CN102836425B - 包含潜伏感染阶段期间所表达的抗原的结核疫苗 - Google Patents

包含潜伏感染阶段期间所表达的抗原的结核疫苗 Download PDF

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Publication number
CN102836425B
CN102836425B CN201210332759.0A CN201210332759A CN102836425B CN 102836425 B CN102836425 B CN 102836425B CN 201210332759 A CN201210332759 A CN 201210332759A CN 102836425 B CN102836425 B CN 102836425B
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vaccine
mycobacterium
polypeptide
tuberculosis
vaccination
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CN201210332759.0A
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Chinese (zh)
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CN102836425A (zh
Inventor
克劳斯·奥高
卡里纳·温斯波-伦德贝里
彼得·安德森
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National Serum Research Center
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National Serum Research Center
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201210332759.0A 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗 Expired - Fee Related CN102836425B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200500924 2005-06-23
DKPA200500924 2005-06-23
DKPA200501393 2005-10-05
DKPA200501393 2005-10-05
CN2006800223234A CN101248084B (zh) 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗

Related Parent Applications (1)

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CN2006800223234A Division CN101248084B (zh) 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗

Publications (2)

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CN102836425A CN102836425A (zh) 2012-12-26
CN102836425B true CN102836425B (zh) 2015-08-19

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CN201210332759.0A Expired - Fee Related CN102836425B (zh) 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗

Country Status (12)

Country Link
US (4) US7968105B2 (https=)
EP (4) EP2163255B1 (https=)
JP (2) JP5219808B2 (https=)
KR (2) KR101035053B1 (https=)
CN (1) CN102836425B (https=)
AU (1) AU2006261445B2 (https=)
BR (1) BRPI0612833A2 (https=)
CA (2) CA2612900C (https=)
ES (1) ES2647070T3 (https=)
IL (3) IL188222A (https=)
MX (1) MX2007016165A (https=)
WO (1) WO2006136162A2 (https=)

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TWI638829B (zh) * 2012-07-10 2018-10-21 法商傳斯堅公司 分枝桿菌抗原疫苗
RU2520078C1 (ru) * 2013-04-25 2014-06-20 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "НИИЭМ им. Н.Ф. Гамалеи" Минздрава России) СПОСОБ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА Ag85A-DBD И ДЕКСТРАНА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА pAg85A-DBD, ШТАММ Escherichia coli [pREP4, pAg85A-DBD], ХИМЕРНЫЙ БЕЛОК Ag85A-DBD
RU2520737C1 (ru) * 2013-04-25 2014-06-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почётного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "НИИЭМ им. Н.Ф. Гамалеи" Минздрава России) СПОСОБ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА pESAT6-DBD И ДЕКСТРАНА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА pESAT6-DBD, ШТАММ Escherichia coli, ХИМЕРНЫЙ БЕЛОК ESAT6-DBD И ИХ ПРИМЕНЕНИЕ
RU2539026C1 (ru) * 2013-06-11 2015-01-10 Федеральное государственное бюджетное учреждение "Центральный научно-исследовательский институт туберкулеза" Российской академии медицинских наук РЕКОМБИНАНТНАЯ ПЛАЗМИДА pESAT6-CFP10-DBD, РЕКОМБИНАНТНЫЙ ШТАММ Escherichia coli M15 [pREP4, pESAT6-CFP10-DBD], СПОСОБ ПОЛУЧЕНИЯ, ИММОБИЛИЗАЦИИ, КОНЦЕНТРИРОВАНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО БЕЛКА ESAT6-CFP10-DBD НА ДЕКСТРАНЕ, РЕКОМБИНАНТНЫЙ БЕЛОК ESAT6-CFP10-DBD И ИММУНОГЕННАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ БЕЛОК ESAT6-CFP10-DBD
ES2925950T3 (es) 2013-06-25 2022-10-20 Int Aids Vaccine Initiative Inc Composiciones para la tuberculosis y procedimientos de uso de las mismas
WO2015104380A1 (en) * 2014-01-09 2015-07-16 Transgene Sa Fusion of heterooligomeric mycobacterial antigens
AU2017285424B2 (en) * 2016-06-16 2022-08-18 International Aids Vaccine Initiative, Inc. Tuberculosis compositions and methods of treating or preventing tuberculosis
CN107970444B (zh) * 2016-10-25 2022-03-01 中国人民解放军第三0九医院 复合佐剂及含有该复合佐剂的疫苗
EP3983011A1 (en) 2019-06-14 2022-04-20 Statens Serum Institut Fusion proteins for tuberculosis vaccines
EP4217066A4 (en) * 2020-09-23 2024-10-23 The General Hospital Corporation BCG VACCINES TO PREVENT COVID-19 AND OTHER INFECTIOUS DISEASES
KR102709729B1 (ko) * 2020-12-04 2024-09-25 주식회사 제넥신 결핵의 예방 또는 치료용 약학적 조성물
CN115598041B (zh) * 2021-07-07 2025-08-19 中国科学院微生物研究所 结核鉴别诊断细胞因子及其在结核感染风险评估中的应用
CN118765203A (zh) 2022-02-21 2024-10-11 史坦恩斯血清研究所 一种新型阳离子佐剂组合物
CN117531001A (zh) * 2023-11-15 2024-02-09 首都医科大学附属北京胸科医院 结核分枝杆菌毒素抗毒素系统及其相关应用
CN118108815B (zh) * 2024-04-23 2024-07-23 成都康华生物制品股份有限公司 结核分枝杆菌多免疫原抗原、编码其的mRNA、应用

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Also Published As

Publication number Publication date
EP2380589A2 (en) 2011-10-26
KR20100122130A (ko) 2010-11-19
US8703151B2 (en) 2014-04-22
IL222915A0 (en) 2012-12-31
KR20080027877A (ko) 2008-03-28
JP2013121959A (ja) 2013-06-20
US20130095132A1 (en) 2013-04-18
US8101193B2 (en) 2012-01-24
US8293250B2 (en) 2012-10-23
IL188222A (en) 2015-11-30
HK1179855A1 (zh) 2013-10-11
CA2612900A1 (en) 2006-12-28
US20120114687A1 (en) 2012-05-10
HK1124071A1 (en) 2009-07-03
CA2836319A1 (en) 2006-12-28
IL188222A0 (en) 2008-03-20
ES2647070T3 (es) 2017-12-19
CN102836425A (zh) 2012-12-26
EP1910409A2 (en) 2008-04-16
EP2163255B1 (en) 2017-08-09
US20110206713A1 (en) 2011-08-25
KR101035053B1 (ko) 2011-05-19
MX2007016165A (es) 2008-03-14
IL222914A0 (en) 2012-12-31
AU2006261445A1 (en) 2006-12-28
JP2008543890A (ja) 2008-12-04
EP2380589A3 (en) 2012-09-12
CA2612900C (en) 2016-08-09
JP5219808B2 (ja) 2013-06-26
WO2006136162A3 (en) 2007-11-15
KR101188045B1 (ko) 2012-10-05
US7968105B2 (en) 2011-06-28
US20090186048A1 (en) 2009-07-23
BRPI0612833A2 (pt) 2010-11-30
EP2163255A1 (en) 2010-03-17
EP2380590A2 (en) 2011-10-26
AU2006261445B2 (en) 2011-03-31
EP2380590A3 (en) 2012-08-22
WO2006136162A2 (en) 2006-12-28

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