CN103372174B - A kind of herbal mixture that is used for the treatment of depression - Google Patents
A kind of herbal mixture that is used for the treatment of depression Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition that is used for the treatment of depression. It is dialled as raw material taking Chinese herbaceous peony, radix bupleuri, turmeric, hypericum perforatum, purple perilla, the wind-weed, Bi, separate through 0～75% alcohol extract, make medically acceptable oral formulations, as formulations such as tablet, capsule (soft capsule or hard shell capsules), granules. Drafting function cures mainly: soothing liver-qi stagnation, disperse blood stasis and dredge collateral. For light moderate depressive patients. Pharmacodynamic study shows: it is movable that pharmaceutical composition can significantly strengthen spacious of chronic stress depression model rat, increases its syrup consumption; The depression model mouse movement of antagonism reserpine induction can not and body temperature reduce, can make outstanding tail and the desperate animal model autonomic activities number of forced swimming induction, outstanding tail and non-swimming time increase. The present invention has the function of soothing liver-qi stagnation, is the effectively specially medicine of Cure of depression.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of medicine of Cure of depression, be specifically comprise Chinese herbaceous peony,The herbal mixture that the wind-weed, turmeric, hypericum perforatum, radix bupleuri, purple perilla, Bi dial.
Background technology
Depression is a kind of common emotion and phrenoblabia disease, along with the quickening of social life rhythm, presses downStrongly fragrant disease has become the disease occurred frequently of society. World Health Organization 2005 statistics, various depression illRate accounts for 11% of population in the world. Show according to China's epidemiology survey in 2003, China has 3,600 ten thousand depressions at leastDisease patient, wherein only has 5% severe patient to accept associated treatment. There are many major depression patients because of not timelyCarry out regular treatment and committed suicide. According to the death toll of 2003 according to one's analysis, China has 28.7 ten thousand people every year at leastMouth committed suicide. Suicide is the 5th cause of the death in population of China, is first cause of the death of 15～34 years old crowd. CauseThis, the drug research of strengthening Cure of depression has important society and economic implications.
For the treatment of depression, doctor trained in Western medicine adopts serotonin reuptake depressant, monoamine oxidase to press down more at presentPharmacy, phenyl piperazines, serotonin-norepinephrine reuptake inhibitor, aminoketones, threeThe 7 class antidepressants such as piperazine azatropylidene class are sent at lopps, Fourth Ring, but synthetic antidepressants mostly exist antidepression spectrum narrow,Toxic and side effect is large, medicine valency is high and the defect such as easy recurrence. Therefore, the domestic and international development at antidepressants and exploitation sideFace is more and more focused on traditional medicine (particularly having more than 2,000 year historical Chinese herbal medicine), is even good at exploitation synthetic drugThe also main force's medicine using some true medicable traditional medicines as Cure of depression of American-European countries.
Depressed card belongs to the melancholia category of the traditional Chinese medical science, and disease is complicated and changeable, how to cause because feelings will is upset.Chinese medicine compound prescription has the advantages that composition is many, effect link is many, target spot is many, and multicomponent synergy, makes upThe low feature of active constituent content, reduced side effect. Therefore, development antidepression good effect, side effect little,Be applicable to long-term taking and safe and reliable Chinese medicine composition and become current study hotspot. The present invention has soothing the liver solutionThe feature of strongly fragrant, disperse blood stasis and dredge collateral, is mainly used in light, moderate depressive patients.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition and preparation thereof that is used for the treatment of depression.
The pharmaceutical composition of Cure of depression of the present invention, the Chinese medicine material that comprises following weight portion proportioning: Chinese herbaceous peony0.8～3 part, 0.3～2 part, turmeric, 0.2～1 part of hypericum perforatum, 0.5～2 part of radix bupleuri, 0.5～2 part of purple perilla.
Preferably, the Chinese medicine material that comprises following weight portion proportioning: 0.8～3 part of Chinese herbaceous peony, 0.3～2 part, turmeric,0.2～1 part of hypericum perforatum, 0.5～2 part of radix bupleuri, 0.5～2 part of purple perilla, 0～3 part of the wind-weed.
And then more preferably, the Chinese medicine material that comprises following weight portion proportioning: 0.8～3 part of Chinese herbaceous peony, turmeric 0.3～2Part, 0.2～1 part of hypericum perforatum, 0.5～2 part of radix bupleuri, 0.5～2 part of purple perilla, 0～3 part of the wind-weed, Bi dial 0～1Part.
Aforementioned pharmaceutical compositions is taken after can decocting, also can water or alcohol extract after make Chinese patent drug and take.
The preparation method of drug combination preparation of the present invention can adopt the conventional method of pharmaceutical field, uses conventionalPharmaceutic adjuvant carry out. For example adopt conventional method by normal in extract and any one or more than one pharmacyWith carrier or auxiliary material mix, then make various peroral dosage forms. Described carrier for example excipient, filler,Diluent, lubricant, wetting agent, disintegrant, surfactant, anticorrisive agent, sweetener, aromatic etc.Particularly, for example starch, dextrin, lactose, microcrystalline cellulose, HPMC, poly-second of described carrierGlycol, dolomol, superfine silica gel powder, glucose, sweet mellow wine, xylitol, glycine etc.
As required, pharmaceutical composition of the present invention can be made into the preparation that is suitable for oral medication, can be followingArbitrary formulation: tablet, capsule, granule, pill, oral liquid etc., preferably soft capsule, dispersing tablet,Oral disnitegration tablet, dripping pill.
Another object of the present invention is that a kind of preferred preparation method is also provided, and Cure of depression or depression are providedThe preparation method of the Chinese medicine composition of state, the method comprises the steps:
In Chinese medicine material, add 0～70% ethanol, extract 2～3 times, add 4～12 times of amount solvents at every turn; OftenInferior extraction 1～2 hour, extract filters, and reclaims solvent concentrated, dry, pulverize, as composite preparationRaw material.
Another object of the present invention is to provide the application of this pharmaceutical composition at aspects such as Cure of depressions.
The present invention's flavour of a drug of writing out a prescription share, and have the function of soothing liver-qi stagnation, disperse blood stasis and dredge collateral. The group that the party is extractedThe pharmacological research of compound shows, said composition all has the anti-inhibitory action of specificity to multiple depression model.
Detailed description of the invention
For the present invention is further described in detail, provide specific embodiment, but only as illustratingThe present invention, instead of in order to limit the scope of the invention.
The particle formulation of embodiment 1 pharmaceutical composition of the present invention
Adopt routine to prepare granule method, get 3 parts of Chinese herbaceous peonies, 2.4 parts of the wind-weeds, 1.2 parts, turmeric, pass through leaf evenStick up 0.9 part, 1.8 parts of radix bupleuri, 1.8 parts of purple perillas, Bi and dial 0.3 part, soak after 0.5 hour and extract 2 times,Amount of water is respectively 10 times, 8 times, extracts for the first time 2 hours, extracts for the second time 1.5 hours, filter,Merging filtrate, concentrated, dry, add right amount of auxiliary materials after pulverizing, mix, granulate, sieve, dry, makeThe drug combination preparation of granula type.
The tablet form of embodiment 2 pharmaceutical compositions of the present invention
Adopt the conventional method of preparing tablet, get 0.8 part of Chinese herbaceous peony, 1 part of the wind-weed, 0.3 part, turmeric, pass through leaf evenStick up 0.2 part, 0.5 part of radix bupleuri, 0.5 part of purple perilla, Bi and dial 0.5 part, soak after 0.5 hour and extract 2 times,Amount of water is respectively 6 times, 4 times, extracts for the first time 2 hours, extracts for the second time 1 hour, filters, and mergesFiltrate, concentrated, dry, add right amount of auxiliary materials after pulverizing, mix, granulate, sieve, dry, by makeGrain is through further compressing tablet, dry, makes the drug combination preparation of Tabules.
The capsule formulation of embodiment 3 pharmaceutical compositions of the present invention
Adopt the conventional method of preparing capsule, get 2 parts of Chinese herbaceous peonies, 1.5 parts of the wind-weeds, 1 part, turmeric, pass through leaf evenStick up 0.6 part, 1.5 parts of radix bupleuri, 1.5 parts of purple perillas, Bi and dial 1 part, add 60% alcohol immersion and extract after 0.5 hour2 times, amount of water is respectively 7 times, 5 times, extracts for the first time 2 hours, extracts for the second time 1 hour, filter,Merging filtrate, adds right amount of auxiliary materials after concentrating, be dried, pulverize, and mixes, and granulates, and sieves, dry, will makeParticle incapsulate shell, make capsule, make the drug combination preparation of capsule formulation.
The drops of embodiment 4 present compositions
Preparation: adopt the conventional technique of preparing dripping pill, get 1.5 parts of Chinese herbaceous peonies, 1.5 parts of the wind-weeds, 0.8 part, turmeric,0.5 part of hypericum perforatum, 1 part of radix bupleuri, 1 part of purple perilla, Bi dial 0.8 part, add 50% alcohol immersion 0.5 hourRear extraction 2 times, amount of water is respectively 6 times, 4 times, extracts for the first time 2 hours, extract for the second time 1 hour,Filter, merging filtrate, adds right amount of auxiliary materials after concentrating, be dried, pulverize, and makes the dripping pill of this pharmaceutical composition.
The soft capsule dosage form of embodiment 5 present compositions
Preparation: adopt the conventional technique of preparing soft capsule, get 1.2 parts of Chinese herbaceous peonies, 1.5 parts of the wind-weeds, 1 part, turmeric,0.3 part of hypericum perforatum, 0.7 part of radix bupleuri, 0.8 part of purple perilla, Bi dial 0.6 part, add 40% alcohol immersion 0.5 littleTime after extract 2 times, amount of water is respectively 7 times, 5 times, extracts for the first time 2 hours, extracts for the second time 1 littleTime, filter, merging filtrate, concentrated, dry, add right amount of auxiliary materials after pulverizing, mix, make softgel shell material with gelatinMaterial, is pressed into soft capsule, makes the soft capsule of this pharmaceutical composition.
The micropill formulation of embodiment 6 present compositions
Preparation: adopt the conventional technique of preparing micropill, get 1 part of Chinese herbaceous peony, 1 part of the wind-weed, 0.6 part, turmeric, pass through0.3 part of the leaf capsule of weeping forsythia, 0.9 part of radix bupleuri, 0.7 part of purple perilla, Bi dial 0.4 part, add 30% alcohol immersion 0.5 hourRear extraction 2 times, amount of water is respectively 6 times, 4 times, extracts for the first time 2 hours, extract for the second time 1 hour,Filter, merging filtrate, adds right amount of auxiliary materials after concentrating, be dried, pulverize, and makes the micropill of this pharmaceutical composition.
The oral disnitegration tablet of embodiment 7 present compositions
Preparation: adopt the conventional technique of preparing oral disnitegration tablet, get 1.5 parts of Chinese herbaceous peonies, 1.2 parts of the wind-weeds, turmeric0.9 part, 0.5 part of hypericum perforatum, 1 part of radix bupleuri, 1 part of purple perilla, Bi are dialled 0.4 part, add 50% alcohol immersion 0.5After hour, extract 2 times, amount of water is respectively 6 times, 4 times, extracts for the first time 2 hours, extracts for the second time 1Hour, filter, merging filtrate, concentrated, dry, add right amount of auxiliary materials after pulverizing, make this pharmaceutical compositionOral disnitegration tablet.
The dispersing tablet of embodiment 8 present compositions
Preparation: adopt the conventional technique of preparing dispersing tablet, get 0.9 part of Chinese herbaceous peony, 1 part of the wind-weed, 0.7 part, turmeric,0.3 part of hypericum perforatum, 0.6 part of radix bupleuri, 0.6 part of purple perilla, Bi dial 0.6 part, add 70% alcohol immersion 0.5 littleTime after extract 2 times, amount of water is respectively 6 times, 4 times, extracts for the first time 2 hours, extracts for the second time 1 littleTime, filtering, merging filtrate, adds right amount of auxiliary materials after concentrating, be dried, pulverize, and makes dividing of this pharmaceutical compositionLoose sheet.
The test of pesticide effectiveness of embodiment 9 present compositions
The object of this test is to observe the therapeutic action of the present composition to depression model mice. Of the present invention groupCompound A, B, C all adopt medicinal extract, and the used time is prepared desired concn with pure water, and other reagent chemicalses have reserpineParenteral solution, 1mg/ml, Guangdong Bang Min pharmaceutical Co. Ltd produces. Prozac, specification 20mg/ sheet, LillyS.AProduce.
Composition A: get 3 parts of Chinese herbaceous peonies, 1.2 parts, turmeric, 0.9 part of hypericum perforatum, 1.8 parts of radix bupleuri, 1.8 parts of purple perillas,Soak after 0.5 hour and extract 2 times, amount of water is respectively 10 times, 8 times, extracts for the first time second 2 hoursInferior extraction 1 hour, filters, and merging filtrate is concentrated, obtains composition A dry extract after dry, pulverize.
Composition B: get 3 parts of Chinese herbaceous peonies, 1.2 parts, turmeric, 0.9 part of hypericum perforatum, 1.8 parts of radix bupleuri, purple perilla2.4 parts of 1.8 parts, the wind-weed add 50% alcohol immersion and after 0.5 hour, extract 2 times, add 50% amount of alcohol and are respectively 8Doubly, 6 times, extract for the first time 2 hours, extract for the second time 1 hour, filter, merging filtrate, concentrated, dryDry, after pulverizing, obtain composition B dry extract.
Composition C: get 3 parts of Chinese herbaceous peonies, 1.2 parts, turmeric, 0.9 part of hypericum perforatum, 1.8 parts of radix bupleuri, 1.8 parts of purple perillas,2.4 parts of the wind-weeds, Bi dial 0.3 part, add 70% alcohol immersion and after 0.5 hour, extract 2 times, add 70% amount of alcohol and are respectively 7Doubly, 5 times, extract for the first time 2 hours, extract for the second time 1 hour, filter, merging filtrate, concentrated, dry,After pulverizing, obtain composition C dry extract.
Animal used as test: male ICR mouse, western pul-Bi Kai animal used as test Co., Ltd provides by Shanghai. ExperimentAnimal production licence number: SCXK (Shanghai) 2008-0016. The animal used as test environmental facility quality certification number: SYXK(Hunan) 2009-0001.
This test data is all with the processing of EXCEL software, and result is checked between organizing with t check analysis.
1, the impact on chronic stress depression model rat
The preparation of animal grouping and model: reference literature method, select the Open-Field method close rat of marking50, be divided at random 6 groups, i.e. physiological saline group, model group, Prozac group, composition A group, combinationThing B group, composition C group, except physiological saline group, accepts various stimulation in 21 days for each group altogether, bagDraw together: 4 DEG C of ice-water bath 3min, 40 DEG C of tepidarium 5min, fasting 24h, prohibits water 24h, the 45 ° of 24h of cage that incline,Put upside down round the clock 24h, 50V electric shock, folder tail 1min. Wherein incline 45 ° of 24h of cage, put upside down 24h, 50 round the clockV electric shock, folder tail 1min 2 times weekly, all the other stimulate weekly. Homologous stimulus can not occur continuously,Make rat can not expect the generation stimulating. Stimulated and finish rear beginning ig administration in first week, dosage is in table 1.
(1) impact on rat body weight: measure the body weight of animal for 1,7,14,21 day after medicine. The 21stIt body weight the results are shown in Table 1.
(2) behaviouristics detects: modeling finishes rear employing open-field method and carries out behaviouristics observation. Wear with animalMore bottom surface block number is horizontal anomalous movement score, taking upright (two fore paws are simultaneously liftoff) number of times as vertical activity score,After medicine 21 days, every rat was only measured once, minute 3min. The results are shown in Table 1.
(3) impact syrup being consumed: within the 22nd day, measure syrup consumption, in the time carrying out syrup consumption test,The single cage of all animals is raised and fasting, and every animal adds 1% sucrose solution 130ml, calculates animal 24h and drinksThe amount of 1% sucrose solution. The results are shown in Table 1.
Table 1 present composition on rat behavior learn, the impact of syrup consumption and body weight (n＝10)
Note: compared with blank group:*P＜0.05，**P < 0.01; Compared with model group:#P＜0.05，##P＜0.01。
As known from Table 1, with model group comparison, the horizontal movement of Prozac group and present composition A, B, C groupScore, the score that moves both vertically, syrup consumption and body weight gain amount be all significantly increased (P < 0.05 or P < 0.01).Prompting, the present composition can obviously improve mobility, the exploring ability and emerging of chronic stress depression model ratInterest.
2, the impact of acquired desperate model mice
1) on the impact of outstanding tail dead time of acquired desperate model mice
Get 75 of ♂ ICR mouse, SPF level, body weight 18-22g, is divided into 5 groups at random, 15 every group: i.e. mouldType group, prozac group, composition A group, composition B group, composition C group, ig administration volume 20ml/kg, everyDay 1 time, respectively to organize mouse and give respectively relative medicine, model group gives same volume distilled water, successive administration 7 days.30min after last administration, is inverted mouse to be fixed on outstanding tail apparatus, and head is apart from the about 10cm of desktop, recordThe dead time of 4min after in 6min. Hang both sides and separate animal sight line with plate, influence each other preventing. ResultIn table 2.
The impact of table 2 present composition on the mouse tail suspension dead time (n＝15，S)
Note: with model group comparison*P＜0.05，**P＜0.01。
As known from Table 2, with model group comparison, the outstanding tail dead time of Prozac treated animal reduces (P < 0.05);Composition A, B, outstanding tail dead time of C treated animal reduce (P < 0.05).
2) impact on the mouse forced swimming dead time
Grouping is the same with administration. 1h after last administration, individually puts into mouse the beaker of depth of water 10cm, waterTemperature (25 ± 2) DEG C forced swimming, observes 6min, after record, in 4min, keeps the motionless state time (s), motionlessRefer to that mouse stops struggling in water, or floating state, small limb activity only had to keep head to keep afloat.The results are shown in Table 3.
The impact of table 3 present composition on the mouse forced swimming dead time (n＝15，S)
Note: with model group comparison,#P＜0.05，##P＜0.01。
As known from Table 3, with model group comparison, Prozac treated animal non-swimming time shortens (P < 0.01);Composition A, B, C treated animal non-swimming time shorten (P < 0.05).
2, the impact of the depression model mouse on reserpine induction
(1) the depression model mice behavior on reserpine induction and the impact of body temperature
1) impact that can not behavior on the depression model mouse lapsus palpebrae superioris of reserpine induction and motion
Get ♂ ICR mouse, SPF level, 120, body weight 18-22g, is divided into 6 groups, every group 20 at randomOnly: blank group, model group, prozac group, composition A group, composition B group, composition C group, igAdministration volume 20ml/kg, every day 1 time, respectively organizes mouse and gives respectively relative medicine, and blank group is given with model groupGive same volume distilled water, successive administration 18 days. Lumbar injection reserpine 4mg/kg when administration in the 15th day,After injection reserpine, 1h, 2h, 6h are put in animal and on support, observe the number of animals that in each group, eye alkali is closed,Close and close the difference degree of grade with eye alkali between each group of rank test. And giving reserpine 2h, 4h, 6hAfter animal is placed in to diameter 7.5cm circle refer in vain central authorities, observe 15 seconds, record each treated animal 15 seconds still slow-wittedNumber of animals in circle, and carry out statistical procedures. The results are shown in Table 4.
The impact of the depression model mouse catacleisis degree of table 4 on reserpine induction (n＝20)
Note: with model group comparison,#P＜0.05，##P＜0.01。
As known from Table 4, with model group comparison, after Prozac group, composition A, B, the administration of C group 1,2,The degree that 6h animal eyelid is closed significantly reduces (P < 0.05 or P < 0.01). Prompting, composition A, B, CThere is the effect of the depression model mouse catacleisis degree that reduces reserpine induction.
Table 5 on depression model mouse zero paper of reserpine induction go too far rate impact (n＝20)
Note: with the comparison of blank group,*P＜0.05，**P < 0.01; With model group comparison#P＜0.05，##P＜0.01.
As known from Table 5, with the comparison of blank group, the model group animal zero paper rate (2h, 4h, 6h after medicine) that goes too farSignificantly reduce (P < 0.01), show modeling success. With model group comparison, Prozac group after medicine 2,4h goes outCircle rate number of animals significantly increases, through X2Inspection difference has statistical significance (P < 0.01 or P < 0.05); CombinationThing A, B, C group significantly increase (P < 0.01 or P < 0.05) in 2h, 4h, the 6h zero paper number of animals that goes too far.Prompting, composition A, B, C have increases the go too far effect of rate of depression model mouse zero paper of reserpine induction.
Pharmacological tests shows, the present invention can significantly improve mobility, the spy of chronic stress depression model ratSuo Nengli and interest, the depression model mouse movement of antagonism reserpine induction can not and body temperature reduce, can make to hangThe desperate animal model autonomic activities number of tail and forced swimming induction, outstanding tail and non-swimming time increase. ShowThe present invention has obvious antidepressant effect.
Claims (14)
1. a herbal mixture that is used for the treatment of depression, is characterized in that: it is made up of the Chinese medicine material of following weight portion proportioning: 0.8 ~ 3 part of Chinese herbaceous peony, 0.3 ~ 2 part, turmeric, 0.2 ~ 1 part of hypericum perforatum, 0.5 ~ 2 part of radix bupleuri, 0.5 ~ 2 part of purple perilla.
2. the herbal mixture that is used for the treatment of depression according to claim 1, is characterized in that being made up of the Chinese medicine material of following weight portion proportioning: 3 parts of Chinese herbaceous peonies, 1.2 parts, turmeric, 0.9 part of hypericum perforatum, 1.8 parts of radix bupleuri, 1.8 parts of purple perillas.
3. a herbal mixture that is used for the treatment of depression, is characterized in that: it is made up of the Chinese medicine material of following weight portion proportioning: 0.8 ~ 3 part of Chinese herbaceous peony, 0.3 ~ 2 part, turmeric, 0.2 ~ 1 part of hypericum perforatum, 0.5 ~ 2 part of radix bupleuri, 0.5 ~ 2 part of purple perilla, 0 ~ 3 part of the wind-weed.
4. the herbal mixture that is used for the treatment of depression according to claim 3, is characterized in that being made up of the Chinese medicine material of following weight portion proportioning: 3 parts of Chinese herbaceous peonies, 1.2 parts, turmeric, 0.9 part of hypericum perforatum, 1.8 parts of radix bupleuri, 1.8 parts of purple perillas, 2.4 parts of the wind-weeds.
5. a herbal mixture that is used for the treatment of depression, is characterized in that: it is made up of the Chinese medicine material of following weight portion proportioning: 0.8 ~ 3 part of Chinese herbaceous peony, 0.3 ~ 2 part, turmeric, 0.2 ~ 1 part of hypericum perforatum, 0.5 ~ 2 part of radix bupleuri, 0.5 ~ 2 part of purple perilla, 0 ~ 3 part of the wind-weed, 0 ~ 1 part of the Bi roots of grass.
6. the herbal mixture that is used for the treatment of depression according to claim 5, is characterized in that being made up of the Chinese medicine material of following weight portion proportioning: 3 parts of Chinese herbaceous peonies, 1.2 parts, turmeric, 0.9 part of hypericum perforatum, 1.8 parts of radix bupleuri, 1.8 parts of purple perillas, 2.4 parts of the wind-weeds, 0.3 part of the Bi roots of grass.
7. according to the herbal mixture that is used for the treatment of depression described in claim 1,3,5 any one, it is characterized in that this herbal mixture makes acceptable peroral dosage form clinically.
8. the herbal mixture that is used for the treatment of depression according to claim 7, is characterized in that this herbal mixture makes tablet, capsule, granule, pill, oral liquid.
9. the herbal mixture that is used for the treatment of depression according to claim 8, is characterized in that this herbal mixture makes soft capsule, dispersing tablet, oral disnitegration tablet, dripping pill.
10. according to the herbal mixture that is used for the treatment of depression described in claim 1,3,5 any one, it is characterized in that the ethanol adding in bulk drug below water or 70%, extract 2 ~ 3 times, add 4 ~ 12 times of amount solvents at every turn; Each extraction 1 ~ 2 hour, extract filters, and reclaims solvent concentrated preparation.
11. herbal mixtures that are used for the treatment of depression according to claim 10, is characterized in that adding the ethanol below water or 70%, extract 2 times, add 4 ~ 10 times of amount solvents at every turn; Each extraction 1 ~ 2 hour, extract filters, and reclaims solvent concentrated preparation.
12. herbal mixtures that are used for the treatment of depression according to claim 10, is characterized in that adding the ethanol below water or 70%, extract 2 times, and the solvent that adds for the first time 6-10 doubly to measure, extracts 2 hours, and the solvent that adds for the second time 4-8 doubly to measure extracts 1 hour; Extract filters, and reclaims solvent concentrated preparation.
13. herbal mixtures that are used for the treatment of depression according to claim 10, is characterized in that adding water extraction to get.
The application of herbal mixture described in 14. claims 1,3,5 any one in the medicine of preparing Cure of depression.
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| CN108079249A (en) * | 2017-12-28 | 2018-05-29 | 晨光生物科技集团邯郸有限公司 | A kind of Chinese medicine preparation with liver protection and preparation method thereof |
| CN114392260A (en) * | 2022-02-15 | 2022-04-26 | 重庆市九龙坡区精神卫生中心(重庆市九龙坡区石坪桥医院) | Medicine for relieving anxiety and depression |
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| 抗抑郁单味中药研究进展;周王谊等;《医学综述》;20111231;第17卷(第23期);3624-3627 * |
| 荜茇化学成分及药理活性研究进展;毕赢等;《中国药学杂志》;20111130;第46卷(第22期);1697-1700 * |
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Effective date of registration: 20230113 Address after: No. 300, bachelor Road, Hanpu science and Education Industrial Park, Yuelu District, Changsha City, Hunan Province, 410000 Patentee after: Hunan University of Chinese Medicine Address before: The First Affiliated Hospital of Hunan University of traditional Chinese medicine, 95 Shaoshan Middle Road, Changsha, Hunan 41007 Patentee before: Wang Yuhong Patentee before: Han Yuanshan |
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