CN102872324A - 一种治疗胸外科手术后呼吸窘迫综合征的中药雾化合剂 - Google Patents
一种治疗胸外科手术后呼吸窘迫综合征的中药雾化合剂 Download PDFInfo
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Abstract
本发明公开了一种治疗胸外科手术后呼吸窘迫综合征的中药雾合化剂。胸外科手术后及严重胸外伤后，由于创伤、气管插管、气管切开和鼻饲管的应用，使气管和支气管内积血或痰液阻塞，致使患者出现不同程度的胸闷、憋喘、痰粘难咯出等症状，以至诱发呼吸窘迫综合征。本发明选择中药万丈深、鸭儿芹、菜豆树、通光散、山白菊、川贝母、鱼腥草、麦冬、甘草制成中药雾化合剂，用于术后雾化吸入治疗，经我院临床试验，总有效率达到98.3％，明显优于对照组，且无副作用，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗胸外科手术后呼吸窘迫综合征的中药雾化合剂。
背景技术
开胸手术是治疗许多疾病的重要手段，但由于手术时间长、创伤大，术后肺功能损害明显，粘液分泌紊乱和清除障碍，加之全麻时气管插管破坏了粘膜的清除功能及术后切口疼痛患者不敢用力咳嗽，使呼吸道分泌物滞留，极易发生呼吸道感染和肺部并发症，严重者可致死亡。故协助患者有效排痰是术后护理的重要内容和促进患者康复的重要环节。传统协助排痰法是庆大霉素、a一糜蛋白酶、地塞米松加生理盐水雾化吸入来稀释痰液促进排痰，但仍有部分患者发生痰液潴留。
发明内容
本发明的目的是提供一种治疗胸外科手术后呼吸窘迫综合征的中药雾合化剂，胸外科手术后及严重胸外伤后，由于创伤、气管插管、气管切开和鼻饲管的应用，使气管和支气管内积血或痰液阻塞，致使患者出现不同程度的胸闷、憋喘、痰粘难咯出等症状，以至诱发呼吸窘迫综合征。
本发明的目的是通过以下技术方案实现的，该治疗胸外科手术后呼吸窘迫综合征的中药雾合化剂由以下重量份的中药制成：万丈深20-25份、鸭儿芹20-25份、菜豆树15-20份、通光散10-15份、山白菊10-12份、川贝母4-6份、鱼腥草10-12份、麦冬6-8份、甘草3-5份。
优选的，万丈深22份、鸭儿芹22份、菜豆树18份、通光散13份、山白菊11份、川贝母5份、鱼腥草11份、麦冬7份、甘草4份。
制备方法：按传统方法树成中药雾化合剂。
方中：万丈深润肺止咳，清热解毒；鸭儿芹消炎解毒，活血消肿；菜豆树清热解毒，散瘀止痛；通光散清热解毒，止咳平喘；山白菊疏风，清热解毒，祛痰镇咳；川贝母清热化痰，润肺止咳，散结消肿；鱼腥草清热解毒，消痈排脓，利尿通淋；麦冬：养阴润肺，益胃生津，清心除烦；甘草益气补中，清热解毒，祛痰止咳，缓解止痛。
临床资料
1、一般资料 选择胸外科常规性手术和严重胸外伤手术，伤情级别III～IV级患者200例，按就诊时单、双日随机分为两组；治疗组120例，男96例，女24例；年龄20～69岁，平均(54.2±7.1)岁；对照组80例，男62例，女18例；年龄21～66岁，平均(54.1±6.78)岁。手术情况：(1)食道癌116例(治疗组72例，对照组44例)行食管癌切除术，其中92例经左胸入路，22例行颈、胸(右)、腹三切口入路；2例行颈、腹入路结肠代食管手术(有胃大部切除术史)；(2)肺癌34例(治疗组20例，对照组14例)中行肺叶切除28例，全肺切除6例，(左肺4例，右肺2例)；(3)纵膈肿瘤20例(治疗组12例，对照组8例)均行肿瘤切除术；(4)胸外伤30例(治疗组16例，对照组14例)，10例行隔肌修补术，2例行肺叶切除术，18例行胸腔闭式引流术。上述患者均不同程度地表现为伤口疼痛、胸闷、呼吸动度减弱、胸闷憋喘、痰粘难咯。两组资料在年龄、性别、手术种类、病情程度选择上无显著性差异(P＞0.05)。
2、治疗方法 两组患者术前处理和麻醉方法相同，术后处理按照病种和手术方式不同，采用相应的胸外科手术后常规性治疗。在此基础上治疗组应用上述中药雾化合剂雾化吸入治疗，对照组应用生理盐水80ml加入a-麻黄蛋白酶4000u及庆大霉素，8万u混合进行雾化吸入治疗。两组均5天为一个疗程。使用方法：将药液加入消毒处理后的YC-800型雾化器中，按2-2.5ml/min的雾化量持续应用20min，每次消耗液体40-60ml，每6-8h，雾化吸入治疗1次，每天34次。
3、疗效标准 (1)显效：粘痰变稀，易咯，胸闷憋喘等症状明显减轻或消失，无术后发热(体温升高＜1℃)，无白细胞升高及肺炎等并发症；(2)有效：粘痰变稀、易咯，胸闷憋喘等症状改善；(3)无效：上述症状无改善甚至加重，或同时出现术后发热及白细胞升高及肺炎等并发症。
4、治疗结果 (1)两组治疗一个疗程后观察疗效：治疗组120例，显效80例(66.7％)，有效38例(31.7％)，无效2例(1.7％)，总有效率达到98.3％；对照组80例，显效28例(35.0％)，有效37例(46.3％)，无效15例(18.9％)，总有效率81.2％；两组的显效率和总有效率比较有显著性差异(P＜0.05)。
(2)两组患者胸闷憋喘、痰粘难咯等症状改善情况：治疗组120例，112例(93.3％)，咯痰容易，胸闷憋喘症状减轻；对照组80例(50％)症状减轻。两组比较有显著性差异(P＜0.01)。出现咯黄痰治疗组8例(6.7％)，对照组24例30.0％，两组比较有显著性差异(P＜0.01)。
具体实施方式
实施例一：称取万丈深22g、鸭儿芹22g、菜豆树18g、通光散13g、山白菊11g、川贝母5g、鱼腥草11g、麦冬7g、甘草4g，按传统的方法制成中药雾化合剂。
实施例二：称取万丈深20g、鸭儿芹20g、菜豆树15g、通光散10g、山白菊10g、川贝母4g、鱼腥草10g、麦冬6g、甘草3g，按传统的方法制成中药雾化合剂。
实施例三：称取万丈深25g、鸭儿芹25g、菜豆树20g、通光散15g、山白菊12g、川贝母6g、鱼腥草12g、麦冬8g、甘草5g，按传统的方法制成中药雾化合剂。
Claims (2)
1.一种治疗胸外科手术后呼吸窘迫综合征的中药雾化合剂，其特征在于该中药雾合化剂由以下重量份的中药制成：万丈深20-25份、鸭儿芹20-25份、菜豆树15-20份、通光散10-15份、山白菊10-12份、川贝母4-6份、鱼腥草10-12份、麦冬6-8份、甘草3-5份。
2.根据权利要求1所述的一种治疗胸外科手术后呼吸窘迫综合征的中药雾化合剂，其特征在于该中药雾合化剂由以下重量份的中药制成：万丈深22份、鸭儿芹22份、菜豆树18份、通光散13份、山白菊11份、川贝母5份、鱼腥草11份、麦冬7份、甘草4份。
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| CN105125874A (zh) * | 2015-09-29 | 2015-12-09 | 陈年康 | 一种用于治疗成人呼吸窘迫综合征的中药 |
| CN105535789A (zh) * | 2016-01-18 | 2016-05-04 | 陈丽媛 | 一种用于开胸手术术后护理的中药制剂 |
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| CN101869619A (zh) * | 2010-06-11 | 2010-10-27 | 张秀芝 | 一种治疗体癣的药物及其制作方法 |
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| CN105125874A (zh) * | 2015-09-29 | 2015-12-09 | 陈年康 | 一种用于治疗成人呼吸窘迫综合征的中药 |
| CN105535789A (zh) * | 2016-01-18 | 2016-05-04 | 陈丽媛 | 一种用于开胸手术术后护理的中药制剂 |
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