CN102960560B - Composite acidifier for reducing post-weaning diarrhea rate - Google Patents
Composite acidifier for reducing post-weaning diarrhea rate Download PDFInfo
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- CN102960560B CN102960560B CN201210478863.0A CN201210478863A CN102960560B CN 102960560 B CN102960560 B CN 102960560B CN 201210478863 A CN201210478863 A CN 201210478863A CN 102960560 B CN102960560 B CN 102960560B
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Abstract
The invention relates to a composite acidifier for reducing post-weaning diarrhea rate, and the composite acidifier comprises citric acid, formic acid, lactic acid and butyric acid at the mass ratio of 1:1:(0.5-0.8):0.5; and the citric acid, the formic acid, the lactic acid and the butyric acid are carried by being absorbed by silica gel. The composite acidifier can be used for increasing the daily feed intake and the daily gain of piglets, reducing the material weight ratio, saving the feeding cost and reducing the diarrhea rate of the piglets.
Description
Technical field
The invention belongs to field of feed additive technology, relate to a kind of compound acidulant that reduces diarrhea of weaned piglets rate.
Background technology
In order farthest to bring into play the reproductive performance of sow, carrying out early weaning piglet (3-4 age in week) is a kind of mode generally adopting on producing.Yet early-weaned piglets is because digestive system development is still immature, neural and endocrine regulation mechanism is not also set up completely, thereby after weaned piglet, by sucking breast milk excessively in the process of the solid feed of searching for food, easily occur the speed of growth slowly, the ablactation stress syndrome such as diarrhea rate and death rate rising.Especially, in weanling pig enteron aisle, pH is higher, not only can affect the activity of small intestine digestive ferment, also can cause the propagation of pathogen, causes piglet to occur trophism or pathogenicity diarrhoea.
In breeding production, find, in animal (especially young animal) diet, add acidulant and can increase the activity of the acidity in animal alimentary canal, the enzyme that stimulates digestion, improve the eupepsy of animal to nutrient; Meanwhile, acidulant both can suppress or kill the microorganism that feed itself exists, and can suppress or kill the harmful microorganism in animal alimentary canal again, and promoted the growth of beneficial bacterium in alimentary canal.In addition, important intermediate product in some organic acid or energy conversion process, can participate in the metabolic process of body directly, and finally by the microorganism in animal or alimentary canal, be utilized completely.Thereby in animal diet, add acidulant can promote animal health, minimizing disease that animal growth rate and efficiency of feed utilization occur, improve.
In recent years; all there is much in weanling pig daily ration, adding the relevant report that acidulant solves this difficult problem of stress of baby pigs caused ablaction syndrome both at home and abroad; but in these reports, related acidulant product major part is not passed through conservation treatment; easily in piglet stomach, discharge fast H+; also may be cushioned by feed a part raw material; and can not arrive Small Intestine of Piglets and large intestine performance acidization, therefore can not make the enteron aisle adaptation after weaned piglet complete as early as possible.
By retrieval, find also do not have bibliographical information that acidulant is carried and reached the object that overcomes above-mentioned defect by silica gel absorption at present both at home and abroad.
Summary of the invention
In view of the deficiencies in the prior art, order of the present invention is, by conventional organic acid inorganic acid is studied, to provide a kind of compound acidulant that reduces diarrhea of weaned piglets rate.
The object of the present invention is achieved like this:
A kind of compound acidulant that reduces diarrhea of weaned piglets rate, contain citric acid, formic acid, lactic acid and butyric acid, the mass ratio of citric acid, formic acid, lactic acid and butyric acid is 1:1:0.5-0.8:0.5, and citric acid, formic acid, lactic acid and butyric acid carry by silica gel absorption.
Preferably, the compound acidulant of described reduction diarrhea of weaned piglets rate, the mass ratio of citric acid, formic acid, lactic acid and butyric acid is 1:1:0.7:0.5.
The compound acidulant of described reduction diarrhea of weaned piglets rate, wherein citric acid, formic acid, lactic acid and butyric acid adsorb carrying as follows by silica gel:
(1) 500-600 weight portion sodium metasilicate being diluted to silica concentration is 12-16%(W/V) sodium silicate aqueous solution;
(2) 30 ℃ and stir under, by described sodium silicate aqueous solution and the 25-30%(W/V of half amount) hydrochloric acid solution mixes, and obtains acidic silicasol;
(3) the described sodium silicate aqueous solution of second half amount is heated to 60-70 ℃, adds 25-30%(W/V) hydrochloric acid solution, under stirring, add step (2) gained acidic silicasol, add 20-25 weight portion ethyl acetate simultaneously, insulation ageing 0.5h, spraying is dry, obtains carrier silica gel;
(4) described carrier silica gel is mixed with citric acid, formic acid, lactic acid and butyric acid, stir, standing rear filtration, filter cake drying obtains compound acidulant.
Compared with prior art, the compound acidulant tool the present invention relates to has the following advantages and is significant progressive:
(1) overcome classical acid agent and discharge H in piglet stomach
+excessive velocities, can not effectively regulate the problem of intestine of young pigs acid-base balance, makes the acidization of compound acidulant extend to intestine of young pigs.
(2) overcome the interpolation level of classical acid agent in piglet diet improper, destroyed the electrolyte balance of daily ration, affected the problem of daily ration palatability, weaned piglets is effectively strengthened.
(3) improve daily ingestion amount and the daily gain of piglet, reduced material anharmonic ratio, saved feeding cost, reduced the diarrhea rate of piglet simultaneously.
The specific embodiment
Be below the concrete preparation example of compound acidulant of the present invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 compound acidulant
(1) 550g sodium metasilicate being diluted to silica concentration is 12%(W/V) sodium silicate aqueous solution;
(2) 30 ℃ and constantly stir under, sodium silicate aqueous solution and 30%(W/V prepared by half amount step (1)) hydrochloric acid solution mixes, and obtains acidic silicasol;
(3) sodium silicate aqueous solution of being prepared by second half amount step (1) is heated to 65 ℃, adds 30%(W/V) hydrochloric acid solution, under stirring, add step (2) gained acidic silicasol, add 20g ethyl acetate simultaneously, insulation ageing 0.5h, 450 ℃ of sprayings are dry, obtain carrier silica gel;
(4) step (3) gained carrier silica gel is mixed with 315g citric acid, 315g formic acid, 220g lactic acid and 158g butyric acid, stir, standing rear filtration, filter cake drying obtains compound acidulant.
The preparation of embodiment 2 compound acidulants
(1) 550g sodium metasilicate being diluted to silica concentration is 15%(W/V) sodium silicate aqueous solution;
(2) 30 ℃ and constantly stir under, sodium silicate aqueous solution and 25%(W/V prepared by half amount step (1)) hydrochloric acid solution mixes, and obtains acidic silicasol;
(3) sodium silicate aqueous solution of being prepared by second half amount step (1) is heated to 60 ℃, adds 25%(W/V) hydrochloric acid solution, under stirring, add step (2) gained acidic silicasol, add 25g ethyl acetate simultaneously, insulation ageing 0.5h, 450 ℃ of sprayings are dry, obtain carrier silica gel;
(4) step (3) gained carrier silica gel is mixed with 315g citric acid, 315g formic acid, 160g lactic acid and 160g butyric acid, stir, standing rear filtration, filter cake drying obtains compound acidulant.
The impact of embodiment 3 compound acidulants on Production Performance of Weaning Pigs and diarrhea rate
48 of Landrace (♂) * Large White (♀) two-way cross piglets of 28 ages in days wean, average weight 7 scholar 0.1kg are selected in test, press single factor experiment design principle, if 3 processed group (referring to table 1), each processes 4 repetitions, each repeats 4 pigs (male and female half and half), after raising in advance 3 days, carry out the test of 5 weeks by a definite date, wherein test and in piglet diet, do not add antibiotic.
Table 1 test grouping and Feed formulation
The formula of autogamy compound acidulant is 315g citric acid, 315g formic acid, 220g lactic acid and 158g butyric acid.
Corn-soybean-expanded soybean type basis diet is selected in test, and with reference to the nutritional need of NRC (1998) pig, after minute weaned piglet, 1-3 week and 4-5 two stages of week are carried out Feed formulation, feed formula is (by weight): corn 58%, dregs of beans 17%, expanded full-fat bean 17%, fish meal 4.5%, whey powder 4.5%, inferior powder 5.0%, calcium monohydrogen phosphate 1.5%, salt 0.25%, stone flour 1.1%, B B-complex-microelement pre-mix material 1.0%, lysine 0.15%.Wherein, in per kilogram feed, contain: vitamin A 1500IU, vitamin D 200IU, vitamin E 10IU, vitamin K 0.5mg, biotin 0.05mg, folic acid 0.3mg, pantothenic acid 10mg, nicotinic acid 10mg, Cobastab
23.6mg, Cobastab
11.0mg, Cobastab
61.5mg, Cu 6mg, Fe 100mg, Zn 110mg, Mn 3mg, Se 0.30mg, I 0.14mg.
Test is carried out at piglet nursing shed, and nursery house adopts slatted floor child care equipment, and house temperature control is at 25 ~ 28 ℃, and relative humidity is controlled at 50 ~ 70%.Piglet timing feeding, feeding time is respectively at 8:00,12:00,16:00 and the 20:00 of every day.Feed adopts powder to mix wet mode and feeds, and each feeding capacity is there to be a small amount of clout to be advisable in hopper.Piglet is at wean restricted scale of rationing in initial 3 days afterwards, free choice feeding after 3 days, and duration of test is freely drunk water.Clean nursery house every day once, every four days, nursery house is carried out to spraying disinfection once.Piglet immunological program and other feedings and managements are undertaken by pig farm routine.
When on-test and end, respectively each piglet is carried out to empty stomach and weigh.Record inventory and the surplus material amount (clout amount+waste) of every circle, actual feed intake=inventory-surplus material amount.According to average daily gain and average daily ingestion amount, calculate material anharmonic ratio.
Every morning, 7:30 was to the defecation situation of 21:30 Continuous Observation piglet in evening, the each ight soil of discharging of every pig is carried out to sense organ scoring, stools scored standard is: bar shaped or particle shape (0 minute), soft excrement, shaping (1 minute), thick shape, shaping, liquid dung are without segregation phenomenon (2 minutes), and aqueous, shapeless, liquid dung has segregation phenomenon (3 minutes).Will be divided into 2 minutes and 3 minutes persons are defined as suffering from diarrhoea.Statistics grice diarrhoea head number of times, and calculate diarrhea rate (diarrhea rate=[a diarrhoea number of times/(piglet number * test number of days)] * 100%).
Production Performance of Weaning Pigs is in Table 2.As can be seen from Table 2: in whole experimental period, test I group is compared with control group, can improve average daily gain 7.4%, reduces material anharmonic ratio 6.3% (P < 0.05); Test II group piglet is compared with control group, can improve average daily gain 22.2% (P < 0.05), reduces material anharmonic ratio 9.20% (P < 0.01); Test II group is compared with test I group, can improve average daily gain 13.8%, reduces material anharmonic ratio 5.7% (P < 0.05); But in whole experimental period, average daily ingestion amount difference all not significantly (P > 0.05) between each processed group piglet.
The impact of table 2 compound acidulant on Production Performance of Weaning Pigs
With control group comparison, * P < 0.05, * * P < 0.01;
With the comparison of test I group, #P < 0.05, ##P < 0.01.
Diarrhea of weaned piglets rate is in Table 3.As can be seen from Table 3: test is respectively organized grice diarrhoea rate all lower than control group.Test I group is compared with control group with test II group piglet, and diarrhea rate declines respectively 25%, 58%; Test II group is compared with test I group, and diarrhea rate declines 44%.
The impact of table 3 compound acidulant on diarrhea of weaned piglets rate
Claims (2)
1. a compound acidulant that reduces diarrhea of weaned piglets rate, by citric acid, formic acid, lactic acid, butyric acid and carrier silica gel, formed, it is characterized in that: the mass ratio of citric acid, formic acid, lactic acid and butyric acid is 1:1:0.5-0.8:0.5, and citric acid, formic acid, lactic acid and butyric acid carry by silica gel absorption, and method is as follows:
(1) 500-600 weight portion sodium metasilicate being diluted to silica concentration is 12-16%(W/V) sodium silicate aqueous solution;
(2) 30 ℃ and stir under, by described sodium silicate aqueous solution and the 25-30%(W/V of half amount) hydrochloric acid solution mixes, and obtains acidic silicasol;
(3) the described sodium silicate aqueous solution of second half amount is heated to 60-70 ℃, adds 25-30%(W/V) hydrochloric acid solution, under stirring, add step (2) gained acidic silicasol, add 20-25 weight portion ethyl acetate simultaneously, insulation ageing 0.5h, spraying is dry, obtains carrier silica gel;
(4) gained carrier silica gel is mixed with citric acid, formic acid, lactic acid and butyric acid, stir, standing rear filtration, filter cake drying obtains compound acidulant.
2. the compound acidulant of reduction diarrhea of weaned piglets rate according to claim 1, is characterized in that: the mass ratio of citric acid, formic acid, lactic acid and butyric acid is 1:1:0.7:0.5.
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| CN103271237A (en) * | 2013-05-09 | 2013-09-04 | 广州智特奇生物科技股份有限公司 | Phosphoric acid type feed acidifying agent and preparation method thereof |
| CN103349171A (en) * | 2013-06-20 | 2013-10-16 | 南京宝迪农业科技有限公司 | Health-care feed additive for pigs |
| CN104222527B (en) * | 2014-09-30 | 2016-12-07 | 湖南农业大学 | The application process of belulinic acid Betulinic acid |
| CN104758318B (en) * | 2015-03-06 | 2018-11-30 | 山东宝来利来生物工程股份有限公司 | A kind of compound formulation and preparation method thereof reducing diarrhea of weaned piglets rate |
| CN104982669A (en) * | 2015-07-22 | 2015-10-21 | 四川农业大学 | Organic compound acidifier added in domestic rabbit high-fiber feed and preparation method thereof |
| CN106561824A (en) * | 2015-10-08 | 2017-04-19 | 中创云牧(内蒙古)科技咨询有限公司 | Formula of acidified milk for calves and feeding method therefor |
| CN107259162A (en) * | 2017-08-07 | 2017-10-20 | 南京正宽医药科技有限公司 | A kind of feed lysine electuary and its preparation method and application |
| CN109601738A (en) * | 2019-01-14 | 2019-04-12 | 福建傲农生物科技集团股份有限公司 | A kind of drinking water type acidulant and its preparation method and application |
| CN113424898A (en) * | 2021-05-25 | 2021-09-24 | 无锡金杰中盛生物科技有限公司 | Liquid feed composite acidity regulator and preparation method thereof |
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Address after: 400711 North Hot Springs Street, Beibei District, Chongqing City, Chongqing photoelectric instrument City Industrial Park Patentee after: Chongqing gifted biotechnology Limited by Share Ltd Address before: 400711 North Hot Springs Street, Beibei District, Chongqing City, Chongqing photoelectric instrument City Industrial Park Patentee before: UNIBIO BIOLOGICAL TECHNOLOGY CO., LTD. |