CN102961661B

CN102961661B - Compound preparation for treating upper respiratory infection and tracheitis

Info

Publication number: CN102961661B
Application number: CN201210543199.3A
Authority: CN
Inventors: 刘新义; 刘艳
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-12-16
Filing date: 2012-12-16
Publication date: 2014-06-25
Anticipated expiration: 2032-12-16
Also published as: CN102961661A

Abstract

The invention discloses a compound preparation for treating upper respiratory infection and tracheitis. The compound preparation is characterized by comprising the following components by weight ratio: 500g of fig dried fruits, 150g of Chinese arborvitae twig, 150g of echinacea purpurea, 100g of radix platycodi, 60g of radix stemonae and 40g of radix glycyrrhizae. The compound preparation is prepared by the following steps: carrying out pretreatment to obtain water extract and decoction, concentrating, adding ethanol, standing and depositing to obtain supernate, concentrating the supernate into paste, mixing the paste with cane sugar and dextrin according to a proportion of 1:3:1, and drying to obtain 0.5g of finished tablets or capsules. The compound preparation has the efficacies of clearing heat and removing toxicity, dispelling the wind and resuscitating, relieving cough and reducing sputum, eliminating phlegm and relieving asthma, removing stasis and dispersing blood stasis, relieving swelling and pain, purging fire for removing toxin, prompting the function reconstruction and healing of upper respiratory tract mucosa, and the like, and can prompt the wound healing aiming at postoperative wound of the oral cavity, laryngeal part of pharynx, and the upper respiratory tract, and prevent the infection of the wound. The compound preparation has no toxic and side effects and is used for treating acute and chronic upper respiratory infection, and has outstanding advantages of being good in property, easy to prepare, low in cost, free from toxic and side effects, and the like.

Description

One is treated upper respiratory tract infection and tracheitis compound preparation

Technical field

The present invention relates to Chinese patent medicine compound preparation, be specifically related to one and treat upper respiratory tract infection and tracheitis compound preparation.

Background technology

As everyone knows, upper respiratory tract infection and acute and chronic tracheitis and bronchitis sickness rate are very high, account for the more than 20% of systemic disease, as treatment not in time, often cause pathological changes and the general complication of adjacent organs, as: the complication such as acute and chronic otitis media, sinusitis, bronchitis, pneumonia, myocarditis, rheumatic fever, acute stomatitis, ulcerative stomatitis, acute and chronic pharyngitis, acute and chronic tonsillitis, angina nosocomii.The methods that adopt at present antibiotic anti-inflammations both at home and abroad more, drug side effect is larger, easily causes whole body complication; And cure the symptoms, not the disease, relapse rate is high, and side effect is large.

In addition, after oral cavity, bottleneck throat and upper respiratory tract operation, because operation wound heals slower, and Chang Yinwei localized bacterial infection and affect wound healing, at present, can only apply antibiotic therapy clinically, to prevent or to control inflammation, both increase patient economy burden, easily cause again untoward reaction.

Summary of the invention

The present invention overcomes the defect existing in existing upper respiratory tract infection and acute and chronic trachea-bronchia the treatment of inflammatory diseases technological means, propose one and there is heat-clearing and toxic substances removing, dispel the wind have one's ideas straightened out, relieving cough and resolving phlegm, eliminating phlegm and relieving asthma, eliminating stagnation blood stasis dispelling, reducing swelling and alleviating pain, the effects such as eliminating fire and detoxication, promotion oral cavity and the reparation of upper respiratory tract mucosa function and healing, and the treatment upper respiratory tract infection having no side effect and acute and chronic tracheitis and bronchitis compound preparation.

The present invention reaches by following measure.

One is treated upper respiratory tract infection and tracheitis compound preparation, it is characterized in that comprising each component of following weight proportion: Fructus Fici dry fruit 500 g, Cacumen Platycladi 150g, Echinacea 150g, Radix Platycodonis 100g, Radix Stemonae 60g, Radix Glycyrrhizae 40g, first take raw material by above-mentioned weight proportion, and carry out preorder processing, preorder processing comprises etc. that 500 g that add water concoct 3-4 hour, then extract and carry out water extraction liquid, then 500 g that add water decoct 1 hour, obtain the first decocting liquid 200g, 500 g that add water decoct 1 hour, obtain the second decocting liquid 200g, 500 g that add water decoct 1 hour, obtain the 3rd decocting liquid 200g, remerge decocting liquid and concentrate, after this after adding the ethanol of qdx 70-75% to staticly settle 24 hours to carry out, get supernatant, supernatant concentration is become to cream, qinghuo reagent again, sucrose, dextrin mixes one-tenth tablet or the granule of drying 0.5g processed in 1:3:1 ratio.

Fructus Fici of the present invention contains 18 seed amino acids (10 kinds be human body institute essential) and multivitamin and mineral, and there is improving eyesight and promote the production of body fluid, anti-inflammation detumescence, the drug effects such as spleen invigorating pain relieving, Fructus Fici dry fruit, mellow fruit, crude fruit with and root, stem and leaf all contain anticancer active constituent, it mainly comprises benzaldehyde, furocoumarin lactone, Psoralen, the materials such as bergapton, show that after deliberation it can improve developing of body immunity energy anticancer, simultaneously, healthy body cell is not caused to any infringement, in addition, show after deliberation to contain in Fructus Fici citric acid, Fumaric acid, succinic acid, malic acid, the third acetic acid, oxalic acid, the materials such as quininic acid, there is the merit of anti-inflammation detumescence, so there is the effect of good sharp anti-inflammation detumescence.

The main active of Echinacea is polyphenol, caffeic acid derivant, inulin and polysaccharide etc., there is immunostimulation, wherein inulin can play a role by increasing granulocyte and leukocytic number, can improve mononuclear cell and produce bacteriolysis with the chemotaxis of neutral virus.Polysaccharide part makes the Hydrocarbon receptor of T lymphocyte and Macrophage Surface produce immunostimulation, can increase the phagocytic activity of macrophage, and stimulating expression of macrophage increases the number of tumor necrosis factor, interferon, leukocyte betweenness; Echinacea crude polysaccharides (EPS) can kill and wound the activity of P815 oncocyte by obvious stimulation macrophage, and can destroy tumor cell.Caffeic acid derivant, can increase macrophage phagocytic ability.Echinacea can suppress the effect of hyaluronidase (hyaluronidase) in addition, stimulate the growth of fibroblast and synthesizing of glucosaminidase, produce the effect of cortex ketone, promote the secretion of adrenocortical hormone, upgrade and anti-sense bacterium and antiviral effect so there is tissue.

Cacumen Platycladi is containing volatile oil, and in oil, main component is α-absinthol, thujene, fenchone etc., and other is still containing flavones ingredient, as aromadendrin, Quercetin, myricetin, hinokiflavone etc.; In leaf, also contain the trace element such as potassium, sodium, nitrogen, phosphorus, calcium, magnesium, manganese and zinc.α-absinthol, thujene, fenchone etc. can assign to bring into play antiinflammatory action by suppressing the activity of 5-lipoxygenase and the one-tenth of Cycloxygenase, and streptococcus pneumoniae, hemophilus influenza, staphylococcus aureus, pneumobacillus, alpha streptococcus, micrococcus catarrhalis, dysentery bacterium, Bacillus typhi, diphtheria corynebacterium etc. are all had to inhibitory action; Cacumen Platycladi decoct has inhibitory action to the 68-1 of capital section type virus; Its active ingredient of meletin and tannin in Cacumen Platycladi decoct, can obviously shorten bleeding time and clotting time; In addition effects such as, still having antitussive, eliminate the phlegm, relieving asthma, be calm.Contained alcohol Saponin phlegm-dispelling functions is stronger, and in leaf, contained flavone has obvious antitussive effect.

Radix Platycodonis root is containing multiple kikyosaponin, and hydrolysis produces the mixture that ruscogenin is triterpenic acid, is respectively platycodigenin, Polygalacic acid, platycogenic acid A, B, C, in addition, also contains inulin, platycodonin, glucose and plant sterol.The direct stimulation of platycodin to oral cavity, throat, gastric mucosa, makes sputum dilution thereby reflexive ground increases bronchial mucosa hypersecretion, is easy to discharge; Kikyosaponin has stronger antitussive effect.There are the antiinflammatory of enhancing and immunization, multiple coccus, bacillus and acrothesium floccosum are had to inhibitory action.Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves lysozyme activity; Stress ulcer is had to preventive effect.The thick saponin of Radix Platycodonis has calmness, analgesia, refrigeration function, again can blood sugar lowering, cholesterol reducing, relaxing smooth muscle, blood vessel dilating, blood pressure lowering, antiulcer action.

Radix Stemonae chemical composition: containing multiple alkaloid: as (-)-Stemoninine, Stemonidine, protostermonine, inferior (-)-Stemoninine, sessilistemonine, tuberostemonine, stemonamine etc., also sugary, lipid, protein, succinic acid etc.Radix Stemonae sweet in the mouth, has the effect of nourishing the lung to arrest cough, and effect of controlling chronic cough is very good, no matter diseases caused by exogenous pathogenic factor, internal injury, cruelly cough, chronic cough, all can use it.The contained alkaloid of the Radix Stemonae can reduce respiratory center irritability, suppresses coughre flex, and plays the effect of cough-relieving.Bronchospasm is had to relaxation effect, and intensity is similar to aminophylline.In vitro tests is to Bacillus tuberculosis, streptococcus pneumoniae, staphylococcus, streptococcus, diphtheria corynebacterium, dysentery bacterium, bacillus pyocyaneus, Bacillus typhi, bacillus pestis, anthrax bacillus, vibrio cholera all has inhibitory action, popularity cold virus, all dermatophytess also have inhibitory action.

Radix Glycyrrhizae has antiinflammatory, anti-allergic effects; can protect gastrointestinal mucosal and the tunica mucosa tracheae of inflammation; some poisonous substance there is the Detoxication of similar glucuronic acid simultaneously; in addition; the gastroxia that Radix Glycyrrhizae can also cause histamine has inhibitory action, and has the effect of antiacid gentle and gastrointestinal smooth muscle spasm.

The present invention proves through clinical practice, to the treatment of the diseases such as upper respiratory tract infection and acute and chronic tracheitis and bronchitis, pharyngolaryngitis, acute and chronic tonsillitis, there is heat-clearing and toxic substances removing, dispel the wind have one's ideas straightened out, relieving cough and resolving phlegm, eliminating phlegm and relieving asthma, eliminating stagnation blood stasis dispelling, reducing swelling and alleviating pain, the effects such as eliminating fire and detoxication, promotion oral cavity and the reparation of upper respiratory tract mucosa function and healing.There is in addition promoting blood circulation and hemostasis, enhancing human body immunity power and resistance, the symptom of improving, shorten the course of disease, promote the function that tissue injury repairs fast, can promote wound healing to oral cavity, bottleneck throat and upper respiratory tract wound after surgery, and prevent wound infection.And have that good, the easy making of performance, cost are low, the remarkable advantage such as have no side effect.

Detailed description of the invention:

Below in conjunction with embodiment, the invention will be further described.

Embodiment, one is treated upper respiratory tract infection and tracheitis compound preparation, it is characterized in that comprising each component of following weight proportion: Fructus Fici dry fruit 500 g, Cacumen Platycladi 150g, Echinacea 150g, Radix Platycodonis 100g, Radix Stemonae 60g, Radix Glycyrrhizae 40g, first take raw material by above-mentioned weight proportion, and carry out preorder processing, preorder processing comprises etc. that 500 g that add water concoct 3-4 hour, then extract and carry out water extraction liquid, then 500 g that add water decoct 1 hour, obtain the first decocting liquid 200g, 500 g that add water decoct 1 hour, obtain the second decocting liquid 200g, 500 g that add water decoct 1 hour, obtain the 3rd decocting liquid 200g, remerge decocting liquid and concentrate, after this after adding the ethanol of qdx 70-75% to staticly settle 24 hours to carry out, get supernatant, supernatant concentration is become to cream, qinghuo reagent again, sucrose, dextrin mixes one-tenth tablet or the granule of drying 0.5g processed in 1:3:1 ratio.

The present invention, with regard to clinical effectiveness and adverse effect, has carried out zoopery, and concrete condition is as follows:

To 20 of normal adult male rabbit, be divided at random two groups, A group is experimental group, B group is matched group.

A group is fed by 0.4g/kg/ every day, continuous application 30 days;

B group is fed by normal nursing program;

Observing respectively two groups of untoward reaction situations, there is not any side effect and untoward reaction in result, illustrates that this medicine is safe and effective.

Prove through clinical practice, the treatment of the present invention to diseases such as pathogenic bacterium and the acute and chronic upper respiratory tract infection that causes of virus and acute and chronic tracheitis and bronchitis, pharyngolaryngitis, acute and chronic tonsillitis, there is heat-clearing and toxic substances removing, dispel the wind have one's ideas straightened out, relieving cough and resolving phlegm, eliminating phlegm and relieving asthma, eliminating stagnation blood stasis dispelling, reducing swelling and alleviating pain, the effects such as eliminating fire and detoxication, promotion oral cavity and the reparation of upper respiratory tract mucosa function and healing.There is in addition promoting blood circulation and hemostasis, enhancing human body immunity power and resistance, the symptom of improving, shorten the course of disease, promote the function that tissue injury repairs fast, can promote wound healing to oral cavity, bottleneck throat and upper respiratory tract wound after surgery, and prevent wound infection.And have that good, the easy making of performance, cost are low, the remarkable advantage such as have no side effect.

The present invention, in the time of clinical use, adopts oral administering mode, and with tablet, pill and the each 2g of electuary form, treat every day for 2-3 time, and its concrete condition is as follows:

Select acute bronchitis 50 examples, chronic bronchitis 60 examples, acute and chronic pharyngitis 50 examples, acute tonsillitis 20 examples, chronic tonsillitis 30 examples, angina nosocomii 30 examples, total effective rate 98%, cure rate is more than 90%.

Claims

1. treat upper respiratory tract infection and tracheitis compound preparation for one kind, it is characterized in that being formed by each component of following weight proportion: Fructus Fici dry fruit 500 g, Cacumen Platycladi 150g, Echinacea 150g, Radix Platycodonis 100g, Radix Stemonae 60g, Radix Glycyrrhizae 40g, first take raw material by above-mentioned weight proportion, and carry out preorder processing, preorder processing comprises that 500 g that add water carry out brewed 3-4 hour, obtain extracting solution, then 500 g that add water decoct 1 hour, obtain the first decocting liquid 200g, 500 g that add water decoct 1 hour, obtain the second decocting liquid 200g, 500 g that add water decoct 1 hour, obtain the 3rd decocting liquid 200g, remerge decocting liquid, concentrate, after this after adding the ethanol of qdx 70-75% to staticly settle 24 hours, get supernatant, supernatant concentration is become to cream, qinghuo reagent again, sucrose, the dextrin by weight ratio of 1:3:1 mixes, dry, making every weight is one-tenth tablet or the granule of 0.5g.