CN102836142A - Hollow capsule and preparation method thereof - Google Patents
Hollow capsule and preparation method thereof Download PDFInfo
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- CN102836142A CN102836142A CN2012102748075A CN201210274807A CN102836142A CN 102836142 A CN102836142 A CN 102836142A CN 2012102748075 A CN2012102748075 A CN 2012102748075A CN 201210274807 A CN201210274807 A CN 201210274807A CN 102836142 A CN102836142 A CN 102836142A
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Abstract
The invention discloses a hollow capsule, which comprises the following components in parts by weight: 10 to 30 parts of kappa-carrageenan, 90 to 180 parts of water-soluble crosslinked starch, and 20 to 40 parts of plasticizer. The invention also discloses a preparation of the hollow capsule, which comprises the following steps of: 1) dissolving gum, wherein carrageenan and water-soluble crosslinked starch are stirred, water at a temperature of between 70 and 90 DEG C is added into the mixture, the plasticizer in the amount of the prescription is added and completely dissolved, and the mixture is stirred uniformly; 2) culturing the gum, wherein the gum liquid obtained in the step 1) is cooled to a temperature of between 40 and 45 DEG C, the gum liquid is insulated and stood for 30 to 60 minutes, and the gum liquid is put into a gum soaking tank; and 3) soaking the gum, wherein when the temperature of the gum liquid in the gum soaking tank is cooled to 35 DEG C, operations of gum soaking, drying, shell pulling out, cutting and buckling are automatically carried out through a capsule template. According to the hollow capsule disclosed by the invention, the transparency and toughness are remarkably improved, the friability is remarkably reduced, and the product yield is greatly increased.
Description
Technical field
The present invention relates to a kind of Capsules and preparation method thereof.
Background technology
Medicine and health product are a kind of special adjuvants with the duricrust Capsules.It gets into digestion with preparation, by human body is absorbed, so its quality standard and safety are directly connected to the quality and the safety of medicine and health food finished product.Animal gelatin is with its raw material sources widely, stable physicochemical property and outstanding inherent advantages such as processing characteristics, the status that is keeping Capsules main flow capsule material always.Yet in secular use, potential many quality of gelatin Capsules and safety issue are but remarkable day by day.Particularly in the last few years, the frequent appearance of American-European countries's foot and mouth disease and bovine spongiform encephalopathy made the safety problem of gelatin Capsules enjoy query.Therefore, risen the upsurge of novel duricrust Capsules capsule material development in the world.At present, the U.S., the existing vegetalitas Capsules launch of Japan and other countries are like U.S. Vcaps, Japanese Qualicaps etc.Though price is higher 10 ~ 15 times than gelatin Capsules, but still receives very much the welcome of consumer, have much the trend that replaces the gelatin Capsules.
The plant hollow capsule market of China is occupied by foreign brand name fully at present; Though China has multinomial plant hollow capsule prescription and production patent; But the product of really realizing large-scale production and putting on market but rarely has report; Its main cause is reasons such as formula for a product is complicated, production technology is unstable, the product quality qualification rate is low, makes it lack the prospect of marketing.
Summary of the invention
In order to solve the problems of the technologies described above; A kind of Capsules of the present invention; Be specially novel crosslinked starch base seaweed plants Capsules, its prescription is simple, production technology and existing manufacturing of gelatin process compatible, constant product quality, with the volume production of the plant hollow capsule of realizing domesticizing.
Capsules provided by the invention, contain following compositions in portion by weight:
Kappa-carrageenan 10-30 part;
Water-soluble cross-linked starch 90-180 part;
Plasticizer 20-40 part.
Preferably, above-mentioned Capsules also contains ι-carrageenan 5-15 part.
Preferably, above-mentioned water-soluble cross-linked starch is a kind of or its two or more combination in any in water solublity Ipomoea batatas Lam. crosslinked starch, water solublity potato crosslinking starch or the water solublity Maninot esculenta crantz. crosslinked starch.
Preferably, above-mentioned plasticizer is a kind of or its two or more combination in any in glycerol, maltose alcohol or the corn syrup.
Preferably, above-mentioned Capsules also contains antiseptic 0.5-3 part.
Preferably, above-mentioned Capsules also contains food coloring 0.5-3 part.
Preferably, also contain water in the above-mentioned Capsules, wherein the percentage by weight of water in above-mentioned Capsules is less than 10%.
The present invention also provides the method for preparing of above-mentioned Capsules, comprises the steps:
1) colloidal sol: get carrageenan and water-soluble cross-linked starch, stir in the water that adds 70-90 ℃ down, add above-mentioned amount plasticizer,, stir to dissolving fully;
2) support glue: after the glue that step 1) obtains was cooled to 40 ~ 45 ℃, 30-60min was left standstill in insulation, puts into then and is stained with the glue groove;
3) be stained with glue: the temperature of glue is reduced to 35 ℃ in being stained with the glue groove, is stained with glue automatically, dries, pulls out shell, cutting and fastening through the capsule template, promptly can be made into Capsules.
Also add antiseptic in water when preferably, adding plasticizer in the step 1).
Also add food coloring in water when preferably, adding plasticizer in the step 1).
The present invention can reach following effect:
1) the present invention has thoroughly abandoned the use of gelatin raw material, stopped fundamentally that the gelatin Capsules exists like many quality and safety issues such as chromium exceed standard, and the scope of application is wider.
2) the crosslinked starch base seaweed plants Capsules of the present invention development significantly strengthens with similar plant hollow capsule phase reduced transparency and toughness, and friability obviously reduces, significantly improved the qualification rate of product.
3) preparation of Capsules of the present invention can be completely achieved the recycling of cutting material and does not influence transparency of products and color and luster through the repeatedly melt back key technology of original creation.Production cost of products is significantly reduced, improved its market competitiveness.
4) this product needed raw material is simple and easy to, and production technology and existing gelatin Capsules production technology are compatible, is easy to realize applying on a large scale.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment the present invention is described further so that those skilled in the art can better understand the present invention and implementing, but the embodiment that lifts not conduct to qualification of the present invention.
Capsules provided by the invention contains following compositions in portion by weight:
Kappa-carrageenan 10-30 part;
Water-soluble cross-linked starch 90-180 part;
Plasticizer 20-40 part.
Preferably, also can contain ι-carrageenan 5-15 part.
Its production technology is: take by weighing raw material (kappa-carrageenan, ι-carrageenan and water-soluble cross-linked starch) → hot water dissolving's (water of 70-90 ℃) → interpolation adjuvant (plasticizer, coloring agent, antiseptic etc.) → cooling stirring → constant temperature and support glue (40-45 ℃) → be stained with glue groove bin stock → be stained with glue (35 ℃) → shaping and drying (35 ℃ air-dry) → demoulding cutting fastenings → finished product automatically to put in storage.
The melt back experiment: in the actual production, the Capsules of same prescription can divide multiple batches of production.Be fully used for making raw material; The present invention with first Capsules in cutting step, produce leftover pieces collect; The colloidal sol step that is used for second batch of Capsules adds glue pot to produce second batch of Capsules with kappa-carrageenan and potato crosslinking starch, is called the secondary melt back.The leftover pieces that second batch of Capsules produces in cutting step are collected, and the colloidal sol step that is used for the 3rd batch of Capsules adds glue pot to produce the 3rd batch of Capsules with kappa-carrageenan and potato crosslinking starch, is called melt back three times.By that analogy.
Embodiment 1 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 30 grams, water solublity potato crosslinking starch 150 grams, glycerol 20 grams, antiseptic 0.5 gram and food coloring 0.5 gram.Method for preparing is following:
Colloidal sol: the hot water with injecting 70-90 ℃ in the glue pot, then kappa-carrageenan and potato crosslinking starch are added glue pot in whipping process, add plasticizer glycerol, antiseptic and food coloring.It is dissolved fully;
Support glue: after glue stirring colloidal sol is even, stop to stir, be cooled to 40-45 ℃, be incubated the 40-45 ℃ of quiet 30-60min of putting then, glue is put into be stained with the glue groove;
Be stained with glue: when the temperature of glue is reduced to 35 ℃ in being stained with the glue groove, through the capsule template be stained with automatically glue, oven dry (to water content be lower than Capsules weight 10%), pull out shell, cutting and fastening and promptly can be made into capsule.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Embodiment 2 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 20 grams, water solublity potato crosslinking starch 100 grams, glycerol 40 grams, antiseptic 3 grams and food coloring 3 grams.Production method is with instance 1.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Embodiment 3 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 20 grams, ι-carrageenan 15 grams, water solublity potato crosslinking starch 110 grams, glycerol 20 grams, antiseptic 2 grams and food coloring 2 grams.
Method for preparing is following:
Colloidal sol: the hot water with injecting 70-90 ℃ in the glue pot, then kappa-carrageenan, ι-carrageenan and potato crosslinking starch are added glue pot in whipping process, add plasticizer glycerol, antiseptic and food coloring.It is dissolved fully;
Support glue: after glue stirring colloidal sol is even, stop to stir, be cooled to 40-45 ℃, be incubated the 40-45 ℃ of quiet 30-60min of putting then, glue is put into be stained with the glue groove;
Be stained with glue: when the temperature of glue is reduced to 35 ℃ in being stained with the glue groove, through the capsule template be stained with automatically glue, oven dry (to water content be lower than Capsules weight 10%), pull out shell, cutting and fastening and promptly can be made into capsule.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Embodiment 4 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 10 grams, water solublity potato crosslinking starch 100 grams, water solublity Ipomoea batatas Lam. crosslinked starch 80 grams, glycerol 20 grams, maltose alcohol 20 grams.Production method is with instance 1.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Embodiment 5 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 30 grams, ι-carrageenan 5 grams, water solublity potato crosslinking starch 90 grams, glycerol 20 grams, maltose alcohol 20 grams.Production method is with embodiment 3.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Embodiment 6 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 10 grams, ι-carrageenan 15 grams, water solublity Maninot esculenta crantz. crosslinked starch 140 grams, corn syrup 20 grams, maltose alcohol 20 grams.Production method is with instance 3.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Embodiment 7 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 30 grams, ι-carrageenan 10 grams, water solublity Ipomoea batatas Lam. crosslinked starch 130 grams, glycerol 40 grams.Production method is with instance 3.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Embodiment 8 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 30 grams, ι-carrageenan 12 grams, water solublity Ipomoea batatas Lam. crosslinked starch 160 grams, 10 milliliters of glycerol, corn syrup 10 grams, maltose alcohol 10 grams.Production method is with instance 3.
Present embodiment is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out, obviously influence capsular each index and character behind 10 melt backs, the repeatedly melt back use of prescription of present embodiment is described.
Reference examples 1 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 20 grams, ι-carrageenan 15 grams, water solublity potato crosslinking starch 200 grams, glycerol 40 grams.Production method is with instance 3.
This reference examples is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out that indexs such as capsular friability, transparency, viscosity and elasticity all can't satisfy the GB requirement behind 10 melt backs.
Reference examples 2 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 20 grams, ι-carrageenan 15 grams, common potato starch (non-crosslinked) 160 grams, glycerol 20 grams, corn syrup 10 grams, maltose alcohol 10 grams.Production method is with instance 3.
This reference examples is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out that indexs such as capsular friability, transparency, viscosity and elasticity all can't satisfy the GB requirement behind 10 melt backs.
Reference examples 3 is by 1 kg of water, and the Capsules proportioning of present embodiment is following: kappa-carrageenan 20 grams, ι-carrageenan 15 grams, common sweet potato starch (non-crosslinked) 110 grams, glycerol 20 grams, corn syrup 10 grams, maltose alcohol 10 grams, antiseptic 2 grams and food coloring 2 grams.Production method is with instance 1.
This reference examples is behind 10 melt backs, and each index of the Capsules that makes and character are seen table 1.Can find out that indexs such as capsular friability, transparency, viscosity and elasticity all can't satisfy the GB requirement behind 10 melt backs.
" Chinese pharmacopoeia pharmaceutic adjuvant part " gelatin Capsules " and " gelatinum pro capsulae " quality standard and detection method were checked embodiment and reference examples Capsules product index of correlation with reference to version in 2010.
The preparation synopsis of table 1. embodiment and reference examples
? | Transparency (%) | Elasticity (grain) | Disintegration (min) | Loss on drying (%) | Friability (grain) | Heavy metal (ppm) | Microbial limit | Viscosity (mm 2/s) |
Chinese Pharmacopoeia | 450nm,≥50 | ≤1 | ≤10 | 4.0~10.0 | ≤5 | ≤10 | Bacterial population<=1000/g; Fungi count<=100/g; Escherichia coli: must not detect | ≥60 |
Embodiment 1 | ≥65 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | Meet the requirements | 60~70 |
Embodiment 1 is through 10 melt backs | ≥60 | ≤2 | ≤10 | 4.0~10.0 | ≤3 | ≤2 | Meet the requirements | 60~70 |
Embodiment 2 | ≥65 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
Embodiment 2 is through 10 melt backs | ≥60 | ≤2 | ≤10 | 4.0~10.0 | ≤3 | ≤2 | The same | 60~70 |
Embodiment 3 | ≥85 | ≤0 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
Embodiment 3 is through 10 melt backs | ≥80 | ≤0 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
Embodiment 4 | ≥65 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
Embodiment 4 is through 10 melt backs | ≥60 | ≤2 | ≤10 | 4.0~10.0 | ≤3 | ≤2 | The same | 60~70 |
Embodiment 5 | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 60~70 |
Embodiment 5 is through 10 melt backs | ≥75 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
Embodiment 6 | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 60~70 |
Embodiment 6 is through 10 melt backs | ≥75 | ≤1 | ≤10 | 4.0~10.0 | ≤2 | ≤2 | The same | 60~70 |
Embodiment 7 | ≥85 | ≤0 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
Embodiment 7 is through 10 melt backs | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤0 | ≤2 | The same | 70-80 |
Embodiment 8 | ≥80 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 70-80 |
Embodiment 8 is through 10 melt backs | ≥75 | ≤1 | ≤10 | 4.0~10.0 | ≤1 | ≤2 | The same | 70-80 |
Comparative Examples 1 | ≥50 | ≤3 | ≤10 | 4.0~10.0 | ≤5 | ≤2 | The same | <60 |
Comparative Examples 1 is through 10 melt backs | ≥40 | ≤5 | ≤10 | 4.0~10.0 | ≤8 | ≤2 | The same | <60 |
Comparative Examples 2 | ≥50 | ≤4 | ≤10 | 4.0~10.0 | ≤6 | ≤2 | The same | <60 |
Comparative Examples 2 is through 10 melt backs | ≥30 | ≤8 | ≤10 | 4.0~10.0 | ≤15 | ≤2 | The same | <60 |
Comparative Examples 3 | ≥50 | ≤4 | ≤10 | 4.0~10.0 | ≤6 | ≤2 | The same | <60 |
Comparative Examples 3 is through 10 melt backs | ≥30 | ≤8 | ≤10 | 4.0~10.0 | ≤15 | ≤2 | The same | <60 |
Data from above form can find out, adopt each item indexs such as Capsules elasticity that method of the present invention makes, disintegration all to meet the NF requirement, and character are good, has good friability and transparency.Repeatedly still can keep good character and index behind the melt back.And Comparative Examples friability, transparency behind 10 melt backs obviously reduce.And, promptly can not be up to state standards through measuring common gelatin Capsules its friability behind melt back more than 3 times.
The above embodiment is the preferred embodiment that proves absolutely that the present invention lifts, and protection scope of the present invention is not limited thereto.Being equal to that the technical staff in present technique field is done on basis of the present invention substitutes or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (10)
1. a Capsules is characterized in that, contains following compositions in portion by weight:
Kappa-carrageenan 10-30 part;
Water-soluble cross-linked starch 90-180 part;
Plasticizer 20-40 part.
2. Capsules according to claim 1 is characterized in that, said Capsules also contains ι-carrageenan 5-15 part.
3. Capsules according to claim 1 is characterized in that, said water-soluble cross-linked starch is a kind of or its two or more combination in any in water solublity Ipomoea batatas Lam. crosslinked starch, water solublity potato crosslinking starch or the water solublity Maninot esculenta crantz. crosslinked starch.
4. Capsules according to claim 1 is characterized in that, said plasticizer is a kind of or its two or more combination in any in glycerol, maltose alcohol or the corn syrup.
5. Capsules according to claim 1 is characterized in that, said Capsules also contains antiseptic 0.5-3 part.
6. Capsules according to claim 1 is characterized in that, said Capsules also contains food coloring 0.5-3 part.
7. Capsules according to claim 1 is characterized in that, also contains water in the said Capsules, and wherein the percentage by weight of water in said Capsules is less than 10%.
8. the method for preparing of each described Capsules of claim 1 ~ 7 is characterized in that, comprises the steps:
1) colloidal sol: get carrageenan and water-soluble cross-linked starch, stir in the water that adds 70-90 ℃ down, add said amount plasticizer,, stir to dissolving fully;
2) support glue: after the glue that step 1) obtains was cooled to 40 ~ 45 ℃, 30-60min was left standstill in insulation, puts into then and is stained with the glue groove;
3) be stained with glue: the temperature of glue is reduced to 35 ℃ in being stained with the glue groove, is stained with glue automatically, dries, pulls out shell, cutting and fastening through the capsule template, promptly can be made into Capsules.
9. method for preparing according to claim 8 is characterized in that, also adds antiseptic in water when adding plasticizer in the step 1).
10. method for preparing according to claim 8 is characterized in that, also adds food coloring in water when adding plasticizer in the step 1).
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Cited By (8)
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CN103070845A (en) * | 2013-01-14 | 2013-05-01 | 北京爱特康科贸有限责任公司 | Starch hollow capsule and preparation method thereof |
CN103191433A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Safe hollow capsules using plant starch as raw material and preparation process thereof |
CN104072811A (en) * | 2014-06-27 | 2014-10-01 | 浙江神能光降解材料有限公司 | Method for preparing hard capsule shells from plant-derived modified starch |
CN104800852A (en) * | 2015-05-04 | 2015-07-29 | 湖南尔康制药股份有限公司 | Method for melting gelatin for preparing starch hollow capsule |
CN107126424A (en) * | 2017-04-21 | 2017-09-05 | 陈建峰 | A kind of preparation method of enteric solubility Capsules |
CN108210479A (en) * | 2018-03-21 | 2018-06-29 | 浙江新维士生物科技有限公司 | Soft capsule shell, the composition and preparation method for being used to prepare soft capsule shell |
CN112608520A (en) * | 2020-12-01 | 2021-04-06 | 苏州固韧纳米材料技术有限公司 | Thermoplastic material, hollow capsule and preparation method and application thereof |
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CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
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CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
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CN103070845A (en) * | 2013-01-14 | 2013-05-01 | 北京爱特康科贸有限责任公司 | Starch hollow capsule and preparation method thereof |
CN103070845B (en) * | 2013-01-14 | 2014-10-22 | 北京爱特康科贸有限责任公司 | Starch hollow capsule and preparation method thereof |
CN103191433A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Safe hollow capsules using plant starch as raw material and preparation process thereof |
CN104072811A (en) * | 2014-06-27 | 2014-10-01 | 浙江神能光降解材料有限公司 | Method for preparing hard capsule shells from plant-derived modified starch |
CN104800852A (en) * | 2015-05-04 | 2015-07-29 | 湖南尔康制药股份有限公司 | Method for melting gelatin for preparing starch hollow capsule |
CN104800852B (en) * | 2015-05-04 | 2017-12-22 | 湖南尔康制药股份有限公司 | A kind of sol gel process for being used to prepare starch hollow capsule |
CN107126424A (en) * | 2017-04-21 | 2017-09-05 | 陈建峰 | A kind of preparation method of enteric solubility Capsules |
CN108210479A (en) * | 2018-03-21 | 2018-06-29 | 浙江新维士生物科技有限公司 | Soft capsule shell, the composition and preparation method for being used to prepare soft capsule shell |
CN112608520A (en) * | 2020-12-01 | 2021-04-06 | 苏州固韧纳米材料技术有限公司 | Thermoplastic material, hollow capsule and preparation method and application thereof |
CN112608520B (en) * | 2020-12-01 | 2022-04-12 | 苏州固韧纳米材料技术有限公司 | Thermoplastic material, hollow capsule and preparation method and application thereof |
CN117562158A (en) * | 2024-01-16 | 2024-02-20 | 广东亿超生物科技有限公司 | Chocolate candy wrapping capsule skin and preparation method thereof |
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