CN102985425A - 作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途 - Google Patents

作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途 Download PDF

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Publication number
CN102985425A
CN102985425A CN2011800339890A CN201180033989A CN102985425A CN 102985425 A CN102985425 A CN 102985425A CN 2011800339890 A CN2011800339890 A CN 2011800339890A CN 201180033989 A CN201180033989 A CN 201180033989A CN 102985425 A CN102985425 A CN 102985425A
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pyrimidine
pyrrolo
nonane
diaza spiro
ketone
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Chinese (zh)
Inventor
S·F·尼尔森
D·R·格雷夫
G·格鲁-索伦森
C·里特斯嘉德
S·C·舒
A·G·萨姆斯
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Leo Pharma AS
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Leo Pharma AS
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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  • Health & Medical Sciences (AREA)
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  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2011800339890A 2010-07-09 2011-07-08 作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途 Pending CN102985425A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36309510P 2010-07-09 2010-07-09
US61/363,095 2010-07-09
PCT/DK2011/000080 WO2012003829A1 (fr) 2010-07-09 2011-07-08 Nouveaux dérivés d'homopipérazine comme inhibiteurs de protéines tyrosine kinases et leur utilisation pharmaceutique

Publications (1)

Publication Number Publication Date
CN102985425A true CN102985425A (zh) 2013-03-20

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CN2011800339890A Pending CN102985425A (zh) 2010-07-09 2011-07-08 作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途

Country Status (7)

Country Link
US (1) US9586961B2 (fr)
EP (1) EP2590981B1 (fr)
JP (1) JP2013533868A (fr)
CN (1) CN102985425A (fr)
RU (1) RU2013105450A (fr)
TW (1) TW201204732A (fr)
WO (1) WO2012003829A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103242321A (zh) * 2013-05-21 2013-08-14 苏州科捷生物医药有限公司 苄基哌嗪类化合物及其抗肿瘤用途
CN103396414A (zh) * 2013-07-16 2013-11-20 浙江医药高等专科学校 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途
CN104072499A (zh) * 2013-03-29 2014-10-01 黄传满 哌嗪取代嘧啶类化合物及其用途
CN105712998A (zh) * 2014-12-05 2016-06-29 上海润诺生物科技有限公司 氮杂吲哚类衍生物、其制备方法及其在医药上的应用
CN106061973A (zh) * 2013-12-05 2016-10-26 辉瑞公司 吡咯并[2,3‑d]嘧啶基、吡咯并[2,3‑b]吡嗪基和吡咯并[2,3‑d]吡啶基丙烯酰胺
CN108069986A (zh) * 2017-12-08 2018-05-25 牡丹江医学院 一种治疗角膜炎的活性药物及其制备方法
CN109689663A (zh) * 2016-09-14 2019-04-26 詹森药业有限公司 Menin-mll相互作用的螺二环抑制剂

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101214A1 (es) * 2014-07-22 2016-11-30 Bayer Cropscience Ag Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas
CN110291090A (zh) * 2017-01-20 2019-09-27 利奥制药有限公司 作为新型jak激酶抑制剂的双环胺
US10799507B2 (en) * 2017-02-03 2020-10-13 Leo Pharma A/S 5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
WO2020092015A1 (fr) 2018-11-02 2020-05-07 University Of Rochester Atténuation thérapeutique d'une infection épithéliale
CN114599364A (zh) 2019-09-05 2022-06-07 因赛特公司 用于减少特应性皮炎瘙痒的鲁索替尼制剂
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)

Citations (4)

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WO1999065908A1 (fr) * 1998-06-19 1999-12-23 Pfizer Products Inc. COMPOSES DE PYRROLO[2,3d]PYRIMIDINE
CN1305479A (zh) * 1998-06-19 2001-07-25 辉瑞产品公司 吡咯并[2,3－d]嘧啶化合物
WO2009021169A2 (fr) * 2007-08-08 2009-02-12 Lexicon Pharmaceuticals, Inc. Inhibiteurs de kinase, compositions les contenant et procédés d'utilisation
CN101679440A (zh) * 2007-04-02 2010-03-24 帕劳制药股份有限公司 作为jak3抑制剂的吡咯并嘧啶衍生物

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AU2005249380C1 (en) 2004-04-23 2012-09-20 Exelixis, Inc. Kinase modulators and methods of use
ATE477252T1 (de) 2006-07-14 2010-08-15 Merck Sharp & Dohme Substituierte diazepane als antagonisten an orexinrezeptoren
WO2009017838A2 (fr) 2007-08-01 2009-02-05 Exelixis, Inc. Combinaisons d'inhibiteurs jak-2 et d'autres agents
EA017952B1 (ru) 2008-02-06 2013-04-30 Новартис Аг ПИРРОЛО[2,3-d]ПИРИДИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ТИРОЗИНКИНАЗЫ
WO2009131687A2 (fr) 2008-04-22 2009-10-29 Portola Pharmaceuticals, Inc. Inhibiteurs de protéines kinases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999065908A1 (fr) * 1998-06-19 1999-12-23 Pfizer Products Inc. COMPOSES DE PYRROLO[2,3d]PYRIMIDINE
CN1305479A (zh) * 1998-06-19 2001-07-25 辉瑞产品公司 吡咯并[2,3－d]嘧啶化合物
CN101679440A (zh) * 2007-04-02 2010-03-24 帕劳制药股份有限公司 作为jak3抑制剂的吡咯并嘧啶衍生物
WO2009021169A2 (fr) * 2007-08-08 2009-02-12 Lexicon Pharmaceuticals, Inc. Inhibiteurs de kinase, compositions les contenant et procédés d'utilisation

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104072499A (zh) * 2013-03-29 2014-10-01 黄传满 哌嗪取代嘧啶类化合物及其用途
CN103242321A (zh) * 2013-05-21 2013-08-14 苏州科捷生物医药有限公司 苄基哌嗪类化合物及其抗肿瘤用途
CN103396414A (zh) * 2013-07-16 2013-11-20 浙江医药高等专科学校 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途
CN103396414B (zh) * 2013-07-16 2015-06-03 浙江医药高等专科学校 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途
CN106061973A (zh) * 2013-12-05 2016-10-26 辉瑞公司 吡咯并[2,3‑d]嘧啶基、吡咯并[2,3‑b]吡嗪基和吡咯并[2,3‑d]吡啶基丙烯酰胺
CN107417684A (zh) * 2013-12-05 2017-12-01 辉瑞公司 杂环丙烯酰胺
CN106061973B (zh) * 2013-12-05 2019-07-09 辉瑞公司 吡咯并[2,3-d]嘧啶基、吡咯并[2,3-b]吡嗪基和吡咯并[2,3-d]吡啶基丙烯酰胺
CN105712998A (zh) * 2014-12-05 2016-06-29 上海润诺生物科技有限公司 氮杂吲哚类衍生物、其制备方法及其在医药上的应用
CN105712998B (zh) * 2014-12-05 2019-12-13 上海润诺生物科技有限公司 氮杂吲哚类衍生物、其制备方法及其在医药上的应用
CN109689663A (zh) * 2016-09-14 2019-04-26 詹森药业有限公司 Menin-mll相互作用的螺二环抑制剂
CN109689663B (zh) * 2016-09-14 2023-04-14 詹森药业有限公司 Menin-mll相互作用的螺二环抑制剂
CN108069986A (zh) * 2017-12-08 2018-05-25 牡丹江医学院 一种治疗角膜炎的活性药物及其制备方法

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JP2013533868A (ja) 2013-08-29
EP2590981A1 (fr) 2013-05-15
EP2590981B1 (fr) 2014-09-03
TW201204732A (en) 2012-02-01
RU2013105450A (ru) 2014-08-20
US9586961B2 (en) 2017-03-07
WO2012003829A1 (fr) 2012-01-12
US20130172325A1 (en) 2013-07-04

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