CN102895226B - Aphanamixoid A在制备降低血糖药物中的应用 - Google Patents
Aphanamixoid A在制备降低血糖药物中的应用 Download PDFInfo
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- CN102895226B CN102895226B CN201210414599.4A CN201210414599A CN102895226B CN 102895226 B CN102895226 B CN 102895226B CN 201210414599 A CN201210414599 A CN 201210414599A CN 102895226 B CN102895226 B CN 102895226B
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- aphanamixoid
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- medicines
- blood glucose
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- 229930193702 aphanamixoid Natural products 0.000 title claims abstract description 31
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 239000008280 blood Substances 0.000 title claims description 28
- 210000004369 blood Anatomy 0.000 title claims description 28
- 229940079593 drug Drugs 0.000 title abstract description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 18
- 239000008103 glucose Substances 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 9
- 230000003178 anti-diabetic effect Effects 0.000 abstract description 15
- 239000003472 antidiabetic agent Substances 0.000 abstract description 13
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 description 11
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 238000011552 rat model Methods 0.000 description 5
- 238000003304 gavage Methods 0.000 description 4
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 240000003906 Aphanamixis grandifolia Species 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 150000002630 limonoids Chemical class 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229960001052 streptozocin Drugs 0.000 description 2
- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical group C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000013295 T2DM animal model Methods 0.000 description 1
- 230000001887 anti-feedant effect Effects 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
Abstract
Description
组别 | 动物数(只) | 给药量(mg/kgBW) |
正常对照组 | 12 | |
模型对照组 | 12 | |
阳性药物组 | 12 | 35.5 |
低剂量组 | 12 | 0.16 |
中剂量组 | 12 | 0.5 |
高剂量组 | 12 | 1.5 |
组别 | 动物数(只) | 给药前血糖值 | 给药后血糖值 |
正常对照组 | 10 | 5.6±0.27 | 5.57±0.30 |
模型对照组 | 9 | 13.62±2.23 | 31.56±2.46 |
阳性药物组 | 9 | 31.63±2.42 | 18.54±2.34**△△ |
低剂量组 | 8 | 31.64±2.24 | 23.59±2.23**△△ |
中剂量组 | 10 | 32.66±1.93 | 19.58±2.69**△△ |
高剂量组 | 9 | 35.67±2.55 | 14.58±3.06**△△ |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210414599.4A CN102895226B (zh) | 2012-10-25 | 2012-10-25 | Aphanamixoid A在制备降低血糖药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210414599.4A CN102895226B (zh) | 2012-10-25 | 2012-10-25 | Aphanamixoid A在制备降低血糖药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102895226A CN102895226A (zh) | 2013-01-30 |
CN102895226B true CN102895226B (zh) | 2014-04-16 |
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210414599.4A Active CN102895226B (zh) | 2012-10-25 | 2012-10-25 | Aphanamixoid A在制备降低血糖药物中的应用 |
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CN (1) | CN102895226B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103638006B (zh) * | 2013-12-04 | 2015-04-22 | 韩瑛 | Oleaceran在降低血糖药物中的应用 |
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- 2012-10-25 CN CN201210414599.4A patent/CN102895226B/zh active Active
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Effective date of registration: 20200423 Address after: No. 10, Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Rudong industrial and commercial information consulting service center Address before: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee before: Rudong science and Technology Center |
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