CN102907673B - Health-care food composition with auxiliary function of protecting gastric mucosa and preparation method of composition - Google Patents
Health-care food composition with auxiliary function of protecting gastric mucosa and preparation method of composition Download PDFInfo
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- CN102907673B CN102907673B CN201210415948.4A CN201210415948A CN102907673B CN 102907673 B CN102907673 B CN 102907673B CN 201210415948 A CN201210415948 A CN 201210415948A CN 102907673 B CN102907673 B CN 102907673B
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Abstract
The invention discloses a health-care food composition with the auxiliary function of protecting gastric mucosa and a preparation method of the composition. The health-care food composition comprises the extracts of following medical components: salvia, salep, aucklandia root, villous amomum, alpinia officinarum, rhizoma cyperi, lily bulb and fingered citron. The invention further comprises the preparation method of the health-care food composition. The animal experiments show that the health-care food composition has the auxiliary function of protecting gastric mucosa and has no toxic and side effects.
Description
Technical field
The present invention relates to a kind of health-care food composition that stomach lining is had to assistant protection function and preparation method thereof, belong to field of health care food.
Background technology
Mucosal lesion is clinical common disease; modern medicine is thought that this disease is by the invasion and attack factor of stomach lining and protection factor is unbalance and is caused; invasion and attack factor mainly contains acid, alkali, ethanol, cholate, helicobacter pylori, acute bleeding, spiritual stress reaction, drug abuse etc., and protection factor mainly refers to the protection repair of stomach lining self.At present the medicine aspect gastric mucosal protection has containing aluminium porcelain enamelling (as ulcerlmin, aluminium hydroxide, magaldrate, SIDASHU, only pacify woods, lucky stomach happy etc.), bismuth agent (as CBS, Li Zhu get Le, colloidal bismmth pectin, Bitnal, stomach must be happy, get Bi Tai etc.), H
2receptor antagonist (thunderous miaow is for fourth, ranitidine, famotidine etc.); containing zinc preparation (as licorzinc, acexamic acid zinc etc.); derivatives of prostaglandins (as grace prostatitis alcohol, Misoprostol etc.); proton pump inhibitor (as Omeprazole, Lansoprazole etc.); anti-HP medicine, other also have sanodin, selbex see teprenone, Xin Luowei and numerous mucosa protective agent (as dioctahedral smectite, Marzulene-S Granules etc.).Above preparation is for dissimilar mucosal lesion, and effect is fast, but have cure the symptoms, not the disease, toxic and side effect is large, the high shortcoming of recurrence rate after drug withdrawal.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of health-care food composition that stomach lining is had to assistant protection function.
The health-care food composition that stomach lining is had to assistant protection function of the present invention, the extract that contains following effective component: the red sage root, bletilla, the banksia rose, fructus amomi, galangal, rhizoma cyperi, lily and Buddha's hand.
Preferably, the above-mentioned health-care food composition that stomach lining is had to assistant protection function, the parts by weight of each effective component are as follows:
The red sage root 2200 ~ 2800;
Bletilla 1200 ~ 1800;
The banksia rose 1200 ~ 1800;
Fructus amomi 1200 ~ 1800;
Galangal 1700 ~ 2300;
Rhizoma cyperi 1700 ~ 2300;
Lily 1700 ~ 2300;
Buddha's hand 1200 ~ 1800.
Further preferably, above-mentioned stomach lining is had to the health-care food composition of assistant protection function is granule, also contains the composition of following parts by weight: starch 1200 ~ 1800; Sucrose 2000 ~ 3000.
Preferably, the above-mentioned health-care food composition that stomach lining is had to assistant protection function, the parts by weight of each effective component are as follows:
The red sage root 2500;
Bletilla 1500;
The banksia rose 1500;
Fructus amomi 1500;
Galangal 2000;
Rhizoma cyperi 2000;
Lily 2000;
Buddha's hand 1500.
Further, above-mentioned stomach lining is had to the health-care food composition of assistant protection function is granule, also contains the composition of following parts by weight: starch 1500; Sucrose 2500.
The present invention also provides the above-mentioned preparation method who stomach lining is had to the health-care food composition of assistant protection function; comprise the steps: to extract the extract of each effective component: Salvia root P.E, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract, Bulbus Lilii extract and Fructus Citri Sarcodactylis extract; mix, be prepared into capsule, particle, tablet or pulvis with pharmaceutically acceptable carrier or auxiliary material.
The present invention separately provides a kind of above-mentioned preparation method who stomach lining is had to the health-care food composition of assistant protection function; comprise the steps: to extract the extract of each described amount effective component: Salvia root P.E, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract, Bulbus Lilii extract, Fructus Citri Sarcodactylis extract; starch and sucrose mix; add ethanol water; stir softwood processed, gained soft material granulation; dry, whole grain.
Wherein, the extraction process of the extract of each effective component is as follows:
Red sage root extraction process: the red sage root with ethanol water refluxing extraction after, the dregs of a decoction are again with water boiling and extraction, merge extract, concentrated, dry, obtain Salvia root P.E;
The merging extraction process of bletilla and lily: bletilla and lily heating and refluxing extraction in water, extract 50 ~ 70 DEG C of temperature, extract is concentrated, dry, obtains the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract;
The merging extraction process of the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand: the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand are added to the water to decoct extracts, extract is concentrated, dry, obtains the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
Wherein, the extraction process of each extract is preferably as follows:
1) extraction process of the red sage root: the ethanol water of a. concentration of volume percent 85 ~ 95% extracts: the red sage root is added in the ethanol water of concentration of volume percent 85 ~ 95 % of 2 ~ 4 times of its weight to refluxing extraction 1 ~ 2 hour, extract filters, obtain extract 1, for subsequent use; The ethanol water of b, concentration of volume percent 45 ~ 60 % extracts: in the dregs of a decoction of step a, add the ethanol water heating and refluxing extraction 1 ~ 2 hour of concentration of volume percent 45 ~ 60 % of 4 ~ 7 times of its weight, extract filters, and obtains extract 2, for subsequent use; C, water extraction are got: the decocting that adds 2 ~ 5 times of its weight in the dregs of a decoction of step b boils 1 ~ 3 hour, and decocting liquid filters, and obtains extract 3, for subsequent use; D, concentrated: merge extract 1,2,3, decompression recycling ethanol, concentrated; E, dry, pulverize, cross 80 mesh sieves, obtain Salvia root P.E;
2) the merging extraction process of bletilla and lily: a, water extraction are got: to the water that adds 10 ~ 15 times of its gross weights in bletilla and lily, heating and refluxing extraction 2 ~ 4 times, the time is respectively 1 ~ 4 h, and extracting temperature is 50 ~ 70 DEG C, and extract filters, for subsequent use; B, concentrated: merge said extracted liquid, reduced pressure concentration; C, dry, pulverize, cross 80 mesh sieves, obtain the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract;
3) the merging extraction process of the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand: a, water extraction are got: to the water that adds 8 ~ 13 times of its gross weights in the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand, boil, 8 ~ 10 h, extract filters, for subsequent use; B, concentrated, dry, pulverize, cross 80 mesh sieves, obtain the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
Health-care food composition of the present invention has has assistant protection function function to stomach lining, without any side effects, and composition is clear and definite, and steady quality is easy to control, and stomach lining is had to auxiliary protection function.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, can be implemented, but illustrated embodiment is not as a limitation of the invention so that those skilled in the art can better understand the present invention also.
The invention provides a kind of health-care food composition that stomach lining is had to assistant protection function, the extract that contains following effective component: the red sage root, bletilla, the banksia rose, fructus amomi, galangal, rhizoma cyperi, lily and Buddha's hand.
Motherland's medical science thinks that mucosal lesion belongs to " epigastric pain " category, mainly, overstrain irregular by disorder of emotion, diet causes, can be divided into clinically the different disease types such as damp and hot middle resistance, liver-qi attacking stomach, syndrome of liver-stomach heat, hemostasis stagnation, stomach-Yin virtual loss, deficiency-cold in spleen and stomach.Treatment mainly contains the methods such as strengthening the spleen and replenishing qi, soothing liver and harmonizing stomach, promoting blood circulation and removing blood stasis, replenishing the vital essence and removing heat.
The red sage root is bitter, be slightly cold.The thoughts of returning home, Liver Channel.Promoting blood circulation, the cool blood carbuncle that disappears.
Bletilla, bitter, sweet, warm.Return spleen, stomach warp.Strengthening the spleen and replenishing qi.
The banksia rose, acrid, bitter, warm.Return spleen, stomach, large intestine channel.Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.
Fructus amomi, pungent, warm.Return spleen, stomach, kidney channel.Dampness elimination appetizing, warm spleen is regulated the flow of vital energy.In health-care food composition of the present invention, it can protect stomach lining, promotes stomach and intestine function, and pain relieving, antidiarrheal promote the secretion of digestive juice, get rid of the effects such as digest tube pneumatosis.
Galangal, pungent, heat.Return spleen, stomach warp.Warming stomach for dispelling cold pain relieving.In health-care food composition of the present invention, galangal can reduce the formation of constraint-water logging stress gastric ulcer, and this model serum epidermal growth factor, proleulzin level are had to certain regulating action.
Rhizoma cyperi, pungent, be slightly cold, micro-sweet, flat.Return liver, the spleen channel.Regulating the flow of QI to ease the stomach, soothing liver-qi stagnation.
Lily is sweet, cold.The thoughts of returning home, lung channel.Clearing away the heart fire and tranquillizing, Yin nourishing and lung moistening.
Buddha's hand, pungent, hardship, acid, temperature.Return liver, spleen, stomach, lung channel.And stomach and alleviating pain, the eliminating dampness of regulating the flow of vital energy.
Preferably, the health-care food composition of above-mentioned protection stomach lining and renovating tummy mucous membrane damage, the parts by weight of above-mentioned effective component:
The red sage root 2200 ~ 2800;
Bletilla 1200 ~ 1800;
The banksia rose 1200 ~ 1800;
Fructus amomi 1200 ~ 1800;
Galangal 1700 ~ 2300;
Rhizoma cyperi 1700 ~ 2300;
Lily 1700 ~ 2300;
Buddha's hand 1200 ~ 1800.
Wherein the extraction process of each extract can be common process, is preferably as follows:
1) extraction process of the red sage root: the ethanol water of a. concentration of volume percent 85 ~ 95% extracts: the red sage root is added in the ethanol water of concentration of volume percent 85 ~ 95 % of 2 ~ 4 times of its weight to refluxing extraction 1 ~ 2 hour, extract filters, obtain extract 1, for subsequent use; The ethanol water of b, concentration of volume percent 45 ~ 60 % extracts: in the dregs of a decoction of step a, add the ethanol water heating and refluxing extraction 1 ~ 2 hour of concentration of volume percent 45 ~ 60 % of 4 ~ 7 times of its weight, extract filters, and obtains extract 2, for subsequent use; C, water extraction are got: the decocting that adds 2 ~ 5 times of its weight in the dregs of a decoction of step b boils 1 ~ 3 hour, and decocting liquid filters, and obtains extract 3, for subsequent use; D, concentrated: merge extract 1,2,3, decompression recycling ethanol, concentrated; E, dry, pulverize, cross 80 mesh sieves, obtain Salvia root P.E;
2) the merging extraction process of bletilla and lily: a, water extraction are got: to the water that adds 10 ~ 15 times of its gross weights in bletilla and lily, heating and refluxing extraction 2 ~ 4 times, the time is respectively 1 ~ 4 h, and extracting temperature is 50 ~ 70 DEG C, and extract filters, for subsequent use; B, concentrated: merge said extracted liquid, reduced pressure concentration; C, dry, pulverize, cross 80 mesh sieves, obtain the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract;
3) the merging extraction process of the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand: a, water extraction are got: to the water that adds 8 ~ 13 times of its gross weights in the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand, boil, 8 ~ 10 h, extract filters, for subsequent use; B, concentrated, dry, pulverize, cross 80 mesh sieves, obtain the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
Health-care food composition of the present invention is not limited by formulation, can be made into multiple formulation, as: capsule, particle, tablet and pulvis etc.
By following preferred embodiment, the present invention is further described:
Embodiment 1 granule
The present embodiment stomach lining is had to the health-care food composition of assistant protection function, the extract that contains effective component and auxiliary material, specifically made by the raw material of following parts by weight:
The red sage root 2500;
Bletilla 1500;
The banksia rose 1500;
Fructus amomi 1500;
Galangal 2000;
Rhizoma cyperi 2000;
Lily 2000;
Buddha's hand 1500;
Starch 1500;
Sucrose 2500.
Preparation method is:
(1) red sage root extraction process
1), 95% alcohol extract
In the red sage root, add 95% ethanol (concentration of volume percent the is 95% ethanol water) heating and refluxing extraction 1.5 hours of its 3 times of weight, extract filters, and obtains extract 1, for subsequent use.
2), 50% alcohol extract
50% alcohol heating reflux that the dregs of a decoction add 5 times of weight extracts 1.5 hours, and extract filters, and obtains extract 2, for subsequent use.
3), water extraction is got
The decocting that the dregs of a decoction add 3 times of weight boils 2 hours, and decocting liquid filters, and obtains extract 3, for subsequent use.
4), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
5), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
6), pulverize, sieve
Pulverize, cross 80 mesh sieves, obtain Salvia root P.E.
(2) merging of bletilla and lily is extracted
1), water extraction is got
In bletilla and lily, add the water of 12 times of its gross weights, heating and refluxing extraction 3 times, the time is respectively 3h, 2h, 2h, and extracting temperature is 60 degree, and extract filters, for subsequent use.(that is, add the water of 12 times of its gross weights in bletilla and lily, heating and refluxing extraction 3h, filters, and obtains dregs of a decoction and an extract; It is that in the water of 12 times of bletilla and lily gross weights, heating and refluxing extraction 2h, filters, and obtains the secondary dregs of a decoction and secondary raffinate that dregs of a decoction add weight; It is in the water of 12 times of bletilla and lily gross weights that the secondary dregs of a decoction add weight, heating and refluxing extraction 2h, and three dregs of a decoction and No. three extracts of filtration, extracting temperature is 60 degree, extract merges, and filters, for subsequent use.）
2), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract.
(3) merging of the banksia rose, fructus amomi, galangal, rhizoma cyperi, Buddha's hand is extracted
1), water extraction is got
In the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand, add the water of 10 times of its gross weights, boil and extract 1 time, the time is respectively 10h, and extract filters, for subsequent use.
2), concentrated
Extract reduced pressure concentration, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
(4) mix, granulate
Sucrose was pulverized 80 mesh sieves, and starch is crossed 80 mesh sieves.
Get each extract, starch, sucrose and jointly mix 30 minutes, add 70% ethanolic solution, stir 10 minutes, softwood processed, gained softwood 16 orders are granulated.
(5) whole grain
60 DEG C of wet granulars are dry, and the whole grain of dry particle 14 orders of gained, packs and get final product.
Specification: 6g/ bag.
Suitable crowd: slight mucosal lesion person.
Eating method and amount: Instant Drinks, every day 2 times, each 1 bag.
Embodiment 2 granules
The present embodiment stomach lining is had to the health-care food composition of assistant protection function, the extract that contains effective component and auxiliary material, specifically made by the raw material of following parts by weight:
The red sage root 2200;
Bletilla 1800;
The banksia rose 1200;
Fructus amomi 1800;
Galangal 1700;
Rhizoma cyperi 2300;
Lily 1700;
Buddha's hand 1800;
Starch 1200;
Sucrose 3000.
Preparation method is:
(1) red sage root extraction process
1), 95% alcohol extract
In the red sage root, add 95% ethanol (concentration of volume percent the is 95% ethanol water) heating and refluxing extraction 1.5 hours of its 3 times of weight, extract filters, and obtains extract 1, for subsequent use.
2), 50% alcohol extract
50% alcohol heating reflux that the dregs of a decoction add 5 times of weight extracts 1.5 hours, and extract filters, and obtains extract 2, for subsequent use.
3), water extraction is got
The decocting that the dregs of a decoction add 3 times of weight boils 2 hours, and decocting liquid filters, and obtains extract 3, for subsequent use.
4), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
5), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
6), pulverize, sieve
Pulverize, cross 80 mesh sieves, obtain Salvia root P.E.
(2) merging of bletilla and lily is extracted
1), water extraction is got
In bletilla and lily, add the water of 12 times of its gross weights, heating and refluxing extraction 3 times, the time is respectively 3h, 2h, 2h, and extracting temperature is 60 degree, and extract filters, for subsequent use.
2), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract.
(3) merging of the banksia rose, fructus amomi, galangal, rhizoma cyperi, Buddha's hand is extracted
1), water extraction is got
In the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand, add the water of 10 times of its gross weights, boil and extract 1 time, the time is respectively 10h, and extract filters, for subsequent use.
2), concentrated
Extract reduced pressure concentration, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
(4) mix, granulate
Sucrose was pulverized 80 mesh sieves, and starch is crossed 80 mesh sieves.
Get each extract, starch, sucrose and jointly mix 30 minutes, add 70% ethanolic solution, stir 10 minutes, softwood processed, gained softwood 16 orders are granulated.
(5) whole grain
60 DEG C of wet granulars are dry, and the whole grain of dry particle 14 orders of gained, packs and get final product.
Specification: 6g/ bag.
Suitable crowd: slight mucosal lesion person.
Eating method and amount: Instant Drinks, every day 2 times, each 1 bag.
Embodiment 3 granules
The red sage root 2800;
Bletilla 1200;
The banksia rose 1800;
Fructus amomi 1200;
Galangal 2300;
Rhizoma cyperi 1700;
Lily 2300;
Buddha's hand 1200;
Starch 1800;
Sucrose 2700.
Preparation method is:
(1) red sage root extraction process
1), 95% alcohol extract
In the red sage root, add 95% ethanol (concentration of volume percent the is 95% ethanol water) heating and refluxing extraction 1.5 hours of its 3 times of weight, extract filters, and obtains extract 1, for subsequent use.
2), 50% alcohol extract
50% alcohol heating reflux that the dregs of a decoction add 5 times of weight extracts 1.5 hours, and extract filters, and obtains extract 2, for subsequent use.
3), water extraction is got
The decocting that the dregs of a decoction add 3 times of weight boils 2 hours, and decocting liquid filters, and obtains extract 3, for subsequent use.
4), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
5), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
6), pulverize, sieve
Pulverize, cross 80 mesh sieves, obtain Salvia root P.E.
(2) merging of bletilla and lily is extracted
1), water extraction is got
In bletilla and lily, add the water of 12 times of its gross weights, heating and refluxing extraction 3 times, the time is respectively 3h, 2h, 2h, and extracting temperature is 60 degree, and extract filters, for subsequent use.
2), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract.
(3) merging of the banksia rose, fructus amomi, galangal, rhizoma cyperi, Buddha's hand is extracted
1), water extraction is got
In the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand, add the water of 10 times of its gross weights, boil and extract 1 time, the time is respectively 10h, and extract filters, for subsequent use.
2), concentrated
Extract reduced pressure concentration, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
(4) mix, granulate
Sucrose was pulverized 80 mesh sieves, and starch is crossed 80 mesh sieves.
Get each extract, starch, sucrose and jointly mix 30 minutes, add 70% ethanolic solution, stir 10 minutes, softwood processed, gained softwood 16 orders are granulated.
(5) whole grain
60 DEG C of wet granulars are dry, and the whole grain of dry particle 14 orders of gained, packs and get final product.
Specification: 6g/ bag.
Suitable crowd: slight mucosal lesion person.
Eating method and amount: Instant Drinks, every day 2 times, each 1 bag.
Embodiment 4 tablets
The red sage root 2500;
Bletilla 1500;
The banksia rose 1500;
Fructus amomi 1500;
Galangal 2000;
Rhizoma cyperi 2000;
Lily 2000;
Buddha's hand 1500;
Starch 400;
Lactose 500;
Dolomol 26.
Preparation method is:
(1) red sage root extraction process
1), 95% alcohol extract
In the red sage root, add 95% ethanol (concentration of volume percent the is 95% ethanol water) heating and refluxing extraction 1.5 hours of its 3 times of weight, extract filters, and obtains extract 1, for subsequent use.
2), 50% alcohol extract
50% alcohol heating reflux that the dregs of a decoction add 5 times of weight extracts 1.5 hours, and extract filters, and obtains extract 2, for subsequent use.
3), water extraction is got
The decocting that the dregs of a decoction add 3 times of weight boils 2 hours, and decocting liquid filters, and obtains extract 3, for subsequent use.
4), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
5), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
6), pulverize, sieve
Pulverize, cross 80 mesh sieves, obtain Salvia root P.E.
(2) merging of bletilla and lily is extracted
1), water extraction is got
In bletilla and lily, add the water of 12 times of its gross weights, heating and refluxing extraction 3 times, the time is respectively 3h, 2h, 2h, and extracting temperature is 60 degree, and extract filters, for subsequent use.
2), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract.
(3) merging of the banksia rose, fructus amomi, galangal, rhizoma cyperi, Buddha's hand is extracted
1), water extraction is got
In the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand, add the water of 10 times of its gross weights, boil and extract 1 time, the time is respectively 10h, and extract filters, for subsequent use.
2), concentrated
Extract reduced pressure concentration, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3.
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%.
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
(4) mix, granulate
Sucrose was pulverized 80 mesh sieves, and starch is crossed 80 mesh sieves.
Get each extract, starch, lactose and jointly mix 30 minutes, add 70% ethanolic solution, stir 10 minutes, softwood processed, gained softwood 16 orders are granulated.
(5) whole grain
60 DEG C of wet granulars are dry, the whole grain of dry particle 14 orders of gained
(6) always mixed
Dry particle and dolomol be mixed 5min always, and compressing tablet, to obtain final product.
Specification: 0.8g/ sheet.
Suitable crowd: slight mucosal lesion person.
Eating method: every day 2 times, each 4.
Embodiment 5 compliance test result experiments
Below study auxiliary protection function and the edible safety (according to " health food inspection and assessment technique specification (2003 edition) " content test) of health-care food composition of the present invention to stomach lining.
Acute toxicity test
1. sample: by the sample that described in embodiment 1 prepared by formula and technique.
2. animal used as test: SPF level Kunming mouse.
3. its mouse oral acute toxicity test (MTD): select 20 of 18～22 grams of SPF level Kunming mouses, male and female half and half, with the dosage per os secondary gavage of 22.5g/kgBW, Continuous Observation 14 days after administration.Record poisoning manifestations and death condition.
4. acute toxicity test: with the mouse of two kinds of sexes of dosage gavage of 22.5g/kgBW, observe 14 days.Experimental session has no obvious poisoning manifestations, and in the observation period, nothing is dead.The acute oral toxicity (MTD) of the mouse of tested material to two kinds of sexes is all greater than 22.5g/kgBW, according to " toxicological evaluation of food safety procedure and method " (version in 2003) acute toxicity classification, belongs to nontoxic level.
The acute toxicity tests of mouse
30 days feeding trials
1. sample: by the sample that described in embodiment 1 prepared by formula and technique.People intend with dosage be 12g/60kgBW day, amount to edible raw material 4g/60kg.BW.
2. animal used as test: select body weight 60～80g, 80 of SD rats, male and female half and half.
3. test method: dosage is designed to: 1.667,3.334,6.668g/kgBW(is equivalent to respectively people and intends 25 times, 50 times, 100 times with dosage).Rat is divided into three tested material groups and control group at random, 20 every group, male and female half and half.Control group is fed and is raised arm's length basis piece material, and tested material group is fed to raise and mixed various dose sample.Continuous Observation 30 days.
4. observation index and result
4.1 ordinary circumstances are observed:
Observe performance, behavior, toxicity performance and the death condition of animal every day.Weigh weekly 1 time and twice food intake dose, calculate weekly and total food utilization.The each treated animal of result grows, activity is all normal, without poisoning manifestations and death, each treated animal weekly body weight, body weight recruitment, food-intake and food utilization and the equal no difference of science of statistics of TBW recruitment, food-intake and food utilization (
p>0.05).
4.2 hematological examinations:
Measuring hemoglobin content (Hgb), red blood cell (RBC) and leucocyte (WBC) counting, leukocyte differential count (lymph, monokaryon, neutral grain, have a liking for acid, basophilic).Experiment latter stage, hematological indices was all in range of normal value, each treated animal hemoglobin, red blood cell and white blood cell count(WBC), leukocyte differential count compared with control group equal no difference of science of statistics (
p>0.05).
4.3 Biochemical Indexes:
Measure serum alanine aminotransferase (ALT), aspartate amino transferase (AST), urea nitrogen (BUN), cholesterol (CHO), triglycerides (TG), blood sugar (GLU), total protein (TP), albumin (ALB), creatinine (CRE).Experiment experimental animal in latter stage every biochemical indicator all in range of normal value, each treated animal blood biochemistry index compared with control group equal no difference of science of statistics (
p>0.05).
4.4 gross examination of skeletal muscle and pathologic diagnosis:
Animal is put to death in the dislocation of test cervical vertebra in latter stage, observes each main organs and chest, the change of abdominal cavity general pathology.Take out liver, kidney, spleen, the testis of all animals, weigh and calculate organ coefficient.Take out liver, kidney, spleen, testis (or ovary), stomach and the duodenum of control group and high dose group animal, fix with 12% formalin, histological examination is carried out in FFPE, section, HE dyeing under light microscopic.Each main organs (heart, liver, spleen, lung, kidney, stomach, intestines etc.) is showed no significant pathological change.
Above-mentioned acute toxicity test and 30 days feeding trial results show that this product belongs to nontoxic level, can long-term taking.
Mucosal lesion is had to assistant protection function test
1. sample: by the sample that described in embodiment 1 prepared by formula and technique.People intend with dosage be 12g/60kgBW day, amount to edible raw material 4g/60kg.BW.
2. experimental animal: healthy SD rat, body weight 180～220g, 12 every group.
3. experiment grouping, method and result
3.1 acute gastric mucosal injury modellings
3.1.1 36 of body weight 160 ~ 180 g male SD rats are got in animal used as test grouping, are divided at random 4 groups by the weight of animals, are: (1) negative control group: gavage aqua sterilisa.(2) low dose group: gavage 0333 g/kg.BW tested material.(3) dosage group in: gavage 0.667g/kg.BW tested material.(4) high dose group: gavage 0.999g/kg.BW tested material.Be equivalent to respectively 5 times, 10 times, 15 times with maximum recommended dosage of people.
3.1.2 experimental technique and observation index gastric infusion every day 1 time, continuous 30 d.Weigh weekly 1 time, regulate gavage volume according to body weight.Within the 29th day, start fasting and can't help water 24 h.After the 30th day gavage tested material 1 h, gavage absolute ethyl alcohol 1.0 ml/ only, make acute gastric mucosal injury model again.After 1 h, put to death animal, dissect and get stomach, fix 20 min by 10% formalin, stomach is cut off along greater curvature, clean content, launch stomach lining, with the area of vernier caliper measurement hyperemia and the hemorrhage band of diffuse type.Area and the negative control group of the hyperemia of each dosage group and the hemorrhage band of diffuse type are compared.
3.2 chronic gastric ulcer model methods
3.2.1 50 of body weight 160 ~ 180 g female rats are got in animal used as test grouping, are divided at random 5 groups, each dosage group and the same 3.1.1. of negative control group by body weight
3.2.2 experimental technique and observation index rat fasting 40 h, with the yellow Jackets anesthesia of 36 mg/kg BW, lumbar injection, volume injected is 10 ml/kg BW, sterilization belly cuts abdominal cavity under xiphoid-process, and stomach is pulled out,, sew up the incision in glacial acetic acid 20 μ l/ of stomach lining pylorus place serous coat hemostasis 30% with micro syringe.Every day gastric infusion 1 time, continuous 14 d, weigh weekly 1 time, regulate gavage volume according to body weight.Within the 13rd day, start animal fasting and can't help water 24 h; put to death animal; stomach is got in dissection; fix 20 min by 10% formalin, stomach is cut off along greater curvature, clean content; getting gland area launches to be laid on glass plate; paper using blots moisture in ulcer, measures its area and volume: under the disecting microscope with scale, count the shared number of squares of ulcer, measure the area of ulcer; Blue ink is injected in ulcer with micro syringe, ulcer is filled up to concordant with periphery, read the scale of ink used on micro syringe and be the volume of ulcer.The ulcer area of each dosage group, positive controls and volume and negative control group are compared.
Acute gastric mucosal injury model protection contractile studies (x ± s)
| Group | Initial body weight g | Body weight g after 30 days | Hyperemia and the hemorrhage band area of diffuse type (cm 2) |
| Negative control group | 173.8±5.2 | 266.3±18.5 | 0.92±0.55 |
| Low dose group | 173.6±5.8 | 284.2±14.6﹡ | 0.88±0.38 |
| Middle dosage group | 173.4±4.9 | 284.2±14.6﹡ | 0.53±0.27﹡ |
| High dose group | 173.7±4.8 | 283.7±14.3* | 0.56±0.30﹡ |
* represent with negative control group comparing difference significantly (
p<0.05)
Chronic gastric ulcer model defencive function experimental result (x ± s)
| Group | Initial body weight g | Body weight g after 14 days | Ulcer area (cm 2) | (μ l) for ulcer volume |
| Negative control group | 165.0±3.8 | 203.1±10.2 | 1.93±1.03 | 1.33±0.77 |
| Low dose group | 164.1±3.7 | 266.2±10.1 | 0.61±0.63** | 0.34±0.44** |
| Middle dosage group | 163.7±3.7 | 200.8±10.0 | 0.95±0.86* | 0.62±0.71* |
| High dose group | 163.4±4.1 | 203.0±10.8 | 0.81±0.80* | 0.62±0.59* |
* represent with negative control group comparing difference significantly (
p<0.05), * * represent with negative control group comparing difference highly significant (
p<0.01)
Above-mentioned experimental result shows: one or more dosage groups of tested material and model control group compare, gross examination of skeletal muscle scoring all shows that with histopathologic examination's appraisal result mucosal lesion obviously improves, and can judge that this given the test agent results of animal is positive.Know that by result this health-care food composition has assistant protection function to mucosal lesion.
The health-care food composition of embodiment 2 ~ 4 preparations carries out above-mentioned zoopery equally, and result shows: all have no side effect, and the Mouse Stomach mucosa injury of gastric infusion all obviously improves.Health-care food composition of the present invention truly has assistant protection function to mucosal lesion.
The above embodiment is only the preferred embodiment for absolutely proving that the present invention lifts, and protection scope of the present invention is not limited to this.What those skilled in the art did on basis of the present invention is equal to alternative or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (6)
1. a health-care food composition that stomach lining is had to assistant protection function, is characterized in that, the extract that contains following effective component, and the parts by weight of each effective component are as follows:
The red sage root 2200 ~ 2800;
Bletilla 1200 ~ 1800;
The banksia rose 1200 ~ 1800;
Fructus amomi 1200 ~ 1800;
Galangal 1700 ~ 2300;
Rhizoma cyperi 1700 ~ 2300;
Lily 1700 ~ 2300;
Buddha's hand 1200 ~ 1800;
Wherein,
Red sage root extraction process step is:
1), 95% alcohol extract
95% alcohol heating reflux that adds its 3 times of weight in the red sage root extracts 1.5 hours, and extract filters, and obtains extract 1, for subsequent use;
2), 50% alcohol extract
50% alcohol heating reflux that the dregs of a decoction add 5 times of weight extracts 1.5 hours, and extract filters, and obtains extract 2, for subsequent use;
3), water extraction is got
The decocting that the dregs of a decoction add 3 times of weight boils 2 hours, and decocting liquid filters, and obtains extract 3, for subsequent use;
4), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3;
5), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%;
6), pulverize, sieve
Pulverize, cross 80 mesh sieves, obtain Salvia root P.E;
The merging extraction step of bletilla and lily is:
1), water extraction is got
In bletilla and lily, add the water of 12 times of its gross weights, heating and refluxing extraction 3 times, the time is respectively 3h, 2h, 2h, and extracting temperature is 60 degree, and extract filters, for subsequent use;
2), concentrated
Merge said extracted liquid, decompression recycling ethanol, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3;
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%;
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Pseudobulbus Bletillae (Rhizoma Bletillae) extract and Bulbus Lilii extract;
The merging extraction step of the banksia rose, fructus amomi, galangal, rhizoma cyperi, Buddha's hand is:
1), water extraction is got
In the banksia rose, fructus amomi, galangal, rhizoma cyperi and Buddha's hand, add the water of 10 times of its gross weights, boil and extract 1 time, the time is respectively 10h, and extract filters, for subsequent use;
2), concentrated
Extract reduced pressure concentration, vacuum 0.06Mpa ~ 0.08Mpa, being concentrated into relative density is 1.2 ~ 1.3;
3), dry
Vacuum drying, vacuum 0.08 Mpa～0.1Mpa, below 70 DEG C, is dried to moisture <5%;
4), pulverize, sieve
Pulverize, cross 80 mesh sieves, the mixture of Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract and Fructus Citri Sarcodactylis extract.
2. the health-care food composition that stomach lining is had to assistant protection function according to claim 1, is characterized in that, described health-care food composition is granule, also contains the composition of following parts by weight: starch 1200 ~ 1800; Sucrose 2000 ~ 3000.
3. the health-care food composition that stomach lining is had to assistant protection function according to claim 1, is characterized in that, the parts by weight of each effective component are as follows:
The red sage root 2500;
Bletilla 1500;
The banksia rose 1500;
Fructus amomi 1500;
Galangal 2000;
Rhizoma cyperi 2000;
Lily 2000;
Buddha's hand 1500.
4. the health-care food composition that stomach lining is had to assistant protection function according to claim 3, is characterized in that, described health-care food composition is granule, also contains the composition of following parts by weight: starch 1500; Sucrose 2500.
5. described in claim 1 or 3, stomach lining is had to the preparation method of the health-care food composition of assistant protection function; it is characterized in that; comprise the steps: to extract according to described method the extract of each effective component: Salvia root P.E, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract, Bulbus Lilii extract and Fructus Citri Sarcodactylis extract; mix, be prepared into capsule, particle, tablet or pulvis with pharmaceutically acceptable carrier or auxiliary material.
6. described in claim 2 or 4, stomach lining is had to the preparation method of the health-care food composition of assistant protection function; it is characterized in that; comprise the steps: to extract according to described method the extract of each described amount effective component: Salvia root P.E, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Aucklandiae extract, Fructus Amomi extract, galangal rhizome extract, Rhizoma Cyperi extract, Bulbus Lilii extract, Fructus Citri Sarcodactylis extract; starch and sucrose mix, and add ethanol water, stir; softwood processed; gained soft material granulation, dry, whole grain.
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| EP1388344A1 (en) * | 2002-07-31 | 2004-02-11 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Composition comprising Salvia Miltiorrhizae, Ginseng, Borneol for treating heart disease, and cerebrovascular diseases |
| CN1836719A (en) * | 2005-11-08 | 2006-09-27 | 许景连 | Pharmaceutical composition for treating gastritis, gastric ulcer and duodenal ulcer |
| CN101856476A (en) * | 2009-04-09 | 2010-10-13 | 刘君峰 | Chinese medicament for treating stomachache |
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| EP1388344A1 (en) * | 2002-07-31 | 2004-02-11 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Composition comprising Salvia Miltiorrhizae, Ginseng, Borneol for treating heart disease, and cerebrovascular diseases |
| CN1836719A (en) * | 2005-11-08 | 2006-09-27 | 许景连 | Pharmaceutical composition for treating gastritis, gastric ulcer and duodenal ulcer |
| CN101856476A (en) * | 2009-04-09 | 2010-10-13 | 刘君峰 | Chinese medicament for treating stomachache |
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