CN102885977A - Composition with memory improving function - Google Patents
Composition with memory improving function Download PDFInfo
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- CN102885977A CN102885977A CN2012104382379A CN201210438237A CN102885977A CN 102885977 A CN102885977 A CN 102885977A CN 2012104382379 A CN2012104382379 A CN 2012104382379A CN 201210438237 A CN201210438237 A CN 201210438237A CN 102885977 A CN102885977 A CN 102885977A
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Abstract
The invention discloses a composition with a memory improving function, and relates to a composition which is used for solving the problem that the memory improving medicines prepared from the existing traditional Chinese medicines and the extracts thereof are great in side effect and high in cost. The composition with the memory improving function is prepared from phosphatidylserine, Chinese wolfberry, polygonatum, ginkgo and tuckahoe. The phosphatidylserine has a favorable memory improving function and is low in cost and easily available; the four traditional Chinese medicines belong to food and medicines, so that the safety and the effect are provided; and according to the combination of the phosphatidylserine and the traditional Chinese medicines, the mechanism of a brain can be improved, the brain injury can be repaired and the memory can be improved. The composition with the memory improving function is applied to the field of traditional Chinese medicines.
Description
Technical field
The present invention relates to a kind of compositions.
Background technology
Learning and memory is human central nervous system's senior function, is that brain substantially the most also is one of most important higher nerve function, is to weigh the important indicator that human intelligence is grown.It is an important behaviour of alzheimer disease (AD) that ability of learning and memory descends.
Hypomnesis is a kind of dysmnesia, and is more common clinically.Can show as going down of memory far away and nearly memory.Be mainly seen in cerebral organic psychosis.What brain organic infringement patient occurred the earliest is going down of nearly memory, and the patient does not remember these last few days, even the feed situation on the same day, or does not remember within the next few days who once came to visit etc.The rear memory far away that is in a bad way also goes down, and for example, can not recall my experience etc.
In recent years relevant Chinese medicine and extract thereof come into one's own day by day on the research of animal learning memory function impact, studies show that Chinese medicine has its unique distinction to improving going down of animal learning memory function, but because some Chinese medicine long-term taking has certain side effect and part Chinese medicine price is high, the medicine that improves memory function that therefore existing Chinese medicine and extract thereof are made exists side effect to reach greatly the high problem of cost.
Summary of the invention
The present invention will solve the medicine that improves memory function that existing Chinese medicine and extract thereof make to exist side effect to reach greatly the high problem of cost, and a kind of compositions of improving memory function that has is provided.
A kind of compositions of improving memory function that has of the present invention is to be made by 0.8～2 part of Phosphatidylserine, 8～12 portions of Fructus Lyciis, 4～8 parts of Rhizoma Polygonatis, 1～4 portion of Semen Ginkgo and 1～4 part of Poria by mass fraction.
The pharmacology of each crude drug and drug effect among the present invention:
1, Phosphatidylserine: Phosphatidylserine, English name Phosphatidylserine is called for short PS, is extracted by crude soya bean oil expression residue.Be the active substance of cell membrane, it is present in the brain cell.Phosphatidylserine has following function: (1) improves cerebral function, improves senile dementia: with age growth, chemical substance can reduce gradually in Phosphatidylserine and other important brain, thereby causes memory, cognitive power to weaken.Replenishing phosphatidyl silk amino acid can increase the mobile of brain bur number, brain cell membrane and promote glucose metabolism in the brain cell, thereby makes brain cell more active.The old and feeble dementia that causes and old memory loss are treated by Italy and other European countries all extensive use Phosphatidylserine supplement.(2) help to repair cerebral lesion, Phosphatidylserine is one of main component of brain neuroblastoma, have nutrition and the activity that activates various enzymes in the brain, can delay the minimizing process of neurotransmitter, help to repair, upgrade the brain damaged cell and remove harmful substance.(3) relieving stress, promote recovery, the balance emotion of brain fag: multinomial studies show that, the level of too much stress hormone in Phosphatidylserine can significantly reduce work strain person's body, ease off the pressure, it is tired to alleviate brain, can also promote that attention is concentrated, stepping up vigilance property and memory, the improper release emotion.
2, Fructus Lycii---carry according to Compendium of Material Medica: Fructus Lycii has vital essence, the hard muscles and bones of benefit, makes eye bright and calm the nerves, and it is not old to make light of one's life by commiting suicide, the effect of life prolonging.Fructus Lycii has protective effect to the experimental animal models learning and memory, and can resist the memory impairment due to the chemical factors.Especially lycium barbarum polysaccharide has widely pharmacological action, as strengthens immunity, improves memory, protects the liver antitumor, the functions such as slow down aging.
3, Rhizoma Polygonati---polygonatum polysaccharide can significantly improve old rats learning and memory and memory represents ability, reduces errors number.Related tests shows that Rhizoma Polygonati administration group can obviously shorten the latent time of rat in the test of labyrinth.Modern pharmacological research: Rhizoma Polygonati includes trace element, the aminoacid of multiple needed by human.Polygonatum polysaccharide can strengthen cardiac contractile force, strengthens coronary artery blood flow, and vessel softening reduces blood pressure and the effect of blood glucose.Improve immunity of organisms, slow down aging.
4, Semen Ginkgo---claim again Semen Ginkgo, carry according to Compendium of Material Medica: Semen Ginkgo warming the lung and benefiting QI, relieving cough and asthma.Modern pharmacological research: the contained Semen Ginkgo lactone of Semen Ginkgo extract GBE is the strong antagonist of a kind of specificity platelet activating factor PAF, has strong thrombolytic, the expansion cerebrovascular; increase cerebral blood flow; improve and the protection brain cell, strengthen the content of neurotransmitter, reduce the damage of neurocyte.Improve energy metabolism and the nutriture of anoxia brain cell.Improve the brain cell hypoxia-bearing capability.
5, Poria---carry according to Compendium of Material Medica: Poria has that the peace soul is reposed, not hungryly prolonged life, happy Fructus Alpiniae Oxyphyllae, only forgetful, warm waist knee joint, diuresis, the effects such as beneficial dry and middle QI invigorating go out wet.Related documents report, land are built medium employing Morris water maze laboratory and are dyed plumbous experiment and survey blood lead and bone lead content.The result shows: each dosage group blood lead of Poria extract and bone lead content obviously reduce, and with model group significant difference are arranged relatively.Simultaneously, each dosage group of Poria extract can obviously shorten the escape time that mice arrives platform, and the Poria extract high dose group also can obviously suppress the expression of Cerebral Cortex and hippocampus Fas antigen, can promote to dye plumbous eliminating the in the plumbous Mice Body, to improving the brain memory function obvious effect is arranged.
Among the present invention take Fructus Lycii as monarch drug, Fructus Lycii, sweet, flat.Return liver, kidney channel.It has vital essence, the hard muscles and bones of benefit, makes eye bright and calm the nerves, and it is not old to make light of one's life by commiting suicide, the effect of life prolonging.Take Rhizoma Polygonati as ministerial drug, its property is sweet, and is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Fructus Lycii, Rhizoma Polygonati all belong to the kidney tonifying, essence replenishing medicine.Relevant studies show that, the Chinese medicine with nootropic effect mostly is the kidney tonifying, essence replenishing medicine.Semen Ginkgo, sweet; Bitter; Puckery; Property is put down; Mild toxicity.Poria, sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Fructus Lycii, Rhizoma Polygonati, Semen Ginkgo, Poria four flavor Chinese medicines, cooperative compensating is played the effect of improving memory, defying age altogether.And it is that food is again the Chinese medicine of medicine that four flavor Chinese medicines belong to, safe and effective.Phosphatidylserine is extracted by crude soya bean oil expression residue, is the active substance of cell membrane, and it is present in the brain cell, has the function of good improvement memory, and cheap and easy to get, is the new resources that are worth being widely used.Four flavor compatibility Chinese medicines and Phosphatidylserine combination improve cerebral function, repair brain injury, and slow down aging is played the effect of improving memory altogether.
The specific embodiment
The specific embodiment one: present embodiment a kind of has the compositions of improving memory function, is to be made by 0.8～2 part of Phosphatidylserine, 8～12 portions of Fructus Lyciis, 4～8 parts of Rhizoma Polygonatis, 1～4 portion of Semen Ginkgo and 1～4 part of Poria by mass fraction.
The compositions that having in the present embodiment improved memory function can be prepared into oral liquid, and concrete grammar is: get 10 parts of Fructus Lycii, 6 parts of Rhizoma Polygonatis, 3 portions of Semen Ginkgoes, 3 parts of Poria, add 8～12 times of amount deionized waters and decoct 2 times, each 1.5 hours, get water extract; Then add 1 part of Phosphatidylserine in the water extract and fully dissolve, add again proper honey, make oral liquid.Press practice of pharmacy, can also will have a kind of in the middle of the agent of compositions granulation, tablet, capsule, pill, drop pill and the suspensoid that improves memory function in the present embodiment.Present embodiment has in the various dosage forms of the compositions of improving memory function, also can add conventional drug excipient, such as solvent, disintegrating agent, correctives, antiseptic, painted etc.
The pharmacology of each crude drug and drug effect in the present embodiment:
1, Phosphatidylserine: Phosphatidylserine, English name Phosphatidylserine is called for short PS, is extracted by crude soya bean oil expression residue.Be the active substance of cell membrane, it is present in the brain cell.Phosphatidylserine has following function: (1) improves cerebral function, improves senile dementia: with age growth, chemical substance can reduce gradually in Phosphatidylserine and other important brain, thereby causes memory, cognitive power to weaken.Replenishing phosphatidyl silk amino acid can increase the mobile of brain bur number, brain cell membrane and promote glucose metabolism in the brain cell, thereby makes brain cell more active.The old and feeble dementia that causes and old memory loss are treated by Italy and other European countries all extensive use Phosphatidylserine supplement.(2) help to repair cerebral lesion, Phosphatidylserine is one of main component of brain neuroblastoma, have nutrition and the activity that activates various enzymes in the brain, can delay the minimizing process of neurotransmitter, help to repair, upgrade the brain damaged cell and remove harmful substance.(3) relieving stress, promote recovery, the balance emotion of brain fag: multinomial studies show that, the level of too much stress hormone in Phosphatidylserine can significantly reduce work strain person's body, ease off the pressure, it is tired to alleviate brain, can also promote that attention is concentrated, stepping up vigilance property and memory, the improper release emotion.
2, Fructus Lycii---carry according to Compendium of Material Medica: Fructus Lycii has vital essence, the hard muscles and bones of benefit, makes eye bright and calm the nerves, and it is not old to make light of one's life by commiting suicide, the effect of life prolonging.Fructus Lycii has protective effect to the experimental animal models learning and memory, and can resist the memory impairment due to the chemical factors.Especially lycium barbarum polysaccharide has widely pharmacological action, as strengthens immunity, improves memory, protects the liver antitumor, the functions such as slow down aging.
3, Rhizoma Polygonati---polygonatum polysaccharide can significantly improve old rats learning and memory and memory represents ability, reduces errors number.Related tests shows that Rhizoma Polygonati administration group can obviously shorten the latent time of rat in the test of labyrinth.Modern pharmacological research: Rhizoma Polygonati includes trace element, the aminoacid of multiple needed by human.Polygonatum polysaccharide can strengthen cardiac contractile force, strengthens coronary artery blood flow, and vessel softening reduces blood pressure and the effect of blood glucose.Improve immunity of organisms, slow down aging.
4, Semen Ginkgo---claim again Semen Ginkgo, carry according to Compendium of Material Medica: Semen Ginkgo warming the lung and benefiting QI, relieving cough and asthma.Modern pharmacological research: the contained Semen Ginkgo lactone of Semen Ginkgo extract GBE is the strong antagonist of a kind of specificity platelet activating factor PAF, has strong thrombolytic, the expansion cerebrovascular; increase cerebral blood flow; improve and the protection brain cell, strengthen the content of neurotransmitter, reduce the damage of neurocyte.Improve energy metabolism and the nutriture of anoxia brain cell.Improve the brain cell hypoxia-bearing capability.
5, Poria---carry according to Compendium of Material Medica: Poria has that the peace soul is reposed, not hungryly prolonged life, happy Fructus Alpiniae Oxyphyllae, only forgetful, warm waist knee joint, diuresis, the effects such as beneficial dry and middle QI invigorating go out wet.Related documents report, land are built medium employing Morris water maze laboratory and are dyed plumbous experiment and survey blood lead and bone lead content.The result shows: each dosage group blood lead of Poria extract and bone lead content obviously reduce, and with model group significant difference are arranged relatively.Simultaneously, each dosage group of Poria extract can obviously shorten the escape time that mice arrives platform, and the Poria extract high dose group also can obviously suppress the expression of Cerebral Cortex and hippocampus Fas antigen, can promote to dye plumbous eliminating the in the plumbous Mice Body, to improving the brain memory function obvious effect is arranged.
In the present embodiment take Fructus Lycii as monarch drug, Fructus Lycii, sweet, flat.Return liver, kidney channel.It has vital essence, the hard muscles and bones of benefit, makes eye bright and calm the nerves, and it is not old to make light of one's life by commiting suicide, the effect of life prolonging.Take Rhizoma Polygonati as ministerial drug, its property is sweet, and is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Fructus Lycii, Rhizoma Polygonati all belong to the kidney tonifying, essence replenishing medicine.Relevant studies show that, the Chinese medicine with nootropic effect mostly is the kidney tonifying, essence replenishing medicine.Semen Ginkgo, sweet; Bitter; Puckery; Property is put down; Mild toxicity.Poria, sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Fructus Lycii, Rhizoma Polygonati, Semen Ginkgo, Poria four flavor Chinese medicines, cooperative compensating is played the effect of improving memory, defying age altogether.And it is that food is again the Chinese medicine of medicine that four flavor Chinese medicines belong to, safe and effective.Phosphatidylserine is extracted by crude soya bean oil expression residue.Be the active substance of cell membrane, it is present in the brain cell, has the function of good improvement memory, and cheap and easy to get, is the new resources that are worth being widely used.Four flavor compatibility Chinese medicines and Phosphatidylserine combination improve cerebral function, repair brain injury, and slow down aging is played the effect of improving memory altogether.
Phosphatidylserine in the present embodiment is bought the extraction biotechnology Co., Ltd from Xian District, Shanxi Province China.
The specific embodiment two: present embodiment and the specific embodiment one are different is that to have the compositions of improving memory function be to be made by 1 part of Phosphatidylserine, 10 portions of Fructus Lyciis, 6 parts of Rhizoma Polygonatis, 3 portions of Semen Ginkgoes and 3 parts of Poria by mass fraction.Other are identical with the specific embodiment one.
By following verification experimental verification beneficial effect of the present invention:
Test 1: this test is divided into test group and matched group.
1, subjects
Four groups of tests are set, and every group is got 12 young mices is subjects.
2, test method
The negative matched group of A group mice.
B group mice throw something and feed every day Fructus Lycii 1000mg, Rhizoma Polygonati 600mg, Poria 300mg and Semen Ginkgo 300mg threw something and fed for 12 weeks continuously.
The C group mice Phosphatidylserine 10mg that throws something and feeds every day threw something and fed for 12 weeks continuously.
D group mice throw something and feed every day Fructus Lycii 1000mg, Rhizoma Polygonati 600mg, Poria 300mg, Semen Ginkgo 300mg and Phosphatidylserine 10mg threw something and fed for 12 weeks continuously.
3, result of the test
This trial drug has no side effect to mice, after 12 weeks four groups of mices is carried out maze test and step down test, and result of the test as shown in Table 1 and Table 2.
Table 1, four groups of rat/mouse labyrinth test effects are relatively
| Group | Sample number (only) | Accuracy |
| The A group | 12 | 66.7％ |
| The B group | 12 | 75％ |
| The C group | 12 | 83.3％ |
| The D group | 12 | 91.7％ |
Table 2, four groups of mice step down test results are relatively
As apparent from Table 1, taking D group compositions has certain effect to mice, and D group composite preparation effective percentage is higher than B group and C group compositions.
Taking as apparent from Table 2 D group compositions has certain effect to mice, and D group composite preparation effective percentage is higher than B group and C group compositions.
Claims (2)
1. one kind has the compositions of improving memory function, and it is characterized in that having the compositions of improving memory function is to be made by 0.8～2 part of Phosphatidylserine, 8～12 portions of Fructus Lyciis, 4～8 parts of Rhizoma Polygonatis, 1～4 portion of Semen Ginkgo and 1～4 part of Poria by mass fraction.
2. a kind of compositions of improving memory function that has according to claim 1, it is characterized in that having the compositions of improving memory function is to be made by 1 part of Phosphatidylserine, 10 portions of Fructus Lyciis, 6 parts of Rhizoma Polygonatis, 3 portions of Semen Ginkgoes and 3 parts of Poria by mass fraction.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106538996A (en) * | 2016-10-31 | 2017-03-29 | 烟台新时代健康产业有限公司 | A kind of Folium Bambosae flavone compositionss and its preparation for improving learning and memory ability |
| CN107158298A (en) * | 2017-06-14 | 2017-09-15 | 芜湖福民生物药业股份有限公司 | Chinese herbal granules and preparation method thereof |
| CN107158191A (en) * | 2017-06-14 | 2017-09-15 | 芜湖福民生物药业股份有限公司 | Chinese herbal granules and preparation method thereof |
| CN107281361A (en) * | 2017-06-14 | 2017-10-24 | 芜湖福民生物药业股份有限公司 | Chinese herbal granules and preparation method thereof |
| CN112089056A (en) * | 2020-09-22 | 2020-12-18 | 上海泓商生物科技有限公司 | Memory improving probiotic composition |
| CN113144043A (en) * | 2021-04-24 | 2021-07-23 | 湖州润合医药科技有限公司 | Composition for preventing and improving hypomnesis and senile dementia and preparation method and application thereof |
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| CN1701723A (en) * | 2005-06-08 | 2005-11-30 | 张国平 | Health caring beverage |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106538996A (en) * | 2016-10-31 | 2017-03-29 | 烟台新时代健康产业有限公司 | A kind of Folium Bambosae flavone compositionss and its preparation for improving learning and memory ability |
| CN107158298A (en) * | 2017-06-14 | 2017-09-15 | 芜湖福民生物药业股份有限公司 | Chinese herbal granules and preparation method thereof |
| CN107158191A (en) * | 2017-06-14 | 2017-09-15 | 芜湖福民生物药业股份有限公司 | Chinese herbal granules and preparation method thereof |
| CN107281361A (en) * | 2017-06-14 | 2017-10-24 | 芜湖福民生物药业股份有限公司 | Chinese herbal granules and preparation method thereof |
| CN112089056A (en) * | 2020-09-22 | 2020-12-18 | 上海泓商生物科技有限公司 | Memory improving probiotic composition |
| CN113144043A (en) * | 2021-04-24 | 2021-07-23 | 湖州润合医药科技有限公司 | Composition for preventing and improving hypomnesis and senile dementia and preparation method and application thereof |
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Inventor after: Wang Lina Inventor after: Liu Qiuli Inventor after: Li Yuntao Inventor after: Ren Ruitao Inventor after: Chen Yu Inventor after: Wu Zhijun Inventor after: Dan Yuyu Inventor before: Wang Lina Inventor before: Dan Yuyu Inventor before: Li Yuntao Inventor before: Ren Ruitao Inventor before: Wu Zhijun Inventor before: Chen Yu |
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Free format text: CORRECT: INVENTOR; FROM: WANG LINA DAN YUYU LI YUNTAO REN RUITAO WU ZHIJUN CHEN YU TO: WANG LINA LIU QIULI LI YUNTAO REN RUITAO CHEN YU WU ZHIJUN DAN YUYU |
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Effective date of registration: 20211220 Address after: 150000 room a307-169, building 20, innovation and entrepreneurship Plaza, science and technology innovation city, high tech Industrial Development Zone, Harbin, Heilongjiang Province (178 Xiuyue Street) Patentee after: Harbin Pharmaceutical Group traditional Chinese Medicine Co.,Ltd. Address before: 150078 No. 243 Airport Road, Daoli District, Heilongjiang, Harbin Patentee before: The Second Chinese Medicine Factory, Harbin Pharmaceutical Group Co.,Ltd. |
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