CN102836425B - 包含潜伏感染阶段期间所表达的抗原的结核疫苗 - Google Patents

包含潜伏感染阶段期间所表达的抗原的结核疫苗 Download PDF

Info

Publication number
CN102836425B
CN102836425B CN201210332759.0A CN201210332759A CN102836425B CN 102836425 B CN102836425 B CN 102836425B CN 201210332759 A CN201210332759 A CN 201210332759A CN 102836425 B CN102836425 B CN 102836425B
Authority
CN
China
Prior art keywords
vaccine
mycobacterium
polypeptide
tuberculosis
vaccination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201210332759.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN102836425A (zh
Inventor
克劳斯·奥高
卡里纳·温斯波-伦德贝里
彼得·安德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Serum Research Center
Original Assignee
National Serum Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Serum Research Center filed Critical National Serum Research Center
Priority claimed from CN2006800223234A external-priority patent/CN101248084B/zh
Publication of CN102836425A publication Critical patent/CN102836425A/zh
Application granted granted Critical
Publication of CN102836425B publication Critical patent/CN102836425B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201210332759.0A 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗 Expired - Fee Related CN102836425B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200500924 2005-06-23
DKPA200500924 2005-06-23
DKPA200501393 2005-10-05
DKPA200501393 2005-10-05
CN2006800223234A CN101248084B (zh) 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2006800223234A Division CN101248084B (zh) 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗

Publications (2)

Publication Number Publication Date
CN102836425A CN102836425A (zh) 2012-12-26
CN102836425B true CN102836425B (zh) 2015-08-19

Family

ID=37134239

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201210332759.0A Expired - Fee Related CN102836425B (zh) 2005-06-23 2006-06-20 包含潜伏感染阶段期间所表达的抗原的结核疫苗

Country Status (12)

Country Link
US (4) US7968105B2 (enExample)
EP (4) EP2380589A3 (enExample)
JP (2) JP5219808B2 (enExample)
KR (2) KR101035053B1 (enExample)
CN (1) CN102836425B (enExample)
AU (1) AU2006261445B2 (enExample)
BR (1) BRPI0612833A2 (enExample)
CA (2) CA2612900C (enExample)
ES (1) ES2647070T3 (enExample)
IL (3) IL188222A (enExample)
MX (1) MX2007016165A (enExample)
WO (1) WO2006136162A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19529931C1 (de) 1995-08-02 1997-04-03 Mannesmann Ag Plattenkokille zur Erzeugung von Strängen aus Stahl
EP1523331B1 (en) * 2002-07-13 2013-02-27 Statens Serum Institut Therapeutic tb vaccine
MX2009010800A (es) * 2007-04-04 2010-01-29 Infectious Disease Res Inst Id Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos.
HRP20150177T1 (hr) * 2007-04-12 2015-04-10 Mico Bio, Inc. Cjepivo protiv tuberkuloze i postupak upotrebe tog cjepiva
WO2009003474A1 (en) * 2007-06-29 2009-01-08 Statens Serum Institut The use of monomycolyl glycerol (mmg) as an adjuvant
CN101969976A (zh) * 2008-01-11 2011-02-09 美国政府健康与人类服务部秘书处 针对分枝杆菌的多肽疫苗和接种策略
US20100015171A1 (en) * 2008-07-15 2010-01-21 Statens Serum Institute Vaccines comprising tb 10.4
UA107330C2 (uk) 2008-07-25 2014-12-25 Глаксосмітклайн Байолоджікалз С.А. Туберкульозний білок rv3616c та його застосування
US9603919B2 (en) * 2009-03-31 2017-03-28 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
CN102413837B (zh) 2009-04-24 2015-11-25 国立血清研究所 预防再激活的结核病tb疫苗
WO2011013097A2 (en) * 2009-07-29 2011-02-03 Bernd Helmut Adam Rehm Polymer particles and uses thereof
US10357555B2 (en) * 2012-07-10 2019-07-23 Transgene Sa Mycobacterial antigen vaccine
RU2520078C1 (ru) * 2013-04-25 2014-06-20 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "НИИЭМ им. Н.Ф. Гамалеи" Минздрава России) СПОСОБ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА Ag85A-DBD И ДЕКСТРАНА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА pAg85A-DBD, ШТАММ Escherichia coli [pREP4, pAg85A-DBD], ХИМЕРНЫЙ БЕЛОК Ag85A-DBD
RU2520737C1 (ru) * 2013-04-25 2014-06-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почётного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "НИИЭМ им. Н.Ф. Гамалеи" Минздрава России) СПОСОБ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА pESAT6-DBD И ДЕКСТРАНА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА pESAT6-DBD, ШТАММ Escherichia coli, ХИМЕРНЫЙ БЕЛОК ESAT6-DBD И ИХ ПРИМЕНЕНИЕ
RU2539026C1 (ru) * 2013-06-11 2015-01-10 Федеральное государственное бюджетное учреждение "Центральный научно-исследовательский институт туберкулеза" Российской академии медицинских наук РЕКОМБИНАНТНАЯ ПЛАЗМИДА pESAT6-CFP10-DBD, РЕКОМБИНАНТНЫЙ ШТАММ Escherichia coli M15 [pREP4, pESAT6-CFP10-DBD], СПОСОБ ПОЛУЧЕНИЯ, ИММОБИЛИЗАЦИИ, КОНЦЕНТРИРОВАНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО БЕЛКА ESAT6-CFP10-DBD НА ДЕКСТРАНЕ, РЕКОМБИНАНТНЫЙ БЕЛОК ESAT6-CFP10-DBD И ИММУНОГЕННАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ БЕЛОК ESAT6-CFP10-DBD
EP3013364B1 (en) 2013-06-25 2022-08-03 International AIDS Vaccine Initiative, Inc. Tuberculosis compositions and methods of using the same
RU2695462C2 (ru) * 2014-01-09 2019-07-23 Трансген Са Гибридизация гетероолигомерных микобактериальных антигенов
WO2017218867A1 (en) * 2016-06-16 2017-12-21 Aeras Tuberculosis compositions and methods of treating or preventing tuberculosis
CN107970444B (zh) * 2016-10-25 2022-03-01 中国人民解放军第三0九医院 复合佐剂及含有该复合佐剂的疫苗
PH12021553146A1 (en) * 2019-06-14 2024-04-22 Statens Seruminstitut Fusion proteins for tuberculosis vaccines
US20250345408A1 (en) * 2020-09-23 2025-11-13 The General Hospital Corporation Bcg vaccinations for prevention of covid-19 and other infectious diseases
KR102709729B1 (ko) * 2020-12-04 2024-09-25 주식회사 제넥신 결핵의 예방 또는 치료용 약학적 조성물
CN115598041B (zh) * 2021-07-07 2025-08-19 中国科学院微生物研究所 结核鉴别诊断细胞因子及其在结核感染风险评估中的应用
KR20240153581A (ko) 2022-02-21 2024-10-23 스태튼스 세룸 인스티튜트 신규한 양이온 어주번트 조성물
CN117531001A (zh) * 2023-11-15 2024-02-09 首都医科大学附属北京胸科医院 结核分枝杆菌毒素抗毒素系统及其相关应用
CN118108815B (zh) * 2024-04-23 2024-07-23 成都康华生物制品股份有限公司 结核分枝杆菌多免疫原抗原、编码其的mRNA、应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004006952A2 (en) * 2002-07-13 2004-01-22 Statens Serum Institut Therapeutic tuberculosis vaccines
WO2004083448A2 (en) * 2003-03-14 2004-09-30 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the m.tuberculosis complex

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1331C (da) 1897-11-15 Hans Daae Militær- og Skilygte.
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US6641814B1 (en) 1997-04-02 2003-11-04 Statens Serum Institut Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis
EP2045261A1 (en) * 1994-09-20 2009-04-08 Hitachi Chemical Co., Ltd. Chlamydia pneumoniae antigenic polypeptides
ATE339436T1 (de) 1995-06-07 2006-10-15 Sanofi Pasteur Inc Expression von lipoproteinen
CN1377355A (zh) 1999-09-30 2002-10-30 纽罗杰有限公司 氨基取代的吡唑并[1,5-a]-1,5-嘧啶和吡唑并[1,5-a]-1,3,5-三嗪
WO2001079274A2 (en) 2000-04-19 2001-10-25 Statens Serum Institut Tuberculosis antigens and methods of use thereof
WO2002004018A2 (en) 2000-07-10 2002-01-17 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
US20030180953A1 (en) * 2000-12-29 2003-09-25 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
US20030119013A1 (en) * 2001-04-23 2003-06-26 Bo Jiang Identification of essential genes of Aspergillus fumigatus and methods of use
EP2196473A1 (en) * 2001-07-04 2010-06-16 Health Protection Agency Mycobacterial antigens expressed during latency

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004006952A2 (en) * 2002-07-13 2004-01-22 Statens Serum Institut Therapeutic tuberculosis vaccines
WO2004083448A2 (en) * 2003-03-14 2004-09-30 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the m.tuberculosis complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Structure and function of carbonic anhydrases from Mycobacterium tuberculosis";Suarez Covarrubias A;《J Biol Chem》;20050513;第280卷(第19期);全文 *

Also Published As

Publication number Publication date
CA2612900C (en) 2016-08-09
MX2007016165A (es) 2008-03-14
US20110206713A1 (en) 2011-08-25
KR101188045B1 (ko) 2012-10-05
CN102836425A (zh) 2012-12-26
CA2612900A1 (en) 2006-12-28
HK1179855A1 (zh) 2013-10-11
WO2006136162A3 (en) 2007-11-15
AU2006261445A1 (en) 2006-12-28
KR20080027877A (ko) 2008-03-28
US8101193B2 (en) 2012-01-24
EP2380590A3 (en) 2012-08-22
US8703151B2 (en) 2014-04-22
IL188222A (en) 2015-11-30
EP2380589A2 (en) 2011-10-26
KR20100122130A (ko) 2010-11-19
US20130095132A1 (en) 2013-04-18
US20120114687A1 (en) 2012-05-10
BRPI0612833A2 (pt) 2010-11-30
EP1910409A2 (en) 2008-04-16
US7968105B2 (en) 2011-06-28
IL222915A0 (en) 2012-12-31
US8293250B2 (en) 2012-10-23
EP2163255A1 (en) 2010-03-17
JP2008543890A (ja) 2008-12-04
HK1124071A1 (en) 2009-07-03
IL188222A0 (en) 2008-03-20
ES2647070T3 (es) 2017-12-19
KR101035053B1 (ko) 2011-05-19
AU2006261445B2 (en) 2011-03-31
CA2836319A1 (en) 2006-12-28
JP2013121959A (ja) 2013-06-20
IL222914A0 (en) 2012-12-31
EP2380589A3 (en) 2012-09-12
WO2006136162A2 (en) 2006-12-28
US20090186048A1 (en) 2009-07-23
JP5219808B2 (ja) 2013-06-26
EP2380590A2 (en) 2011-10-26
EP2163255B1 (en) 2017-08-09

Similar Documents

Publication Publication Date Title
CN102836425B (zh) 包含潜伏感染阶段期间所表达的抗原的结核疫苗
EP1523331B1 (en) Therapeutic tb vaccine
US10519202B2 (en) Tuberculosis TB vaccine to prevent reactivation
WO2005061534A2 (en) Improved tuberculosis vaccines
US20040013685A1 (en) Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
CN101248084B (zh) 包含潜伏感染阶段期间所表达的抗原的结核疫苗
AU2013206297A1 (en) Tuberculosis vaccines comprising antigens expressed during the latent infection phase
HK1124071B (en) Tuberculosis vaccines comprising antigens expressed during the latent infection phase
HK1179855B (en) Tuberculosis vaccines comprising antigens expressed during the latent infection phase
CIPO Prophylactic GP studies

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1179855

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1179855

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150819

Termination date: 20160620

CF01 Termination of patent right due to non-payment of annual fee