CN102357119B - Production technique of Baikal skullcap root detoxification powder spray-dried flour - Google Patents
Production technique of Baikal skullcap root detoxification powder spray-dried flour Download PDFInfo
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- CN102357119B CN102357119B CN 201110306417 CN201110306417A CN102357119B CN 102357119 B CN102357119 B CN 102357119B CN 201110306417 CN201110306417 CN 201110306417 CN 201110306417 A CN201110306417 A CN 201110306417A CN 102357119 B CN102357119 B CN 102357119B
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Abstract
The invention relates to a production technique of Baikal skullcap root detoxification powder spray-dried flour, which comprises the following steps: (1) mixing Baikal skullcap root detoxification powder and 50% ethanol which is 6 times of the Baikal skullcap root detoxification powder by mass, heating until the solution is boiled, and decocting for 2 hours in the boiling state; filtering the decoction liquid, reserving the filtrate, mixing the decoction dregs and 50% ethanol which is 4 times of the initial Baikal skullcap root detoxification powder by mass, heating to a reflux state, and keeping for 1 hour to obtain a reflux liquid; (2) merging the filtrate and the reflux liquid obtained in the step (1), and concentrating with an external-cycle double effect concentrator for 2-3 hours; and (3) carrying out spray drying on the concentrated filtrate obtained in the step (2) to obtain the finished product. The invention has the advantages of quick moisture evaporation, short drying time, fine powder and good quality, and is suitable for large-scale production.
Description
Technical field
The present invention relates to poultry practical technique field, especially relate to scutellaria detoxification powder is processed, obtain the method for spray-dried powders.
Background technology
Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root have that heat clearing and damp drying, removing heat from blood are antiabortive, the effect of detoxifcation.Contain multiple flavone compound, mainly contain baicalin (baicalin), baicalin (baicalein), wogonoside (wogonoside), wogonin (wogonin), 7-methoxyl group baicalin, 7-methoxyl group demethyl wogonin, skullcapflavone I, skullcapflavone II etc.Have the pharmacological actions such as antibiotic, antiviral, antifungal, analgesic, blood pressure lowering, antiinflammatory, antiallergic.Utilize advantage and the function of Radix Scutellariae, extract the scutellaria detoxification powder of developing, can be used as the Organism immunoregulation agent, improving animal body immunity and controlling animal immune and suppress to have significant effect aspect the disease.
Application number is 201010126275.1 patent documentation, the preparation method of a kind of scutellaria detoxification powder that provides for the applicant.In the method, adopt white carbon to mix with extracting solution, then carried out dry method.White carbon act as absorption carrier, the absorption carrier of scutellaria detoxification powder also has the silicon dioxide molecule at present, utilizes absorption carrier and the method that the loose extracting solution of Radix Scutellariae detoxifcation mixes, need to dry for a long time, and the dry products water content is still larger.
Summary of the invention
For the problems referred to above that prior art exists, the applicant provides a kind of production technology of scutellaria detoxification powder spray drying powder, utilizes spray drying to the loose dried of carrying out of Radix Scutellariae detoxifcation.Water evaporates of the present invention is rapid, and drying time is short, and powder is fine and smooth, and quality is good, is fit to large-scale production.
Technical scheme of the present invention is as follows:
A kind of production technology of scutellaria detoxification powder spray drying powder, step is as follows:
(1) is that 50% ethanol of 6 times of scutellaria detoxification powders mixes with scutellaria detoxification powder and quality, is heated to boiling, under fluidized state, decocted 2 hours; Then the decoction liquor that obtains is filtered, filtrate is kept, 50% ethanol that filters the medicinal residues that obtain and quality and be 4 times of initial scutellaria detoxification powders mixes, and is heated to reflux state, keeps 1 hour, obtains backflow;
(2) after the filtrate that step (1) is obtained and backflow merge, adopt the outer circulation dual-effect concentrator concentrated, concentration time is 2 ~ 3 hours;
(3) concentrated filtrate that step (2) is obtained carries out spray drying, obtains finished product, and spray-dired parameter is: concentrated solution relative density 1.14 ~ 1.18, and 140 ~ 160 ℃ of inlet temperature, 70 ~ 90 ℃ of leaving air temps, pan feeding flow are 1.0 ~ 1.4kg/min.
Described scutellaria detoxification powder is the mixture of Radix Scutellariae and Herba Euphorbiae Humifusae, and the mass ratio of Radix Scutellariae and Herba Euphorbiae Humifusae is 1 ~ 3:1.
The technique effect that the present invention is useful is:
The prescription of scutellaria detoxification powder spray of the present invention is shown in the patent documentation that application number is 201010126275.1, mixture for Radix Scutellariae and Herba Euphorbiae Humifusae, main goal of the invention of the present invention is that the mixture to this Radix Scutellariae and Herba Euphorbiae Humifusae extracts, and with spray-dired method the liquid rapid draing after extracting.Spray-dired method is come dry, does not only need to add the adsorption aids such as white carbon, silicon dioxide, and the time of oven dry is short, and product moisture content is few after the oven dry.It is key point of the present invention that parameter during spray drying is selected.It is low to the experiment proved that scutellaria detoxification powder extracts spray drying gained fine powder moisture, good fluidity.Under the method condition, product moisture content is 3-4%, content of baicalin 5%～8%.
The specific embodiment
Embodiment 1
(1) is that 50% ethanol of 6 times in the mixture of Radix Scutellariae and Herba Euphorbiae Humifusae mixes with the mixture of 30 kilograms of Radix Scutellariaes and 10 kilograms of Herba Euphorbiae Humifusaes and quality, is heated to boiling, under fluidized state, decocted 2 hours; Then the decoction liquor that obtains is filtered, filtrate is kept, 50% ethanol that filters the medicinal residues that obtain and quality and be 4 times in the mixture of initial Radix Scutellariae and Herba Euphorbiae Humifusae mixes, and is heated to reflux state, keeps 1 hour, obtains backflow;
(2) after the filtrate that step (1) is obtained and backflow merge, adopt the outer circulation dual-effect concentrator concentrated, concentration time is 3 hours;
(3) concentrated filtrate is carried out spray drying, parameter is that concentrated solution relative density 1.18(is the ratio of the density of the density of concentrated solution and 4 ℃ of water), 160 ℃ of inlet temperature, 70 ℃ of leaving air temps, pan feeding flow are 1.4kg/min; Obtain finished product; Last moisture is 4.70%, content of baicalin 5.10%.
Embodiment 2
(1) is that 50% ethanol of 6 times in the mixture of Radix Scutellariae and Herba Euphorbiae Humifusae mixes with the mixture of 20 kilograms of Radix Scutellariaes and 10 kilograms and quality, is heated to boiling, under fluidized state, decocted 2 hours; Then the decoction liquor that obtains is filtered, filtrate is kept, 50% ethanol that filters the medicinal residues that obtain and quality and be 4 times in the mixture of initial Radix Scutellariae and Herba Euphorbiae Humifusae mixes, and is heated to reflux state, keeps 1 hour, obtains backflow;
(2) after the filtrate that step (1) is obtained and backflow merge, adopt the outer circulation dual-effect concentrator concentrated, concentration time is 2.5 hours;
(3) concentrated filtrate is carried out spray drying, parameter is concentrated solution relative density 1.16,140 ℃ of inlet temperature, and 90 ℃ of leaving air temps, pan feeding flow are 1.2kg/min; Obtain finished product; Last moisture is 4.46%, content of baicalin 5.16%.
Embodiment 3
(1) is that 50% ethanol of 6 times in the mixture of Radix Scutellariae and Herba Euphorbiae Humifusae mixes with the mixture of 10 kilograms of Radix Scutellariaes and 10 kilograms and quality, is heated to boiling, under fluidized state, decocted 2 hours; Then the decoction liquor that obtains is filtered, filtrate is kept, 50% ethanol that filters the medicinal residues that obtain and quality and be 4 times in the mixture of initial Radix Scutellariae and Herba Euphorbiae Humifusae mixes, and is heated to reflux state, keeps 1 hour, obtains backflow;
(2) after the filtrate that step (1) is obtained and backflow merge, adopt the outer circulation dual-effect concentrator concentrated, concentration time is 2 hours;
(3) concentrated filtrate is carried out spray drying, parameter is concentrated solution relative density 1.14,150 ℃ of inlet temperature, and 80 ℃ of leaving air temps, pan feeding flow are 1.0kg/min; Obtain finished product; Last moisture is 4.56%, content of baicalin 5.07%.
Among the embodiment 1 ~ 3, moisture adopts takes the detection of Xiu Shi method, and content of baicalin adopts high performance liquid chromatography to detect according to No. 1295 bulletins of the Ministry of Agriculture, and detecting instrument is high performance liquid chromatography.
Above-described only is preferred implementation of the present invention, the invention is not restricted to above embodiment.Be appreciated that other improvement and variation that those skilled in the art directly derive or associate under the prerequisite that does not break away from spirit of the present invention and design, all should think to be included within protection scope of the present invention.
Claims (1)
1. the production technology of a scutellaria detoxification powder spray drying powder is characterized in that step is as follows:
(1) is that 50% ethanol of 6 times of scutellaria detoxification powders mixes with scutellaria detoxification powder and quality, is heated to boiling, under fluidized state, decocted 2 hours; Then the decoction liquor that obtains is filtered, filtrate is kept, 50% ethanol that filters the medicinal residues that obtain and quality and be 4 times of initial scutellaria detoxification powders mixes, and is heated to reflux state, keeps 1 hour, obtains backflow;
(2) after the filtrate that step (1) is obtained and backflow merge, adopt the outer circulation dual-effect concentrator concentrated, concentration time is 2 ~ 3 hours;
(3) concentrated filtrate that step (2) is obtained carries out spray drying, obtains finished product, and spray-dired parameter is: concentrated solution relative density 1.14 ~ 1.18, and 140 ~ 160 ℃ of inlet temperature, 70 ~ 90 ℃ of leaving air temps, pan feeding flow are 1.0 ~ 1.4kg/min;
Described scutellaria detoxification powder is the mixture of Radix Scutellariae and Herba Euphorbiae Humifusae, and the mass ratio of Radix Scutellariae and Herba Euphorbiae Humifusae is 1 ~ 3:1.
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| CN 201110306417 CN102357119B (en) | 2011-10-11 | 2011-10-11 | Production technique of Baikal skullcap root detoxification powder spray-dried flour |
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| CN102357119B true CN102357119B (en) | 2013-05-01 |
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| CN106344507A (en) * | 2016-11-17 | 2017-01-25 | 无锡奔牛生物科技有限公司 | Preparation method of radix scutellariae toxin-resolving powder oral liquid |
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| CN101780143A (en) * | 2010-03-18 | 2010-07-21 | 无锡正大畜禽有限公司 | Method for producing scutellaria detoxification powder of veterinary medicament |
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| CN101554420A (en) * | 2009-05-25 | 2009-10-14 | 江西中成中药原料有限公司 | Radix scutellariae and humifuse euphorbia herb powder and preparation technology and quality control method thereof |
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| CN101780143A (en) * | 2010-03-18 | 2010-07-21 | 无锡正大畜禽有限公司 | Method for producing scutellaria detoxification powder of veterinary medicament |
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Address after: The new plum village in Jiangsu province 214112 city Wuxi Qunxing Road No. 51 Patentee after: WUXI ZHENGDA BIOLOGY CO., LTD. Address before: The new plum village in Jiangsu province 214112 city Wuxi Qunxing Road No. 51 Patentee before: Wuxi Zhengda Poultry Co., Ltd. |