CN102895380A - Production process of chronic gastritis-treating tablet - Google Patents

Abstract

The invention relates to a production process of a chronic gastritis-treating tablet. The production process is characterized by comprising an extracting step and a preparation step, wherein the extracting step comprises the following specific steps of: picking each medicinal material, and weighing coptis root and medicinal evodia fruit according to parts by weight; removing impurities, molded substances and moth-eaten substances in the coptis root and medicinal evodia fruit; and weighing and distributing the treated coptis root and medicinal evodia fruit, loading into a clean and dry container respectively, attaching a Chinese medicinal material state plate and an ingredient extraction order, spraying and washing the coptis root and medicinal evodia fruit medicinal materials which are required to be washed in boiler batches respectively by using a medicine washing machine, cleaning and examining; and the preparation step is used for sieving extract powder obtained in the extracting step with a sieve of 70-90 meshes. The production process has the advantages of simple process, sufficient and complete components in an extracting process, small using quantity of film coatings, convenience in taking, easiness for patients to absorb and effective treatment of chronic gastritis.

Description

The production technology of left gold plaque

Technical field

The present invention relates to a kind of production technology of left gold plaque.

Background technology

Left gold plaque is a kind of active drug for the treatment of chronic gastritis, has kept the Therapeutic Characteristics of ancient prescription Zuojin Wan, and the main component of left gold plaque is Rhizoma Coptidis and Fructus Evodiae, major function is pathogenic fire purging, and is soothing the liver, stomach function regulating, pain relieving, be used for liver-fire invading the stomach, abdominal and hypochondriac pain, bitter taste is noisy, acid regurgitation, desire for hot drinks not, and existing left gold plaque complex production process in process of production, production cost is high, and the film coating consumption is large, take inconvenience, greatly reduce drug effect, what composition extracted in leaching process is insufficient, greatly increased production cost, therefore, for addressing the above problem, the spy provides a kind of new technical scheme.

Summary of the invention

The production technology that the purpose of this invention is to provide a kind of left gold plaque.

The technical solution used in the present invention is:

The production technology of left gold plaque comprises extraction step and preparation step, described extraction step:

A, each medical material is chosen medicine, take by weighing by weight each medical material: Rhizoma Coptidis 900-1000 part, Fructus Evodiae 100-200 part;

B, respectively remove impurity in Rhizoma Coptidis, the Fructus Evodiae, product and the product of damaging by worms go mouldy;

C, will remove good Rhizoma Coptidis and Fructus Evodiae divides pot to claim to join, be respectively charged in the dry container of cleaning, attached middle school's medicine material state board and extract charger sheet divides pot to use respectively the medicine-washing machine spray washing to clean Rhizoma Coptidis, the Fructus Evodiae medical material of need wash, carries out cleaning inspection again; It is an amount of to get washed medical material, rinsing in the beaker that fills 300 milliliters of-500 milliliters of drinking waters;

D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed extraction pot, add for the first time 70% ethanol that medical material weight 5-7 doubly measures, extracted 1-3 hour, second adds respectively 70% ethanol that medical material weight 5-7 doubly measures for the third time, each extracted 0.5-1.5 hour, pump into tank through the filter filtration, filtrate is left standstill;

E, filtrate being sucked in the single-effect vacuum concentration tank, control vacuum is-0.02～-0.08Mpa, be evaporated to the thick paste that relative density is 1.2-1.3;

F, place vacuum desiccator dry above-mentioned thick paste, temperature is 70-80 ℃, and the time is 10-14 hour, and the extract powder that drying is good is pulverized, sieved, and namely gets extract powder;

Described preparation step is:

A, the extract powder that obtains in the extraction step is crossed the 70-90 mesh sieve, take by weighing by weight batching: extract powder 200-230 part, starch 160-180 part, microcrystalline Cellulose 6-10 part, ethanol 14-18 part of volumetric concentration 70%, 0.5% magnesium stearate 1-5 part takes by weighing the coating solution prescription by weight: film coating machine 15-20 part, purified water 110-120 part;

B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed trough type mixing machine, mix 10-20 minute, add volumetric concentration and be 70% ethanol, continue to stir 8-12 minute, make soft material; Soft material is crossed the 12-16 eye mesh screen, namely get wet granular;

C, wet granular is sub-packed in the basin, baking temperature is 70-80 ℃, and control moisture content≤3% dry 2-6 hour, is chilled to room temperature;

D, dried granule placed the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in the three-dimensional motion mixer, add 0.5% magnesium stearate and mixed 8-12 minute, the granule that mixes is contained in the container of liner cleaning dry plastics bag, and attached inside and outside label is sent into the intermediate station tabletting that carries out at last to be tested;

E, purified water is added electrical heating stir in the heat insulation tank, stirring makes liquid level form vortex adding film coating agent, film coating agent added in 3-7 minute, continue to stir 40-50 minute, film coating agent is fully dissolved evenly, preparation obtains coating material, and the coating material of preparation must use in 24 hours;

F, when film coating, setting inlet temperature is 60-70 ℃, and pot body rotating speed is 4-6 rev/min, every clear rifle 8000-10000 second, compressed-air actuated pressure is 3-5Kg, make coated tablet rapid draing, adhesion and exquisiteness are after coating finishes, Film coated tablets is put into the beanbag of the dry antistatic of cleaning, and be placed in the drying baker that dry it is to be tested to send into intermediate station more than 12 hours, enter packing after qualified.

The extract powder that the f step is good with drying in the described extraction step sieves after pulverizing, and crosses the 70-90 eye mesh screen.

Advantage of the present invention is: technique is simple, and fully and complete, the film coating consumption is little for composition in the process of extracting, and taking convenience is easy to the patient and absorbs, and effectively treats chronic gastritis.

The specific embodiment

Embodiment 1

The production technology of left gold plaque comprises extraction step and preparation step,

Extraction step:

A, each medical material is chosen medicine, take by weighing by weight each medical material: Rhizoma Coptidis 900g, Fructus Evodiae 100 g;

B, respectively remove impurity in Rhizoma Coptidis, the Fructus Evodiae, product and the product of damaging by worms go mouldy;

C, will remove good Rhizoma Coptidis and Fructus Evodiae divides pot to claim to join, be respectively charged in the dry container of cleaning, attached middle school's medicine material state board and extract charger sheet divides pot to use respectively the medicine-washing machine spray washing to clean Rhizoma Coptidis, the Fructus Evodiae medical material of need wash, carries out cleaning inspection again; It is an amount of to get washed medical material, rinsing in the beaker that fills 300 milliliters of drinking waters;

D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed extraction pot, add 70% ethanol of 5 times of amounts of medical material weight for the first time, extracted 1 hour, second adds respectively 70% ethanol of 5 times of amounts of medical material weight for the third time, each extracted 0.5 hour, filtered through filter and pumped into tank, and filtrate is left standstill;

E, filtrate is sucked in the single-effect vacuum concentration tank, control vacuum is-0.02pa, is evaporated to relative density and is 1.2 thick paste;

F, place vacuum desiccator dry above-mentioned thick paste, temperature is 70 ℃, and the time is 10 hours, and the extract powder that drying is good is pulverized, and crosses 70 eye mesh screens, namely gets extract powder;

The preparation step is:

A, the extract powder that obtains in the extraction step is crossed 70 mesh sieves, take by weighing by weight batching: extract powder 200 g, starch 160 g, microcrystalline Cellulose 6 g, ethanol 14 g of volumetric concentration 70%, 0.5% magnesium stearate, 1 g takes by weighing the coating solution prescription by weight: film coating machine 15 g, purified water 110 g;

B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed trough type mixing machine, mix 10-20 minute, add volumetric concentration and be 70% ethanol, continue to stir 8-12 minute, make soft material; Soft material is crossed the 12-16 eye mesh screen, namely get wet granular;

C, wet granular is sub-packed in the basin, baking temperature is 70 ℃, and control moisture content≤3% dry 2 hours, is chilled to room temperature;

D, dried granule placed the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in the three-dimensional motion mixer, add 0.5% magnesium stearate and mixed 8 minutes, the granule that mixes is contained in the container of liner cleaning dry plastics bag, and attached inside and outside label is sent into the intermediate station tabletting that carries out at last to be tested;

E, purified water is added electrical heating stir in the heat insulation tank, stirring makes liquid level form vortex adding film coating agent, film coating agent added in 3 minutes, continue to stir 40 minutes, film coating agent is fully dissolved evenly, preparation obtains coating material, and the coating material of preparation must use in 24 hours;

F, when film coating, setting inlet temperature is 60 ℃, and pot body rotating speed is 4 rev/mins, the clear rifle every 8000 seconds, compressed-air actuated pressure is 3Kg, make coated tablet rapid draing, adhesion and exquisiteness are after coating finishes, Film coated tablets is put into the beanbag of the dry antistatic of cleaning, and be placed in the drying baker that dry it is to be tested to send into intermediate station more than 12 hours, enter packing after qualified.

Embodiment 2

The production technology of left gold plaque comprises extraction step and preparation step,

Extraction step:

A, each medical material is chosen medicine, take by weighing by weight each medical material: Rhizoma Coptidis 960g, Fructus Evodiae 160g;

B, respectively remove impurity in Rhizoma Coptidis, the Fructus Evodiae, product and the product of damaging by worms go mouldy;

C, will remove good Rhizoma Coptidis and Fructus Evodiae divides pot to claim to join, be respectively charged in the dry container of cleaning, attached middle school's medicine material state board and extract charger sheet divides pot to use respectively the medicine-washing machine spray washing to clean Rhizoma Coptidis, the Fructus Evodiae medical material of need wash, carries out cleaning inspection again; It is an amount of to get washed medical material, rinsing in the beaker that fills 400 milliliters of drinking waters;

D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed extraction pot, add 70% ethanol of 6 times of amounts of medical material weight for the first time, extracted 2 hours, second adds respectively 70% ethanol of 6 times of amounts of medical material weight for the third time, each extracted 1 hour, filtered through filter and pumped into tank, and filtrate is left standstill;

E, filtrate is sucked in the single-effect vacuum concentration tank, control vacuum is-0.05Mpa, is evaporated to relative density and is 1.25 thick paste;

F, place vacuum desiccator dry above-mentioned thick paste, temperature is 75 ℃, and the time is 12 hours, and the extract powder that drying is good is pulverized, and crosses 80 eye mesh screens, namely gets extract powder;

The preparation step is:

A, the extract powder that obtains in the extraction step is crossed 80 mesh sieves, take by weighing by weight batching: extract powder 215 g, starch 170 g, microcrystalline Cellulose 8 g, ethanol 16 g of volumetric concentration 70%, 0.5% magnesium stearate, 3 g take by weighing the coating solution prescription by weight: film coating machine 16 g, purified water 117 g;

B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed trough type mixing machine, mix 15 minutes, add volumetric concentration and be 70% ethanol, continue to stir 10 minutes, make soft material; Soft material is crossed 14 eye mesh screens, namely get wet granular;

C, wet granular is sub-packed in the basin, baking temperature is 75 ℃, and control moisture content≤3% dry 4 hours, is chilled to room temperature;

D, dried granule placed the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in the three-dimensional motion mixer, add 0.5% magnesium stearate and mixed 10 minutes, the granule that mixes is contained in the container of liner cleaning dry plastics bag, and attached inside and outside label is sent into the intermediate station tabletting that carries out at last to be tested;

E, purified water is added electrical heating stir in the heat insulation tank, stirring makes liquid level form vortex adding film coating agent, film coating agent added in 5 minutes, continue to stir 45 minutes, film coating agent is fully dissolved evenly, preparation obtains coating material, and the coating material of preparation must use in 24 hours;

F, when film coating, setting inlet temperature is 65 ℃, and pot body rotating speed is 5 rev/mins, the clear rifle every 9000 seconds, compressed-air actuated pressure is 4Kg, make coated tablet rapid draing, adhesion and exquisiteness are after coating finishes, Film coated tablets is put into the beanbag of the dry antistatic of cleaning, and be placed in the drying baker that dry it is to be tested to send into intermediate station more than 12 hours, enter packing after qualified.

Embodiment 3

The production technology of left gold plaque comprises extraction step and preparation step,

Extraction step:

A, each medical material is chosen medicine, take by weighing by weight each medical material: Rhizoma Coptidis 1000 g, Fructus Evodiae 200 g;

B, respectively remove impurity in Rhizoma Coptidis, the Fructus Evodiae, product and the product of damaging by worms go mouldy;

C, will remove good Rhizoma Coptidis and Fructus Evodiae divides pot to claim to join, be respectively charged in the dry container of cleaning, attached middle school's medicine material state board and extract charger sheet divides pot to use respectively the medicine-washing machine spray washing to clean Rhizoma Coptidis, the Fructus Evodiae medical material of need wash, carries out cleaning inspection again; It is an amount of to get washed medical material, rinsing in the beaker that fills 300 milliliters of-500 milliliters of drinking waters;

D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed extraction pot, add 70% ethanol of 7 times of amounts of medical material weight for the first time, extracted 3 hours, second adds respectively 70% ethanol of 7 times of amounts of medical material weight for the third time, each extracted 1.5 hours, filtered through filter and pumped into tank, and filtrate is left standstill;

E, filtrate is sucked in the single-effect vacuum concentration tank, control vacuum is-0.08Mpa, is evaporated to relative density and is 1.3 thick paste;

F, place vacuum desiccator dry above-mentioned thick paste, temperature is 80 ℃, and the time is 14 hours, and the extract powder that drying is good is pulverized, and crosses 90 eye mesh screens, namely gets extract powder;

The preparation step is:

A, the extract powder that obtains in the extraction step is crossed 90 mesh sieves, take by weighing by weight batching: extract powder 230 g, starch 180 g, microcrystalline Cellulose 10 g, ethanol 18 g of volumetric concentration 70%, 0.5% magnesium stearate, 5 g take by weighing the coating solution prescription by weight: film coating machine 20 g, purified water 120 g;

B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed trough type mixing machine, mix 20 minutes, add volumetric concentration and be 70% ethanol, continue to stir 12 minutes, make soft material; Soft material is crossed 16 eye mesh screens, namely get wet granular;

C, wet granular is sub-packed in the basin, baking temperature is 80 ℃, and control moisture content≤3% dry 6 hours, is chilled to room temperature;

D, dried granule placed the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in the three-dimensional motion mixer, add 0.5% magnesium stearate and mixed 12 minutes, the granule that mixes is contained in the container of liner cleaning dry plastics bag, and attached inside and outside label is sent into the intermediate station tabletting that carries out at last to be tested;

E, purified water is added electrical heating stir in the heat insulation tank, stirring makes liquid level form vortex adding film coating agent, film coating agent added in 7 minutes, continue to stir 50 minutes, film coating agent is fully dissolved evenly, preparation obtains coating material, and the coating material of preparation must use in 24 hours;

F, when film coating, setting inlet temperature is 70 ℃, and pot body rotating speed is 6 rev/mins, the clear rifle every 10000 seconds, compressed-air actuated pressure is 5Kg, make coated tablet rapid draing, adhesion and exquisiteness are after coating finishes, Film coated tablets is put into the beanbag of the dry antistatic of cleaning, and be placed in the drying baker that dry it is to be tested to send into intermediate station more than 12 hours, enter packing after qualified.

Claims (2)

1. the production technology of left gold plaque is characterized in that: comprise extraction step and preparation step, described extraction step:

A, each medical material is chosen medicine, take by weighing by weight each medical material: Rhizoma Coptidis 900-1000 part, Fructus Evodiae 100-200 part;

B, respectively remove impurity in Rhizoma Coptidis, the Fructus Evodiae, product and the product of damaging by worms go mouldy;

C, will remove good Rhizoma Coptidis and Fructus Evodiae divides pot to claim to join, be respectively charged in the dry container of cleaning, attached middle school's medicine material state board and extract charger sheet divides pot to use respectively the medicine-washing machine spray washing to clean Rhizoma Coptidis, the Fructus Evodiae medical material of need wash, carries out cleaning inspection again; It is an amount of to get washed medical material, rinsing in the beaker that fills 300 milliliters of-500 milliliters of drinking waters;

D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed extraction pot, add for the first time 70% ethanol that medical material weight 5-7 doubly measures, extracted 1-3 hour, second adds respectively 70% ethanol that medical material weight 5-7 doubly measures for the third time, each extracted 0.5-1.5 hour, pump into tank through the filter filtration, filtrate is left standstill;

E, filtrate being sucked in the single-effect vacuum concentration tank, control vacuum is-0.02～-0.08Mpa, be evaporated to the thick paste that relative density is 1.2-1.3;

F, place vacuum desiccator dry above-mentioned thick paste, temperature is 70-80 ℃, and the time is 10-14 hour, and the extract powder that drying is good is pulverized, sieved, and namely gets extract powder;

Described preparation step is:

A, the extract powder that obtains in the extraction step is crossed the 70-90 mesh sieve, take by weighing by weight batching: extract powder 200-230 part, starch 160-180 part, microcrystalline Cellulose 6-10 part, ethanol 14-18 part of volumetric concentration 70%, 0.5% magnesium stearate 1-5 part takes by weighing the coating solution prescription by weight: film coating machine 15-20 part, purified water 110-120 part;

B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed trough type mixing machine, mix 10-20 minute, add volumetric concentration and be 70% ethanol, continue to stir 8-12 minute, make soft material; Soft material is crossed the 12-16 eye mesh screen, namely get wet granular;

C, wet granular is sub-packed in the basin, baking temperature is 70-80 ℃, and control moisture content≤3% dry 2-6 hour, is chilled to room temperature;

D, dried granule placed the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in the three-dimensional motion mixer, add 0.5% magnesium stearate and mixed 8-12 minute, the granule that mixes is contained in the container of liner cleaning dry plastics bag, and attached inside and outside label is sent into the intermediate station tabletting that carries out at last to be tested;

E, purified water is added electrical heating stir in the heat insulation tank, stirring makes liquid level form vortex adding film coating agent, film coating agent added in 3-7 minute, continue to stir 40-50 minute, film coating agent is fully dissolved evenly, preparation obtains coating material, and the coating material of preparation must use in 24 hours;

F, when film coating, setting inlet temperature is 60-70 ℃, and pot body rotating speed is 4-6 rev/min, every clear rifle 8000-10000 second, compressed-air actuated pressure is 3-5Kg, make coated tablet rapid draing, adhesion and exquisiteness are after coating finishes, Film coated tablets is put into the beanbag of the dry antistatic of cleaning, and be placed in the drying baker that dry it is to be tested to send into intermediate station more than 12 hours, enter packing after qualified.

2. the production technology of left gold plaque according to claim 1 is characterized in that: sieve after the extract powder pulverizing that the f step is good with drying in the described extraction step, cross the 70-90 eye mesh screen.