CN102846686B - 一种种鸡或蛋鸡用液体维生素及其制备方法 - Google Patents
一种种鸡或蛋鸡用液体维生素及其制备方法 Download PDFInfo
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Abstract
本发明提供一种新型种鸡或蛋鸡用液体维生素及其制备方法，由下列重量配比的组分配制而成：焦亚硫酸钠0.005-0.01份；维生素C 0.2-0.8份；维生素B10.2-0.4份；维生素B60.1-0.3份；泛酸钙0.2-0.5份；维生素K 0.04-0.09份；肉毒碱0.05-0.12份；复合氨基酸0.05-0.09份；山梨醇5-10份；BHT 0.02-0.05份；苯甲酸钠0.1-0.3份；吐温809-15份；丙二醇10-15份；维生素A 0.3-0.9份；维生素E 0.2-0.4份；维生素D30.005-0.01份；人参茎叶皂苷0.2-0.8份；注射用水50-70份。
Description
技术领域
本发明属于药物制备技术领域，尤其是一种新型种鸡或蛋鸡用液体维生素及其制备方法。
背景技术
维生素是动物维持正常生理功能必不可少的有机化合物，对于体内的代谢活动具有重要的调节作用。维生素对机体的物质代谢非常重要，能促进鸡的生长，提高饲料转化率和利用率，增强机体免疫力和抗疾病能力等。尽管对它们的需要是微量的，但是机体本身难以合成出足量和营养均衡的维生素，而饲料中的含量也是有限的，不能够满足养殖业对于所饲喂动物快速、健康生长和营养均衡的需要。
维生素A棕榈酸酯别名视黄醇棕酸脂，对空气、热、光和湿度敏感，不溶于水，溶于乙醇，易溶于油脂中。其主要作用表现为维生素A可促进眼内感光色素的形成，防止夜盲症和视力减退；抗呼吸系统感染；维持上皮组织结构的完整和健全；增强机体免疫反应和抵抗力；保持组织或器官表层的健康；促进发育，强壮骨骼，维护皮肤、头发、牙齿、牙床的健康；对脓包、疖疮、皮肤表面溃疡等症有良好的治疗作用；有助于对肺气肿、甲状腺机能亢进的治疗；能抑制毒素的形成，参与羟基类固醇的脱氢、胆固醇的合成、硫酸盐的活化、膜通透性的调节，以及药物在肝微粒体中去甲基和羟基化过程。
维生素E油是一种脂溶性维生素，别名生育酚，维他命E，易溶于无水乙醇或植物油，具有抗氧化、抗动脉粥样硬化、调节免疫功能、延缓衰老、 对神经系统和骨骼肌的保护作用、促进胚胎发育和生殖能力。近年来还发现维生素E可抑制眼睛晶状体内的过氧化脂反应，使末稍血管扩张，改善血液循环，促进微循环。
维生素D3，又名烟碱酸胺、胆骨化醇，维生素D3是活性的7-脱氢胆固醇，由大多数高级动物真皮层的7-脱氢胆固醇经紫外线照射后生成。实际上它是一种激素原，本身无活性，需先在肝脏中代谢成25-羟胆钙化醇，再在肾脏进一步羟基化后才有活性。具有以下生理功能，提高肌体对钙、磷的吸收，使血浆钙和血浆磷的水平达到饱和程度；促进生长和骨骼钙化，促进牙齿健全；通过肠壁增加磷的吸收，并通过肾小管增加磷的再吸收；维持血液中柠檬酸盐的正常水平。
L-肉毒碱即我们常说的肉碱，是一种特殊的氨基酸。L-肉毒碱作为一般健康材料在市场上流通。在日本食品卫生法上将其列在“作为一般食品材料可在饮食中供食用的添加物”的位置，不管是天然的，还是合成的，L-肉毒碱可促进体内有益激素的释放，促成黄体生成素的合成，并维持神经系统的良好功能，提高睡眠质量。动物经常食用肉毒碱，可增强肌肉组织，减少疲劳，降低发病几率，减少疾病的发生，提高机体免疫力，提高产能。
现有技术中给鸡补充维生素普遍采用固体混合物添加到饲料中的方法，由于禽类的消化道短，吸收程度低，效果欠佳。另外口服固体维生素生物利用度低，生产过程中粉尘多，不利于环保和劳动保护，因此，制备营养丰富、稳定性强、吸收好、生物利用度高的液体维生素溶液已势在必行。
发明内容
本发明的目的是克服现有技术的不足，提出一种溶解性好、安全性好、 质量稳定性高、配伍合理、应用范围广、给药方便、的一种新型种鸡或蛋鸡用液体维生素。
为解决上述技术问题，本发明采用的技术方案是：
一种新型种鸡或蛋鸡用液体维生素，由下列重量配比的组分配制而成：
本发明的另一目的在于提供一种新型种鸡或蛋鸡用液体维生素的制备方法，该制备方法简单可行。
为实现上述目的，本发明采用的技术方案为：
一种防治家禽支原体病的中兽药组合物的制备方法，包括以下步骤：
(1)称取处方量的BHT，加入10倍量的吐温80中，加热70℃溶解，备用；
(2)称取处方剩余量的吐温80和处方量的丙二醇，加热，搅拌下加入维生素A、维生素E、维生素D3、以及步骤(1)所得的溶液，搅拌45分钟，得到脂溶性维生素溶液，备用；
(3)称取处方量的焦亚硫酸钠、维生素C、维生素B1、维生素B6、维生素K、泛酸钙、肉毒碱、复合氨基酸、人参茎叶皂苷，加注射用水搅拌使其溶解，加入步骤(2)所得脂溶性维生素溶液、处方量的山梨醇、苯甲酸钠，并加注射用水定容，搅拌120分钟，冷却；
(4)分装，即得所述液体维生素。
其中，所述步骤(2)的加热温度控制在35-40℃。
所述步骤(3)中冷却至16-18℃。
本发明具有的优点和积极效果是：
1、本发明创新了液体维生素间配伍使用，其配方中涉及的高含量的VA及VD3可提高肉鸡体液和细胞免疫功能；高含量VC提高育雏期的抗应激能力和抗坏血酸能力；高含量的液体山梨醇，可最大程度地保肾护肾健肾。L-肉毒碱不仅可以完全替代烟酸的作用而且可以预防脂肪肝，起到保肝护肝的作用。山梨醇和肉毒碱加入到液体维生素中，能显著提高种鸡和蛋鸡的产蛋率和受精率；完整的配方，在开产时和产蛋高峰后期使用该产品可以缩短到达产蛋高峰期的时间以及延长产蛋高峰期。维生素A棕榈酸酯、维生素E油、维生素D3、L-肉毒碱、山梨醇和人参茎叶皂苷联用，营养均衡，应用范围广，充分体现了液体维生素在防病、增加肉鸡机体免疫力和抗应激应用中的优势。
2、本发明根据肉鸡营养标准和不同阶段对维生素需要量制成的液体维生素克服了常规维生素不溶解、不稳定或吸收难的问题，减少养殖户给药的繁琐步骤和溶解性难的问题，减少给药次数延长免疫和保健作用时间。
3、液体维生素是各种维生素添加适宜溶剂，根据相似相容原理利用最佳工艺制成的液体溶液，溶解性及生物利用度较粉剂、散剂、预混剂高；用量准确，差异较小；具有质量稳定、使用、应用都比较方便；可机械化生产，产量大，成本低，并且卫生标准也容易达到。
4、本发明涉及的工艺具有生产设备简单、操作容易，使用方便、适合扩大生产的优点。
具体实施方式
实施例1
1、配方组成
2、制备方法
称取处方量的BHT，加入10倍量的吐温80中，加热70℃溶解，备用；称取处方剩余量的吐温80和处方量的丙二醇，加热，温度控制在35-40℃，搅拌下加入维生素A、维生素E、维生素D3、以及含BHT的吐温80溶液，搅拌45分钟，得到脂溶性维生素溶液，备用；称取处方量的焦亚硫酸钠、维生素C、维生素B1、维生素B6、维生素K、泛酸钙、肉毒碱、复合氨基酸、人参茎叶皂苷，加注射用水700ml搅拌溶解，脂溶性维生素溶液、处方量的山梨醇、苯甲酸钠，并加注射用水定容至1000ml，搅拌120分钟，冷却至16-18℃；分装，即得。
实施例2
1、处方组成
2、制备方法
本实施例制备方法的步骤同于实施例1。
实施例3
1、处方组成
2、制备方法
本实施例制备方法的步骤同于实施例1。
试验1：溶解度试验
将1ml本发明溶液加入10ml乙醇中，立即完全溶解。
试验2：稳定性试验
通过稳定性试验，该药物24个月内未发生质量变化。
试验3：
分别取2050只种鸡和2050只蛋鸡试验，将其分为六组，组1、组2为空白对照组，分别选取25只种鸡，25只蛋鸡，组3、组4为给药组，分别选取1000只种鸡，1000只蛋鸡。鸡群用药15天，每5天为一个疗程，一次的服用剂量为：将1000ml的本发明液体维生素对水200公斤，集中一次饮用。组5、组6为复合维生素给药组，分别选取1000只种鸡，1000只蛋鸡。
从上表得出，经本发明给药组用药后，能显著提高种鸡和蛋鸡的产蛋率和受精率，用药后种鸡或蛋鸡产蛋率为26.2％-26.6％，受精率为18.1-18.6％。
以上对本发明的一个实施例进行了详细说明，但所述内容仅为本发明的 较佳实施例，不能被认为用于限定本发明的实施范围。凡依本发明申请范围所作的均等变化与改进等，均应仍归属于本发明的专利涵盖范围之内。
Claims (9)
1.一种种鸡或蛋鸡用液体维生素，其特征在于，由下列重量配比的组分配制而成：
2.根据权利要求1所述的液体维生素，其特征在于：所述维生素A为维生素A棕榈酸酯，含量为170万单位/克以上。
3.根据权利要求1所述的液体维生素，其特征在于：所述维生素E为维生素E油。
4.根据权利要求1所述的液体维生素，其特征在于：所述维生素D3含量为4000万单位/克以上。
5.根据权利要求1所述的液体维生素，其特征在于：所述肉毒碱为L型。
6.根据权利要求1所述的液体维生素，其特征在于：所述山梨醇为液体山梨醇。
7.一种制备如权利要求1所述的种鸡或蛋鸡用液体维生素的方法，其特征在于，所述的方法包括以下步骤：
(1)称取处方量的BHT，加入10倍量的吐温80中，加热70℃溶解，备用；
(2)称取处方剩余量的吐温80和处方量的丙二醇，加热，搅拌下加入维生素A、维生素E、维生素D3、以及步骤(1)所得的溶液，搅拌45分钟，得到脂溶性维生素溶液，备用；
(3)称取处方量的焦亚硫酸钠、维生素C、维生素B1、维生素B6、维生素K、泛酸钙、肉毒碱、复合氨基酸、人参茎叶皂苷，加注射用水搅拌使其溶解，加入步骤(2)所得脂溶性维生素溶液、处方量的山梨醇、苯甲酸钠，并加注射用水定容，搅拌120分钟，冷却；
(4)分装，即得所述液体维生素。
8.根据权利要求7所述的制备方法，其特征在于：所述步骤(2)的加热温度控制在35-40℃。
9.根据权利要求7所述的制备方法，其特征在于：所述步骤(3)中冷却至16-18℃。
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Inventor after: Wang Chunxia Inventor after: Wangruili Inventor after: Pei Yi Inventor after: Ju Boyan Inventor after: Li Fanfan Inventor after: Wang Xiangang Inventor after: Zheng Aibin Inventor after: Liu Yongkang Inventor after: Fan Peisong Inventor before: Yuan Junying Inventor before: Wangruili Inventor before: Pei Yi Inventor before: Ju Boyan Inventor before: Li Fanfan Inventor before: Wang Xiangang Inventor before: Zheng Aibin Inventor before: Liu Yongkang Inventor before: Fan Peisong |
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Inventor after: Wang Chunxia Inventor after: Yu Minmin Inventor after: Jiao Haishan Inventor after: Wangruili Inventor after: Pei Yi Inventor after: Ju Boyan Inventor after: Li Fanfan Inventor after: Wang Xiangang Inventor after: Zheng Aibin Inventor after: Liu Yongkang Inventor after: Fan Peisong Inventor before: Wang Chunxia Inventor before: Wangruili Inventor before: Pei Yi Inventor before: Ju Boyan Inventor before: Li Fanfan Inventor before: Wang Xiangang Inventor before: Zheng Aibin Inventor before: Liu Yongkang Inventor before: Fan Peisong |
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Effective date of registration: 20170918 Address after: 050000 incubator of Tianshan science and Technology Industrial Park, No. 319, Xiangjiang Road, Shijiazhuang hi tech Development Zone, Hebei, A-1-1411 Patentee after: Hebei nice farming technology Co.,Ltd. Address before: 300380, Tianjin, Xiqing District, Beizhen Road, No. 16, Jasper Road (Xinxing garden, 7-1, 2-601) Patentee before: TIANJIN BIJIA BIOTECHNOLOGY CO.,LTD. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140507 Termination date: 20211016 |