CN102884049B - 用作rock抑制剂的杂环酰胺 - Google Patents

用作rock抑制剂的杂环酰胺 Download PDF

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Publication number
CN102884049B
CN102884049B CN201180011949.6A CN201180011949A CN102884049B CN 102884049 B CN102884049 B CN 102884049B CN 201180011949 A CN201180011949 A CN 201180011949A CN 102884049 B CN102884049 B CN 102884049B
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CN201180011949.6A
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Chinese (zh)
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CN102884049A (zh
Inventor
D·雷森
O·戴非尔特
N·卡瓦尔
P·布罗姆
S·波兰德
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Ph Pharmaceutical Co ltd
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Amakem NV
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Priority claimed from PCT/EP2011/053343 external-priority patent/WO2011107608A1/en
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180011949.6A 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺 Expired - Fee Related CN102884049B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1018996.7 2010-11-10
GB201018996A GB201018996D0 (en) 2010-11-10 2010-11-10 Novel ROCK inhibitors
PCT/EP2011/053343 WO2011107608A1 (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2013102026660A Division CN103316000A (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺

Publications (2)

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CN102884049A CN102884049A (zh) 2013-01-16
CN102884049B true CN102884049B (zh) 2016-08-24

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Family Applications (2)

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CN201180011949.6A Expired - Fee Related CN102884049B (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺
CN2013102026660A Pending CN103316000A (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺

Family Applications After (1)

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CN2013102026660A Pending CN103316000A (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺

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JP (1) JP5710650B2 (enrdf_load_stackoverflow)
CN (2) CN102884049B (enrdf_load_stackoverflow)
GB (1) GB201018996D0 (enrdf_load_stackoverflow)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2751079A1 (en) * 2011-08-31 2014-07-09 Amakem NV Biphenylcarboxamides as rock kinase inhibitors
CN108101885A (zh) * 2017-12-31 2018-06-01 佛山市赛维斯医药科技有限公司 含异丙胺和硝基噻吩酰胺类结构化合物、其制备方法及用途
CN108047194A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 含甲基萘和丙二醇噻吩酰胺类化合物、制备方法及其用途
CN107935987A (zh) * 2017-12-31 2018-04-20 佛山市赛维斯医药科技有限公司 含甲基萘和噻吩酰胺结构的rock抑制剂、制备方法及其用途
CN107935986A (zh) * 2017-12-31 2018-04-20 佛山市赛维斯医药科技有限公司 异丙胺和卤代噻吩酰胺类结构化合物、其制备方法及用途
CN108191820A (zh) * 2017-12-31 2018-06-22 佛山市赛维斯医药科技有限公司 一种含异丙胺和噻吩酰胺类结构的化合物
CN108129452A (zh) * 2017-12-31 2018-06-08 佛山市赛维斯医药科技有限公司 一种含异丙基萘和丙二醇硝基噻吩酰胺类化合物及其用途
CN108047193A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 烷氧噻吩酰胺类rock抑制剂、制备方法及其用途
CN108191821A (zh) * 2017-12-31 2018-06-22 佛山市赛维斯医药科技有限公司 一种含甲基萘和腈基噻吩酰胺类结构的rock抑制剂及用途
CN108047195A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 一种含丙二醇腈基噻吩酰胺类化合物及其用途
CN107915717A (zh) * 2017-12-31 2018-04-17 佛山市赛维斯医药科技有限公司 一类含异丙基萘和丙二醇噻吩酰胺类化合物及其用途
CN114956977B (zh) * 2022-06-09 2024-03-26 朗捷睿(苏州)生物科技有限公司 一种联苯类化合物、药物组合物及其制备方法和应用
CN120569383A (zh) * 2023-01-13 2025-08-29 武汉朗来科技发展有限公司 一种rock抑制剂中间体的制备方法
CN117126072A (zh) * 2023-08-24 2023-11-28 中国药科大学 一种含酯链pd-1/pd-l1小分子抑制剂及其制备方法和应用
CN119569655A (zh) * 2024-11-21 2025-03-07 西北大学 含吡唑甲酰胺基的苯甲酸氟甲基硫酯类化合物及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133622A2 (en) * 2006-05-12 2007-11-22 Vertex Pharmaceuticals Incorporated Selective inhibitors of rock protein kinase and uses thereof
CN101248046A (zh) * 2005-07-11 2008-08-20 德福根有限公司 作为激酶抑制剂的酰胺衍生物
CN101287707A (zh) * 2005-10-13 2008-10-15 德福根有限公司 激酶抑制剂
WO2009027392A1 (en) * 2007-08-27 2009-03-05 Abbott Gmbh & Co. Kg 4-(4-pyridinyl)-benzamides and their use as rock activity modulators
WO2010032875A2 (en) * 2008-09-18 2010-03-25 Astellas Pharma Inc. Heterocyclic carboxamide compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0615522A2 (pt) * 2005-07-11 2012-04-10 Devgen Nv derivados da amida como inibidores da quinase

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101248046A (zh) * 2005-07-11 2008-08-20 德福根有限公司 作为激酶抑制剂的酰胺衍生物
CN101287707A (zh) * 2005-10-13 2008-10-15 德福根有限公司 激酶抑制剂
WO2007133622A2 (en) * 2006-05-12 2007-11-22 Vertex Pharmaceuticals Incorporated Selective inhibitors of rock protein kinase and uses thereof
WO2009027392A1 (en) * 2007-08-27 2009-03-05 Abbott Gmbh & Co. Kg 4-(4-pyridinyl)-benzamides and their use as rock activity modulators
WO2010032875A2 (en) * 2008-09-18 2010-03-25 Astellas Pharma Inc. Heterocyclic carboxamide compounds

Also Published As

Publication number Publication date
GB201018996D0 (en) 2010-12-22
JP5710650B2 (ja) 2015-04-30
CN103316000A (zh) 2013-09-25
JP2013527136A (ja) 2013-06-27
CN102884049A (zh) 2013-01-16

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