CN102895380B - Production process of chronic gastritis-treating tablet - Google Patents
Production process of chronic gastritis-treating tablet Download PDFInfo
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- CN102895380B CN102895380B CN201210423928.1A CN201210423928A CN102895380B CN 102895380 B CN102895380 B CN 102895380B CN 201210423928 A CN201210423928 A CN 201210423928A CN 102895380 B CN102895380 B CN 102895380B
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Abstract
The invention relates to a production process of a chronic gastritis-treating tablet. The production process is characterized by comprising an extracting step and a preparation step, wherein the extracting step comprises the following specific steps of: picking each medicinal material, and weighing coptis root and medicinal evodia fruit according to parts by weight; removing impurities, molded substances and moth-eaten substances in the coptis root and medicinal evodia fruit; and weighing and distributing the treated coptis root and medicinal evodia fruit, loading into a clean and dry container respectively, attaching a Chinese medicinal material state plate and an ingredient extraction order, spraying and washing the coptis root and medicinal evodia fruit medicinal materials which are required to be washed in boiler batches respectively by using a medicine washing machine, cleaning and examining; and the preparation step is used for sieving extract powder obtained in the extracting step with a sieve of 70-90 meshes. The production process has the advantages of simple process, sufficient and complete components in an extracting process, small using quantity of film coatings, convenience in taking, easiness for patients to absorb and effective treatment of chronic gastritis.
Description
Technical field
The present invention relates to a kind of production technology of left gold plaque.
Background technology
Left gold plaque is a kind of active drug for the treatment of chronic gastritis, the Therapeutic Characteristics that has kept ancient prescription Zuojin Wan, the main component of left gold plaque is Rhizoma Coptidis and Fructus Evodiae, major function is pathogenic fire purging, soothing the liver, stomach function regulating, pain relieving, for liver-fire invading the stomach, abdominal and hypochondriac pain, bitter taste is noisy, acid regurgitation, desire for hot drinks not, and existing left gold plaque complex production process in process of production, production cost is high, and film coating consumption is large, take inconvenience, greatly reduce drug effect, what in leaching process, composition extracted is insufficient, greatly increased production cost, therefore, for addressing the above problem, spy provides a kind of new technical scheme.
Summary of the invention
The production technology that the object of this invention is to provide a kind of left gold plaque.
The technical solution used in the present invention is:
The production technology of left gold plaque, comprises extraction step and preparation step, described extraction step:
A, each medical material is chosen to medicine, take by weight each medical material: Rhizoma Coptidis 900-1000 part, Fructus Evodiae 100-200 part;
B, remove impurity in Rhizoma Coptidis, Fructus Evodiae respectively, product and the product of damaging by worms go mouldy;
C, divide pot to claim to join the Rhizoma Coptidis of having removed and Fructus Evodiae, be respectively charged in clean dry container, attached middle school's medicine material state board and extraction charger sheet, divide pot to use respectively medicine-washing machine spray washing to clean the Rhizoma Coptidis, the Fructus Evodiae medical material that need wash, then carry out cleaning inspection; Get washed medical material appropriate, rinsing in the beaker that fills 300 milliliters of-500 milliliters of drinking waters;
D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed in to extraction pot, 70% ethanol that adds for the first time medical material weight 5-7 doubly to measure, extract 1-3 hour, second adds respectively 70% ethanol that medical material weight 5-7 doubly measures for the third time, each extracts 0.5-1.5 hour, through filter, filter and pump into tank, filtrate is standing;
E, filtrate is sucked in single-effect vacuum concentration tank, controlling vacuum is-0.02～-0.08Mpa, is evaporated to the thick paste that relative density is 1.2-1.3;
F, that above-mentioned thick paste is placed in to vacuum desiccator is dry, and temperature is 70-80 ℃, and the time is 10-14 hour, and dried extract powder is pulverized, sieved, and obtains extract powder;
Described preparation step is:
A, the extract powder obtaining in extraction step is crossed to 70-90 mesh sieve, take by weight batching: extract powder 200-230 part, starch 160-180 part, microcrystalline Cellulose 6-10 part, ethanol 14-18 part of volumetric concentration 70%, 0.5% magnesium stearate 1-5 part, takes coating solution formula by weight: film coating agent 15-20 part, purified water 110-120 part;
B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed in to trough type mixing machine, are uniformly mixed 10-20 minute, adding volumetric concentration is 70% ethanol, continues to stir 8-12 minute, makes soft material; Soft material is crossed to 12-16 eye mesh screen, obtain wet granular;
C, wet granular is sub-packed in basin, baking temperature is 70-80 ℃, controls moisture content≤3%, and dry 2-6 hour, is chilled to room temperature;
D, dry granule is placed in to the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in three-dimensional motion mixer, add 0.5% magnesium stearate to mix 8-12 minute, the granule mixing is contained in the container of the clean dry plastics bag of liner, and attached inside and outside label, sends into the intermediate station tabletting that finally carries out to be tested;
E, add electrical heating to stir in heat insulation tank purified water, stirring makes liquid level formation vortex add film coating agent, film coating agent added in 3-7 minute, continue to stir 40-50 minute, film coating agent is sufficiently uniformly dissolved, preparation obtains coating material, and the coating material of preparation must use in 24 hours;
F, when film coating, setting inlet temperature is 60-70 ℃, and pot body rotating speed is 4-6 rev/min, every clear rifle 8000-10000 second, compressed-air actuated pressure is 3-5Kg, make coated tablet rapid draing, adhesion and exquisiteness, after coating finishes, Film coated tablets is put into the beanbag of clean dry antistatic, and be placed in drying baker and dryly more than 12 hours send into intermediate station to be tested, enter packing after qualified.
In described extraction step, f step is sieved after dried extract powder is pulverized, and crosses 70-90 eye mesh screen.
Advantage of the present invention is: technique is simple, and in the process of extracting, fully and completely, film coating consumption is little for composition, and taking convenience is easy to patient and absorbs, and effectively treats chronic gastritis.
The specific embodiment
Embodiment 1
The production technology of left gold plaque, comprises extraction step and preparation step,
Extraction step:
A, each medical material is chosen to medicine, take by weight each medical material: Rhizoma Coptidis 900g, Fructus Evodiae 100 g;
B, remove impurity in Rhizoma Coptidis, Fructus Evodiae respectively, product and the product of damaging by worms go mouldy;
C, divide pot to claim to join the Rhizoma Coptidis of having removed and Fructus Evodiae, be respectively charged in clean dry container, attached middle school's medicine material state board and extraction charger sheet, divide pot to use respectively medicine-washing machine spray washing to clean the Rhizoma Coptidis, the Fructus Evodiae medical material that need wash, then carry out cleaning inspection; Get washed medical material appropriate, rinsing in the beaker that fills 300 milliliters of drinking waters;
D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed in to extraction pot, add for the first time 70% ethanol of 5 times of amounts of medical material weight, extract 1 hour, second adds respectively 70% ethanol of 5 times of amounts of medical material weight for the third time, each extracts 0.5 hour, through filter, filters and pumps into tank, and filtrate is standing;
E, filtrate is sucked in single-effect vacuum concentration tank, control vacuum and be-0.02pa, be evaporated to relative density and be 1.2 thick paste;
F, that above-mentioned thick paste is placed in to vacuum desiccator is dry, and temperature is 70 ℃, and the time is 10 hours, and dried extract powder is pulverized, and crosses 70 eye mesh screens, obtains extract powder;
Preparation step is:
A, the extract powder obtaining in extraction step is crossed to 70 mesh sieves, take by weight batching: extract powder 200 g, starch 160 g, microcrystalline Cellulose 6 g, ethanol 14 g of volumetric concentration 70%, 0.5% magnesium stearate 1 g, takes coating solution formula by weight: film coating agent 15 g, purified water 110 g;
B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed in to trough type mixing machine, are uniformly mixed 10-20 minute, adding volumetric concentration is 70% ethanol, continues to stir 8-12 minute, makes soft material; Soft material is crossed to 12-16 eye mesh screen, obtain wet granular;
C, wet granular is sub-packed in basin, baking temperature is 70 ℃, controls moisture content≤3%, dry 2 hours, is chilled to room temperature;
D, dry granule is placed in to the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in three-dimensional motion mixer, add 0.5% magnesium stearate to mix 8 minutes, the granule mixing is contained in the container of the clean dry plastics bag of liner, and attached inside and outside label, sends into the intermediate station tabletting that finally carries out to be tested;
E, add electrical heating to stir in heat insulation tank purified water, stirring makes liquid level formation vortex add film coating agent, film coating agent added in 3 minutes, continue to stir 40 minutes, film coating agent is sufficiently uniformly dissolved, preparation obtains coating material, and the coating material of preparation must use in 24 hours;
F, when film coating, setting inlet temperature is 60 ℃, and pot body rotating speed is 4 revs/min, the clear rifle every 8000 seconds, compressed-air actuated pressure is 3Kg, make coated tablet rapid draing, adhesion and exquisiteness, after coating finishes, Film coated tablets is put into the beanbag of clean dry antistatic, and be placed in drying baker and dryly more than 12 hours send into intermediate station to be tested, enter packing after qualified.
Embodiment 2
The production technology of left gold plaque, comprises extraction step and preparation step,
Extraction step:
A, each medical material is chosen to medicine, take by weight each medical material: Rhizoma Coptidis 960g, Fructus Evodiae 160g;
B, remove impurity in Rhizoma Coptidis, Fructus Evodiae respectively, product and the product of damaging by worms go mouldy;
C, divide pot to claim to join the Rhizoma Coptidis of having removed and Fructus Evodiae, be respectively charged in clean dry container, attached middle school's medicine material state board and extraction charger sheet, divide pot to use respectively medicine-washing machine spray washing to clean the Rhizoma Coptidis, the Fructus Evodiae medical material that need wash, then carry out cleaning inspection; Get washed medical material appropriate, rinsing in the beaker that fills 400 milliliters of drinking waters;
D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed in to extraction pot, add for the first time 70% ethanol of 6 times of amounts of medical material weight, extract 2 hours, second adds respectively 70% ethanol of 6 times of amounts of medical material weight for the third time, each extracts 1 hour, through filter, filters and pumps into tank, and filtrate is standing;
E, filtrate is sucked in single-effect vacuum concentration tank, control vacuum and be-0.05Mpa, be evaporated to relative density and be 1.25 thick paste;
F, that above-mentioned thick paste is placed in to vacuum desiccator is dry, and temperature is 75 ℃, and the time is 12 hours, and dried extract powder is pulverized, and crosses 80 eye mesh screens, obtains extract powder;
Preparation step is:
A, the extract powder obtaining in extraction step is crossed to 80 mesh sieves, take by weight batching: extract powder 215 g, starch 170 g, microcrystalline Cellulose 8 g, ethanol 16 g of volumetric concentration 70%, 0.5% magnesium stearate 3 g, take coating solution formula by weight: film coating agent 16 g, purified water 117 g;
B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed in to trough type mixing machine, are uniformly mixed 15 minutes, adding volumetric concentration is 70% ethanol, continues to stir 10 minutes, makes soft material; Soft material is crossed to 14 eye mesh screens, obtain wet granular;
C, wet granular is sub-packed in basin, baking temperature is 75 ℃, controls moisture content≤3%, dry 4 hours, is chilled to room temperature;
D, dry granule is placed in to the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in three-dimensional motion mixer, add 0.5% magnesium stearate to mix 10 minutes, the granule mixing is contained in the container of the clean dry plastics bag of liner, and attached inside and outside label, sends into the intermediate station tabletting that finally carries out to be tested;
E, add electrical heating to stir in heat insulation tank purified water, stirring makes liquid level formation vortex add film coating agent, film coating agent added in 5 minutes, continue to stir 45 minutes, film coating agent is sufficiently uniformly dissolved, preparation obtains coating material, and the coating material of preparation must use in 24 hours;
F, when film coating, setting inlet temperature is 65 ℃, and pot body rotating speed is 5 revs/min, the clear rifle every 9000 seconds, compressed-air actuated pressure is 4Kg, make coated tablet rapid draing, adhesion and exquisiteness, after coating finishes, Film coated tablets is put into the beanbag of clean dry antistatic, and be placed in drying baker and dryly more than 12 hours send into intermediate station to be tested, enter packing after qualified.
Embodiment 3
The production technology of left gold plaque, comprises extraction step and preparation step,
Extraction step:
A, each medical material is chosen to medicine, take by weight each medical material: Rhizoma Coptidis 1000 g, Fructus Evodiae 200 g;
B, remove impurity in Rhizoma Coptidis, Fructus Evodiae respectively, product and the product of damaging by worms go mouldy;
C, divide pot to claim to join the Rhizoma Coptidis of having removed and Fructus Evodiae, be respectively charged in clean dry container, attached middle school's medicine material state board and extraction charger sheet, divide pot to use respectively medicine-washing machine spray washing to clean the Rhizoma Coptidis, the Fructus Evodiae medical material that need wash, then carry out cleaning inspection; Get washed medical material appropriate, rinsing in the beaker that fills 300 milliliters of-500 milliliters of drinking waters;
D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed in to extraction pot, add for the first time 70% ethanol of 7 times of amounts of medical material weight, extract 3 hours, second adds respectively 70% ethanol of 7 times of amounts of medical material weight for the third time, each extracts 1.5 hours, through filter, filters and pumps into tank, and filtrate is standing;
E, filtrate is sucked in single-effect vacuum concentration tank, control vacuum and be-0.08Mpa, be evaporated to relative density and be 1.3 thick paste;
F, that above-mentioned thick paste is placed in to vacuum desiccator is dry, and temperature is 80 ℃, and the time is 14 hours, and dried extract powder is pulverized, and crosses 90 eye mesh screens, obtains extract powder;
Preparation step is:
A, the extract powder obtaining in extraction step is crossed to 90 mesh sieves, take by weight batching: extract powder 230 g, starch 180 g, microcrystalline Cellulose 10 g, ethanol 18 g of volumetric concentration 70%, 0.5% magnesium stearate 5 g, take coating solution formula by weight: film coating agent 20 g, purified water 120 g;
B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed in to trough type mixing machine, are uniformly mixed 20 minutes, adding volumetric concentration is 70% ethanol, continues to stir 12 minutes, makes soft material; Soft material is crossed to 16 eye mesh screens, obtain wet granular;
C, wet granular is sub-packed in basin, baking temperature is 80 ℃, controls moisture content≤3%, dry 6 hours, is chilled to room temperature;
D, dry granule is placed in to the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in three-dimensional motion mixer, add 0.5% magnesium stearate to mix 12 minutes, the granule mixing is contained in the container of the clean dry plastics bag of liner, and attached inside and outside label, sends into the intermediate station tabletting that finally carries out to be tested;
E, add electrical heating to stir in heat insulation tank purified water, stirring makes liquid level formation vortex add film coating agent, film coating agent added in 7 minutes, continue to stir 50 minutes, film coating agent is sufficiently uniformly dissolved, preparation obtains coating material, and the coating material of preparation must use in 24 hours;
F, when film coating, setting inlet temperature is 70 ℃, and pot body rotating speed is 6 revs/min, the clear rifle every 10000 seconds, compressed-air actuated pressure is 5Kg, make coated tablet rapid draing, adhesion and exquisiteness, after coating finishes, Film coated tablets is put into the beanbag of clean dry antistatic, and be placed in drying baker and dryly more than 12 hours send into intermediate station to be tested, enter packing after qualified.
Claims (1)
1. the production technology of left gold plaque, is characterized in that: comprise extraction step and preparation step, described extraction step:
A, each medical material is chosen to medicine, take by weight each medical material: Rhizoma Coptidis 900-1000 part, Fructus Evodiae 100-200 part;
B, remove impurity in Rhizoma Coptidis, Fructus Evodiae respectively, product and the product of damaging by worms go mouldy;
C, divide pot to claim to join the Rhizoma Coptidis of having removed and Fructus Evodiae, be respectively charged in clean dry container, attached middle school's medicine material state board and extraction charger sheet, divide pot to use respectively medicine-washing machine spray washing to clean the Rhizoma Coptidis, the Fructus Evodiae medical material that need wash, then carry out cleaning inspection; Get washed medical material appropriate, rinsing in the beaker that fills 300 milliliters of-500 milliliters of drinking waters;
D, same above-mentioned two kinds of medical material full doses of extracting pot time are placed in to extraction pot, 70% ethanol that adds for the first time medical material weight 5-7 doubly to measure, extract 1-3 hour, second adds respectively 70% ethanol that medical material weight 5-7 doubly measures for the third time, each extracts 0.5-1.5 hour, through filter, filter and pump into tank, filtrate is standing;
E, filtrate is sucked in single-effect vacuum concentration tank, controlling vacuum is-0.02～-0.08Mpa, is evaporated to the thick paste that relative density is 1.2-1.3;
F, that above-mentioned thick paste is placed in to vacuum desiccator is dry, and temperature is 70-80 ℃, and the time is 10-14 hour, and dried extract powder is pulverized, sieved, and crosses 70-90 eye mesh screen, obtains extract powder;
Described preparation step is:
A, the extract powder obtaining in extraction step is crossed to 70-90 mesh sieve, take by weight batching: extract powder 200-230 part, starch 160-180 part, microcrystalline Cellulose 6-10 part, ethanol 14-18 part of volumetric concentration 70%, 0.5% magnesium stearate 1-5 part, takes coating solution formula by weight: film coating agent 15-20 part, purified water 110-120 part;
B, above-mentioned load weighted extract powder, starch and microcrystalline Cellulose are placed in to trough type mixing machine, are uniformly mixed 10-20 minute, adding volumetric concentration is 70% ethanol, continues to stir 8-12 minute, makes soft material; Soft material is crossed to 12-16 eye mesh screen, obtain wet granular;
C, wet granular is sub-packed in basin, baking temperature is 70-80 ℃, controls moisture content≤3%, and dry 2-6 hour, is chilled to room temperature;
D, dry granule is placed in to the oscillating granulator granulate that 14 eye mesh screens are housed; Granule is packed in three-dimensional motion mixer, add 0.5% magnesium stearate to mix 8-12 minute, the granule mixing is contained in the container of the clean dry plastics bag of liner, and attached inside and outside label, sends into the intermediate station tabletting that finally carries out to be tested;
E, add electrical heating to stir in heat insulation tank purified water, stirring makes liquid level formation vortex add film coating agent, film coating agent added in 3-7 minute, continue to stir 40-50 minute, film coating agent is sufficiently uniformly dissolved, preparation obtains coating material, and the coating material of preparation must use in 24 hours;
F, when film coating, setting inlet temperature is 60-70 ℃, and pot body rotating speed is 4-6 rev/min, every clear rifle 8000-10000 second, compressed-air actuated pressure is 3-5Kg, make coated tablet rapid draing, adhesion and exquisiteness, after coating finishes, Film coated tablets is put into the beanbag of clean dry antistatic, and be placed in drying baker and dryly more than 12 hours send into intermediate station to be tested, enter packing after qualified.
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| CN201210423928.1A CN102895380B (en) | 2012-10-31 | 2012-10-31 | Production process of chronic gastritis-treating tablet |
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| CN102895380B true CN102895380B (en) | 2014-03-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1965930A (en) * | 2006-10-20 | 2007-05-23 | 四川大学 | Duodenum targeted orally administered pharmaceutical formulation, preparation method and application thereof |
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| CN1965930A (en) * | 2006-10-20 | 2007-05-23 | 四川大学 | Duodenum targeted orally administered pharmaceutical formulation, preparation method and application thereof |
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Address after: 226100 No. 172, Renmin Middle Road, Haimen City, Jiangsu, Nantong Applicant after: JIANGSU CHENPAI PHARMACEUTICAL Co.,Ltd. Address before: 226100 No. 172, Renmin Middle Road, Haimen City, Jiangsu, Nantong Applicant before: Jiangsu morning brand pharmaceutical Limited by Share Ltd. Address after: 226100 No. 172, Renmin Middle Road, Haimen City, Jiangsu, Nantong Applicant after: Jiangsu morning brand pharmaceutical Limited by Share Ltd. Address before: 226100 No. 172, Renmin Middle Road, Haimen City, Jiangsu, Nantong Applicant before: JIANGSU CHENPAI PHARMACEUTICAL Co.,Ltd. |
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