CN102920815A - Application of active parts of gambir plant total alkaloids - Google Patents
Application of active parts of gambir plant total alkaloids Download PDFInfo
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- CN102920815A CN102920815A CN 201210486928 CN201210486928A CN102920815A CN 102920815 A CN102920815 A CN 102920815A CN 201210486928 CN201210486928 CN 201210486928 CN 201210486928 A CN201210486928 A CN 201210486928A CN 102920815 A CN102920815 A CN 102920815A
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- total alkaloids
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- active parts
- gambir plant
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the field of biological medicines, and relates to an application of active parts of gambir plant total alkaloids in the aspect of in vivo antihypertension and also describes a medicinal composition which contains the gambir plant total alkaloids and is used for preventing and treating hypertension.
Description
Technical field
The invention belongs to biomedicine field, relate to the new purposes of antihypertensive function in the uncaria total alkaloids effective site body.
Background technology
Hypertension (hypertensive disease) is a kind of chronic disease take the lasting rising of arteriotony as main manifestations, often cause the pathological changes of the vitals such as the heart, brain, kidney and corresponding consequence occurs, hypertension belongs to " headache ", " dizzy " category of the traditional Chinese medical science.The blood pressure standard that World Health Organization's suggestion is used is: the normal adult systolic pressure should be less than or equal to 140mmHg, and diastolic pressure is less than or equal to 90mmHg; Systolic pressure is between 141-159mmHg, and diastolic pressure is borderline hypertension between 91-94mmHg.
Doctor trained in Western medicine is emphasized individualized treatment, and the traditional Chinese medical science is then paid attention to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Western medicine hypertension adopts the index treatment, often too is concerned about an index of hypertension therapeutic, and namely the blood pressure values index under treatment-resistant, seems the blood pressure index normal, in fact easily repeatedly.On theory of Chinese medical science, Chinese medicine because row neutralization, in just, the road of middle row, in hypertensive control, the conditioning viscera function is prevented and treated complication, and its relatively unique " treating both the principal and secondary aspects of a disease " advantage is arranged.Treatment by Chinese herbs mainly is environment in the blood disorderly in adjusting body, repairs impaired blood vessel wall, improves oxygen content, recovers injured cranial nerve cell, the adjustment vital organs of the human body, and qi blood balance, dredging the meridian reaches equilibrium between yin and yang.Common blood pressure lowering Chinese patent medicine has An ' gong blood pressure-reducing ball, Chinese hawthorn blood-pressure-reducing capsule, compound recipe antelope angle hypertension pill, chiang ya wan, chrysanthemum publicly price-reduction tabletting, Bezoar pill for lowering blood pressure etc.; Common Chinese hypotensor has Ramulus Uncariae Cum Uncis, Folium Apocyni Veneti, Radix Puerariae, the Radix Astragali etc.
Summary of the invention
The object of the present invention is to provide the new purposes of uncaria total alkaloids effective site in resisting hypertension.
Further, be used for preventing and treating the hypertensive pharmaceutical composition that contains uncaria total alkaloids effective site.
Uncaria total alkaloids effective site can effectively reduce blood pressure, and controls preferably the systolic pressure of spontaneous hypertensive rat (SHR).
The medicine of uncaria total alkaloids effective site of the present invention also contains the pharmaceutics acceptable carrier, comprises excipient and adjuvant, and dosage form can be the dosage form on any pharmaceutics.
The specific embodiment
The embodiment 1. uncaria total alkaloids effective sites activity that reduces blood pressure
Uncaria total alkaloids effective site is available from Shenyang Long Pu Science and Technology Ltd., purity＞60% in the present embodiment.
10～12 week spontaneous hypertensive rats in age (SHR) are pressed the blood pressure grouping, and concrete dosage sees Table 1, and administration is the arteria caudalis pressure measurement after 7 days.
Statistical analysis: measurement data mean+SD
Expression, t check between relatively employing group of data between two groups.
The result: uncaria total alkaloids effective site can effectively reduce the SHR rat blood pressure, and relatively there were significant differences (P＜0.05) with model control group, sees Table 1.
Table 1. uncaria total alkaloids effective site successive administration is on the impact of SHR rat blood pressure
Compare with model control group
△P＜0.05.
Claims (2)
1. the new purposes of a Chinese medicine extract is characterized in that: the new purposes of antihypertensive function in the uncaria total alkaloids effective site body.
2. the new purposes of a kind of Chinese medicine extract according to claim 1 is characterized in that: be used for preventing and treating the hypertensive pharmaceutical composition that contains uncaria total alkaloids effective site.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210486928 CN102920815A (en) | 2012-11-26 | 2012-11-26 | Application of active parts of gambir plant total alkaloids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210486928 CN102920815A (en) | 2012-11-26 | 2012-11-26 | Application of active parts of gambir plant total alkaloids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102920815A true CN102920815A (en) | 2013-02-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210486928 Pending CN102920815A (en) | 2012-11-26 | 2012-11-26 | Application of active parts of gambir plant total alkaloids |
Country Status (1)
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| CN (1) | CN102920815A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343232A (en) * | 2015-11-11 | 2016-02-24 | 安徽生物肽产业研究院有限公司 | Composition of effective parts of ground beetle small peptides for treating cardiovascular diseases |
| CN105535924A (en) * | 2016-01-13 | 2016-05-04 | 安徽生物肽产业研究院有限公司 | Compound lumbricus small peptide composition for treating cardiovascular diseases |
-
2012
- 2012-11-26 CN CN 201210486928 patent/CN102920815A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343232A (en) * | 2015-11-11 | 2016-02-24 | 安徽生物肽产业研究院有限公司 | Composition of effective parts of ground beetle small peptides for treating cardiovascular diseases |
| CN105535924A (en) * | 2016-01-13 | 2016-05-04 | 安徽生物肽产业研究院有限公司 | Compound lumbricus small peptide composition for treating cardiovascular diseases |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130213 |