CN102949472A - Dynamic circulating processing method of prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece - Google Patents
Dynamic circulating processing method of prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece Download PDFInfo
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- CN102949472A CN102949472A CN2012104116012A CN201210411601A CN102949472A CN 102949472 A CN102949472 A CN 102949472A CN 2012104116012 A CN2012104116012 A CN 2012104116012A CN 201210411601 A CN201210411601 A CN 201210411601A CN 102949472 A CN102949472 A CN 102949472A
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Abstract
The invention discloses a dynamic circulating processing method of a prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece, which comprises the following steps of: 1, purifying, namely, cleaning radix aconiti and radix aconiti kusnezoffii raw materials by using clear water, and removing impurities; 2, preparing an auxiliary material solution, namely, weighing liquorice root and black beans according to the required quantity of each batch of processed product, placing in a basket and adding water which accounts for 10 times of the total quantity of the auxiliary materials in a dynamic circulating soaking and cooking tank, heating, boiling and maintaining the boiling state; 3, soaking the processed product, namely, placing the radix aconiti and radix aconiti kusnezoffii raw materials in the soaking and cooking tank for dynamically circulating and soaking for 3-4 hours; and 4, cooking and processing the prepared radix aconiti and the prepared radix aconiti kusnezoffii, namely, soaking the radix aconiti and the radix aconiti kusnezoffii for detoxicating, pouring the prepared auxiliary material solution in the cooking tank in which a soaked product is placed, then slowly heating until boiling, and maintaining micro-boiling and keeping the pressure to be between 20kPa and 50kPa for 2 hours. The dynamic circulating processing method has the advantages that production period is shortened, production efficiency is increased, the loss of effective components of the radix aconiti and the radix aconiti kusnezoffii is reduced, and the quality and the treatment effect of the prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece are improved.
Description
Technical field
The invention belongs to the raw material of Chinese medicine processing technology field.
Background technology
Radix Aconiti is the parent root of ranunculaceae plant Ka Shi Aconitum carmichjaelii Debx..Late June to early August excavates, and removes daughter root, fibrous root and silt, dries.
[gathering and processing] generally excavates in the cultivation Second Year mid-June, removes stem and leaf on the ground, draws silt, and parent root and daughter root are separated, and is called after parent root dries " Radix Aconiti ".
[properties and characteristics] root is the irregular roundness taper, and slightly crooked, often there is residual stem on the top, and the multidirectional side in middle part is expanded, long 2～7.5cm, diameter 1.2～2.5cm.Surface sepia or taupe brown have the vestige after tubercle shape lateral root and daughter root break away from.Matter is solid, section off-white color or ecru, and the cambium layer ring grain is polygon.Feeble QI, acrid in the mouth, numb tongue.
[chemical constituent] is total
AlkaloidContent 2.3%, ester 1.0%, aconitine 0.3%.Mainly contain aconitine (aconitine), mesaconitine (mesaconitine), tower skill aconine (talatisamine), outstanding this aconine (jasaconitine), benzoyl aconine (benzoylaconine), benzoyl mesaconitine
(benzoylmesaconine) aconine (benzoylhypaconine) etc. and under the benzoyl.In the molecular structure of this constituents, because of the acetylation of 8 hydroxyls and 14 hydroxyl aroylation, thereby presenting strong toxicity, is the main toxic component in the Aconitum carmichjaelii Debx..
[meridian distribution of property and flavor] is hot, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.
[function cures mainly] expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.Be used for the treatment of the diseases such as anemofrigid-damp arthralgia, arthralgia.For oral administration after general the process of preparing Chinese medicine.Radix Aconiti tincture external energy chafe produces feeling of numbness then, so be used as the analgesics of some neuralgia and rheumatism outward.
Radix Aconiti Kusnezoffii, another name: Caput Anas domestica, medicine sheep Artemisia, Caput Gallus domesticus grass, Kusnezoff Monkshood Root.
Phytomorph: perennial herb.Stem is upright, and high 50～150cm is without hair.The stem middle leaf has slightly long handle or short handle; Blade papery or nearly keratin, pentagon, 3 totally cleave, the wide rhombus of middle sliver, point gradually, nearly pinniform drastic crack, the lobelet lanceolar, the above dredges by short bent hair, below without hair.Raceme is long narrow; Long 2～the 5cm of bennet; Squamella is linear; Honor sheet 5, hyacinthine. upper sepal helmet shape; Petal 2 has long pawl, apart from curling; Stamen is most; Carpel 3-5.Follicle.Florescence～JIUYUE, really October phase.Be born in patana or the sparse woods.Main product Shanxi, Hebei, the Inner Mongol and northeast.
Gather and process: excavate autumn, removes residual stem, fibrous root and mud scholar, cleaning, drying.
Character: root is irregular conico-acuminate, and is slightly crooked, long 2～7cm, and diameter 0.6～1.8cm, often there are residual stem and minority adventitious root residue in the top.The surface ash exhausts color or dark brown, and shrinkage has vertical wrinkle, point-like mark of fibrous root and several tumors shape lateral root of dashing forward.Matter is hard, section canescence or lead, the large or hollow of cambium layer ring grain polygon or similar round, marrow.Hide pungent, numb tongue.
Chemical constituent contains aconitine (aconitine), middle Aconitum carmichjaelii Debx. (mesaconitine), atisine alkali (atisine) etc.
Nature and flavor are hot in nature, acrid in the mouth, hardship.
Function cures mainly expelling wind and removing dampness, antalgic.Be used for that anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type are had a pain, pain relieving.
The concocting method of existing traditional Radix Aconiti and Radix Aconiti Kusnezoffii: get crude drug flushing with clean water cleaning, place the pond to soak and change water more than 3 times every day, 3 days repeatedly, open Radix Aconiti, Radix Aconiti Kusnezoffii sees the white heart of thing, mouth is tasted slight numb feeling in the tongue, and then bleed off immersion water, i.e. steaming and decocting 2 hours in Radix Glycyrrhizae, Semen sojae atricolor water, and then section is dried.Traditional process of preparing Chinese medicine mode wastes time and energy, be easy to cause Radix Aconiti, Radix Aconiti Kusnezoffii at the immersion process mesometamorphism, go mouldy.Traditional concocting method wastes time and energy, and labor efficiency is low, is unsuitable for large-scale production.
Summary of the invention
The timely problem that the present invention will solve is to provide the concocting method of a kind of Radix Aconiti, the Radix Aconiti Kusnezoffii prepared slices of Chinese crude drugs, to boost productivity; Guarantee product quality and curative effect; Reduce the wastage.This method is applicable to large-scale production, saves production cost, and greatly enhances productivity.
The dynamic circulation concocting method of Radix Aconiti Preparata and the Radix Aconiti Kusnezoffii prepared slices of Chinese crude drugs is characterized in that implementing in accordance with the following steps:
(1) clean system: get Radix Aconiti, Radix Aconiti Kusnezoffii crude drug 100 weight portions, flushing with clean water is removed impurity;
(2) preparation of auxiliary material liquid: the adjuvant of Radix Aconiti, Radix Aconiti Kusnezoffii is concocted in configuration, and 5 parts of extracting liquorices, 10 parts of requirements by every batch of processed product of Semen sojae atricolor are carried out weighing, put into cage, adds 10 times to the water of adjuvant total amount in dynamic circulation soaking cooking tank; Cage is slowly put into the soaking cooking tank heat, make the pressure in the tank be no more than 180kPa to boiling, keep later on little boiling, at this moment the tank internal pressure remains between 20～50kPa, after the steaming and decocting of 1h, the material of adjuvant is fully leached; Take a sample to check, mouth is tasted adjuvant when almost tasteless, i.e. stopped heating, and adjuvant is concocted liquid squeeze in the measuring tank for subsequent use; Mention cage and bleed off the adjuvant residue;
(3) immersion of processed product: Radix Aconiti, Radix Aconiti Kusnezoffii Chinese crude drug are carried out 100 parts of weighings, put into cage.Make cage put into the soaking cooking tank and carry out dynamic circulation immersion, soak time 3～4h; When temperature in the tank reaches 50 ℃, stop immediately circulation immersion and soak is bled off; Then add the same water yield, proceed dynamic circulation and soak, operation is the same, so repeatedly, until after soaking detoxification and reaching requirement, namely is dipped in Radix Aconiti, the Radix Aconiti Kusnezoffii without the dried heart, and little when mouthful tasting have a numb feeling in the tongue degree of being, bleeds off last soak;
(4) steaming and decocting of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii is concocted: Radix Aconiti, Radix Aconiti Kusnezoffii are soaked after the detoxification, the auxiliary material liquid of preparation is poured into by measuring tank placed in the cooker that soaks product, and then slowly heating was boiled 2 hours to the rear maintenance of boiling is little, and pressure remains between 20～50kPa; After processed product reaches quality standards, i.e. stopped heating, and bleed off adjuvant and concoct liquid; Mention cage, emit processed product, then take a sample and carry out assay at high performance liquid chromatograph, reach the state-promulgated pharmacopoeia standard, the rear cold to 6 of cooling completely becomes that dried to process cutting in blocks.Drying and packaging gets product.
Principle of the present invention is: the contained alkaloid of Radix Aconiti, Radix Aconiti Kusnezoffii is by the water soaking detoxification, traditional static poison-removing method inefficiency, and 200 kilograms of Radix Aconiti Preparatas of general every production need more than 72 hours.Adopting the dynamic circulation processing technique is by little heating in hermetic container, make the saturating Radix Aconiti of water rapid soaking, brew more uniform at short notice (month 12-18h) rapid detoxification of Radix Aconiti that makes by recirculated water again, can also in passes during brewing, rinse out the harmful substances such as esters that Radix Aconiti itself also has and farming be residual, can also prevent that Radix Aconiti, Radix Aconiti Kusnezoffii from going bad, adopt the dynamic circulation processing technique to produce 200 kilograms of Radix Aconitis and only need about 20 hours, greatly enhance productivity.In the dynamic circulation processing technique, at first Radix Aconiti, Radix Aconiti Kusnezoffii greatly reduce soak time in the blister process, only need 12-18 hour, save 65% than traditional 48-60 hour.Increase work efficiency.Next is to be conducive to rinse out in Radix Aconiti, the Radix Aconiti Kusnezoffii harmful substances such as lipid and farming be residual in the dynamic passes during brewing.The Effective Raise work efficiency reduces labor intensity like this, effectively controls the toxicity effective ingredient in Radix Aconiti, the Radix Aconiti Kusnezoffii.
The invention has the advantages that:
1, can shorten 48 hours production cycles, enhance productivity 3 times, greatly enhance productivity.
2, the effective ingredient that reduces course of processing Radix Aconiti, Radix Aconiti Kusnezoffii runs off, and pollutes, and protein variations has improved quality and the curative effect of decoction pieces.The finished product rate brings up to 87% by original less than 50%.
3, production process is easy to control, has realized automatization, scale and the standardization of concocting.New technique adopts mechanized operation, as: circulating pump, cooker, airtight steeping tank.
4, be conducive to environmental conservation, made things convenient for administration of health.The traditional handicraft open type is produced, and pollutes production environment, is difficult to cleaning.
5, guarantee the quality safety of product
Description of drawings
Figure is process chart of the present invention.
The specific embodiment
Raw material and finished product detection: assay is carried out in the physics and chemistry test according to Radix Aconiti, Radix Aconiti Kusnezoffii.Guarantee Product quality and safety.Concocting process is as follows: 1, clean system: get Radix Aconiti, Radix Aconiti Kusnezoffii crude drug, flushing with clean water is removed impurity.2, the preparation of auxiliary material liquid, the adjuvant of Radix Aconiti, Radix Aconiti Kusnezoffii is concocted in configuration, extracting liquorice 5KG, Semen sojae atricolor 10kg (100kg Rhizoma Pinelliae ratio) carry out weighing by the requirement of every batch of processed product, put into cage, add 10 times to the water of adjuvant total amount in dynamic circulation soaking cooking tank.Start electric block, cage is slowly put into the soaking cooking tank.Start cap relief valve, heating makes the pressure in the tank be no more than 180kPa to boiling.Keep later on little boiling, at this moment the tank internal pressure remains between 20～50kPa.After the steaming and decocting of 1h, the material of adjuvant is fully leached, to take a sample to check, mouth is tasted adjuvant when almost tasteless, namely closes cap relief valve, starts the rustless steel circulating pump, makes adjuvant concoct liquid and squeezes in the measuring tank for subsequent use.Mention cage and bleed off the adjuvant residue.
3, the immersion of processed product
The Radix Aconiti Chinese crude drug is carried out weighing.100kg(determines according to volume, the quality of medical material, is advisable with 60% of cage volume), put into cage.Start electric block, make cage put into the soaking cooking tank.Start immediately the rustless steel circulating pump, carry out dynamic circulation and soak soak time 3～4h.When dynamic circulation is soaked, because friction generates heat, soak coolant-temperature gage and constantly raise.When temperature in the tank reaches 50 ℃, immediately termination of pumping, and soak bled off.Then add the same water yield, proceed dynamic circulation and soak, operation is the same, so repeatedly, until after soaking detoxification and reaching requirement, namely is dipped in the Radix Aconiti without the dried heart, and little when mouthful tasting have a numb feeling in the tongue degree of being, bleeds off last soak.The length of dynamic circulation soak time is to be determined by the differing texture of toxic traditional Chinese medicine material and height size etc., is generally 12～18h.
4, the steaming and decocting of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii is concocted
Radix Aconiti, Radix Aconiti Kusnezoffii are soaked after the detoxification, the auxiliary material liquid of preparation is poured into by measuring tank placed in the cooker that soaks product.Then start cap relief valve, slowly heating after boiling, turns down steam valve, keeps little boil 2 hours (the tank internal pressure is the same).After processed product reaches quality standards, i.e. stopped heating, and bleed off adjuvant and concoct liquid.Mention cage with electric block, emit processed product, then take a sample and carry out assay at high performance liquid chromatograph, reach the state-promulgated pharmacopoeia standard, the rear cold to 6 of cooling completely becomes that dried to process cutting in blocks.Drying and packaging gets product.
Claims (1)
1. the dynamic circulation concocting method of Radix Aconiti Preparata and the Radix Aconiti Kusnezoffii prepared slices of Chinese crude drugs is characterized in that implementing in accordance with the following steps:
(1) clean system: get Radix Aconiti, Radix Aconiti Kusnezoffii crude drug 100 weight portions, flushing with clean water is removed impurity;
(2) preparation of auxiliary material liquid: the adjuvant of Radix Aconiti, Radix Aconiti Kusnezoffii is concocted in configuration, and 5 parts of extracting liquorices, 10 parts of requirements by every batch of processed product of Semen sojae atricolor are carried out weighing, put into cage, adds 10 times to the water of adjuvant total amount in dynamic circulation soaking cooking tank; Cage is slowly put into the soaking cooking tank heat, make the pressure in the tank be no more than 180kPa to boiling, keep later on little boiling, at this moment the tank internal pressure remains between 20～50kPa, after the steaming and decocting of 1h, the material of adjuvant is fully leached; Take a sample to check, mouth is tasted adjuvant when almost tasteless, i.e. stopped heating, and adjuvant is concocted liquid squeeze in the measuring tank for subsequent use; Mention cage and bleed off the adjuvant residue;
(3) immersion of processed product: Radix Aconiti, Radix Aconiti Kusnezoffii Chinese crude drug are carried out 100 parts of weighings, put into cage.Make cage put into the soaking cooking tank and carry out dynamic circulation immersion, soak time 3～4h; When temperature in the tank reaches 50 ℃, stop immediately circulation immersion and soak is bled off; Then add the same water yield, proceed dynamic circulation and soak, operation is the same, so repeatedly, until after soaking detoxification and reaching requirement, namely is dipped in Radix Aconiti, the Radix Aconiti Kusnezoffii without the dried heart, and little when mouthful tasting have a numb feeling in the tongue degree of being, bleeds off last soak;
(4) steaming and decocting of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii is concocted: Radix Aconiti, Radix Aconiti Kusnezoffii are soaked after the detoxification, the auxiliary material liquid of preparation is poured into by measuring tank placed in the cooker that soaks product, and then slowly heating was boiled 2 hours to the rear maintenance of boiling is little, and pressure remains between 20～50kPa; After processed product reaches quality standards, i.e. stopped heating, and bleed off adjuvant and concoct liquid; Mention cage, emit processed product, then take a sample and carry out assay at high performance liquid chromatograph, reach the state-promulgated pharmacopoeia standard, the rear cold to 6 of cooling completely becomes that dried to process cutting in blocks.Drying and packaging gets product.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168412A (en) * | 2015-10-19 | 2015-12-23 | 江苏七O七天然制药有限公司 | Preparing method for radix aconiti |
| CN105708913A (en) * | 2016-02-26 | 2016-06-29 | 江西青春康源中药饮片有限公司 | Preparing method suitable for radix aconiti kusnezoffi preparata |
| CN106389555A (en) * | 2016-09-27 | 2017-02-15 | 青川县农村产业技术服务中心 | Treatment method for decreasing high toxicity of diester alkaloids in Aconitum type traditional Chinese medicine |
| CN108112864A (en) * | 2018-01-23 | 2018-06-05 | 中国中医科学院中药研究所 | A kind of method of unprocessed Radix Aconiti Lateralis rapid detoxification |
| CN110221001A (en) * | 2019-07-10 | 2019-09-10 | 青岛大学附属医院 | A kind of method of monoester alkaloid in extraction aconiti preparata,radix |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2104017U (en) * | 1991-08-20 | 1992-05-13 | 吕法纲 | Dynamic cycle chinese medicine-preparing device |
-
2012
- 2012-10-24 CN CN2012104116012A patent/CN102949472A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2104017U (en) * | 1991-08-20 | 1992-05-13 | 吕法纲 | Dynamic cycle chinese medicine-preparing device |
Non-Patent Citations (3)
| Title |
|---|
| 吕法纲，等: "毒性中药材动态循环炮制新工艺的研究", 《中国中药杂志》 * |
| 廖冬如，等: "均匀设计法优选川乌、草乌炮制工艺条件", 《中成药》 * |
| 李飞，等: "浸泡时间、加热方式对川乌饮片质量的影响", 《北京中医院大学学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168412A (en) * | 2015-10-19 | 2015-12-23 | 江苏七O七天然制药有限公司 | Preparing method for radix aconiti |
| CN105708913A (en) * | 2016-02-26 | 2016-06-29 | 江西青春康源中药饮片有限公司 | Preparing method suitable for radix aconiti kusnezoffi preparata |
| CN106389555A (en) * | 2016-09-27 | 2017-02-15 | 青川县农村产业技术服务中心 | Treatment method for decreasing high toxicity of diester alkaloids in Aconitum type traditional Chinese medicine |
| CN108112864A (en) * | 2018-01-23 | 2018-06-05 | 中国中医科学院中药研究所 | A kind of method of unprocessed Radix Aconiti Lateralis rapid detoxification |
| CN110221001A (en) * | 2019-07-10 | 2019-09-10 | 青岛大学附属医院 | A kind of method of monoester alkaloid in extraction aconiti preparata,radix |
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Application publication date: 20130306 |