CN102892393B - 用于止血应用的增强的吸收性多层织物 - Google Patents
用于止血应用的增强的吸收性多层织物 Download PDFInfo
- Publication number
- CN102892393B CN102892393B CN201180024450.9A CN201180024450A CN102892393B CN 102892393 B CN102892393 B CN 102892393B CN 201180024450 A CN201180024450 A CN 201180024450A CN 102892393 B CN102892393 B CN 102892393B
- Authority
- CN
- China
- Prior art keywords
- layer
- staple fibers
- synthetic textiles
- absorbent staple
- textiles according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000004744 fabric Substances 0.000 title claims abstract description 35
- 230000002708 enhancing effect Effects 0.000 title description 11
- 239000002874 hemostatic agent Substances 0.000 title description 2
- 239000000835 fiber Substances 0.000 claims abstract description 39
- 229920002994 synthetic fiber Polymers 0.000 claims abstract description 20
- 239000004758 synthetic textile Substances 0.000 claims abstract description 20
- 229920001577 copolymer Polymers 0.000 claims abstract description 16
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 6
- 239000002250 absorbent Substances 0.000 claims description 24
- 230000002745 absorbent Effects 0.000 claims description 24
- 208000032843 Hemorrhage Diseases 0.000 claims description 21
- 230000023597 hemostasis Effects 0.000 claims description 17
- 239000011159 matrix material Substances 0.000 claims description 16
- 108090000190 Thrombin Proteins 0.000 claims description 11
- 229960004072 thrombin Drugs 0.000 claims description 11
- 108010049003 Fibrinogen Proteins 0.000 claims description 8
- 102000008946 Fibrinogen Human genes 0.000 claims description 8
- 229940012952 fibrinogen Drugs 0.000 claims description 8
- 238000009736 wetting Methods 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 5
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 11
- 239000000758 substrate Substances 0.000 description 17
- 238000000034 method Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- 230000002439 hemostatic effect Effects 0.000 description 9
- 238000001356 surgical procedure Methods 0.000 description 7
- 239000004745 nonwoven fabric Substances 0.000 description 6
- 108010021753 peptide-Gly-Leu-amide Proteins 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 238000001467 acupuncture Methods 0.000 description 5
- -1 polypropylene Polymers 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 4
- 238000007596 consolidation process Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000004627 regenerated cellulose Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000002759 woven fabric Substances 0.000 description 3
- PJRSUKFWFKUDTH-JWDJOUOUSA-N (2s)-6-amino-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[(2-aminoacetyl)amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl Chemical compound CSCC[C@H](NC(=O)CN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O PJRSUKFWFKUDTH-JWDJOUOUSA-N 0.000 description 2
- 229920003043 Cellulose fiber Polymers 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 229920002201 Oxidized cellulose Polymers 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 229920003232 aliphatic polyester Polymers 0.000 description 2
- 238000009960 carding Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001723 fibrinogenic effect Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000000025 haemostatic effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229940107304 oxidized cellulose Drugs 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NOPJRYAFUXTDLX-UHFFFAOYSA-N 1,1,1,2,2,3,3-heptafluoro-3-methoxypropane Chemical compound COC(F)(F)C(F)(F)C(F)(F)F NOPJRYAFUXTDLX-UHFFFAOYSA-N 0.000 description 1
- QKAGYSDHEJITFV-UHFFFAOYSA-N 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)pentane Chemical compound FC(F)(F)C(F)(F)C(F)(OC)C(F)(C(F)(F)F)C(F)(F)F QKAGYSDHEJITFV-UHFFFAOYSA-N 0.000 description 1
- SCRCZNMJAVGGEI-UHFFFAOYSA-N 1,4-dioxane-2,5-dione;oxepan-2-one Chemical compound O=C1COC(=O)CO1.O=C1CCCCCO1 SCRCZNMJAVGGEI-UHFFFAOYSA-N 0.000 description 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 238000012752 Hepatectomy Methods 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241000282894 Sus scrofa domesticus Species 0.000 description 1
- 238000012084 abdominal surgery Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000021328 arterial occlusion Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000013130 cardiovascular surgery Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000007590 electrostatic spraying Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229940081104 fibrinogen / thrombin Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002682 general surgery Methods 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 238000005098 hot rolling Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010911 splenectomy Methods 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
- B32B5/022—Non-woven fabric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
- B32B5/06—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer characterised by a fibrous or filamentary layer mechanically connected, e.g. by needling to another layer, e.g. of fibres, of paper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/22—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed
- B32B5/24—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer
- B32B5/26—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer another layer next to it also being fibrous or filamentary
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4326—Condensation or reaction polymers
- D04H1/435—Polyesters
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4374—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece using different kinds of webs, e.g. by layering webs
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/44—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling
- D04H1/46—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
- B32B2262/02—Synthetic macromolecular fibres
- B32B2262/0276—Polyester fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2305/00—Condition, form or state of the layers or laminate
- B32B2305/10—Fibres of continuous length
- B32B2305/18—Fabrics, textiles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/72—Density
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/732—Dimensional properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2535/00—Medical equipment, e.g. bandage, prostheses, catheter
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24942—Structurally defined web or sheet [e.g., overall dimension, etc.] including components having same physical characteristic in differing degree
- Y10T428/2495—Thickness [relative or absolute]
- Y10T428/24967—Absolute thicknesses specified
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24942—Structurally defined web or sheet [e.g., overall dimension, etc.] including components having same physical characteristic in differing degree
- Y10T428/24992—Density or compression of components
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Textile Engineering (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明涉及包括多层非织造物的合成织物,所述多层非织造物由聚乙交酯/聚丙交酯共聚物的短纤维制成,其中每一层均具有不同的密度。所述多层织物可用作增强的吸收性止血医疗装置。
Description
技术领域
本发明涉及可用作如下构造的增强的吸收性多层止血器,所述构造作为医疗装置使用。
背景技术
在外科中,控制出血对于改善手术效果以及缩短在手术室中外科的持续时间为至关重要且关键的。多种止血材料包括氧化纤维素基材料已作为敷料用于多种外科中,包括神经外科、腹部外科、心血管外科、胸外科、头颈外科、盆腔外科、以及皮肤和皮下组织手术。
结合医疗过程来使用多层织物是被普遍认可的。例如,将多层织物用作通用垫、伤口敷料、外科网(包括疝修复网、防粘连网和组织增强网)、缺损封堵装置和止血器。
Lichtenstein等人的美国专利No.5,593,441描述了如下复合材料假体,所述复合材料假体优选具有允许组织向内生长的一片聚丙烯网,例如网。此参考文献公开到,可利用适于组织增强和缺损封堵的其它外科材料,包括吸收性网例如羟基乳酸聚合物910网。Lichtenstein等人的复合材料假体还具有粘连屏障,优选为一片硅氧烷弹性体。
Schilder等人的美国专利No.5,686,090描述了使用结合非吸收性膜或吸收性膜的绒头织物以防止邻近组织的误生长并减少粘连。Schilder等人大致公开到,可将聚丙烯、聚酯、羟基乳酸聚合物、聚对二氧环己酮或聚卡普隆25用作抓绒材料或膜材料。
Dhanaraj等人的已公布的美国专利申请2006/00084930描述了增强的吸收性多层织物,其可在尤其适用于组织工程应用的医疗装置中使用。基本内容包括首先准备用于植入的修复部位,随后将增强的吸收性多层织物设置在所述部位处。第一吸收性非织造物包含含有脂族聚酯聚合物、它们的共聚物或共混物的纤维;而第二吸收性机织物或针织物包含氧化再生纤维素纤维。
Broadnax等人的美国专利No.4,626,253描述了如下装置,所述装置涉及用于控制出血的外科止血器,并且更具体地讲涉及具有优异处理特性和止血特性的氧化纤维素的针织物。
Shetty等人的美国专利No.7,666,803描述了制备可用作止血器的增强的吸收性多层织物的方法。基本内容包括首先准备用于植入的修复部位,随后将增强的吸收性多层织物设置在所述部位处。第一吸收性非织造物包含含有脂族聚酯聚合物、它们的共聚物或共混物的纤维;而第二吸收性机织物或针织物包含氧化再生纤维素纤维。该方法还描述了可用于制备上述特定发明中的基质的适当密度和厚度。
上述参考文献均没有描述出或提出其中各个层具有不同密度的增强的吸收性多层非织造物。此外,上述参考文献均没有描述出或提出具有止血功能的这种非织造双层织物。
发明内容
本发明涉及包含非织造基质的合成织物,所述非织造基质具有由聚乙交酯/聚丙交酯共聚物的第一吸收性短纤维和聚乙交酯/聚丙交酯共聚物的第二吸收性短纤维构成的至少两层,其中第一吸收性织物被压制成约60mg/cc的密度,并且第二吸收性织物被压制成约120mg/cc的密度。第一吸收性织物和第二吸收性织物可由在组合物中比例为90摩尔/10摩尔的乙交酯/丙交酯的共聚物组成。第一吸收性织物和第二吸收性织物可包含具有约0.75至2.5英寸长度的短纤维并/或可来源于约1至4旦尼尔/纤丝。织物短纤维可为卷曲的。第一吸收性织物和第二吸收性片材可被针刺到彼此中以固定非织造物基质。
在一个实施例中,第一吸收性织物被压制成约0.5mm至约1.5mm,更优选约1mm的厚度。作为另外一种选择,第二吸收性织物可被压制成约0.75mm至3mm,更优选约1mm的厚度。在一个实施例中,合成织物尤其是双层基质,可用作医疗装置,例如止血装置。
具体实施方式
本发明为可用作增强的吸收性多层(优选双层)止血装置的合成织物,所述合成织物具有至少两个非织造层,每层基本上由得自聚乙交酯和聚丙交酯纤维的共聚物的短纤维共混物组成,并且每层具有不同的密度。在一个实施例中,止血装置基本上不含任何氧化多糖材料。尽管氧化多糖材料(例如氧化再生纤维素)已知可用作止血器,但是ORC的存在可不利于生物活性止血剂的稳定性,可在伤口附近通过降低此区域内的pH而降低生物活性剂的活性水平,并且通常在放置到伤口上之后降解较快。
用于制备本发明基质的一种方法开始于将聚(乙交酯-丙交酯)共聚物熔纺成PGLA共聚物纤维。可将基于PGLA共聚物纤维的多长丝纱线固结、卷曲并且切割成具有2.0英寸长度的短纤维。短纤维随后可被梳理成网以产生非织造棉絮并且被压制成约1.0mm的厚度和约60mg/cc的密度。可通过下述基本上相同的工序来产生第二非织造棉絮:熔纺、固结、卷曲、切割、梳理成网、以及压制成约1.0mm的厚度和约120mg/cc的密度。将如上述制备的具有60mg/cc的第一密度和120mg/cc的第二密度的两种非织造物材料精确地叠放到彼此之上并且通过在针刺设备中穿行2遍而牢固地附接。将多层织物在3个分立的异丙醇浴中进行修整和擦洗以移除纺丝油剂和任何机械油。将擦洗过的多层织物在70℃的烘箱中干燥30分钟,冷却并称重。随后针刺的多层非织造物基质便适于用作止血装置。
制备本文所述的织物的一种方法是通过下述过程进行的。可将具有约1至4旦尼尔/纤维尺寸的吸收性聚合物纤维固结成约80至120旦尼尔的多长丝纱线,然后固结成约800至1200旦尼尔的纱线,热卷曲并且随后切割成具有约0.75至2.5英寸长度的短纤维。可将短纤维喂入多辊干铺粗梳机一次或多次并且梳理成均匀的非织造棉絮,同时在15-24℃的室温下将湿度控制在约20-60%之间。例如,可利用具有由交替辊和剥离辊覆盖的主圆筒的单圆筒辊盖板梳理机来制备均匀的非织造棉絮,其中将棉絮通过落纱辊从圆筒的表面脱落并且沉积在采集辊上。可通过针刺或任何其它合适的方式例如压延来进一步地处理棉絮。此后,可通过各种技术例如针刺将第一吸收性非织造物附接到第二吸收性机织物或针织物。随后可将增强的吸收性织物通过在适当的溶剂中洗涤来进行擦洗并且在温和状况下干燥10-30分钟。
使用适于溶解任何纺丝油剂的溶剂来擦洗织物。溶剂包括但不限于异丙醇、己烷、乙酸乙酯和二氯甲烷。然后在提供足够干燥且同时最小化回缩的状况下干燥织物。
本文所述的多层非织造止血基质在被施用到需要止血的伤口时提供和维持有效止血。如本文所用,有效止血为在止血领域的技术人员公认的有效时间内控制和/或减轻轻度至中度出血的能力。有效止血的其它表征可由政府管理标准等来提供。轻度至中度出血的实例包括但不限于因脾切除、肝切除、钝性肝损伤和钝性脾损伤导致的出血。
上文所述的多层非织造止血基质可包含一种或多种止血剂。对于本专利申请而言,止血剂为如下试剂,所述试剂具有止血作用,更优选的是,减慢、阻止并最终停止其应用部位处的出血。用于在损伤部位处产生止血作用的一种方法为引入存在于凝血级联过程中的一种或多种因子,所述因子可与自然存在于身体内的另一种或其它因子反应。在一个实施例中例如凝血酶可用于产生止血作用,而在另一个实施例中,凝血酶和纤维蛋白原相结合使用以产生期望的止血作用。还可提供附加的组分例如钙,以进一步增强凝血酶和/或纤维蛋白原的止血作用。
在一个实施例中,多层非织造止血基质将固体凝血酶和/或固体纤维蛋白原保持为粉末、颗粒形式而不存在间距且从其表面具有最小的粉末损耗,这部分地归因于添加止血剂的方式和基质的非织造特性。另外,由于不同的层密度,止血剂并非均匀地分散在整个基质中,使得较多的止血剂存在于相对低密度的非织造层中,所述相对低密度的非织造层被放置在损伤部位处。在用于将凝血酶和/或纤维蛋白原施用到基质的优选方法中,将包含一种或多种生物制剂的溶液分别冻干。然后利用超精细磨机、球磨机、或冷却的刀磨机将冻干的材料研磨成粉末。将粉末称重并且一起悬浮在其中不溶解蛋白质的载流体内。优选的载流体为全氟化烃,包括但不限于HFE-7000、HFE-7100、HFE-7300和PF-5060(可从3M公司(Minnesota)商购获得)。可使用其中不溶解蛋白质的任何其它载流体,例如醇类、酯类或其它有机流体。将悬浮液充分地混合并且通过常规方式例如湿法涂布、干法涂布、或静电喷涂、浸涂、涂抹、或喷洒而施用到吸收性非织造物,同时保持约15至24℃的室温以及约10至60%(优选不超过30%)的相对湿度。然后将多层非织造基质在环境室温下干燥并且包装在合适的防潮容器中。具有凝血酶和/或纤维蛋白原的止血敷料包含不超过25%的水分,优选不超过15%的水分,并且最优选不超过5%的水分。
凝血酶和/或纤维蛋白原可为动物源的、人体的、或可为重组的。敷料上的凝血酶活性可在约20至500IU/cm2,优选约20至200IU/cm2,并且最优选约50至200IU/cm2的范围内。敷料上的纤维蛋白原活性可在约2至15mg/cm2,优选约3至12mg/cm2,并且最优选约5至10mg/cm2的范围内。施用到非织造物的凝血酶和/或纤维蛋白原粉末的量优选为覆盖其表面的足够量,使得不存在可见的未覆盖区域。粉末可主要位于非织造物之上或者更优选地渗入非织造物中。
作为外科敷料,本文所述的止血基质可用作主伤口闭合装置例如动脉闭合装置、缝钉和缝线的辅助件,以密封气体、液体、或固体的潜在泄漏以及提供止血。本发明的基质因改善的拉伸强度而为尤其有利的,特别是相对于由一层或多层纤维素材料制成或包含一层或多层纤维素材料例如氧化再生纤维素的止血基质而言。例如,可利用该敷料以从组织密封气体或从器官和组织密封流体,所述流体包括但不限于胆汁、淋巴液、脑脊髓液、胃肠液、间隙液和尿液。
本文所述的止血器具有附加的医学应用并且可用于多种临床功能,所述临床功能包括但不限于基质/基底(即纤维蛋白原/凝血酶)涂布、组织强固和支持(即对于胃肠道或血管愈合)、组织拉近(即连接难以执行的愈合(即在张力状态下))、以及张力释放。在所有上述情况下,止血基质可附加地促进并且可能改善自然组织愈合过程。该敷料可在体内用于多种外科,包括但不限于心血管、外周血管、心胸、妇科、神经和普通外科。该止血器也可用于将医疗装置(例如,网、夹子和膜)附接至组织,将组织附接至组织,或将医疗装置附接至医疗装置。
实例1-PGLA的双层基质
将聚(乙交酯-丙交酯)共聚物(PGLA,90摩尔/10摩尔)熔纺成PGLA共聚物纤维。将得自PGLA共聚物纤维的多长丝纱线固结、卷曲、并且切割成具有2.0英寸长度的短纤维。短纤维被梳理成网以产生非织造棉絮,然后被压制成约1.0mm的厚度和约60mg/cc的密度。通过类似的工序来制备第二非织造棉絮,然后将其压制成约1.0mm的厚度和约120mg/cc的密度。然后将具有60mg/cc和120mg/cc的密度的两种非织造物针刺到彼此中,以固定非织造双层基质。
实例2在脾模型中实现止血的双层基质
通过在猪脾上制造15mm长且3mm深的切口来制备轻度到中度的出血模型。然后将如实例1所述的双层基质施用到外科部位并且填塞两分钟。在填塞两分钟之后的30秒内检查止血效果。如果在30秒内未观察到自流出血,则记录为止血时间。如果观察到自流出血,则再填塞30秒直至实现止血或者直至测试期达到十分钟(这被定义为止血失效)。从根据实例1制备的双层基质中切割出三个2.5×4.0厘米尺寸的测试样品,这三个测试样品均在5.62±0.76分钟内实现了止血(表1)。
表1.PGLA双层基质在脾模型中的止血
样品编号 | 1 | 2 | 3 | 平均值 | SD |
止血时间(分钟) | 5.12 | 5.25 | 6.50 | 5.62 | 0.76 |
实例3
使用体外测试来表征根据实例1制备的双层基质的机械性能。将双层基质切割成条带(大约3/8英寸宽×2英寸长)。然后在干燥和润湿状况下利用英斯特朗拉伸测试仪来评估双层基质的拉伸强度。在润湿状况下,将条带放置在如下锥管中,所述锥管包含在37℃下pH为7.4的PBS缓冲液。然后在90分钟、4天、7天、11天和14天时测量条带的拉伸强度。双层基质的条带的拉伸强度的测量值示于表2中。
表2.双层基质在干燥和润湿状况下的拉伸强度
Claims (17)
1.一种合成织物,包含非织造基质,所述非织造基质具有由聚乙交酯/聚丙交酯共聚物的第一吸收性短纤维和聚乙交酯/聚丙交酯共聚物的第二吸收性短纤维构成的至少两层,其中所述第一吸收性短纤维的层被压制成60mg/cc的密度,并且所述第二吸收性短纤维的层被压制成120mg/cc的密度。
2.根据权利要求1所述的合成织物,其中所述第一吸收性短纤维的层和第二吸收性短纤维的层由在组合物中比例为90摩尔/10摩尔的乙交酯/丙交酯的共聚物组成。
3.根据权利要求1所述的合成织物,其中所述第一吸收性短纤维的层和第二吸收性短纤维的层由具有0.75-2.5英寸长度的短纤维构成。
4.根据权利要求3所述的合成织物,其中所述短纤维为卷曲的。
5.根据权利要求4所述的合成织物,其中所述第一吸收性短纤维的层被压制成0.5mm至1.5mm的厚度。
6.根据权利要求4所述的合成织物,其中所述第一吸收性短纤维的层被压制成1mm的厚度。
7.根据权利要求5所述的合成织物,其中所述第二吸收性短纤维的层被压制成0.75mm至3mm的厚度。
8.根据权利要求5所述的合成织物,其中所述第二吸收性短纤维的层被压制成1mm的厚度。
9.根据权利要求5所述的合成织物,其中第一吸收性短纤维的层和第二吸收性短纤维的层被针刺到彼此中。
10.根据权利要求9所述的合成织物,其中所述织物还包含至少一种止血剂。
11.根据权利要求10所述的合成织物,其中所述织物还包含纤维蛋白原和凝血酶作为止血剂。
12.根据权利要求11所述的合成织物,其中所述纤维蛋白原和凝血酶以冻干的粉末形式被设置在所述织物上。
13.根据权利要求12所述的合成织物,其中从所述第一吸收性短纤维的层的外表面到所述第二吸收性短纤维的层的外表面所测量,所述冻干的粉末为不均匀分散的。
14.权利要求13的合成织物在制备医疗装置中的用途。
15.根据权利要求14所述的用途,其中所述装置在被施用到需要止血的伤口时提供和维持有效止血。
16.根据权利要求14所述的用途,其中所述装置在1至10分钟的有效时间内控制和减轻轻度至中度出血。
17.根据权利要求1所述的合成织物,其中在英斯特朗拉伸测试仪中测量,3/8英寸宽至2英寸长的条带具有测得的下述拉伸强度(牛顿/厘米):
a. 在干燥状况下为120;
b. 在润湿状况下90分钟为115;
c. 在润湿状况下4天为90;
d. 在润湿状况下7天为52;
e. 在润湿状况下11天为29;
f. 在润湿状况下14天为16。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/781235 | 2010-05-17 | ||
US12/781,235 US8329211B2 (en) | 2010-05-17 | 2010-05-17 | Reinforced absorbable multi-layered fabric for hemostatic applications |
PCT/US2011/036591 WO2011146360A1 (en) | 2010-05-17 | 2011-05-16 | Reinforced absorbable multi-layered fabric for hemostatic applications |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102892393A CN102892393A (zh) | 2013-01-23 |
CN102892393B true CN102892393B (zh) | 2015-08-19 |
Family
ID=44912407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180024450.9A Expired - Fee Related CN102892393B (zh) | 2010-05-17 | 2011-05-16 | 用于止血应用的增强的吸收性多层织物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US8329211B2 (zh) |
EP (1) | EP2571466B1 (zh) |
JP (1) | JP5823506B2 (zh) |
CN (1) | CN102892393B (zh) |
AU (1) | AU2011256404B2 (zh) |
BR (1) | BR112012029190B1 (zh) |
CA (1) | CA2799918C (zh) |
HK (1) | HK1183224A1 (zh) |
MX (1) | MX2012013397A (zh) |
RU (1) | RU2569057C2 (zh) |
WO (1) | WO2011146360A1 (zh) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2890098T3 (es) | 2012-05-14 | 2022-01-17 | Teijin Ltd | Moldeado de láminas y material hemostático |
JP5927061B2 (ja) * | 2012-06-22 | 2016-05-25 | 帝人株式会社 | シート状止血材 |
EP2971320B1 (en) * | 2013-03-13 | 2021-09-29 | Merit Medical Systems, Inc. | Serially deposited fiber materials and associated devices and methods |
AT514063B1 (de) * | 2013-03-26 | 2014-10-15 | Bca Vertriebsgesellschaft M B H | Absorptionsmaterial |
PT3193781T (pt) | 2014-09-18 | 2021-06-03 | Humacyte Inc | Métodos e aparelhos para formar tubos fibrosos |
KR101878774B1 (ko) * | 2015-04-15 | 2018-07-17 | 주식회사 삼양바이오팜 | 다기능성 지혈제 및 그 제조 방법 |
US10188390B2 (en) | 2015-08-31 | 2019-01-29 | Ethicon Llc | Adjunct material to provide heterogeneous drug elution |
US10569071B2 (en) | 2015-08-31 | 2020-02-25 | Ethicon Llc | Medicant eluting adjuncts and methods of using medicant eluting adjuncts |
US10076324B2 (en) | 2015-08-31 | 2018-09-18 | Ethicon Llc | Adjunct material to provide controlled drug elution |
US10349938B2 (en) | 2015-08-31 | 2019-07-16 | Ethicon Llc | Surgical adjuncts with medicants affected by activator materials |
US10086116B2 (en) | 2015-08-31 | 2018-10-02 | Ethicon Llc | Adjunct material to provide controlled drug release |
US10463366B2 (en) | 2015-08-31 | 2019-11-05 | Ethicon Llc | Adjunct materials for delivery to liver tissue |
US10213520B2 (en) | 2015-08-31 | 2019-02-26 | Ethicon Llc | Surgical adjuncts having medicants controllably releasable therefrom |
US10245034B2 (en) | 2015-08-31 | 2019-04-02 | Ethicon Llc | Inducing tissue adhesions using surgical adjuncts and medicants |
US11020116B2 (en) | 2015-08-31 | 2021-06-01 | Ethicon Llc | Surgical adjuncts with medicants affected by activators |
US10076329B2 (en) | 2015-08-31 | 2018-09-18 | Ethicon Llc | Adjunct material to promote tissue growth in a colon |
US10130738B2 (en) | 2015-08-31 | 2018-11-20 | Ethicon Llc | Adjunct material to promote tissue growth |
US9937283B2 (en) | 2015-08-31 | 2018-04-10 | Ethicon Endo-Surgery, Llc | Adjunct material to provide drug elution from vessels |
US10188389B2 (en) | 2015-08-31 | 2019-01-29 | Ethicon Llc | Adjunct material for delivery to colon tissue |
US10285692B2 (en) | 2015-08-31 | 2019-05-14 | Ethicon Llc | Adjuncts for surgical devices including agonists and antagonists |
US10172973B2 (en) | 2015-08-31 | 2019-01-08 | Ethicon Llc | Surgical adjuncts and medicants for promoting lung function |
US10499913B2 (en) | 2015-08-31 | 2019-12-10 | Ethicon Llc | Tubular surgical constructs including adjunct material |
US10279086B2 (en) | 2015-08-31 | 2019-05-07 | Ethicon Llc | Composite adjunct materials for delivering medicants |
US10194936B2 (en) | 2015-08-31 | 2019-02-05 | Ethicon Endo-Surgery, Llc | Adjunct material for delivery to stomach tissue |
US10111661B2 (en) | 2015-08-31 | 2018-10-30 | Ethicon Llc | Matrix metalloproteinase inhibiting adjuncts for surgical devices |
US10034957B2 (en) | 2015-11-06 | 2018-07-31 | Ethicon Llc | Compacted hemostatic cellulosic aggregates |
WO2017153640A1 (fr) * | 2016-03-08 | 2017-09-14 | Urgo Recherche Innovation Et Developpement | Pansement se présentant sous la forme d'une bande autoadhérente |
CN109563662B (zh) | 2016-08-02 | 2020-08-28 | 博爱德国有限公司 | 用于制备聚乳酸非织造织物的系统和方法 |
US11413335B2 (en) | 2018-02-13 | 2022-08-16 | Guangzhou Bioseal Biotech Co. Ltd | Hemostatic compositions and methods of making thereof |
CN107754005B (zh) | 2016-08-15 | 2021-06-15 | 广州倍绣生物技术有限公司 | 止血组合物及其制造方法 |
US11441251B2 (en) | 2016-08-16 | 2022-09-13 | Fitesa Germany Gmbh | Nonwoven fabrics comprising polylactic acid having improved strength and toughness |
US11254061B2 (en) | 2017-01-06 | 2022-02-22 | Ethicon, Inc. | Scaffolds for implanting absorbable hemostats in field conditions |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0647734A1 (en) * | 1993-10-06 | 1995-04-12 | United States Surgical Corporation | Absorbable non-woven fabric |
CN101137402A (zh) * | 2004-10-20 | 2008-03-05 | 伊西康公司 | 供医疗装置用的加固可吸收多层织物及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626253A (en) | 1984-10-05 | 1986-12-02 | Johnson & Johnson Products, Inc. | Surgical hemostat comprising oxidized cellulose |
WO1993017635A1 (en) | 1992-03-04 | 1993-09-16 | C.R. Bard, Inc. | Composite prosthesis and method for limiting the incidence of postoperative adhesions |
CA2114282A1 (en) | 1993-01-28 | 1994-07-29 | Lothar Schilder | Multi-layered implant |
EP1555957A4 (en) | 2002-10-04 | 2010-11-24 | Nanomatrix Inc | CLOSURE FOR SKIN AND OTHER TISSUE |
WO2004064878A1 (ja) * | 2003-01-20 | 2004-08-05 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 止血用材料 |
RU2005134239A (ru) * | 2003-04-04 | 2006-05-10 | Тиссьюмед Лимитед (Gb) | Составы тканевых клеев |
US7818350B2 (en) * | 2005-02-28 | 2010-10-19 | Yahoo! Inc. | System and method for creating a collaborative playlist |
KR101321724B1 (ko) * | 2006-04-10 | 2013-10-29 | 옴릭스 바이오파마슈티칼, 인코포레이티드 | 흡수성이 강화된 지혈용 다층 상처 드레싱 및 이의 제조방법 |
US20080200890A1 (en) | 2006-12-11 | 2008-08-21 | 3M Innovative Properties Company | Antimicrobial disposable absorbent articles |
JP2010069031A (ja) * | 2008-09-19 | 2010-04-02 | Chemo Sero Therapeut Res Inst | シート状フィブリン糊接着剤 |
-
2010
- 2010-05-17 US US12/781,235 patent/US8329211B2/en active Active
-
2011
- 2011-05-16 CA CA2799918A patent/CA2799918C/en active Active
- 2011-05-16 AU AU2011256404A patent/AU2011256404B2/en active Active
- 2011-05-16 MX MX2012013397A patent/MX2012013397A/es active IP Right Grant
- 2011-05-16 JP JP2013511252A patent/JP5823506B2/ja not_active Expired - Fee Related
- 2011-05-16 EP EP11784013.2A patent/EP2571466B1/en active Active
- 2011-05-16 BR BR112012029190-4A patent/BR112012029190B1/pt not_active IP Right Cessation
- 2011-05-16 WO PCT/US2011/036591 patent/WO2011146360A1/en active Application Filing
- 2011-05-16 RU RU2012154329/15A patent/RU2569057C2/ru active
- 2011-05-16 CN CN201180024450.9A patent/CN102892393B/zh not_active Expired - Fee Related
-
2013
- 2013-09-13 HK HK13110612.2A patent/HK1183224A1/zh not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0647734A1 (en) * | 1993-10-06 | 1995-04-12 | United States Surgical Corporation | Absorbable non-woven fabric |
CN101137402A (zh) * | 2004-10-20 | 2008-03-05 | 伊西康公司 | 供医疗装置用的加固可吸收多层织物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
MX2012013397A (es) | 2012-12-10 |
CA2799918A1 (en) | 2011-11-24 |
US20110282364A1 (en) | 2011-11-17 |
EP2571466B1 (en) | 2014-12-10 |
JP5823506B2 (ja) | 2015-11-25 |
US8329211B2 (en) | 2012-12-11 |
JP2013526369A (ja) | 2013-06-24 |
AU2011256404A1 (en) | 2012-12-06 |
EP2571466A1 (en) | 2013-03-27 |
CA2799918C (en) | 2018-01-23 |
BR112012029190B1 (pt) | 2020-05-26 |
EP2571466A4 (en) | 2013-12-04 |
AU2011256404B2 (en) | 2014-06-19 |
RU2569057C2 (ru) | 2015-11-20 |
RU2012154329A (ru) | 2014-06-27 |
HK1183224A1 (zh) | 2013-12-20 |
BR112012029190A2 (pt) | 2016-11-29 |
WO2011146360A1 (en) | 2011-11-24 |
CN102892393A (zh) | 2013-01-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102892393B (zh) | 用于止血应用的增强的吸收性多层织物 | |
CN102892439A (zh) | 用于止血应用的增强的吸收性合成基质 | |
DK2052746T3 (en) | Absorbable hemostatic patch | |
BRPI0621537B1 (pt) | Curativo hemostático de múltiplas camadas absorvível e reforçado para curativo, e método de fabricação |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150819 |