CN102836142B - Hollow capsule and preparation method thereof - Google Patents
Hollow capsule and preparation method thereof Download PDFInfo
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- CN102836142B CN102836142B CN201210274807.5A CN201210274807A CN102836142B CN 102836142 B CN102836142 B CN 102836142B CN 201210274807 A CN201210274807 A CN 201210274807A CN 102836142 B CN102836142 B CN 102836142B
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Abstract
The invention discloses a hollow capsule, which comprises the following components in parts by weight: 10 to 30 parts of kappa-carrageenan, 90 to 180 parts of water-soluble crosslinked starch, and 20 to 40 parts of plasticizer. The invention also discloses a preparation of the hollow capsule, which comprises the following steps of: 1) dissolving gum, wherein carrageenan and water-soluble crosslinked starch are stirred, water at a temperature of between 70 and 90 DEG C is added into the mixture, the plasticizer in the amount of the prescription is added and completely dissolved, and the mixture is stirred uniformly; 2) culturing the gum, wherein the gum liquid obtained in the step 1) is cooled to a temperature of between 40 and 45 DEG C, the gum liquid is insulated and stood for 30 to 60 minutes, and the gum liquid is put into a gum soaking tank; and 3) soaking the gum, wherein when the temperature of the gum liquid in the gum soaking tank is cooled to 35 DEG C, operations of gum soaking, drying, shell pulling out, cutting and buckling are automatically carried out through a capsule template. According to the hollow capsule disclosed by the invention, the transparency and toughness are remarkably improved, the friability is remarkably reduced, and the product yield is greatly increased.
Description
Technical field
The present invention relates to a kind of Capsules and preparation method thereof.
Background technology
Medicine and health product are a kind of special adjuvants with duricrust Capsules.It enters digestion with preparation, by human body is absorbed, so its quality standard and safety are directly connected to quality and the safety of medicine and health food finished product.Animal gelatin is with its raw material sources widely, the inherent advantages such as stable physicochemical property and outstanding processing characteristics, the status that is keeping Capsules main flow capsule material always.But in long-term use procedure, all multimass that gelatin Capsules is potential and safety issue are but day by day remarkable.Particularly in the last few years, the frequent appearance of American-European countries's foot and mouth disease and bovine spongiform encephalopathy, made the safety problem of gelatin Capsules enjoy query.Therefore, risen in the world the upsurge of novel duricrust Capsules capsule material development.At present, the U.S., the existing vegetalitas Capsules launch of Japan and other countries, as U.S. Vcaps, Japanese Qualicaps etc.Although cost ratio gelatin Capsules is high 10 ~ 15 times, but still the welcome of Hen Shou consumer, there is greatly the trend that replaces gelatin Capsules.
The plant hollow capsule market of China is completely occupied by foreign brand name at present, although China has multinomial plant hollow capsule formula and production patent, but the product of really realizing large-scale production and put on market but rarely has report, its main cause is the reasons such as formula for a product complexity, production technology is unstable, Qualified Products Rate is low, makes it lack the prospect of marketing.
Summary of the invention
In order to solve the problems of the technologies described above, a kind of Capsules of the present invention, be specially novel crosslinked starch base seaweed plants Capsules, its formula is simple, production technology and existing manufacturing of gelatin process compatible, constant product quality, to realize the volume production of the plant hollow capsule that domesticizes.
Capsules provided by the invention, the composition that contains following parts by weight:
Kappa-carrageenan 10-30 part;
Water-soluble cross-linked starch 90-180 part;
Plasticizer 20-40 part.
Preferably, above-mentioned Capsules also contains ι-carrageenan 5-15 part.
Preferably, above-mentioned water-soluble cross-linked starch is a kind of or its two or more combination in any in water solublity Ipomoea batatas Lam. crosslinked starch, water solublity Crosslinked Potato Starch or water solublity Maninot esculenta crantz. crosslinked starch.
Preferably, above-mentioned plasticizer is a kind of or its two or more combination in any in glycerol, maltose alcohol or corn syrup.
Preferably, above-mentioned Capsules also contains antiseptic 0.5-3 part.
Preferably, above-mentioned Capsules also contains food coloring 0.5-3 part.
Preferably, also contain water in above-mentioned Capsules, wherein the percentage by weight of water in above-mentioned Capsules is less than 10%.
The present invention also provides the preparation method of above-mentioned Capsules, comprises the steps:
1) colloidal sol: get carrageenan and water-soluble cross-linked starch, add under stirring in the water of 70-90 ℃, add above-mentioned amount plasticizer, to dissolving completely, stir;
2) support glue: the glue that step 1) obtains is cooled to after 40 ~ 45 ℃, insulation leaves standstill 30-60min, then puts into and is stained with glue groove;
3) be stained with glue: be down to 35 ℃ when being stained with the temperature of glue in glue groove, through capsule mould automatic dipping glue, dry, pull out shell, cutting and fastening, can be made into Capsules.
Preferably, when adding plasticizer in step 1), also add antiseptic in water.
Preferably, when adding plasticizer in step 1), also add food coloring in water.
The present invention can reach following effect:
1) the present invention has thoroughly abandoned the use of gelatin raw material, fundamentally stopped that gelatin Capsules exists as all multimass and safety issues such as chromium exceed standard, and the scope of application is wider.
2) the crosslinked starch base seaweed plants Capsules of the present invention development, significantly strengthens with similar plant hollow capsule phase reduced transparency and toughness, and friability obviously reduces, significantly improved the qualification rate of product.
3) preparation of Capsules of the present invention, by the repeatedly melt back key technology of original creation, can be completely achieved the recycling of cutting material and transparency and the color and luster that does not affect product.The production cost of product is significantly reduced, improved its market competitiveness.
4) this product needed raw material is simple and easy to get, and production technology and existing gelatin Capsules production technology compatibility are easy to realize and apply on a large scale.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, the invention will be further described, can be implemented, but illustrated embodiment is not as a limitation of the invention so that those skilled in the art can better understand the present invention also.
The composition that Capsules provided by the invention contains following parts by weight:
Kappa-carrageenan 10-30 part;
Water-soluble cross-linked starch 90-180 part;
Plasticizer 20-40 part.
Preferably, also can contain ι-carrageenan 5-15 part.
Its production technology is: take raw material (kappa-carrageenan, ι-carrageenan and water-soluble cross-linked starch) → hot water dissolving (water of 70-90 ℃) → interpolation adjuvant (plasticizer, coloring agent, antiseptic etc.) → cooling stirring → constant temperature and support glue (40-45 ℃) → be stained with glue groove bin stock → automatic dipping glue (35 ℃) → shaping and drying (35 ℃ air-dry) → demoulding cutting fastenings → finished product and put in storage.
Melt back experiment: in actual production, the Capsules of same formula can divide multiple batches of production.Be fully used for making raw material, the present invention first Capsules is produced in cutting step leftover pieces collect, add glue pot to produce second batch Capsules together with Crosslinked Potato Starch with kappa-carrageenan for the colloidal sol step of second batch Capsules, be called secondary melt back.The leftover pieces that second batch Capsules is produced in cutting step are collected, and add glue pot to produce the 3rd batch of Capsules for the colloidal sol step of the 3rd batch of Capsules with kappa-carrageenan together with Crosslinked Potato Starch, are called melt back three times.By that analogy.
Embodiment 1 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 0.5 gram of 30 grams of kappa-carrageenans, 150 grams of water solublity Crosslinked Potato Starchs, 20 grams of glycerol, 0.5 gram of antiseptic and food coloring.Preparation method is as follows:
Colloidal sol: by the hot water that injects 70-90 ℃ in glue pot, then kappa-carrageenan and Crosslinked Potato Starch are added to glue pot in whipping process, add plasticizer glycerol, antiseptic and food coloring.It is dissolved completely;
Support glue: after liquid cement agitation colloidal sol is even, stop stirring, be cooled to 40-45 ℃, be then incubated the 40-45 ℃ of quiet 30-60min of putting, glue is put into and is stained with glue groove;
Be stained with glue: when being stained with the temperature of glue in glue groove while being down to 35 ℃, through capsule mould automatic dipping glue, oven dry (to water content lower than Capsules weight 10%), pull out shell, cutting and fastening and can be made into capsule.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Embodiment 2 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 20 grams of kappa-carrageenans, 100 grams of water solublity Crosslinked Potato Starchs, 40 grams of glycerol, 3 grams of 3 grams of antiseptic and food colorings.Production method is with example 1.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Embodiment 3 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 20 grams of kappa-carrageenans, 15 grams of ι-carrageenans, 110 grams of water solublity Crosslinked Potato Starchs, 20 grams of glycerol, 2 grams of 2 grams of antiseptic and food colorings.
Preparation method is as follows:
Colloidal sol: by the hot water that injects 70-90 ℃ in glue pot, then kappa-carrageenan, ι-carrageenan and Crosslinked Potato Starch are added to glue pot in whipping process, add plasticizer glycerol, antiseptic and food coloring.It is dissolved completely;
Support glue: after liquid cement agitation colloidal sol is even, stop stirring, be cooled to 40-45 ℃, be then incubated the 40-45 ℃ of quiet 30-60min of putting, glue is put into and is stained with glue groove;
Be stained with glue: when being stained with the temperature of glue in glue groove while being down to 35 ℃, through capsule mould automatic dipping glue, oven dry (to water content lower than Capsules weight 10%), pull out shell, cutting and fastening and can be made into capsule.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Embodiment 4 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 10 grams of kappa-carrageenans, 100 grams of water solublity Crosslinked Potato Starchs, 80 grams of water solublity Ipomoea batatas Lam. crosslinked starchs, 20 grams of glycerol, 20 grams of maltose alcohols.Production method is with example 1.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Embodiment 5 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 30 grams of kappa-carrageenans, 5 grams of ι-carrageenans, 90 grams of water solublity Crosslinked Potato Starchs, 20 grams of glycerol, 20 grams of maltose alcohols.Production method is with embodiment 3.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Embodiment 6 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 10 grams of kappa-carrageenans, 15 grams of ι-carrageenans, 140 grams of water solublity Maninot esculenta crantz. crosslinked starchs, 20 grams of corn syrup, 20 grams of maltose alcohols.Production method is with example 3.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Embodiment 7 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 30 grams of kappa-carrageenans, 10 grams of ι-carrageenans, 130 grams of water solublity Ipomoea batatas Lam. crosslinked starchs, 40 grams of glycerol.Production method is with example 3.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Embodiment 8 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 30 grams of kappa-carrageenans, 12 grams of ι-carrageenans, 160 grams of water solublity Ipomoea batatas Lam. crosslinked starchs, 10 milliliters of glycerol, 10 grams of corn syrup, 10 grams of maltose alcohols.Production method is with example 3.
The present embodiment is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, obviously not affect each index and the character of capsule, the repeatedly melt back use of formula of the present embodiment is described.
Reference examples 1 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 20 grams of kappa-carrageenans, 15 grams of ι-carrageenans, 200 grams of water solublity Crosslinked Potato Starchs, 40 grams of glycerol.Production method is with example 3.
This reference examples is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, the index such as friability, transparency, viscosity and elasticity of capsule all cannot meet GB requirement.
Reference examples 2 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 20 grams of kappa-carrageenans, 15 grams of ι-carrageenans, 160 grams of common potato starch (non-crosslinked), 20 grams of glycerol, 10 grams of corn syrup, 10 grams of maltose alcohols.Production method is with example 3.
This reference examples is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, the index such as friability, transparency, viscosity and elasticity of capsule all cannot meet GB requirement.
Reference examples 3 is by 1 kg of water, and the Capsules proportioning of the present embodiment is as follows: 2 grams of 20 grams of kappa-carrageenans, 15 grams of ι-carrageenans, 110 grams of common sweet potato starch (non-crosslinked), 20 grams of glycerol, 10 grams of corn syrup, 10 grams of maltose alcohols, 2 grams of antiseptic and food colorings.Production method is with example 1.
This reference examples is after 10 melt backs, and the each index of Capsules making and character are in table 1.Can find out, after 10 melt backs, the index such as friability, transparency, viscosity and elasticity of capsule all cannot meet GB requirement.
With reference to version " Chinese Pharmacopoeia " pharmaceutic adjuvant part " gelatin Capsules " in 2010 and " gelatinum pro capsulae " quality standard and detection method, embodiment and reference examples Capsules product index of correlation are checked.
Table 1. embodiment and reference examples prepare synopsis
| ? | Transparency (%) | Elasticity (grain) | Disintegration (min) | Loss on drying (%) | Friability (grain) | Heavy metal (ppm) | Microbial limit | Viscosity (mm 2/s) |
| Chinese Pharmacopoeia | 450nm，≥50 | ≤1 | ≤10 | 4.0~10.0 | ≤5 | ≤10 | Bacterial population≤1000/g; Fungi count≤100/g; Escherichia coli: must not detect | ≥60 |
| Embodiment 1 | ≥65 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | Meet the requirements | 60~70 |
| Embodiment 1 is through 10 melt backs | ≥60 | ≤2 | ≤10 | 4.0~10.0 | ≤3 | ≤2 | Meet the requirements | 60~70 |
| Embodiment 2 | ≥65 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
| Embodiment 2 is through 10 melt backs | ≥60 | ≤2 | ≤10 | 4.0~10.0 | ≤3 | ≤2 | The same | 60~70 |
| Embodiment 3 | ≥85 | ≤0 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
| Embodiment 3 is through 10 melt backs | ≥80 | ≤0 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
| Embodiment 4 | ≥65 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
| Embodiment 4 is through 10 melt backs | ≥60 | ≤2 | ≤10 | 4.0~10.0 | ≤3 | ≤2 | The same | 60~70 |
| Embodiment 5 | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 60~70 |
| Embodiment 5 is through 10 melt backs | ≥75 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
| Embodiment 6 | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 60~70 |
| Embodiment 6 is through 10 melt backs | ≥75 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
| Embodiment 7 | ≥85 | ≤0 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
| Embodiment 7 is through 10 melt backs | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
| Embodiment 8 | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 70-80 |
| Embodiment 8 is through 10 melt backs | ≥75 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 70-80 |
| Comparative example 1 | ≥50 | ≤3 | ≤10 | 4.0~10.0 | ≤5 | ≤2 | The same | ＜60 |
| Comparative example 1 is through 10 melt backs | ≥40 | ≤5 | ≤10 | 4.0~10.0 | ≤8 | ≤2 | The same | ＜60 |
| Comparative example 2 | ≥50 | ≤4 | ≤10 | 4.0~10.0 | ≤6 | ≤2 | The same | ＜60 |
| Comparative example 2 is through 10 melt backs | ≥30 | ≤8 | ≤10 | 4.0~10.0 | ≤15 | ≤2 | The same | ＜60 |
| Comparative example 3 | ≥50 | ≤4 | ≤10 | 4.0~10.0 | ≤6 | ≤2 | The same | ＜60 |
| Comparative example 3 is through 10 melt backs | ≥30 | ≤8 | ≤10 | 4.0~10.0 | ≤15 | ≤2 | The same | ＜60 |
Data from above form can be found out, adopt the indices such as Capsules elasticity, disintegration that method of the present invention makes all to meet state-promulgated pharmacopoeia requirement, and character are good, has good friability and transparency.Repeatedly after melt back, still can keep good character and index.And comparative example friability, transparency after 10 melt backs obviously reduce.And, after measured common gelatin Capsules more than 3 times after melt back its friability can not be up to state standards.
The above embodiment is only the preferred embodiment for absolutely proving that the present invention lifts, and protection scope of the present invention is not limited to this.What those skilled in the art did on basis of the present invention is equal to alternative or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (7)
1. a Capsules, is characterized in that, the composition that contains following parts by weight:
Kappa-carrageenan 10-30 part;
ι-carrageenan 5-15 part;
Water-soluble cross-linked starch 90-180 part;
Plasticizer 20-40 part;
Wherein, described water-soluble cross-linked starch is a kind of or its two or more combination in any in water solublity Ipomoea batatas Lam. crosslinked starch, water solublity Crosslinked Potato Starch or water solublity Maninot esculenta crantz. crosslinked starch;
Described plasticizer is a kind of or its two or more combination in any in glycerol, maltose alcohol or corn syrup.
2. Capsules according to claim 1, is characterized in that, described Capsules also contains antiseptic 0.5-3 part.
3. Capsules according to claim 1, is characterized in that, described Capsules also contains food coloring 0.5-3 part.
4. Capsules according to claim 1, is characterized in that, also contains water in described Capsules, and wherein the percentage by weight of water in described Capsules is less than 10%.
5. the preparation method of the Capsules described in claim 1 ~ 4 any one, is characterized in that, comprises the steps:
1) colloidal sol: get kappa-carrageenan, ι-carrageenan and water-soluble cross-linked starch, add under stirring in the water of 70-90 ℃, add described amount plasticizer, to dissolving completely, stir;
2) support glue: the glue that step 1) obtains is cooled to after 40 ~ 45 ℃, insulation leaves standstill 30-60min, then puts into and is stained with glue groove;
3) be stained with glue: be down to 35 ℃ when being stained with the temperature of glue in glue groove, through capsule mould automatic dipping glue, dry, pull out shell, cutting and fastening, can be made into Capsules.
6. preparation method according to claim 5, is characterized in that, also adds antiseptic in step 1) when adding plasticizer in water.
7. preparation method according to claim 5, is characterized in that, also adds food coloring in step 1) when adding plasticizer in water.
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| CN103070845B (en) * | 2013-01-14 | 2014-10-22 | 北京爱特康科贸有限责任公司 | Starch hollow capsule and preparation method thereof |
| CN103191433A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Safe hollow capsules using plant starch as raw material and preparation process thereof |
| CN104072811B (en) * | 2014-06-27 | 2016-08-17 | 浙江神能光降解材料有限公司 | A kind of method that hard capsule case prepared by plant source modified starch |
| CN104800852B (en) * | 2015-05-04 | 2017-12-22 | 湖南尔康制药股份有限公司 | A kind of sol gel process for being used to prepare starch hollow capsule |
| CN107126424A (en) * | 2017-04-21 | 2017-09-05 | 陈建峰 | A kind of preparation method of enteric solubility Capsules |
| CN108210479B (en) * | 2018-03-21 | 2021-02-19 | 浙江新维士生物科技有限公司 | Plant soft capsule and its preparation process and use |
| CN112608520B (en) * | 2020-12-01 | 2022-04-12 | 苏州固韧纳米材料技术有限公司 | Thermoplastic material, hollow capsule and preparation method and application thereof |
| CN117562158A (en) * | 2024-01-16 | 2024-02-20 | 广东亿超生物科技有限公司 | Chocolate candy wrapping capsule skin and preparation method thereof |
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| CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
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Effective date of registration: 20160718 Address after: 266000, No. 218, West nine water community, Shazikou street, Laoshan District, Shandong, Qingdao Patentee after: Qingdao Cong Biological Technology Co., Ltd. Address before: 266102, No. 218, West nine water community, Shazikou street, Laoshan District, Shandong, Qingdao Patentee before: Qingdao Yuanhaidi Marine Biotechnology Co., Ltd. |