CN105168412A - Preparing method for radix aconiti - Google Patents
Preparing method for radix aconiti Download PDFInfo
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- CN105168412A CN105168412A CN201510671462.0A CN201510671462A CN105168412A CN 105168412 A CN105168412 A CN 105168412A CN 201510671462 A CN201510671462 A CN 201510671462A CN 105168412 A CN105168412 A CN 105168412A
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- radix aconiti
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Abstract
The invention provides a preparing method for radix aconiti. The preparing method comprises the following steps: (1) fetching clean radix aconiti, separating the clean radix aconiti according to sizes, soaking the clean radix aconiti with water until the interior of the soaked radix aconiti is free of dry cores, and taking out the soaked radix aconiti for later use; (2) putting the clean radix aconiti soaked in the step (1) in clean water, carrying out heating for 4-6 hours, changing the water once every 0.5-1.5 hours, collecting and concentrating the changed water, putting remaining clean radix aconiti into a concentrated solution when the volume of the concentrated solution is equal to that of the remaining clean radix aconiti, and continuing to heat the concentrated solution until the concentrated solution is sopped up; and (3) taking out the clean radix aconiti obtained in the step (2), drying the clean radix aconiti in the air until the moisture content is 40%, then, slicing the dried radix aconiti, and carrying out drying and packaging, thereby obtaining prepared radix aconiti. According to the preparing method provided by the invention, the conversion ratio of diester alkaloids is increased, and the content of benzoyl total alkali is controlled; and the processing process is easy and feasible, the loss of effective ingredients is avoided, the quality and treatment effect of the product are guaranteed, and the production efficiency is increased.
Description
Technical field
The present invention relates to Chinese medicine processing field, be specifically related to the concocting method of a kind of Radix Aconiti.
Background technology
Radix Aconiti Preparata is a kind of conventional Chinese medicine, is the Preparation process product of Radix Aconiti.The raw product of Radix Aconiti are poisonous, and wherein contained diester-type alkaloids aconitine, hypaconitine are effective ingredient, are again toxic components, and therapeutic dose and toxic dose close, usually, through process of preparing Chinese medicine after, diester-type alkaloids can be converted into monoester alkaloid, and toxicity also can reduce.Therefore, to the content strictly will monitoring diester-type alkaloids in the concocting process of Radix Aconiti.
On " Chinese Pharmacopoeia " and " Chinese crude drug concocted specification " to the method for making of Radix Aconiti Preparata be " get clean Radix Aconiti, size separately, is soaked in water to interior without the dry heart; take out, add water boil 4 ~ 6 little up in getting large and cutting without the white heart, mouth taste micro-have a numb feeling in the tongue time, take out; dry in the air to sixty percent dry rear section, drying." this kind of method for making along with the lengthening of concocted time, can generate more benzoyl total alkali (comprising benzoyl aconine, benzoyl hypo-aconine, Benzoylmesaconine), benzoyl total alkali is difficult to control.Decocting time does not reach 4 hours, the too high levels of diester-type alkaloids, do not meet standard (content must not more than 0.040%), but decocting time is longer, the content of benzoyl total alkali will raise, the benzoyl total alkali of final Radix Aconiti Preparata, often beyond the upper limit several times of content standard (content accounts for 0.070% ~ 0.150%), is difficult to make qualified product.
Summary of the invention
goal of the invention:the object of the present invention is to provide the concocting method of a kind of Radix Aconiti, simple to operation, and the Radix Aconiti Preparata safety non-toxic obtained.
technical scheme of the present invention:
A concocting method for Radix Aconiti, comprises the steps:
(1) get clean Radix Aconiti, size separately, to be soaked in water to interior without the dry heart, to take out for subsequent use;
(2) the clean Radix Aconiti after step (1) being soaked is placed in clear water, and heating 4 ~ 6h, changes a water every 0.5 ~ 1.5h, collect the water changed also concentrated, when the volume of solution to be concentrated is equal with the volume of the clean Radix Aconiti of residue, clean Radix Aconiti will be remained and drop in concentrated solution, and continue to be heated to concentrated solution and blotted;
(3) take out the clean Radix Aconiti of step (2), dry in the air to sixty percent dry rear section, dry, packaging, obtains Radix Aconiti Preparata.
In step (2), the clear water amount of soaking clean Radix Aconiti is 5 ~ 8 times of clean Radix Aconiti amount.
In step (2), heating-up temperature is 70 ~ 80 DEG C.
In step (2), concentrated temperature is 70 ~ 80 DEG C, and pressure is 40 ~ 60KPa.
In step (2), the Baume degrees of described concentrated solution is 5 ~ 8 ° of B é.
In step (2), the time of changing water spacer is longer, and benzoyl total alkali is higher, and toxicity is larger.
beneficial effect:
Concocting method of the present invention can make the diester-type alkaloids in Radix Aconiti be converted into monoester alkaloid in a large number, improves conversion ratio, and controls the content of benzoyl total alkali by concentrated resorbent method; The course of processing is simple, avoids the loss of effective ingredient, ensures quality and the curative effect of product, improves production efficiency.
Detailed description of the invention
Below by the mode of embodiment, technical solution of the present invention is described in detail, but protection scope of the present invention is not limited to described embodiment.
embodiment 1
The concocting method of Radix Aconiti, comprises the steps:
(1) get clean Radix Aconiti, size separately, to be soaked in water to interior without the dry heart, to take out for subsequent use;
(2) the clean Radix Aconiti after step (1) being soaked is placed in the clear water of 5 times amount, 6h is heated at 70 DEG C, a water is changed every 1.5h, collect the water that changed and be 70 DEG C in temperature, pressure is concentrated under the condition of 60KPa, when the volume of solution to be concentrated is equal with the volume of the clean Radix Aconiti of residue, clean Radix Aconiti will be remained and drop in concentrated solution, and continue to be heated to concentrated solution and blotted;
(3) take out the clean Radix Aconiti of step (2), dry in the air to sixty percent dry rear section, dry, packaging, obtains Radix Aconiti Preparata.
embodiment 2
The concocting method of Radix Aconiti, comprises the steps:
(1) get clean Radix Aconiti, size separately, to be soaked in water to interior without the dry heart, to take out for subsequent use;
(2) the clean Radix Aconiti after step (1) being soaked is placed in the clear water of 6 times amount, 5h is heated at 75 DEG C, a water is changed every 1h, collect the water that changed and be 75 DEG C in temperature, pressure is concentrated under the condition of 50KPa, when the volume of solution to be concentrated is equal with the volume of the clean Radix Aconiti of residue, clean Radix Aconiti will be remained and drop in concentrated solution, and continue to be heated to concentrated solution and blotted;
(3) take out the clean Radix Aconiti of step (2), dry in the air to sixty percent dry rear section, dry, packaging, obtains Radix Aconiti Preparata.
embodiment 3
The concocting method of Radix Aconiti, comprises the steps:
(1) get clean Radix Aconiti, size separately, to be soaked in water to interior without the dry heart, to take out for subsequent use;
(2) the clean Radix Aconiti after step (1) being soaked is placed in the clear water of 8 times amount, 4h is heated at 80 DEG C, a water is changed every 0.5h, collect the water that changed and be 80 DEG C in temperature, pressure is concentrated under the condition of 40KPa, when the volume of solution to be concentrated is equal with the volume of the clean Radix Aconiti of residue, clean Radix Aconiti will be remained and drop in concentrated solution, and continue to be heated to concentrated solution and blotted;
(3) take out the clean Radix Aconiti of step (2), dry in the air to sixty percent dry rear section, dry, packaging, obtains Radix Aconiti Preparata.
embodiment 4
The concocting method of Radix Aconiti, comprises the steps:
(1) get clean Radix Aconiti, size separately, to be soaked in water to interior without the dry heart, to take out for subsequent use;
(2) the clean Radix Aconiti after step (1) being soaked is placed in the clear water of 8 times amount, 4h is heated at 80 DEG C, a water is changed every 1h, collect the water that changed and be 80 DEG C in temperature, pressure is concentrated under the condition of 40KPa, when the volume of solution to be concentrated is equal with the volume of the clean Radix Aconiti of residue, clean Radix Aconiti will be remained and drop in concentrated solution, and continue to be heated to concentrated solution and blotted;
(3) take out the clean Radix Aconiti of step (2), dry in the air to sixty percent dry rear section, dry, packaging, obtains Radix Aconiti Preparata.
embodiment 5
The concocting method of Radix Aconiti, comprises the steps:
(1) get clean Radix Aconiti, size separately, to be soaked in water to interior without the dry heart, to take out for subsequent use;
(2) the clean Radix Aconiti after step (1) being soaked is placed in the clear water of 8 times amount, 4h is heated at 80 DEG C, a water is changed every 1.5h, collect the water that changed and be 80 DEG C in temperature, pressure is concentrated under the condition of 40KPa, when the volume of solution to be concentrated is equal with the volume of the clean Radix Aconiti of residue, clean Radix Aconiti will be remained and drop in concentrated solution, and continue to be heated to concentrated solution and blotted;
(3) take out the clean Radix Aconiti of step (2), dry in the air to sixty percent dry rear section, dry, packaging, obtains Radix Aconiti Preparata.
Get the obtained Radix Aconiti Preparata of concocting method of the present invention and the Radix Aconiti Preparata obtained according to the method for " Chinese Pharmacopoeia " in contrast product carry out the mensuration of effective ingredient and toxic component, concrete data are in table 1, and assay method measures with reference to algoscopy under " Chinese Pharmacopoeia " (version one in 2010) Radix Aconiti Preparata item.
Table 1
。
Above experimental data shows, utilize the Radix Aconiti Preparata that the concocting method of Radix Aconiti of the present invention obtains, the content of diester-type alkaloids and benzoyl total alkali is all in critical field, from embodiment 3 ~ 5, there is appreciable impact the time of changing water spacer in step (2) on benzoyl total alkali, interval is longer, and content is higher, and toxicity is larger.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.
Claims (6)
1. a concocting method for Radix Aconiti, is characterized in that, comprises the steps:
(1) get clean Radix Aconiti, size separately, to be soaked in water to interior without the dry heart, to take out for subsequent use;
(2) the clean Radix Aconiti after step (1) being soaked is placed in clear water, and heating 4 ~ 6h, changes a water every 0.5 ~ 1.5h, collect the water changed also concentrated, when the volume of solution to be concentrated is equal with the volume of the clean Radix Aconiti of residue, clean Radix Aconiti will be remained and drop in concentrated solution, and continue to be heated to concentrated solution and blotted;
(3) take out the clean Radix Aconiti of step (2), dry in the air to sixty percent dry rear section, dry, packaging, obtains Radix Aconiti Preparata.
2. the concocting method of a kind of Radix Aconiti according to claim 1, it is characterized in that, in step (2), the clear water amount of soaking clean Radix Aconiti is 5 ~ 8 times of clean Radix Aconiti amount.
3. the concocting method of a kind of Radix Aconiti according to claim 1, it is characterized in that, in step (2), heating-up temperature is 70 ~ 80 DEG C.
4. the concocting method of a kind of Radix Aconiti according to claim 1, is characterized in that, in step (2), concentrated temperature is 70 ~ 80 DEG C, and pressure is 40 ~ 60KPa.
5. the concocting method of a kind of Radix Aconiti according to claim 1, it is characterized in that, in step (2), the Baume degrees of described concentrated solution is 5 ~ 8 ° of B é.
6. the concocting method of a kind of Radix Aconiti according to claim 1, it is characterized in that, in step (2), the time of changing water spacer is longer, and benzoyl total alkali is higher, and toxicity is larger.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510671462.0A CN105168412A (en) | 2015-10-19 | 2015-10-19 | Preparing method for radix aconiti |
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| CN201510671462.0A CN105168412A (en) | 2015-10-19 | 2015-10-19 | Preparing method for radix aconiti |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350656A (en) * | 2018-12-18 | 2019-02-19 | 广州市药材公司中药饮片厂 | A kind of concocting method of monkshood |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949472A (en) * | 2012-10-24 | 2013-03-06 | 宝鸡向源中药饮片有限责任公司 | Dynamic circulating processing method of prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece |
-
2015
- 2015-10-19 CN CN201510671462.0A patent/CN105168412A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949472A (en) * | 2012-10-24 | 2013-03-06 | 宝鸡向源中药饮片有限责任公司 | Dynamic circulating processing method of prepared radix aconiti and radix aconiti kusnezoffii traditional Chinese medicine decoction piece |
Non-Patent Citations (2)
| Title |
|---|
| 方莉: "不同炮制模型对附子化学成分的影响极其指纹图谱的研究", 《中国优秀硕士学位论文全文数据库 医药卫生辑》 * |
| 贾天柱: "《中药炮制学》", 30 June 2013 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350656A (en) * | 2018-12-18 | 2019-02-19 | 广州市药材公司中药饮片厂 | A kind of concocting method of monkshood |
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