CN102919141B - Big mice sleep interferometer - Google Patents
Big mice sleep interferometer Download PDFInfo
- Publication number
- CN102919141B CN102919141B CN201210356645.XA CN201210356645A CN102919141B CN 102919141 B CN102919141 B CN 102919141B CN 201210356645 A CN201210356645 A CN 201210356645A CN 102919141 B CN102919141 B CN 102919141B
- Authority
- CN
- China
- Prior art keywords
- roller
- animal
- power
- equipment
- rotating cage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Housing For Livestock And Birds (AREA)
Abstract
The present invention provides a kind of big mice sleep interferometer, including multiple rollers, there is boom plate in the cage rested for animal respectively in the inside of multiple rollers, and the supply arrangement of supply animal diet followed drinking-water is provided with multiple rollers；The power-equipment for driving multiple rollers to rotate；And for inputting the control device of control signal to power-equipment, the velocity of rotation of multiple rollers is controlled by inputting control signal, control device is connected with power-equipment.Roller velocity of rotation can be adjusted at any time on the control panel of control device as needed, from different parameter combination (rotating speeds, turn-take, time of having a rest and experimental period) it is different to animal progress sleep interference strength, so as to reach different modeling purposes.
Description
Technical field
The invention belongs to test instrument field, more particularly to a kind of interference animal sleep hinders so as to cause animal learning to be remembered
Hinder, and (or) anxiety, and (or) depressed big mice sleep interferometer.
Background technology
Sleep interference refers to because various stimulus cause animal sleep lost condition, and cause mood, learning and memory,
Immunologic function etc. is a series of to be changed.The drum process sleep interferometer of improvement is mainly used in large and small mouse different time and degree
Sleep interference, so as to cause animal learning memory disorders, and (or) anxiety, and (or) the psychoneural such as depression changes, to calm the nerves
The model that nootropic, anxiolytic, the research of antidepressants are provided, has significant application value to pharmacodynamic study.
At present the interference experiment technology of large and small mouse sleep both at home and abroad mainly have physics sleep interference method (chain-wales water environment method,
Drum process, horizontal rotating disc method, treadmill method touches method) and chemistry sleep interference method.Chemistry sleep interference method is because of interference effect and journey
Degree is difficult to grasp, and may have an impact to drug effect and apply less.Physics sleep interference method because its sleep interference effect substantially and
Influence smaller and extensive use, wherein chain-wales water environment method are most widely used because experiment is simple and easy to apply on drug effect, but it is most
Important shortcoming is exactly frequently that the overboard phenomena of mortality of animal occur for overboard stress and extending with interference time；Horizontal rotating disc method because
Equipment is expensive, sample size is few and is studied suitable for sleep mechanism；Treadmill method is easy to cause fatigue of animals, disturbs sleep result, and
Sample size is also few；The method of touching is easily caused the sleep interference of experimenter.
By taking existing drum process as an example, although existing drum process sleep interference effect is substantially, reproducible.But it is existing
There is rolling speed in drum process and time adjustable extent is small；Animal is fed water inconvenient to food；Medicine is not suitable for it because sample size is small
Effect learns research；The problems such as prolonged exercise stress disturb sleep result.Therefore, the appearance of improvement drum process is needed badly with easily and effectively
Ground causes animal sleep to disturb, so as to reach the different purpose of sleep study.
The content of the invention
In order to solve the above-mentioned technical problem, the present invention provides a kind of big mice sleep interferometer, can select different parameters
Combination (rotating speed, turn-takes, time of having a rest and experimental period) is different to animal progress sleep interference strength, so as to reach different make
Mould mesh.
In order to achieve the above object, the present invention provides a kind of big mice sleep interferometer, including：
Multiple rollers, have boom plate in the cage rested for animal in the inside of the multiple roller, in the multiple rolling respectively
The supply arrangement of supply animal diet followed drinking-water is provided with cylinder；
The power-equipment for driving the multiple roller to rotate；And
Control device for inputting from control signal to the power-equipment, it is the multiple by inputting control signal control
The velocity of rotation of roller, the control device is connected with the power-equipment.
Alternatively, the big mice sleep interferometer also includes：Synchronous rotary mechanism, the power-equipment passes through described same
Rotating mechanism is walked, the multiple roller synchronous axial system is driven.
Alternatively, the multiple roller includes：First roller and second tin roller, wherein
First roller includes：
First rotating cage, with the first accommodation space；
First rotating shaft, is connected with the power-equipment, and the power-equipment drives first rotating cage by first rotating shaft
Rotate；
At least one first dividing plate, is arranged in first accommodation space, by first dividing plate by described first
Accommodation space is divided into multiple the first Room for being used to place animal；
Second tin roller includes：
Second rotating cage, with the second accommodation space；
Second rotating shaft, is connected with the power-equipment, and the power-equipment drives second rotating cage by the second rotating shaft
Rotate；
At least one second partition, is arranged in second accommodation space, by the second partition by described second
Accommodation space is divided into multiple second Rooms for being used to place animal.
Alternatively, first rotating cage includes：First rotating cage wall, and it is separately positioned on the two ends of the first rotating cage wall
First baffle and second baffle；
Second rotating cage includes：Second rotating cage wall, and be separately positioned on the second rotating cage wall two ends the 3rd
Baffle plate and fourth gear plate.
Alternatively, the supply arrangement includes：First for supplying the drinking-water of the animal diet followed in first roller supplies
To structure and for supplying the second supply structure that the animal diet followed in the second tin roller is drunk water, wherein
First supply structure includes：
Hamper for supplying animal food, is arranged in first accommodation space；
The first water bottle for storing water, is arranged on outside first rotating cage；
First tap, is connected by the first feed pipe with first water bottle, and first tap is arranged on described
In first accommodation space；
Second supply structure includes：
The second water bottle for storing water, is arranged on outside second rotating cage；
Second tap, is connected by the second feed pipe with second water bottle, and second tap is arranged on described
In second accommodation space.
Alternatively, first supply structure is rotated with the first rotating shaft and is connected, and first supply structure is described
First roller is static relative to first roller during rotating；
Second supply structure is connected with second axis of rotation, and second supply structure is in the second tin roller
It is static relative to the second tin roller during rotation.
Alternatively, anti-baffle plate of lying prone is provided with above the hamper.
Alternatively, the waste collection for receiving animal excrements is provided with below first roller and the second tin roller
Box.
Alternatively, the control device includes：
Housing；
Circuit board for controlling the control device operation, is arranged in the housing；
For the display panel for the parameters for showing experiment in real time, it is connected with the circuit board；
Control panel for inputting control signal, is connected with the circuit board.
Alternatively, the power-equipment includes：Drive motor and adjust the motor speed that the multiple roller is rotated
Decelerator.
As shown from the above technical solution, embodiments of the invention have the advantages that：Can basis using the present invention
Need to adjust roller velocity of rotation at any time on the control panel of control device, from different parameter combination (rotating speed, turn-takes,
Time of having a rest and experimental period) it is different to animal progress sleep interference strength, so as to reach different modeling purposes；Once carry out
Sleep interference animal is a large amount of (mouse 160, rat 32), suitable for pharmacodynamic study；Animal can treat during roller is not rolled
Rested in cage on boom plate, reduce the influence that stress be to sleep that motion is brought；Animal is in consolidating positioned at each drums inside
Determine free water diet in hamper and two taps containing double pearls；Stability of instrument is high, and experimentation is kept an eye on without personnel；
Sleep interference reliable results, degree is easily grasped；Control panel is simple to operate, easily grasps.
Brief description of the drawings
Fig. 1 is the structural representation of big mice sleep interferometer in embodiments of the invention；
Fig. 2 is the theory diagram of control device and other circuits in embodiments of the invention.
Embodiment
In order that the object, technical solutions and advantages of the present invention become apparent from understanding, it is right with reference to embodiment and accompanying drawing
The embodiment of the present invention is described in further detail.Here, the present invention illustrative examples and illustrate be used for explain the present invention,
But it is not intended as the restriction of the present invention.
As shown in figure 1, being the structural representation of big mice sleep interferometer in embodiments of the invention, the experimental provision bag
Include：
Multiple rollers, there is boom plate in the cage rested for animal in the inside of multiple rollers respectively, are set in multiple rollers
There is the supply arrangement of supply animal diet followed drinking-water；
The power-equipment for driving multiple rollers to rotate；And
Control device for inputting from control signal to power-equipment, the multiple roller is controlled by inputting control signal
Velocity of rotation, control device is connected with the power-equipment.
In an embodiment of the present invention, big mice sleep interferometer also includes：Synchronous rotary mechanism, power-equipment passes through institute
Synchronous rotary mechanism is stated, the multiple roller synchronous axial system is driven.
As shown in figure 1, power-equipment drives the multiple roller synchronous axial system by timing belt 31.The multiple roller is same
Step is rolled, it is ensured that learning memory disorder, and (or) anxiety, and (or) the synchronism that depression model makes.
Referring to Fig. 1, the multiple roller includes：First roller 1 and second tin roller 2, wherein
First roller 1 includes：
First rotating cage 11, with the first accommodation space；
First rotating shaft 12, is connected with the power-equipment, and the power-equipment drives described first by first rotating shaft 12
Rotating cage 11 is rotated；
At least one first dividing plate 13, is arranged in first accommodation space, will be described by first dividing plate 13
First accommodation space is divided into multiple rooms for being used to place animal；As shown in figure 1, having 3 the first dividing plates in first roller 1
13, it is of course possible to understanding, the quantity of first dividing plate 13 is not limited in the present embodiment.
Second tin roller 2 includes：
Second rotating cage 21, with the second accommodation space；
Second rotating shaft 22, is connected with the power-equipment, and the power-equipment drives described second by the second rotating shaft 22
Rotating cage is rotated；
At least one second partition 23, is arranged in second accommodation space, will be described by the second partition 23
Second accommodation space is divided into multiple rooms for being used to place animal；As shown in figure 1, having 3 second partitions in the second tin roller 2
23, it is of course possible to understanding, the quantity of the second partition 23 is not limited in the present embodiment.
In an embodiment of the present invention, the diameter of the first roller 1 and second tin roller 2 may be configured as 50cm, and length can be set
For 168cm, the first roller 1 and second tin roller 2 can be surrounded by the black metal sheet containing intensive elongated hole.First roller 1 and
There is the door for the formed objects for facilitating opened/closed on the wall of two rollers 2, conveniently pick and place animal.Of course, it should be understood that at this
The specific size of first roller 1 and second tin roller 2 is not limited in the embodiment of invention.
As shown in figure 1, the inside of the first roller 1 and second tin roller 2 is divided into four rooms (each room width 21cm), room with
Separated between room by lighttight ferrous metal dividing plate.Below by taking the first roller 1 as an example：
First rotating shaft 12 can be made of stainless steel tube, and the stainless steel tube can be used as rotating shaft and the first feed pipe 17.Each
It is provided with first feed pipe 17 of room in two apertures, two taps 16 containing double steel balls into 30 ° of angles of connection, tap 16
Between be the bar hole for having wide 0.8cm on a rectangular hamper 14, hamper 14, have a long 18cm in the top of hamper 14, it is wide
9cm anti-baffle plate 18 of lying prone.The tap 16 of hamper 14 and first will not be rolled during the first roller 1 is rotated, and keep origin-location
It is constant, it is static relative to the first roller 1.The bottom of first roller 1 is provided with the long 25cm of boom plate 25 in boom plate 25 in cage, cage, wide
21cm.Of course, it should be understood that not limiting the specific of the tap 16 of hamper 14 and first in an embodiment of the present invention
Structure.
As shown in figure 1, by the way that the first roller 1 and second tin roller 2 are respectively divided into 4 rooms, wherein the first roller 1 and
The animals such as mouse 80~160, the animal such as rat 16~32, it is ensured that Chinese medicine intelligence promoting and tranquilization can be placed in two rollers 2 altogether
Medicine, antianxiety, the pharmacodynamic study of antidepressants are to the demand of sample size.
In an embodiment of the present invention, first rotating cage 11 includes：First rotating cage wall 111, and it is separately positioned on institute
State the first baffle 112 and second baffle 113 at the two ends of the first rotating cage wall 111；
Second rotating cage 21 includes：Second rotating cage wall 211, and it is separately positioned on the two of the second rotating cage wall 211
The third baffle 212 and fourth gear plate 213 at end.
In an embodiment of the present invention, the supply arrangement includes：For supplying the animal diet followed in first roller 1
First supply structure of drinking-water and the second supply structure for supplying the drinking-water of the animal diet followed in the second tin roller 2, wherein
First supply structure includes：
Hamper 14 for supplying animal food, hamper 14 is arranged in first accommodation space；
The first water bottle 15 for storing water, the first water bottle 15 is arranged on outside first rotating cage 11；
First tap 16, is connected by the first feed pipe 17 with first water bottle 15, and first tap 16 is set
Put in first accommodation space；
Second supply structure includes：
The second water bottle 24 for storing water, is arranged on outside second rotating cage 21；
Second tap, is connected by the second feed pipe 29 with second water bottle, and second tap is arranged on institute
State in the second accommodation space.
In an embodiment of the present invention, first supply structure is rotated with the first rotating shaft and is connected, and described first supplies
To structure first roller 1 rotate during it is static relative to first roller 1；
Second supply structure is connected with second axis of rotation, and second supply structure is in the second tin roller
It is static relative to the second tin roller 2 during 2 rotations.
In an embodiment of the present invention, the top of hamper 14 is provided with anti-baffle plate 18 of lying prone, to prevent animal in hamper 14
Upper rest.
In an embodiment of the present invention, the lower section of first roller 1 and the second tin roller 2 is provided with reception animal row
Let out the waste collection box 19 of thing.One end of the waste collection box 19 is provided with waste baffle plate 20.
In an embodiment of the present invention, power-equipment 21 is by the cooperation of the belt wheel 32 on the roller 1 of timing belt 31 and first,
The first roller 1 is driven to rotate.The power-equipment 21 includes：Drive motor that the multiple roller is rotated and regulation motor speed
Decelerator.The left side of first roller 1 is provided with touching switch, to spread out of meter ring signal and random direction turn signal from
And perform " roll and stop " order and rotation direction order that control device is given in a particular mode.
In an embodiment of the present invention, boom plate 25 is used for animal in modelling intermittent phase or AD HOC " rolling in cage
The rest of dynamic stopping " phase.
In an embodiment of the present invention, the control device includes：
Housing；
Circuit board for controlling the control device operation, is arranged in the housing；
For the display panel for the parameters for showing experiment in real time, it is connected with the circuit board；
Control panel for inputting control signal, is connected with the circuit board.
In an embodiment of the present invention, the parameters tested in real time are shown on display panel, such as rotating speed is turn-taked, stopped
Breath time, experimental period.
In an embodiment of the present invention, the first roller 1 can be adjusted at any time on the control panel of control device as needed
With the velocity of rotation of second tin roller 2, from different parameter combinations (rotating speed, turn-takes, time of having a rest and experimental period) to animal
Sleep interference strength is carried out different, so as to reach different modeling purposes；Once carry out a large amount of (mouse 160 of sleep interference animal
Only, rat 32), suitable for pharmacodynamic study；Animal can stay on boom plate and rest during roller is not rolled, and reduce motion band
The influence that stress be to sleep come；Animal is in the fixation hamper of each drums inside and two taps containing double pearls
Free water diet；Stability of instrument is high, and experimentation is kept an eye on without personnel；Sleep interference reliable results, degree is easily grasped；Control
Control equipment panel operation is simple, easily grasps.
Referring to Fig. 1~2, in embodiments of the present invention, control device controlled motor and the drive of decelerator 30 can hold animal
The first roller 1 and second tin roller 2 rotate.First roller 1 and second tin roller 2 are surrounded by the black metal sheet containing air-vent 27,
The locular wall of first roller 1 and second tin roller 2 has a door for the formed objects for facilitating opened/closed, and inside is divided into four rooms, room with
Separated between room by lighttight black metal sheet, it is ensured that do not interfere with each other between group and group.Below by taking second tin roller 2 as an example：The
The second rotating shaft 22 in two rollers 2 can serve as the stainless steel tube of the axis of rolling and the second feed pipe 29.There are into 30 ° of angles each room
Tap containing double steel balls is opened on the second feed pipe 29, and there is boom plate 25 in the cage rested for animal lower section.First roller 1 and
There is timing belt 31 centre of two rollers 2 so as to drive the synchronous axial system of the first roller 1 and second tin roller 2 by belt wheel 32, the
The side of two rollers 2 has the second drinking bottle 24 to be used to supply water, and there is a water valve 26 that unlatching/closing is supplied water lower section, second tin roller 2 it is another
There is the air bleeding valve 28 for discharging gas in the second water pipe 25 side.There is waste collection box first roller 1 and the lower section of second tin roller 2
19, the surrounding of waste collection box 19 has waste baffle plate 21 to prevent waste splashes.Under the centre of first roller 1 and second tin roller 2
Side is provided with motor and decelerator 30, and it is connected with control device 23, and control device 23 sets sleep interference experiment program and ginseng
Number, is received and processing meter ring signal and random direction turn signal, send rotating speed, turn-take, the time of having a rest, experimental period instruction,
Show experiment process.
Referring to Fig. 2, in an embodiment of the present invention, control device can detect the circle that the first roller and second tin roller are rotated
Number, and the direction rotated, the control device also include keyboard, main menu can be shown on the display panel of the control device,
The main menu includes control menu and sets menu, wherein control menu includes beginning and end, sets menu to include：Rotating speed is set
Put, setting of turn-taking, the time of having a rest set and experimental period set.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (9)
1. a kind of big mice sleep interferometer, it is characterised in that including：
Multiple rollers, have boom plate in the cage rested for animal in the inside of the multiple roller, in the multiple roller respectively
It is provided with the supply arrangement of supply animal diet followed drinking-water；
The power-equipment for driving the multiple roller to rotate；And
Control device for inputting from control signal to the power-equipment, the multiple roller is controlled by inputting control signal
Velocity of rotation, the control device is connected with the power-equipment；
The multiple roller includes：First roller and second tin roller, wherein
First roller includes：
First rotating cage, with the first accommodation space；
First rotating shaft, is connected with the power-equipment, and the power-equipment drives first rotating cage to rotate by first rotating shaft；
At least one first dividing plate, is arranged in first accommodation space, is housed by first dividing plate by described first
Space is divided into multiple the first Room for being used to place animal；
Second tin roller includes：
Second rotating cage, with the second accommodation space；
Second rotating shaft, is connected with the power-equipment, and the power-equipment drives second rotating cage to rotate by the second rotating shaft；
At least one second partition, is arranged in second accommodation space, is housed by the second partition by described second
Space is divided into multiple second Rooms for being used to place animal.
2. big mice sleep interferometer according to claim 1, it is characterised in that the big mice sleep interferometer is also wrapped
Include：Synchronous rotary mechanism, the power-equipment drives the multiple roller synchronous axial system by the synchronous rotary mechanism.
3. big mice sleep interferometer according to claim 1, it is characterised in that first rotating cage includes：First turn
Cage wall, and it is separately positioned on the first baffle and second baffle at the two ends of the first rotating cage wall；
Second rotating cage includes：Second rotating cage wall, and it is separately positioned on the third baffle at the two ends of the second rotating cage wall
With fourth gear plate.
4. big mice sleep interferometer according to claim 1, it is characterised in that the supply arrangement includes：For supplying
To the first supply structure of the animal diet followed drinking-water in first roller and for supplying the drink of the animal in the second tin roller
The second supply structure of drinking-water is eaten, wherein
First supply structure includes：
Hamper for supplying animal food, is arranged in first accommodation space；
The first water bottle for storing water, is arranged on outside first rotating cage；
First tap, is connected by the first feed pipe with first water bottle, and first tap is arranged on described first
In accommodation space；
Second supply structure includes：
The second water bottle for storing water, is arranged on outside second rotating cage；
Second tap, is connected by the second feed pipe with second water bottle, and second tap is arranged on described second
In accommodation space.
5. big mice sleep interferometer according to claim 4, it is characterised in that first supply structure and described the
One axis of rotation is connected, and first supply structure is static relative to first roller during first roller is rotated；
Second supply structure is connected with second axis of rotation, and second supply structure is rotated in the second tin roller
Period is static relative to the second tin roller.
6. big mice sleep interferometer according to claim 4, it is characterised in that anti-gear of lying prone is provided with above the hamper
Plate.
7. big mice sleep interferometer according to claim 1, it is characterised in that first roller and second rolling
The lower section of cylinder is provided with the waste collection box for receiving animal excrements.
8. big mice sleep interferometer according to claim 1, it is characterised in that the control device includes：
Housing；
Circuit board for controlling the control device operation, is arranged in the housing；
For the display panel for the parameters for showing experiment in real time, it is connected with the circuit board；
Control panel for inputting control signal, is connected with the circuit board.
9. big mice sleep interferometer according to claim 1, it is characterised in that the power-equipment includes：Drive institute
State multiple rollers motor rotated and the decelerator for adjusting the motor speed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210356645.XA CN102919141B (en) | 2012-09-24 | 2012-09-24 | Big mice sleep interferometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210356645.XA CN102919141B (en) | 2012-09-24 | 2012-09-24 | Big mice sleep interferometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102919141A CN102919141A (en) | 2013-02-13 |
| CN102919141B true CN102919141B (en) | 2017-09-22 |
Family
ID=47634192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210356645.XA Expired - Fee Related CN102919141B (en) | 2012-09-24 | 2012-09-24 | Big mice sleep interferometer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102919141B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623491B (en) * | 2013-11-07 | 2015-10-07 | 同济大学附属第十人民医院 | A kind of animal sleep deprivation device and application thereof |
| CN105875423B (en) * | 2016-04-29 | 2019-01-15 | 湖北佳境生物科技有限责任公司 | Mice sleep FCS functional check-out set and method |
| CN106614102B (en) * | 2017-01-24 | 2022-07-12 | 中国农业科学院蜜蜂研究所 | Experimental device for simulating influence of automobile transportation on bees |
| CN109699506A (en) * | 2019-01-23 | 2019-05-03 | 浙江中医药大学 | A kind of rats and mice sleep deprivation equipment |
| CN111345824B (en) * | 2020-04-28 | 2020-08-11 | 苏州大学 | Rotating rod fatigue testing device and testing method |
| CN113424772B (en) * | 2021-06-18 | 2024-10-01 | 李鹏军 | Animal sleep deprivation device |
| CN118120647B (en) * | 2024-04-08 | 2024-11-01 | 山东大学 | Experimental device and method for rodent sleep deprivation and running intervention |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201591058U (en) * | 2010-01-19 | 2010-09-29 | 中国人民解放军第四军医大学 | Mouse sleep depriving device for medical experiment |
| CN201775854U (en) * | 2010-07-30 | 2011-03-30 | 淮北正华生物仪器设备有限公司 | Sleep deprivation device |
| CN201797870U (en) * | 2010-08-03 | 2011-04-20 | 张步芳 | White rat sleep deprivation device |
| CN201797869U (en) * | 2010-07-28 | 2011-04-20 | 张步芳 | Sleep deprivation device for white rats |
| CN201807057U (en) * | 2009-07-22 | 2011-04-27 | 李雁鹏 | Design and application of novel experimental equipment for sleep deprivation of rat |
| CN201957556U (en) * | 2011-03-10 | 2011-09-07 | 佳木斯大学 | Multifunctional rat sleep deprivation box based on platform water environment method |
| CN102334464A (en) * | 2010-07-28 | 2012-02-01 | 张步芳 | Sleep deprivation device for white mice |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2938366B1 (en) * | 2008-11-12 | 2010-12-03 | Univ Joseph Fourier | DEVICE FOR THE STUDY OF SLEEP DISTURBANCES ON LABORATORY ANIMALS |
-
2012
- 2012-09-24 CN CN201210356645.XA patent/CN102919141B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201807057U (en) * | 2009-07-22 | 2011-04-27 | 李雁鹏 | Design and application of novel experimental equipment for sleep deprivation of rat |
| CN201591058U (en) * | 2010-01-19 | 2010-09-29 | 中国人民解放军第四军医大学 | Mouse sleep depriving device for medical experiment |
| CN201797869U (en) * | 2010-07-28 | 2011-04-20 | 张步芳 | Sleep deprivation device for white rats |
| CN102334464A (en) * | 2010-07-28 | 2012-02-01 | 张步芳 | Sleep deprivation device for white mice |
| CN201775854U (en) * | 2010-07-30 | 2011-03-30 | 淮北正华生物仪器设备有限公司 | Sleep deprivation device |
| CN201797870U (en) * | 2010-08-03 | 2011-04-20 | 张步芳 | White rat sleep deprivation device |
| CN201957556U (en) * | 2011-03-10 | 2011-09-07 | 佳木斯大学 | Multifunctional rat sleep deprivation box based on platform water environment method |
Non-Patent Citations (1)
| Title |
|---|
| 睡眠干扰所致动物步态行为的改变;金剑等;《中国药理学与毒理学杂志》;20120615;第450页右栏倒数第13行-最后1行 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102919141A (en) | 2013-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102919141B (en) | Big mice sleep interferometer | |
| CN206549687U (en) | A kind of medical test test tube storing unit | |
| CN108404161A (en) | A kind of medical ward movable thimerosal spray appliance | |
| CN203629988U (en) | Improved rock slake durability tester | |
| CN104089888B (en) | Fast and accurate beef quality detection system and method | |
| CN106290735A (en) | A kind of experimental provision for measuring liquid-liquid transfer coefficient | |
| CN207181449U (en) | A kind of chip pin detection fixing device | |
| CN203968862U (en) | A kind of automatics of supplying with for regulating plant growth process moisture | |
| CN203206905U (en) | Animal motion sickness induction device | |
| CN106981240A (en) | A kind of middle school student's physical experiment apparatus | |
| CN104361791B (en) | A kind of Coriolis acceleration demonstrator | |
| CN104089893B (en) | beef quality detection system and method | |
| CN105457166A (en) | Electromagnetic endocrine nursing instrument | |
| Iacono et al. | Perception of bar velocity loss in resistance exercises: accuracy across loads and velocity loss thresholds in the bench press | |
| CN208274396U (en) | A kind of instruction case convenient to use | |
| CN109448509A (en) | A kind of College Maths demonstration device for probability | |
| CN209504167U (en) | Mechanical arm counter weight device and system | |
| CN204865908U (en) | Chemical laboratory table | |
| CN208937581U (en) | A kind of detection device of Soil Environmental Pollution distribution situation | |
| CN108661847A (en) | A kind of water flow generator of detectable water quality | |
| CN209346999U (en) | Touch detection equipment based on volume | |
| CN106361344A (en) | High-integration college student psychology testing and treating system | |
| CN206920211U (en) | A kind of device for microorganism in food assay | |
| CN207996288U (en) | A kind of emetic instrument of paraquat poisoning of adjustable dynamics | |
| CN207570823U (en) | It is a kind of can Stratified Sampling earth pillar leaching device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170922 Termination date: 20190924 |