CN106389555A - Treatment method for decreasing high toxicity of diester alkaloids in Aconitum type traditional Chinese medicine - Google Patents
Treatment method for decreasing high toxicity of diester alkaloids in Aconitum type traditional Chinese medicine Download PDFInfo
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- CN106389555A CN106389555A CN201610851268.5A CN201610851268A CN106389555A CN 106389555 A CN106389555 A CN 106389555A CN 201610851268 A CN201610851268 A CN 201610851268A CN 106389555 A CN106389555 A CN 106389555A
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- aconitum
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- monkshood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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Abstract
The invention discloses a treatment method for decreasing high toxicity of diester alkaloids in Aconitum type traditional Chinese medicine, comprising the steps of (1) adding Chinese honeylocust fruit and ginger in water, adding an alkali liquid, and adjusting pH to 12-13; (2) soaking Aconitum root in the solution of step (1) for 12-24 hours until no dry core is present in; (3) removing the Aconitum root soaked in the step of (3), mixing with licorice root and black bean, and boiling the mixture in water for 2-4 hours; (4) removing the Aconitum root cooked in the step (3), air-curing, slicing, drying, and crushing to obtain an Aconitum preparation. High-performance liquid chromatography for the produced Aconitum processed article obtained by using the method indicates that aconitine, mesaconitine and hypaconitine are not detected in Aconitum processed product obtained herein, and therefore the content of diester alkaloids in Aconitum type traditional Chinese medicine can be effectively reduced, the toxicity of Aconitum type traditional Chinese medicine can be decreased, and medication safety is guaranteed.
Description
Technical field
The invention belongs to Chinese medicine preparation technical field, reduce Aconitum Chinese medicine diester-type alkaloids severe toxicity particularly to a kind of
Processing method.
Background technology
Quite varied, particularly monkshood robbing in critical illness clinically applied by the Aconitum Chinese medicine such as monkshood, monkshood, radix aconiti agrestis
Rescue with the treatment of cureless intractable case in played prominent effect, from ancient times for the first product of Chinese medicine recuperating depleted yang.
Aconitum Chinese medicine have the characteristics that one common, all have that severe toxicity, therapeutic dose and lethal dose are close, security window is narrower,
This brings huge challenge to data for clinical drug use, and such as monkshood is referred to as the Chinese medicine of " most useful be also most difficult to use ".Diester-type alkaloids
It is the major toxicity composition of Aconitum Chinese medicine, mainly include aconitine, mesaconine and three kinds of Hypaconitine, its toxicity is extremely strong,
Mainly nerve and cardiovascular system are caused serious injury, people is administered orally aconitine 0.2mg and can cause poisoning, lethal dose is 2
～5mg.
Due to Aconitum herbal nature acutely, action time is short, and even dead situation of being poisoned because medication is careless is being faced
Of common occurrence on bed.Therefore, how to reduce Aconitum Chinese materia medica tocixity, the major toxicity particularly reducing Aconitum Chinese medicine becomes
Divide the content of diester-type alkaloids, be the main research direction of such Chinese medicine processing procedure, be also such Chinese medicine quality control
The most important thing of system.
Content of the invention
The goal of the invention of the present invention is：The problem existing for prior art, provides a kind of reduction Aconitum Chinese medicine double
The processing method of ester alkaloid severe toxicity, can effectively reduce the content of diester-type alkaloids in Aconitum Chinese medicine, Aconitum Chinese medicine
Toxicity significantly reduce it is ensured that drug safety.
To achieve these goals, the technical solution used in the present invention is：
A kind of processing method reducing Aconitum Chinese medicine diester-type alkaloids severe toxicity, comprises the following steps：
(1) add Chinese honey locust and ginger in water, be subsequently adding alkali lye and adjust pH value to 12～13；
(2) rhizome of Chinese monkshood is soaked in the solution that step (1) obtains, soaks 12～24 hours to the interior no dry heart；
(3) rhizome of Chinese monkshood after step (2) immersion is taken out, mix with Radix Glycyrrhizae and black soya bean, then put into together in water cooking 2～
4 hours to the interior no white heart；
(4) rhizome of Chinese monkshood after step (3) cooking is taken out, dry, section, dry, pulverize, obtain rhizome of Chinese monkshood processed product.
As the preferred technical solution of the present invention, in described step (1), the weight ratio of the Chinese honey locust of addition and ginger and the rhizome of Chinese monkshood
For 0.3:02:1.
As the preferred technical solution of the present invention, in described step (1), alkali lye is sodium hydroxide solution or potassium hydroxide is molten
Liquid.
As the preferred technical solution of the present invention, in described step (3), the weight ratio of the Radix Glycyrrhizae of addition and black soya bean and the rhizome of Chinese monkshood
For 0.2:01:1.
As the preferred technical solution of the present invention, in described step (3), during cooking, temperature control is at 95～100 DEG C.
As the preferred technical solution of the present invention, the described rhizome of Chinese monkshood is monkshood, radix aconiti agrestis or monkshood.
The beneficial effects of the present invention is：
The efficient liquid phase chromatographic analysis of the rhizome of Chinese monkshood processed product being obtained by the inventive method show, the inventive method obtains
Aconitine, mesaconine and Hypaconitine is not detected, therefore, the present invention can effectively reduce in Aconitum Chinese medicine in rhizome of Chinese monkshood processed product
The content of diester-type alkaloids, the toxicity of Aconitum Chinese medicine significantly reduces it is ensured that drug safety.
Specific embodiment
In order that the object, technical solutions and advantages of the present invention are clearer, below will be to the preferred embodiments of the present invention
It is described in detail.
Embodiment 1
(1) add Chinese honey locust and ginger in water, be subsequently adding sodium hydroxide solution and adjust pH value to 12；
(2) monkshood is soaked in the solution that step (1) obtains, the weight of Chinese honey locust and ginger and monkshood is than for 0.3:02:
1, soak 18 hours to the interior no dry heart；
(3) monkshood after step (2) immersion is taken out, mix with Radix Glycyrrhizae and black soya bean, the weight of Radix Glycyrrhizae and black soya bean and monkshood
Than for 0.2:01:1, then put into together in water, temperature control cooks 3 hours to the interior no white heart at 95～100 DEG C；
(4) monkshood after step (3) cooking is taken out, dry, section, dry, pulverize, obtain monkshood processed product.
Through efficient liquid phase chromatographic analysis, in the monkshood processed product that embodiment 1 obtains, do not detect aconitine, mesaconine and secondary
Aconitine.
Embodiment 2
(1) add Chinese honey locust and ginger in water, be subsequently adding sodium hydroxide solution and adjust pH value to 12；
(2) radix aconiti agrestis is soaked in the solution that step (1) obtains, the weight of Chinese honey locust and ginger and radix aconiti agrestis is than for 0.3:02:
1, soak 14 hours to the interior no dry heart；
(3) radix aconiti agrestis after step (2) immersion is taken out, mix with Radix Glycyrrhizae and black soya bean, the weight of Radix Glycyrrhizae and black soya bean and radix aconiti agrestis
Than for 0.2:01:1, then put into together in water, temperature control cooks 2 hours to the interior no white heart at 95～100 DEG C；
(4) radix aconiti agrestis after step (3) cooking is taken out, dry, section, dry, pulverize, obtain radix aconiti agrestis processed product.
Through efficient liquid phase chromatographic analysis, in the radix aconiti agrestis processed product that embodiment 2 obtains, do not detect aconitine, mesaconine and secondary
Aconitine.
Embodiment 3
(1) add Chinese honey locust and ginger in water, be subsequently adding potassium hydroxide solution and adjust pH value to 13；
(2) monkshood is soaked in the solution that step (1) obtains, the weight of Chinese honey locust and ginger and monkshood is than for 0.3:02:
1, soak 24 hours to the interior no dry heart；
(3) monkshood after step (2) immersion is taken out, mix with Radix Glycyrrhizae and black soya bean, the weight of Radix Glycyrrhizae and black soya bean and monkshood
Than for 0.2:01:1, then put into together in water, temperature control cooks 4 hours to the interior no white heart at 95～100 DEG C；
(4) monkshood after step (3) cooking is taken out, dry, section, dry, pulverize, obtain monkshood processed product.
Through efficient liquid phase chromatographic analysis, in the monkshood processed product that embodiment 3 obtains, do not detect aconitine, mesaconine and secondary
Aconitine.
Finally illustrate, above example only in order to technical scheme to be described and unrestricted, although by ginseng
According to the preferred embodiments of the present invention, invention has been described, it should be appreciated by those of ordinary skill in the art that can
So that in the form and details it is made with various changes, the present invention being limited without departing from appended claims
Spirit and scope.
Claims (6)
1. a kind of reduce Aconitum Chinese medicine diester-type alkaloids severe toxicity processing method it is characterised in that：Comprise the following steps：
(1) add Chinese honey locust and ginger in water, be subsequently adding alkali lye and adjust pH value to 12～13；
(2) rhizome of Chinese monkshood is soaked in the solution that step (1) obtains, soaks 12～24 hours to the interior no dry heart；
(3) rhizome of Chinese monkshood after step (2) immersion is taken out, mix with Radix Glycyrrhizae and black soya bean, then put into cooking 2～4 in water together little
Up to the interior no white heart；
(4) rhizome of Chinese monkshood after step (3) cooking is taken out, dry, section, dry, pulverize, obtain rhizome of Chinese monkshood processed product.
2. according to claim 1 reduce Aconitum Chinese medicine diester-type alkaloids severe toxicity processing method it is characterised in that：
In described step (1), the weight of the Chinese honey locust of addition and ginger and the rhizome of Chinese monkshood is than for 0.3:02:1.
3. according to claim 1 reduce Aconitum Chinese medicine diester-type alkaloids severe toxicity processing method it is characterised in that：
In described step (1), alkali lye is sodium hydroxide solution or potassium hydroxide solution.
4. according to claim 1 reduce Aconitum Chinese medicine diester-type alkaloids severe toxicity processing method it is characterised in that：
In described step (3), the weight of the Radix Glycyrrhizae of addition and black soya bean and the rhizome of Chinese monkshood is than for 0.2:01:1.
5. according to claim 1 reduce Aconitum Chinese medicine diester-type alkaloids severe toxicity processing method it is characterised in that：
In described step (3), during cooking, temperature control is at 95～100 DEG C.
6. the processing method reducing Aconitum Chinese medicine diester-type alkaloids severe toxicity according to claim 1 to 5 any one,
It is characterized in that：The described rhizome of Chinese monkshood is monkshood, radix aconiti agrestis or monkshood.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610851268.5A CN106389555A (en) | 2016-09-27 | 2016-09-27 | Treatment method for decreasing high toxicity of diester alkaloids in Aconitum type traditional Chinese medicine |
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| CN201610851268.5A CN106389555A (en) | 2016-09-27 | 2016-09-27 | Treatment method for decreasing high toxicity of diester alkaloids in Aconitum type traditional Chinese medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213295A (en) * | 2017-06-28 | 2017-09-29 | 云南金乌黑药制药有限公司 | It is a kind of to treat rheumatism, medicine of apoplexy diseases and preparation method thereof |
| CN110221001A (en) * | 2019-07-10 | 2019-09-10 | 青岛大学附属医院 | A kind of method of monoester alkaloid in extraction aconiti preparata,radix |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369278A (en) * | 2001-02-16 | 2002-09-18 | 中国科学院长春应用化学研究所 | Preparing process of hypertoxic Chinese-medicinal materials and as aconite root and Chinese monkshood rhizome |
| CN102949472A (en) * | 2012-10-24 | 2013-03-06 | 宝鸡向源中药饮片有限责任公司 | Dynamic circulating processing method of prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece |
-
2016
- 2016-09-27 CN CN201610851268.5A patent/CN106389555A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369278A (en) * | 2001-02-16 | 2002-09-18 | 中国科学院长春应用化学研究所 | Preparing process of hypertoxic Chinese-medicinal materials and as aconite root and Chinese monkshood rhizome |
| CN102949472A (en) * | 2012-10-24 | 2013-03-06 | 宝鸡向源中药饮片有限责任公司 | Dynamic circulating processing method of prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece |
Non-Patent Citations (1)
| Title |
|---|
| 彭成: "《有毒中药附子、川乌、草乌的安全性评价与应用》", 31 August 2014, 四川科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213295A (en) * | 2017-06-28 | 2017-09-29 | 云南金乌黑药制药有限公司 | It is a kind of to treat rheumatism, medicine of apoplexy diseases and preparation method thereof |
| CN107213295B (en) * | 2017-06-28 | 2018-06-22 | 云南金乌黑药制药有限公司 | It is a kind of treat rheumatism, apoplexy diseases drug and preparation method thereof |
| CN110221001A (en) * | 2019-07-10 | 2019-09-10 | 青岛大学附属医院 | A kind of method of monoester alkaloid in extraction aconiti preparata,radix |
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