g, stir and obtain tan supernatant liquid.Be cooled to after room temperature, regulating pH value with sodium hydroxide solution is 6.5-7.0, then adds the water for injection of surplus, makes into 100ml, to obtain final product.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications; these changes and improvements all fall in the claimed scope of the invention, and the claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (2)
1. an astragalin injection, is characterized in that, described astragalin injection comprises the following components by weight percent of every 100ml: astragalus polysaccharides 1.6g, dexamethasone sodium phosphate 0.05g, barbital 0.9g, phenazone 2g, aminophenazone 5g, EDTA-2Na0.015g, surplus is water for injection.
2. the preparation method of an astragalin injection, it is characterized in that, get appropriate water, in the water-bath of 40-50 degree Celsius, heat, in constantly stirring, add aminophenazone, phenazone, keep temperature lasting stirring, make solution become clarification, then in constantly stirring, add barbital, EDTA-2Na, dexamethasone sodium phosphate, stir and make its clarification, add astragalus polysaccharides, stir and obtain tan supernatant liquid.Be cooled to after room temperature, regulating pH value with sodium hydroxide solution is 6.5-7.0, then adds the water of surplus, to obtain final product.
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| CN201210540730.1A CN102988404B (en) | 2012-12-13 | 2012-12-13 | Astragalus polysaccharide injection and preparation method thereof |
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| CN201210540730.1A CN102988404B (en) | 2012-12-13 | 2012-12-13 | Astragalus polysaccharide injection and preparation method thereof |
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| CN102988404A CN102988404A (en) | 2013-03-27 |
| CN102988404B true CN102988404B (en) | 2014-07-23 |
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| CN105456185A (en) * | 2015-12-16 | 2016-04-06 | 浙江大飞龙动物保健品有限公司 | Compound Astragalus polysaccharides injection and preparation method thereof |
| CN111714497B (en) * | 2019-03-22 | 2021-05-25 | 山东大学 | Application of antipyrine derivative in preparation of product for inhibiting candida albicans |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129328A (en) * | 2007-09-13 | 2008-02-27 | 天津药业集团新郑股份有限公司 | Compound aminophenazone barbital Injection and method of producing the same |
| CN101288690A (en) * | 2008-06-18 | 2008-10-22 | 成都中牧生物药业有限公司 | Anti-inflammation, anti-sensitivity, anti-shock medicament and preparation method thereof |
| CN101385704A (en) * | 2008-10-28 | 2009-03-18 | 陈建波 | Compound sulfamonomethoxine sodium injection and preparation method thereof |
| CN101856495A (en) * | 2009-04-09 | 2010-10-13 | 河南惠通天下动物药业有限公司 | Medical composition and mixture for treating chicken infectious bursal disease and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129328A (en) * | 2007-09-13 | 2008-02-27 | 天津药业集团新郑股份有限公司 | Compound aminophenazone barbital Injection and method of producing the same |
| CN101288690A (en) * | 2008-06-18 | 2008-10-22 | 成都中牧生物药业有限公司 | Anti-inflammation, anti-sensitivity, anti-shock medicament and preparation method thereof |
| CN101385704A (en) * | 2008-10-28 | 2009-03-18 | 陈建波 | Compound sulfamonomethoxine sodium injection and preparation method thereof |
| CN101856495A (en) * | 2009-04-09 | 2010-10-13 | 河南惠通天下动物药业有限公司 | Medical composition and mixture for treating chicken infectious bursal disease and preparation method thereof |
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Denomination of invention: Astragalus polysaccharide injection and preparation method thereof Effective date of registration: 20161228 Granted publication date: 20140723 Pledgee: Haimen City Science and Technology Park Service Center Pledgor: Jiangsu Hengfengqiang Biotechnology Co., Ltd. Registration number: 2016980000276 |
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