CN102834105A - 保护免受机械通气诱导的膈膜功能障碍和骨骼肌萎缩的线粒体靶向的抗氧化剂 - Google Patents

保护免受机械通气诱导的膈膜功能障碍和骨骼肌萎缩的线粒体靶向的抗氧化剂 Download PDF

Info

Publication number
CN102834105A
CN102834105A CN2011800185731A CN201180018573A CN102834105A CN 102834105 A CN102834105 A CN 102834105A CN 2011800185731 A CN2011800185731 A CN 2011800185731A CN 201180018573 A CN201180018573 A CN 201180018573A CN 102834105 A CN102834105 A CN 102834105A
Authority
CN
China
Prior art keywords
arg
peptide
lys
phe
dmt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800185731A
Other languages
English (en)
Chinese (zh)
Inventor
黑兹尔·H·司徒
斯科特·克莱恩·鲍尔斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell University
University of Florida Research Foundation Inc
Original Assignee
Cornell University
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University, University of Florida Research Foundation Inc filed Critical Cornell University
Priority to CN201510229774.6A priority Critical patent/CN104922653A/zh
Publication of CN102834105A publication Critical patent/CN102834105A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CN2011800185731A 2010-02-26 2011-02-25 保护免受机械通气诱导的膈膜功能障碍和骨骼肌萎缩的线粒体靶向的抗氧化剂 Pending CN102834105A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510229774.6A CN104922653A (zh) 2010-02-26 2011-02-25 治疗或预防哺乳动物对象中骨骼肌衰弱的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30850810P 2010-02-26 2010-02-26
US61/308,508 2010-02-26
PCT/US2011/026339 WO2011106717A1 (en) 2010-02-26 2011-02-25 Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510229774.6A Division CN104922653A (zh) 2010-02-26 2011-02-25 治疗或预防哺乳动物对象中骨骼肌衰弱的方法

Publications (1)

Publication Number Publication Date
CN102834105A true CN102834105A (zh) 2012-12-19

Family

ID=44507242

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011800185731A Pending CN102834105A (zh) 2010-02-26 2011-02-25 保护免受机械通气诱导的膈膜功能障碍和骨骼肌萎缩的线粒体靶向的抗氧化剂
CN201510229774.6A Pending CN104922653A (zh) 2010-02-26 2011-02-25 治疗或预防哺乳动物对象中骨骼肌衰弱的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510229774.6A Pending CN104922653A (zh) 2010-02-26 2011-02-25 治疗或预防哺乳动物对象中骨骼肌衰弱的方法

Country Status (6)

Country Link
US (6) US20130040901A1 (enExample)
EP (4) EP3167896A1 (enExample)
JP (4) JP2013521231A (enExample)
CN (2) CN102834105A (enExample)
CA (1) CA2790823A1 (enExample)
WO (1) WO2011106717A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109937073A (zh) * 2016-05-19 2019-06-25 康德生物医疗技术公司 用于预防和治疗线粒体肌病的组合物和方法
CN110339339A (zh) * 2013-03-01 2019-10-18 康德生物医疗技术公司 治疗线粒体疾病的方法
CN115400201A (zh) * 2021-05-26 2022-11-29 四川大学华西医院 Ss-31在制备预防和/或治疗香烟诱导的气道炎症及慢性阻塞性肺疾病的药物中的用途
US11771734B2 (en) 2013-03-01 2023-10-03 Stealth Biotherapeutics Inc. Methods and compositions for the prevention or treatment of Barth syndrome

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4302829B1 (en) 2009-08-24 2025-05-21 Stealth BioTherapeutics Inc. Peptide for use in preventing or treating macular degeneration
EP3375449A1 (en) * 2010-03-15 2018-09-19 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
EP3466439A1 (en) * 2011-12-09 2019-04-10 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
WO2013149172A1 (en) * 2012-03-30 2013-10-03 Stealth Peptides International, Inc. Methods and compositions for the prevention and treatment neuropathy
EP3485897A1 (en) 2012-08-02 2019-05-22 Stealth Peptides International, Inc. D-arg-2'6'-dmt-lys-phe-nh2 for decreasing statin side effects
MX2015005102A (es) * 2012-10-22 2016-02-09 Stealth Peptides Int Inc Metodos para la reduccion de los riesgos asociados con el insuficiencia cardiaca y factores asociado con el mismo.
US10047395B2 (en) 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
CA2916492A1 (en) * 2013-06-27 2014-12-31 Stealth Biotherapeutics Corp Peptide therapeutics and methods for using same
ES2870481T3 (es) * 2014-08-21 2021-10-27 Stealth Biotherapeutics Corp Péptido D-Arg-2’,6’-Dmt-Lys-Phe-NH2 para el tratamiento del síndrome de Alport
WO2016144968A1 (en) * 2015-03-09 2016-09-15 University Of Washington Relaxin therapy for disorders of the diaphragm
CN116196389A (zh) * 2016-01-06 2023-06-02 康德生物医疗有限公司 用于预防和治疗杜氏肌肉萎缩症的方法和组合物
US10870678B2 (en) 2016-04-11 2020-12-22 Arcuate Therapeutics, Inc. Chiral peptides
US10398732B2 (en) 2016-10-13 2019-09-03 Marshall University Research Corporation Compositions and methods for treating striated muscle injury, treating striated muscle atrophy and/or for promoting striated muscle growth
KR101986882B1 (ko) * 2017-01-06 2019-06-07 연세대학교 산학협력단 오시멘, 유게놀 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 근육 질환 예방 또는 치료용 조성물
JP2019099488A (ja) * 2017-11-30 2019-06-24 小林製薬株式会社 ペプチド及びその利用
EP4210695A4 (en) 2020-09-09 2025-04-16 Social Profit Network Methods and compositions for delivery of biotin to mitochondria
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法
CN114870000B (zh) * 2022-03-21 2025-10-28 中国人民解放军空军军医大学 用于线粒体靶向治疗的两亲性前药及其纳米颗粒的制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070027087A1 (en) * 2003-02-04 2007-02-01 Szeto Hazel H Methods for preventing mitochondrial permeability transition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
NZ549393A (en) * 2004-01-23 2009-07-31 Cornell Res Foundation Inc Methods for reducing oxidative damage
CN102573881A (zh) * 2009-03-20 2012-07-11 通用医疗公司以马萨诸塞州通用医疗公司名义经营 预防和治疗烧伤损伤和继发性并发症的方法
EP2528934A4 (en) * 2010-01-25 2013-08-21 Univ Cornell AROMATIC-CATIONIC PEPTIDES AND USES THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070027087A1 (en) * 2003-02-04 2007-02-01 Szeto Hazel H Methods for preventing mitochondrial permeability transition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDREAS N. KAVAZIS: "Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production", 《FREE RADICAL BIOLOGY & MEDICINE》, vol. 46, 13 January 2009 (2009-01-13) *
JOSEPH M. MCCLUNG: "Caspase-3 Regulation of Diaphragm Myonuclear Domain during Mechanical Ventilation–induced Atrophy", 《AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE》, vol. 175, 31 December 2007 (2007-12-31), pages 150 - 159, XP008162133 *
SCOTT K. POWERS等: "Oxidative stress and disuse muscle atrophy", 《JOURNAL OF APPLIED PHYSIOLOGY》, vol. 102, no. 6, 8 February 2007 (2007-02-08), pages 2389 - 2397 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110339339A (zh) * 2013-03-01 2019-10-18 康德生物医疗技术公司 治疗线粒体疾病的方法
US11771734B2 (en) 2013-03-01 2023-10-03 Stealth Biotherapeutics Inc. Methods and compositions for the prevention or treatment of Barth syndrome
US12268724B2 (en) 2013-03-01 2025-04-08 Stealth Biotherapeutics Inc. Methods and compositions for the prevention or treatment of Barth Syndrome
CN109937073A (zh) * 2016-05-19 2019-06-25 康德生物医疗技术公司 用于预防和治疗线粒体肌病的组合物和方法
CN115400201A (zh) * 2021-05-26 2022-11-29 四川大学华西医院 Ss-31在制备预防和/或治疗香烟诱导的气道炎症及慢性阻塞性肺疾病的药物中的用途

Also Published As

Publication number Publication date
EP2538958A4 (en) 2013-08-28
US20180311301A1 (en) 2018-11-01
US20130040901A1 (en) 2013-02-14
EP3167896A1 (en) 2017-05-17
WO2011106717A1 (en) 2011-09-01
EP3332795A1 (en) 2018-06-13
EP2538958A1 (en) 2013-01-02
JP2013521231A (ja) 2013-06-10
JP2019069985A (ja) 2019-05-09
JP2017226699A (ja) 2017-12-28
US20230076067A1 (en) 2023-03-09
CN104922653A (zh) 2015-09-23
CA2790823A1 (en) 2011-09-01
JP2016164194A (ja) 2016-09-08
US20170143784A1 (en) 2017-05-25
US20160058826A1 (en) 2016-03-03
US20200282003A1 (en) 2020-09-10
EP3511012A1 (en) 2019-07-17

Similar Documents

Publication Publication Date Title
US20230076067A1 (en) Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy
JP7382607B2 (ja) 心不全の予防又は処置の方法
EP3251686A1 (en) Methods for preventing or treating metabolic syndrome
US11672841B2 (en) Methods for treating heart disease in a subject with Friedreich's ataxia by an aromatic-cationic peptide
CN117752766A (zh) 治疗线粒体疾病的方法
HK1233532A1 (en) Methods for the prevention or treatment of cardiac fibrosis
HK1233532B (en) Methods for the prevention or treatment of cardiac fibrosis
HK1242194A1 (en) Methods for preventing or treating metabolic syndrome
HK1224948A1 (en) Methods for preventing or treating metabolic syndrome

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121219