CN102949687B - Oral medicine for treating tumors and production method thereof - Google Patents

Abstract

The invention provides an oral medicine for treating tumors and a production method thereof. The oral medicine is prepared from the following raw materials in parts by weight: 30-50 parts of long-noded pit viper, 30-50 parts of garter snake, 20-40 parts of scorpio, 20-30 parts of lizard, 30-40 parts of crab, 30-40 parts of glabrous greenbrier rhizome, 20-30 parts of peganum harmala, 30-50 parts of ginseng, 30-50 parts of dried ginger, 30-50 parts of rhizoma galangae, 30-50 parts of wrinkled gianthyssop herb, 30-50 parts of aloe extact, 30-40 parts of licorice extract and 30-50 parts of nutgall. Multiple medicine preparations are prepared according to the taking requirement. The preparation has efficacies of generating dryness and heat, maturing and clearing away abnormal phlegmatic temperament and abnormal savda, dissipating dry-cold, dispelling and drying dampness, dispelling toxicity and detoxicating, and softening and dissipating the tumors and is more ideal oral preparation for treating the tumors.

Description

A kind of oral medicine and production method thereof for the treatment of tumor

Technical field

The present invention relates to treat the production of tumor oral medicine, raw dry, heat-dissipating that this medicament has is ripe, remove abnormal phlegmatic temperament and abnormal black gallbladder matter, dissipate dry cold, damp eliminating dampness, toxic removing removing toxic substances, the effect of softening dissipation tumor, production method and scientific formulation are reasonable, have one's own knack.

Background technology

In all age, tumor belongs to one of difficult disease all the time, the paathogenic factor of tumor is extensive, sickness rate is higher, for many years because Chinese and western medicine does not have unified understanding to the pathological changes mechanism of tumor, still do not have so far desirable healing medicine to use, this is mainly because the pathological changes complicated mechanism of tumor; the clinical manifestation of pathological changes phase is not obvious; Most patients all in, just find late period, incured loss through delay best treatment period, because clinical response is intricate; feeling of patient is varied, also for prevention has increased many difficulty.

Tumor has become the first disease that threatens human health, has a strong impact on patient's life quality.Chinese crude drug, it is natural drug, antitumor action is more and more obtained to admitting of international community, clinical practice and the experimentation of the untoward reaction of natural drug antagonism chemotherapeutics have all obtained greater advance, for the life quality, the extending life aspect that improve the treatment success rate of tumor patient and improve tumour patient, have significant curative effect.In addition, inducing apoptosis of tumour cell and specific chemotherapy regimen is played to the Chinese herbal medicine of potentiation, to reaching the object that still can obtain expected effect in the situation that dosage reduces, thereby further alleviates the untoward reaction of chemotherapy.

The Uygur medicine pharmacy of the present invention's design is thought, the dry cold attribute food of life-time service, the raw attribute of dry cold environment human body of living strengthen, body generates too much abnormal black gallbladder plastid liquid, also has abnormal black gallbladder matter as the final pathological product of the body fluid " burning " such as black gallbladder matter, bile matter, blood matter, phlegmatic temperament, its component is heavier, quality is thicker, easily calm in blood vessel wall, produce the resistance of becoming silted up, stimulate Different Organs histiocyte to cause finally causing the refractory diseases such as tumor; Therefore adopt Uygur medicine pharmacy mechanism, treat tumor and must adopt raw dry heat-dissipating, the ripe and abnormal mucilaginous Therapeutic Principle of removing uses, and treating the poisonous disease with poisonous drugs is auxiliary Dialectical Method, dissipate dry cold, and damp eliminating dampness, toxic removing is detoxified, softening dissipation tumor; Splendid through clinical verification curative effect, there is important application prospect.

Summary of the invention

Order of the present invention is: the oral medicine of the treatment tumor providing, produce raw dry heat-dissipating, and ripe and remove abnormal phlegmatic temperament, there is the effect of softening dissipation tumor, production method is easy to operate, and preparation variation adapts to different patients' demand, receives patient's favor.

The object of the present invention is achieved like this: a kind of oral medicine and production method thereof for the treatment of tumor, and raw material is prepared with parts by weight, implements step by step;

Raw material components: Agkistrodon 30-50 part, Zaocys 30-50 part, Scorpio 20-40 part, Eremiatis argi 20-30 part, Eriocheir sinensis 30-40 part, Rhizoma Smilacis Glabrae 30-40 part, Semen pegani harmalae 20-30 part, Radix Ginseng 30-50 part, Rhizoma Zingiberis 30-50 part, Rhizoma Alpiniae Officinarum 30-50 part, Herba Pogostemonis 30-50 part, Aloe extractum 30-50 part, Radix Glycyrrhizae extractum 30-40 part, Galla Turcica (Galla Helepensis) 30-50 part; Preparation: said components is mixed and be ground into powder, 200 orders that sieve, obtain combination medicament powder standby;

Wherein get 75 parts, combination medicament powder, add 5 parts of starch, 8% part of starch slurry or 12.5 parts of dried starch, 0.4 part of magnesium stearate; Preparation: combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves granulations, put 70 ℃ be dried after in 12 mesh sieve granulate, add dried starch and magnesium stearate mixing, tabletting, obtains tablet;

Wherein get 75 parts, combination medicament powder, add 5 parts of starch, 10 parts of 10% part of starch slurries; Preparation: combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves granulations, put 70 ℃ be dried after in 12 mesh sieve granulate, granulation, packs gelatine capsule into and obtains capsule;

Wherein get 67 parts, combination medicament powder, add 12 parts of starch, 8 parts of 10% part of starch slurries, 10 parts of dried starch; Preparation: combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves granulations, put 70 ℃ be dried after in 12 mesh sieve granulate, pack, obtain granule;

Wherein get 80 parts, combination medicament powder, with 10 times of distilled waters, soak 2 hours, 80 ℃ are extracted 2 hours, filter, and collect filtrate, filtering residue adds 8 times of distilled waters, and 80 ℃ are extracted 1 hour, filter, and collect filtrate, merge filtrate twice, straight 1000 parts of adding distil water, canned, obtain oral liquid;

Wherein first get Saccharum Sinensis Roxb. or crystal sugar and refine into glutinous syrup with the ratio heating of 1:1, then while hot syrup and the combination medicament powder ratio with 1:3 that sticks is mixed, canned, obtain massecuite;

Wherein get combination medicament powder and mix with the ratio of 3:1 with Mel, be heated to 80 ℃, fully mix, canned, obtain sweet cream;

Wherein get combination medicament powder and mix with 1:0.3 ratio with Mel, use kneader to make ball piece, spiral billet cutter is made after ball bar, double drum type rolls ball machine, and to make dosage be 0.5g honey pill agent, natural drying, and packing, obtains honeyed pill;

Wherein get combination medicament powder and mix with 1:0.3 ratio with honey aqueous solution, use piller to become continuously ball machine and coating pan to become ball, by powder and the honey aqueous solution moistening of alternately spreading pesticides, make pill successively be increased to 0.5g pill, natural drying, packing, obtains water-honeyed pill.

The property of medicine pharmacology of the compound recipe dimension medicine composition that the present invention selects is illustrated as follows:

Agkistrodon: tool fall apart gas softening the hard mass, antiinflammatory detumescent, clean blood toxic removing, the strong flesh effect of damp eliminating, cure mainly raw property or phlegmatic temperament disease, as lymphoid tuberculosis, refractory skin, malignant boil, eczema, leprosy and rheumatic arthritis, numb hand and foot, vitiligo.

Scorpio: tool damp eliminating fall apart wind, strong muscle strong flesh, softening the hard mass fossil, diuresis and expelling stone, open ear key, separate scorpion venom effect, cure mainly moist or febrile illness, as soft in moist paralysis, facial paralysis, joint aches, brothers' flaccidity, renal calculus, vesical calculus, vitiligo, leukoderma, the heavy deafness of ear, sexual impotence, hot scorpion sting poisoning.

Eriocheir sinensis: the loose gas softening the hard mass of the dry body of tool, antiinflammatory detumescent, clean blood toxic removing, flesh is good in damp eliminating, antiinflammatory sore, detoxification detoxicating functions, cure mainly xeothermic property or bile matter disease, as thin in weak body, hot sexual impotence, breast tumor, xeothermic property cough, expendable typhoid fever, calculus, not smooth through water, various skin infection, oral inflammation, poisonous insect and poisonous snake sting wound, the mad dog < < note doctor allusion quotation > > such as bite.

Semen pegani harmalae: tool is given birth to and do heat-dissipating, wind-expelling pain-stopping, fertile body tonifying YANG, strong muscle benefit god, antitussive and antiasthmatic, tatoos sensible, cure mainly raw property or phlegmatic temperament disease, as arthralgia, sciatica, the thin sexual impotence of body, paralysis, facial paralysis, cough and asthma, spiritual gloomy, forgetful; Water is decocted in external can curing arthritis, trichomoniasis, fumigation can deinsectization < < visit according to medicine book > >.

Radix Ginseng: tool benefit is subject to mentality, vitality and natural agent, produce optimum body fluid, nerve, nourishing lungs, appetite strengthening, hypersexuality, strengthening superficial resistance to stop perspiration are refreshed oneself, are nourished in benefit brain and enhancing intelligence, reinforcing the heart, mend intestinal antidiarrheal efficacy, cure mainly physical weakness, the < < Uygur medicine medicinal herbs most in use such as brain void is forgetful, the god that has a guilty conscience is weary, neural weak, the deficiency of the lung is breathed hard, anorexia, stool loose stool learn > >.

Rhizoma Zingiberis: tool stomach warming helps digestion, warming middle-JIAO to stop diarrhea, dispersing wind-cold, warm-up tonifying YANG, cold relieving leukorrhagia stopping effect, cure mainly raw property or phlegmatic temperament disease, as raw insufficiency of stomach, anorexia, defecate thin, anemofrigid cold, the cold sexual impotence of waist, the < < note doctor allusion quotation > > such as leucorrhoea grow in quantity.

Rhizoma Alpiniae Officinarum: rhizome cures mainly raw gonosome liquid or phlegmatic temperament various diseases, as gastral cavilty is weak, abdomen gastral cavity is ached, the cold pain of waist lower limb, the < < such as intestinal blocks, oligospermia sexual impotence note doctor allusion quotation > >.

Herba Pogostemonis: the raw dry heat-dissipating of tool, warming middle-JIAO are mended stomach, dampness appetizing, sending down the abnormal ascending QI emesis, antidiarrheal dysentery relieving, dispersing cold for relieving pain, cough-relieving hemostasis, the happy will of the refreshing heart, the hemorrhoid that disappear detumescent, cure mainly raw property or phlegmatic temperament gastroenteropathy, as cold insufficiency of stomach, inappetence, nausea and vomiting, diarrhoea dysentery, sputum mixed with blood, headache, otalgia, toothache, pain of the heart area and hemorrhoid, orchitis is swollen wait < < visit according to medicine book > >.

Aloe extractum: dry manufactured goods cure mainly the raw property of intestinal or phlegmatic temperament disease, as constipation, various dermatosiss, eczema skin ulcer wound, arthralgia, nyctalopia poor or weak eyesight, menoxenia; dysuria, intestinal is infested wait < < visit according to medicine book > >

Radix Glycyrrhizae extractum: the raw dry heat-dissipating of tool, the ripe body fluid that causes a disease, relieving cough and resolving phlegm, make wet Dingchuan, calming the nerves blazes, nourishes internal organs, cure mainly raw property or phlegmatic temperament disease respiratory illness, as polarity cough, asthma, flu, the secret > > of the < < medicines such as pulmonary tuberculosis

Galla Turcica (Galla Helepensis): insect gall cures mainly humid or blood matter disease, as hot gingival swelling and pain, odontoseisis, laryngopharynx swelling and pain, skin infection rot, wound is not healed, moist leukorrhagia, metrorrhagia, dysentery are more than etc.

Technical characterstic of the present invention: the one, by the abnormal phlegmatic temperament of maturation or abnormal black gallbladder plastid liquid, enhancing body natural agent, strengthen dominating organs function and regulate animal economy function, remove wild power, the damp eliminating wind that falls apart, opens retardance, and knot softening the hard mass disappears, putrefaction removing and tissue regeneration promoting makes the tumor patient state of an illness controlled, some patient's focus and transference cure; The 2nd, according to the dialectical opinion of Uygur's medical science, control prescription on the basis of etiology and pathogenesis of principle and tumor and cancer, to hepatocarcinoma, the esophageal carcinoma, gastric cancer, breast carcinoma and intestinal cancer have except cancer this, the effect of the cancer that disappears; The 3rd, medicament fine powder can mix separately or with adjuvant demand percentage, makes the oral patent medicine of the required powder of patient or tablet or capsule particle or pill etc., shows technological progress.

The specific embodiment

The present invention is described further in connection with embodiment.

Embodiment

Medicine crude drug is prepared with parts by weight:

1) get 30 parts of Agkistrodons; 30 parts of Zaocys; 20 parts of Scorpios: 20 parts of Eremiatis argis: 30 parts of Eriocheir sinensiss: 30 parts of Rhizoma Smilacis Glabraes: 20 parts of Semen pegani harmalaes, 30 parts of Radix Ginsengs: 30 parts of Rhizoma Zingiberiss: 30 parts of Rhizoma Alpiniae Officinarums: 30 parts of Herba Pogostemoniss: 30 parts of Aloe extractumes: 30 parts of Radix Glycyrrhizae extractum: 30 parts of compositions of Galla Turcica (Galla Helepensis);

2) get 45 parts of Agkistrodons; 45 parts of Zaocys; 30 parts of Scorpios: 25 parts of Eremiatis argis: 35 parts of Eriocheir sinensiss: 35 parts of Rhizoma Smilacis Glabraes: 25 parts of Semen pegani harmalaes, 40 parts of Radix Ginsengs: 40 parts of Rhizoma Zingiberiss: 40 parts of Rhizoma Alpiniae Officinarums: 40 parts of Herba Pogostemoniss: 40 parts of Aloe extractumes: 35 parts of Radix Glycyrrhizae extractum: 40 parts of compositions of Galla Turcica (Galla Helepensis);

3) get 50 parts of Agkistrodons; 50 parts of Zaocys; 40 parts of Scorpios: 30 parts of Eremiatis argis: 40 parts of Eriocheir sinensiss: 40 parts of Rhizoma Smilacis Glabraes: 30 parts of Semen pegani harmalaes, 50 parts of Radix Ginsengs: 50 parts of Rhizoma Zingiberiss: 50 parts of Rhizoma Alpiniae Officinarums: 50 parts of Herba Pogostemoniss: 50 parts of Aloe extractumes: 40 parts of Radix Glycyrrhizae extractum: 50 parts of compositions of Galla Turcica (Galla Helepensis);

Preparation: by upper step 1) or 2) or 3) medicine raw material mixes and is ground into fine powder, by the sieve of aperture 74um (200 order), mix to such an extent that combination medicament powder is standby;

Example 1 is got 75 parts, combination medicament powder, adds 5 parts of starch, 12.5 parts of 8% part of starch slurries, 0.4 part of magnesium stearate; Combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves, granulate, put 70 ℃ dry after in 12 mesh sieve granulate, after adding dried starch and magnesium stearate to mix, tabletting, obtains tablet.

Example 2 is got 75 parts, combination medicament powder, adds 5 parts of starch, 10 parts of 10% part of starch slurries; Combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves, granulate, put 70 ℃ dry after in 12 mesh sieve granulate, granulation, mixes, and packs gelatine capsule into and obtains capsule.

Example 3 is got 67 parts, combination medicament powder, adds 12 parts of starch, 8 parts of 10% part of starch slurries, 10 parts of dried starch, mix combination medicament powder with starch, add starch slurry and make soft material, with 14 mesh sieves, granulate, put 70 ℃ dry after in 12 mesh sieve granulate, packing, obtains granule.

Example 4 is got 80 parts, combination medicament powder, with 10 times of distilled waters, soaks 2 hours, and 80 ℃ are extracted 2 hours, filter, and collect filtrate, and filtering residue adds 8 times of distilled waters, and 80 ℃ are extracted 1 hour, filter, and collect filtrate.Merge filtrate twice, adding distil water straight 1000 parts (ml), canned, obtain oral liquid.

Example 5 first gets Saccharum Sinensis Roxb. or crystal sugar is refined into glutinous syrup with the ratio heating of 1:1, then while hot syrup and the combination medicament powder ratio with 1:3 that sticks is mixed, canned, obtains massecuite;

Example 6 is mixed with Mel combination medicament powder with the ratio of 3:1, be heated to 80 ℃, fully mixes, canned, obtains sweet cream;

Example 7 is mixed with Mel combination medicament powder with 1:0.3 ratio, use kneader to make ball piece, spiral billet cutter is made after ball bar, and double drum type rolls ball machine, and to make dosage be 0.5g honey pill agent, natural drying, and packing, obtains honeyed pill;

Example 8 is mixed with honey aqueous solution combination medicament powder with 1:0.3 ratio, wherein honey aqueous solution is made with 1:4-5 by Mel and water; Use piller to become continuously ball machine and coating pan to become ball, by powder and the honey aqueous solution moistening of alternately spreading pesticides, make pill successively be increased to 0.5g pill, natural drying, packing, obtains water-honeyed pill.

Drug of choice raw material of the present invention is provided by Xinjiang Jia Paeraji uighur medicine company limited.

The starch that the present invention selects is produced by Zhengzhou sunlight food ingredient company limited; Magnesium stearate is produced by Tianjin Hua Fu Chemical Co., Ltd.; Pulverizer is produced by Jiangyin City Ke Li Machinery Co., Ltd.; Distilled water adopts the equipment of ZLSC-20 Shanghai He Jie Science and Technology Ltd. to make.

Clinical case statistical testing of business cycles result:

(1) the present invention take treatment patients with uterine myoma be example

From in January, 2009, gather this compound preparation treatment hysteromyoma 69 examples, after medication, hysteromyoma obtains control in various degree, and tumor body dwindles, menoxenia, waist abdomen pain and intimitis and with the symptoms such as ovarian cyst be improved significantly; Be reported as follows:

1, clinical data

1.1 case selection

It is 30-49 year that patient age is accepted in outpatient service for medical treatment, and the course of disease is more than 1 year, the abnormal phlegmatic temperament patient of dialectical genus 30 example of dimension doctor, the 39 abnormal black gallbladder matter patients of example.

1.2 diagnostic criteria

Using the medical science obstetrics and gynecology > > of < < Uygur as clinical diagnosis foundation, and have B ultrasonic to confirm.

2, treatment and observational technique

Take preparation of the present invention, every day three times, take January continuously, through doing ultrasound diagnosis (doing in the clean 4-7 of menstruation day), observe muscular tumor and change situation.

3, criterion of therapeutical effect

In the < < traditional Chinese medical science Clinical Researches of New Drugs guideline > > formulating according to Ministry of Public Health, there is uterine fibroid disease efficacy assessment standard: i.e. recovery from illness is reduced to normally for menstrual blood volume, hysteromyoma disappears, and uterus obviously dwindles; Be to be effectively that menstrual blood volume reduces, hysteromyoma dwindles, and uterus dwindles; Be invalidly for menstrual blood volume, not subtract, hysteromyoma size is without changing, and uterus size is unchanged.

4, therapeutic outcome

Treat altogether in 69 examples clinical recovery 52 examples, effective 11 examples, invalid 6 examples.

(2) the present invention take treatment patient with esophageal carcinoma be example

Since in January, 2009, with this compound preparation, treat sub-patient with esophageal carcinoma 16 examples, after medication, disease obtains control in various degree, and tumor body dwindles, and can take food, the quality of obviously making the life better; Be reported as follows:

1, clinical data

1.1 case selection

It is 45-62 year that patient age is accepted in outpatient service for medical treatment, and the course of disease is more than 1 year, the abnormal phlegmatic temperament patient of dialectical genus 3 example of dimension doctor, 13 abnormal black gallbladder matter patients.

1.2 diagnostic criterias:

All there is dysphagia in esophageal carcinoma, dysphagia, and the type body symptom such as become thin, is all made a definite diagnosis the accuracy of pathology by gastroscopy and x-ray film making.

1.3 treatment and observational techniques:

Adopt preparation of the present invention, each 5-10 gram, every day three times, takes January continuously, observes tumor and changes situation and systemic conditions.

1.4 criterions of therapeutical effect: the solid tumor criterion of therapeutical effect evaluation of formulating according to World Health Organization (WHO).

1.5 therapeutic outcomes: alleviate 6 examples completely, partial rcsponse 10 examples;

Wherein model case is put to the proof:

Example 1: patient Cheng Nanshi, 64 years old, peasant, dysphagia 3 months, through gulping down barium x-ray and pathologic finding, is diagnosed as advanced esophageal cancer; Because patient refuses operation and chemotherapy, use this medicine treatment; Ball takes latter 15 minutes first, esophagus open can influent stream food, after ball takes latter three days, patient feels that esophagus is light, serve on 20 days patients and feels that esophagus is swallowed and approach normally, spiritual antisecosis is good, to serve on 30 days basic afterwards recovers normal; This patient's life-saving 3 years, rear dead because suffering from cerebral infarction.

Example 2: patient Wang Nvshi, 52 years old, peasant, dysphagia 3 months, obstructed 4 days of esophagus, is unable to leave the bed January, and build skeletonize, through gulping down barium x-ray and pathologic finding, is diagnosed as advanced esophageal cancer; Use this pill, treat two months, emotion regulation simultaneously, this patient now more than 70 years old, is still living and in good health so far.

Example 3: patient Yan Nvshi, 49 years old, people from Yantai City, after breast cancer operation three and half, find again lumbago, skelalgia is medical in the time of two months, after diagnosing: breast cancer relapse, multiple bone shifts, adhere to this oral agents, and coordinate endocrine therapy, and clinical symptom disappearance after two months, osteopathia is obviously improved, tumor markers numerical value declines, and follows up a case by regular visits to and within 1 year, has no recurrence.

Example 4: patient Li Nanshi, 84 years old, people from Yantai City, main suit's stomachache, poor appetite, weak medical, make a definite diagnosis on inspection gastric cancer late period, hepatic metastasis, ascites, three cycle chemotherapy, physical ability weakens, and adheres to afterwards oral this medicament always, takes medicine 1 year, hepatic neoplasms reduces, ascites disappears, and muscle power is obviously got better and turned, and lives as usual.

Example 5: patient opens man, 56 years old, people from Yantai City, made a definite diagnosis in postoperative 2 years lungs of pulmonary carcinoma and shifts, and patient shows weak, tussiculas and coughs, and adheres to oral this medicament, and focus is stablized seven months, and quality of life obviously improves.

Example 6: patient Wang Nvshi, 57 years old, the first cleaner of Affiliated Hospital of Zhengzhou University, found a plurality of lumps of bimastism and has twinge for 2010, oral capsule lump deliquescing after month, pain disappear, and treat three months, through health check-up, determine that two breast are completely normal.

Example 7: patient's CHENNU scholar, 48 years old, Medical School of Zhengzhou University laboratorian, its mother suffers from breast cancer, and after operation, to be diffused as uterus carcinoma dead, and she finds a plurality of lumps of mammary gland bilateral and has hysteromyoma in health check-up in 2009, the suggestion of refusal doctor operative treatment, require conservative medication treatment, through taking the mammary gland tumor disappearance after two months of this capsule, within 3 years, have a surplus so far, through repeatedly checking and be normally.

Example 8: Mrs Gao, 38 years old, Jiang Qu people from village, Weizhi County, because of cyclomastopathy, mastalgia, takes this capsule three months, and lump in breast disappears.

Example 9: Ms Zhang, 40 years old, people from Yingyang City, the surgical removal one side breast that suffers from breast cancer for 2009, within 2012, opposite side breast is found lump, takes the lump disappearance after two months of this capsule, requires continual cure two months, is still taking this medicament at present.

The oral formulations that the inventive method is made, consumption is every day 3 times, according to doctor's advice, select it a kind of, or each 6 of tablet, or each 6 of capsule, or the each 12g of granule, or the each 10g of Mel cream, or the each 10g of massecuite, or each 8 of water-honeyed pill, or each 8 of honeyed pill, or the each 30ml of oral liquid.

Claims (2)

1. a kind of oral medicine for the treatment of tumor, it is characterized in that: raw material is prepared with parts by weight, implement step by step;

Raw material components: Agkistrodon 30-50 part, Zaocys 30-50 part, Scorpio 20-40 part, Eremiatis argi 20-30 part, Eriocheir sinensis 30-40 part, Rhizoma Smilacis Glabrae 30-40 part, Semen pegani harmalae 20-30 part, Radix Ginseng 30-50 part, Rhizoma Zingiberis 30-50 part, Rhizoma Alpiniae Officinarum 30-50 part, Herba Pogostemonis 30-50 part, Aloe extractum 30-50 part, Radix Glycyrrhizae extractum 30-40 part, Galla Turcica (Galla Helepensis) 30-50 part; Preparation: said components is mixed and be ground into powder, 200 orders that sieve, obtain combination medicament powder standby;

Wherein get 75 parts, combination medicament powder, add 5 parts of starch, 8% 12.5 parts of starch slurries and 12.5 parts of dried starch,0.4 part of magnesium stearate; Preparation: combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves granulations, put 70 ℃ be dried after in 12 mesh sieve granulate, add dried starch and magnesium stearate mixing, tabletting, obtains tablet;

Wherein get 75 parts, combination medicament powder, add 5 parts of starch, 10% starch slurry10 parts; Preparation: combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves granulations, put 70 ℃ be dried after in 12 mesh sieve granulate, granulation, packs gelatine capsule into and obtains capsule;

Wherein get 67 parts, combination medicament powder, add 12 parts of starch, 10% starch slurry10 parts of 8 parts, dried starch; Preparation: combination medicament powder is mixed with starch, adds starch slurry and make soft material, with 14 mesh sieves granulations, put 70 ℃ be dried after in 12 mesh sieve granulate, pack, obtain granule;

Wherein get 80 parts, combination medicament powder, with 10 times of distilled waters, soak 2 hours, 80 ℃ are extracted 2 hours, filter, and collect filtrate, and filtering residue adds 8 times of distilled waters, and 80 ℃ are extracted 1 hour, filter, and collect filtrate, merge twice filtrate, add distilled water extremely1000 parts, canned, obtain oral liquid;

Wherein first get Saccharum Sinensis Roxb. or crystal sugar and refine into glutinous syrup with the ratio heating of 1:1, then while hot syrup and the combination medicament powder ratio with 1:3 that sticks is mixed, canned, obtain massecuite;

Wherein get combination medicament powder and mix with the ratio of 3:1 with Mel, be heated to 80 ℃, fully mix, canned, obtain sweet cream;

Wherein get combination medicament powder and mix with 1:0.3 ratio with Mel, use kneader to make ball piece, spiral billet cutter is made after ball bar, double drum type rolls ball machine, and to make dosage be 0.5g honey pill agent, natural drying, and packing, obtains honeyed pill;

Wherein get combination medicament powder and mix with 1:0.3 ratio with honey aqueous solution, use piller to become continuously ball machine and coating pan to become ball, by powder and the honey aqueous solution moistening of alternately spreading pesticides, make pill successively be increased to 0.5g pill, natural drying, packing, obtains water-honeyed pill.

2. according to claim 1 oral medicine, it is characterized in that: the oral formulations that the method is made, consumption is every day 3 times, according to demand, selects it a kind of, or each 6 of tablet, or each 6 of capsule, or the each 12g of granule, or honey creameach 10g, or the each 10g of massecuite, or each 8 of water-honeyed pill, or each 8 of honeyed pill, or the each 30ml of oral liquid.