CN102824196B - Reeling device of biological bolt and manufacturing method thereof - Google Patents
Reeling device of biological bolt and manufacturing method thereof Download PDFInfo
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- CN102824196B CN102824196B CN201210334421.9A CN201210334421A CN102824196B CN 102824196 B CN102824196 B CN 102824196B CN 201210334421 A CN201210334421 A CN 201210334421A CN 102824196 B CN102824196 B CN 102824196B
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Abstract
The invention relates to a reeling device of a biological bolt for treating fistula and a manufacturing method thereof. The device is provided with a clamping rotary device, a pneumatic tension slide platform, a motor fixing block, a movable platform, a movable platform guiding device, a movable platform moving device, an equipment substrate and a control system, wherein the clamping rotary device is mounted on the equipment substrate through the pneumatic tension slide platform and the motor fixing block; the movable platform is fixedly arranged on the equipment substrate in a vertical direction through the movable platform guiding device and the clamping rotary device; and the movable platform moving device is arranged between the movable platform and the equipment substrate and can be used for driving the movable platform to move frontwards and backwards. According to the reeling device of the biological bolt for treating the fistula, the production efficiency is improved by 1/2-3/4; the uniform yield can be improved to more than 95%; the product yield is improved to more than 85%; and the biological bolt can be reeled by reeling cores with different lengths and softness degrees so that the requirements of different patients are met.
Description
Technical field
The invention belongs to tissue engineering biomaterial for medical purpose technology, specifically a kind of treat the biological bolt of fistula roll processing unit (plant) and preparation method thereof.
Background technology
Fistula is the pathologic pipeline of long-term disunion between hollow organ and hollow organ, hollow organ and skin or mucosa, usually has the opening of more than 2.The conventional method of clinical treatment fistula is operative treatment, and operative treatment exists certain risk, and patient postoperative rehabilitation phase misery is larger.In recent years, along with the development of tissue engineering technique, bring into use the method for tissue engineering bracket material to replace the method for operation, can exempt treatment risk of bringing and misery, its manufacture and exploit has become the focus of fistula treatment.
Biological bolt is a kind of tapered plug shape product, is to adopt tissue engineering bracket material to roll to form.Its Therapeutic Method is: after the debridement of fistula road, biological bolt is penetrated fistula road through internal orifice, involves from collar extension, biological bolt is placed in fistula road; Biological bolt bottom surface and fistula road junction are sewed up, and close fistula road internal orifice; Cut fistula road collar extension excess stock, wound carried out disinfection wrapping, collar extension more change dressings until healing.The pyramidal structure of biological bolt plays occupy-place effect in fistula, and transmitting tissue grows into, thus realizes tissue reconstruction; Internal orifice is closed is easier to healing, and collar extension does not close the effect that key can play again drain, prevents false healing.
Because tissue engineering technique is also in the starting stage, the processing and fabricating of biological bolt there is no ripe special equipment and produces utensil, is mostly to adopt the method manually rolled at present: membranous tissue engineering material is laid on material flat board, and cuts into applicable shape.Core is placed on one side of material, by material twisting cohesion in core, hand-turning core, until material to twist in completely in core and forms tapered external, rolledly directly puts into corresponding mould, lyophilizing afterwards.There is following shortcoming in the method that this craft rolls: 1. production is undertaken by the experience of operator, and production efficiency is low, and cost is high; 2., because operator are different, very easily occur the biological bolt thickness, the degree of tightness difference that roll, product quality and specification are difficult to control, and are difficult to realize standardized production; 3., in operation process, roll by hand and more easily increase pollution risk, cause product endotoxin, cytotoxicity etc. to exceed standard.
Summary of the invention
For the shortcoming that current manual work production biological bolt exists, a kind of semi-automation is the object of the present invention is to provide to make rolling device and the manufacture method of biological bolt.
The present invention, in order to the device of production biological bolt, mainly contains clamping-rotating device, pneumatic tensioning slide unit, motor fixed block, mobile platform, mobile platform mobile device, mobile platform guider, equipment substrate, and control system forms.Clamping-rotating device is arranged on equipment substrate respectively by pneumatic tensioning slide unit and motor fixed block; Mobile platform is fixed on equipment substrate by mobile platform guider and clamping-rotating device in vertical direction; Mobile platform mobile device is arranged between mobile platform and equipment substrate, and mobile platform can be driven to move forward and backward.
Described clamping-rotating device is two covers, is respectively made up of shaft coupling, air spider and electric rotating machine.Relatively coaxial between two cover clamping-rotating devices, horizontal interval 15-30cm, be arranged on pneumatic tensioning slide unit corresponding with it respectively with on motor fixed block: the one group of clamping-rotating device be connected with pneumatic tensioning slide unit can move horizontally, and the one group of clamping-rotating device be connected with motor fixed block is irremovable.Air spider is positioned at centre, and electric rotating machine is in outside, and shaft coupling side is connected with spin motor shaft, and opposite side and air spider are fixed, and the transmission as turning moment connects.Air spider front end has 3-6 to prop up the claw that can inwardly clamp of rounded array; Air spider interposition is equipped with two compressed air inlet ports; Respectively compressed air is passed into two air inlets---can the gathering and release of control card pawl, claw grasp is determined by compressed-air actuated air pressure size.Claw is manufactured by steel alloy material, can fastening diameter 0.7-50mm column.
Described pneumatic tensioning slide unit, it is fixedly connected with electric rotating machine; Pneumatic slid platform bottom surface is fixedly connected with equipment substrate.Pneumatic tensioning slide unit is by compressed air-driven, and the air pressure size that tensile force is supplied by pneumatic tensioning slide unit determines.By the movement of pneumatic tensioning platform, connected clamping-rotating device can be made to move in horizontal direction, to reach the object of stretching core.
Described mobile platform, is processed into by stainless steel.The slide block that mobile platform is connected with its bottom surface is nested in the middle of two cover clamping-rotating devices by the slide rail be fixed on equipment substrate, with clamping-rotating device in vertical direction, and can to move forward and backward along slide rail direction.Mobile platform can place the tissue engineering material to be used of any specification, and completes biological bolt on its surface and roll work.
Described mobile platform mobile device, is made up of platform movement motor, lead screw, the clamped holder assembly of leading screw and leading screw nut.It is middle near clamping-rotating device side that platform movement motor is fixed on two slide rails on equipment substrate, and platform movement motor shaft and slide rail are parallel direction.Lead screw one end is connected with platform movement motor shaft, and the other end is connected with the clamped holder assembly of leading screw.Leading screw nut is engaged by screw thread and leading screw are nested, and its stationary plane and mobile platform underrun screw are fixed.By the rotation of lead screw, the turning moment of platform movement motor is transformed into the moment with slide rail parallel direction by leading screw nut, and it is movable to control mobile platform by motor positive and inverse, and translational speed is determined by platform movement motor rotary speed.
Described mobile platform guiding mechanism, is made up of slide rail and slide block.Two one slide rails are fixed on equipment substrate, parallel with leading screw in mobile platform mobile device and be positioned at its lateral symmetry and install, and mobile platform bottom surface and slide block are fixed.Slide block is nested on slide rail, and can move forward and backward along slide rail direction.
Described equipment substrate, is processed into by stainless steel, is provided with feet, and what be convenient to this device puts leveling and movement.
Described control system, comprises touch screen, Programmable Logic Controller, motor driver and electromagnetic valve; Touch screen is used for display and arranges parameters, comprises the rotating speed of platform movement motor and two electric rotating machines, air spider, the pressure of pneumatic tensioning slide unit, mobile platform displacement; And control gathering and discharging of air spider.Programmable Logic Controller is used for program storage running and issues operating instruction, and it is expanded input and is connected with touch screen, and signal output part is connected with motor driver, electromagnetic valve.The signal input part of motor driver is connected with Programmable Logic Controller, and signal output part is connected with electric rotating machine, platform movement motor respectively---motor speed, direction can be controlled.The signal input part of electromagnetic valve is connected with Programmable Logic Controller, realizes the gathering of claw by opening or closing compressed-air actuated path, discharges, and can control the whether action of tensioning pneumatic slide platform.
The method for coiling of the biological bolt of the present invention and step, as described below:
1. open device power supply (DPS), set electric rotating machine rotating speed, mobile platform translational speed and displacement by the touch screen of control section, provide compressed air pressure by air compressor.
2. will cut into the moistening tissue engineering bracket material of suitable shape and size, place on a mobile platform, then the metal handle at core two ends is positioned in expansion chuck claw respectively.Start clamping button, core is fixedly clamped by claw.
3. press touch screen and run button, stretching rotary apparatus runs, and the clamping-rotating device be connected with Pneumatic slid platform moves, and core is straightened, and starts to rotate under rotary apparatus drives.
4. mobile platform is close to core with setting speed, and after tissue engineering bracket material contacts with core, under liquid tension effect, material to be attached in core and to start to rotate with core.
5., when material is coated in core completely, mobile platform halts after arriving setting displacement, and after rotary apparatus stops the rotation, air spider claw discharges automatically, and mobile platform and biological bolt return initial position together, and coiling process terminates.
Reappose new tissue engineering material, and core is installed, second can be started and take turns and roll.
The making of the biological bolt of the present invention, also semi-automatic preparation method can be adopted: drive core to rotate by dynamic Control, by the surface tension of liquid effect of tissue engineering material, it is made naturally to be attached in core, core continues to rotate, and tissue engineering material is twisted in core completely obtains biological bolt.
Biological bolt rolling device of the present invention and using method, compared with manually rolling at present, have the following advantages:
(1) experimentally add up, use this device to roll biological bolt, the required time only has craft to roll 1/2 to 3/4 of fistula biological bolt, improves production efficiency.
(2) use this device to roll biological bolt, in coiling process, each action all can set relevant parameter according to actual needs, biological bolt stress equalization in coiling process, and size length is unified.Manually roll biological bolt homogeneity at present and be subject to many-sided impact such as operator's individuality, experience, maneuver, homogeneity qualification rate is about 80%, and this device homogeneity qualification rate can be promoted to more than 95%.
(3) this device is adopted to roll fistula biological bolt, by controlling core rotary speed and mobile platform feed speed, the biological bolt of different soft and hard degree can be prepared, therefore roll biological bolt density and soft or hard degree can strictly control, thus ensure the manufacturing quality with product between batch products and between different batches product.
(4) adopt this device to roll fistula biological bolt, decrease artificial participation process, reduce manual pollution risk of bringing into, improve conforming product rate, experimentally add up, manually rolling qualification rate is about 70%, adopts the inventive method to roll conforming product rate and is increased to more than 85%.
(5) adopt this device to roll fistula biological bolt, because be designed with pneumatic tensioning slide unit, automatically can adjust and make core level stretching, therefore this device can use the core of different length and soft or hard degree to roll biological bolt, meets the needs of different patient.
Below in conjunction with drawings and Examples, the present invention is described in further details.
Accompanying drawing explanation
Fig. 1 is the schematic front view be made up of the biological bolt rolling device entirety of the embodiment of the present invention:
Fig. 2 is the schematic top plan view be made up of the biological bolt rolling device entirety of the embodiment of the present invention;
Fig. 3 is the clamping device schematic diagram of the biological bolt rolling device of the present embodiment;
Fig. 4 is the rolling device mobile platform schematic diagram of the present embodiment;
Fig. 5 is the flexible core schematic diagram of the present embodiment.
In figure: 1, feet, 2, equipment substrate, 3, pneumatic tensioning slide unit, 4, electric rotating machine, 5, shaft coupling, 6, air spider, 7, slide rail, 8, slide block, 9, lead screw, 10, leading screw nut, 11, platform movement motor, 12, core, 13, mobile platform, 14, motor fixed block, 15, claw, 16, claw clamping is discharged into QI KOU, 17, tissue engineering material, 18, metal handle, 19, line body.
Detailed description of the invention
Embodiment 1
The key fitment model that the present embodiment adopts is as follows: electric rotating machine and necessary electromotor driver: Panasonic servo A4 series MHMD022P1U motor and supporting MADDT1207003 driver; Platform movement motor and necessary electromotor driver: Panasonic servo A4 series MHMD022P1U motor and supporting MADDT1207003 driver; Touch screen: Rhizoma Sparganii GT1155-QSBD-C; Programmable Logic Controller: Rhizoma Sparganii FX1N-24MR-001; The VF3530-4G-02 of electromagnetic valve: SMC; Air spider: JAP100 precise pneumatic chuck of diaphragm; The MTATR-10-50 of lead screw and supporting leading screw nut: MISUMI and supporting nut support; The SE2BSZ-10-70 of slide rail and slide block: MISUMI; Pneumatic tensioning slide unit: the MXPJ6 of SMC; Flexible core: diameter is 0.5mm length is 15cm operation suture thread, and two ends are provided with long 1.5cm diameter 1mm cylindrical metal handle.
Fig. 1, Fig. 2 from main depending on showing the structure of the present embodiment with depression angle
The biological bolt rolling device of the present embodiment, by clamping-rotating device, pneumatic tensioning slide unit 3, motor fixed block 14, mobile platform 13, mobile platform mobile device, mobile platform guider, equipment substrate 2, control system forms.Clamping-rotating device is arranged on equipment substrate 2 respectively by pneumatic tensioning platform 3 and motor fixed block 14; Mobile platform 13 is fixed on equipment substrate 2 by mobile platform guider and clamping-rotating device in vertical direction; Mobile platform mobile device is arranged between mobile platform 13 and equipment substrate 2, and mobile platform 13 can be driven to move forward and backward.
Fig. 3 shows the structure of the present embodiment clamping-rotating device: clamping-rotating device is two covers, is respectively made up of shaft coupling 5, air spider 6 and electric rotating machine 4.Relatively coaxial between two cover clamping-rotating devices, horizontal interval 20cm, be arranged on pneumatic tensioning slide unit 3 corresponding with it and motor fixed block 14 respectively, the one group of clamping-rotating device be connected with pneumatic tensioning slide unit 3 can move horizontally, and the one group of clamping-rotating device be connected with motor fixed block 14 is irremovable.Air spider 6 is in centre, and electric rotating machine 4 is in outside, and shaft coupling 5 side is connected with spin motor shaft, and opposite side and air spider 6 are fixed by screw.There is the claw 15 that can inwardly clamp of 4 rounded arrays air spider 6 front end, air spider 6 interposition is equipped with claw clamping and is discharged into QI KOU 16, compressed air inlet port passes into compressed air to two air inlets respectively---and control gathering and release of claw 15, the grasp of claw 15 is determined by compressed-air actuated air pressure size.Claw 15 is manufactured by steel alloy material, can fastening diameter 0.7-50mm column;
Between described pneumatic tensioning slide unit 3 and motor fixed block 14, be screwed; Pneumatic tensioning slide unit 3 bottom surface and equipment substrate 2 are screwed.Pneumatic tensioning slide unit 3 is by compressed air-driven, and tensile force supplies air pressure by pneumatic tensioning slide unit 3 and determines, drives the movement of pneumatic tensioning platform 3.
Fig. 4 shows the structure of mobile platform: mobile platform 13 is nested in the middle of two cover clamping-rotating devices by the slide block 8 be connected with its bottom surface by the slide rail 7 be fixed on equipment substrate, with clamping-rotating device in vertical direction, and can to move forward and backward along slide rail 7 direction.Mobile platform 13 in order to place any specification tissue engineering material to be used 17, and completes biological bolt on its surface and rolls work.Be processed into by stainless steel.
Described mobile platform mobile device, is made up of platform movement motor 11, lead screw 9, the clamped holder assembly of leading screw and leading screw nut.Platform movement motor 11 is fixed on the close clamping-rotating device side of two slide rail 7 centres on equipment substrate, and platform movement motor 11 axle and slide rail 7 are in parallel direction.Leading screw 9 one end is connected with platform movement motor shaft, and the other end is connected with the clamped holder assembly of leading screw.Leading screw nut 10 is engaged with lead screw 9 is nested by screw thread, and its stationary plane and mobile platform 13 underrun screw are fixed.By the rotation of lead screw 9, the turning moment of motor is transformed into the moment with slide rail 7 parallel direction by leading screw nut 10, and it is movable to control mobile platform 13 by platform movement motor 11 rotating, translational speed is determined by platform movement motor 11 rotary speed.
Described mobile platform guiding mechanism, is made up of slide rail 7 and slide block 8.Two one slide rails 8 are fixed on equipment substrate 2, parallel with leading screw 9 in mobile platform mobile device and be positioned at its lateral symmetry and install, and mobile platform 13 underrun screw and slide block 8 are fixed in relevant position.Slide block 8 is nested on slide rail 7, and can move forward and backward along slide rail 7 direction;
Described equipment substrate 2 is processed into by stainless steel, is provided with feet 1, and what be convenient to this device puts leveling and movement;
Described control system, comprises touch screen, Programmable Logic Controller, motor driver and electromagnetic valve; Touch screen is used for display and arranges parameters, comprises the rotating speed of platform movement motor 11, two electric rotating machines 4, air spider 6, the pressure of pneumatic tensioning slide unit 3, mobile platform 13 displacement, and can control air spider 6 and carry out gathering and discharging.Programmable Logic Controller is used for program storage running and issues operating instruction, and it is expanded input and is connected with touch screen, and signal output part is connected with motor driver, electromagnetic valve.The signal input part of motor driver is connected with Programmable Logic Controller, and signal output part is connected with electric rotating machine 4, platform movement motor 11 respectively---motor speed, direction can be controlled.The signal input part of electromagnetic valve is connected with Programmable Logic Controller, realizes the gathering of claw 15, discharges, and can control the action of pneumatic tensioning sliding platform 3 by opening or closing compressed-air actuated path.
Fig. 5 shows the structure of the flexible core of the present embodiment: mid portion is the thread line body 19 of operation stitching, diameter 0.5mm length 15cm, and there is metal handle 18 at two ends, and the cylindrical 316L stainless steel material of length 1.5cm diameter 1mm is made.
Described rolling can be divided into flexible core and rigid core by core 12.Flexible core mid portion is that operation suture thread etc. makes line body, diameter 0.3-1.5mm, length 10-25cm, and there is metal handle 18 at two ends.The cylindrical 316L stainless steel material of length 1-4cm diameter 1-3mm is made; The material formations such as rigid core can use diameter to be 0.3-1.5mm rustless steel or polyethylene.
The present embodiment adopts flexible core, and its rolling technology is as follows:
This device is placed in superclean bench, opens stand-by power source.Select core classification to be wire member roll core 12 on the touchscreen, setting core rotary speed is 60rpm, and setting mobile platform pace is 11.5cm/min, and arrange platform movement distance for 27cm, adjustment admission pressure is 0.3MP.By submucous layer of small intestine according to being positioned over shown in Fig. 4 on the mobile platform 13 of equipment.Take special core, one end metal handle 18 is placed in fixation side rotating clamp air spider claw center, press corresponding claw close push button, metal handle 18 is fixedly clamped by air spider claw 15.Fixing operation stitching thread other end metal handle is in opposite side rotating clamp air spider claw center.Press touch screen starting drive to run, pneumatic tensioning slide unit and connected rotary apparatus move to the left and strain core, after 2s, core starts to rotate, mobile platform moves forward, after submucous layer of small intestine touches core, material edge is rolled with core under tension, continue to rotate along with mobile platform 13 moves forward core, submucous layer of small intestine finally twists in completely in core and forms taper biological bolt, mobile platform 13 stops after continuing to move forward to setpoint distance, rotating clamp stops, and discharges claw 15.Metal handle 18 drops out under self gravitation effect from claw 15, and biological bolt is placed on mobile platform 13.Pneumatic tensioning slide unit stops, and left side spin rotary device returns initial position, mobile platform Rapid reset after 3 seconds.Coiling process terminates.
Reappose submucous layer of small intestine, and core 12 is installed can starts to roll work next time.Rolled a collection of biological bolt is put into lyophilizing mould and is carried out lyophilizing by operator, namely completes whole processor.
The preparation method of the semi-automation of embodiment 2. biological bolt: drive core to rotate by dynamic Control, by the surface tension of liquid effect of tissue engineering material, make it naturally be attached in core, core continues to rotate, and tissue engineering material is twisted in core completely obtains biological bolt.
Claims (4)
1. the rolling device of a biological bolt, it is characterized in that having: clamping-rotating device, pneumatic tensioning slide unit (3), motor fixed block (14), mobile platform (13), mobile platform mobile device, mobile platform guider, equipment substrate (2) and control system; Clamping-rotating device is arranged on equipment substrate (2) respectively by pneumatic tensioning slide unit (3) and motor fixed block (14); Mobile platform (13) is fixed on equipment substrate (2) by mobile platform guider and clamping-rotating device in vertical direction; Mobile platform mobile device is arranged between mobile platform (13) and equipment substrate (2), and mobile platform (13) can be driven to move forward and backward;
Described clamping-rotating device, has two covers, is respectively made up of shaft coupling (5), air spider (6) and electric rotating machine (4); Relatively coaxial between two cover clamping-rotating devices, horizontal interval 15-30cm, be arranged on pneumatic tensioning slide unit (3) corresponding with it respectively upper with motor fixed block (14): the one group of clamping-rotating device be connected with pneumatic tensioning slide unit (3) can move horizontally, and the one group of clamping-rotating device be connected with motor fixed block (14) is irremovable; Air spider (6) is in centre, and electric rotating machine (4) is in outside; Shaft coupling (5) side is connected with spin motor shaft, and opposite side is fixedly connected with air spider (6); Air spider (6) front end has 3-6 to prop up the claw (15) that can inwardly clamp of rounded array; Air spider (6) interposition is equipped with two compressed air inlet ports (16), passes into compressed air respectively to two air inlets---control gathering and release of claw (15);
Described pneumatic tensioning slide unit (3) is fixedly connected with between electric rotating machine; Pneumatic tensioning slide unit (3) bottom surface is fixedly connected with equipment substrate (2); Pneumatic tensioning slide unit (3), by compressed air-driven, makes connected clamping-rotating device horizontal direction move;
Described mobile platform (13), the slide block (8) that its bottom surface connects is nested in the middle of two cover clamping-rotating devices by the slide rail (7) be fixed on equipment substrate, with clamping-rotating device in vertical direction, and movable along slide rail (7) direction;
Described mobile platform mobile device, be made up of platform movement motor (11), lead screw (9), the clamped holder assembly of leading screw and leading screw nut (10), platform movement motor (11) is fixed on close clamping-rotating device side equipment substrate being positioned at two slide rail (7) centres, and platform movement motor shaft and slide rail (7) are in parallel direction; Lead screw (9) one end is connected with platform movement motor shaft, and the other end is fixedly connected with the clamped holder assembly of leading screw; Leading screw nut (10) is engaged by screw thread and leading screw are nested, and its stationary plane and mobile platform underrun screw are fixed;
Described mobile platform guider, is made up of slide rail (7) and slide block (8); Two one slide rails (7) are fixed on equipment substrate (2), parallel with lead screw (9) in mobile platform mobile device, and are positioned at the installation of its lateral symmetry, and mobile platform underrun screw and slide block (8) are fixed; Slide block (8) is nested on slide rail (7), and can move forward and backward along slide rail (7) direction;
Described control system, comprises touch screen, Programmable Logic Controller, motor driver and electromagnetic valve;
Touch screen and platform movement motor (11), two electric rotating machines (4), two air spiders (6), pneumatic tensioning slide unit (3) and mobile platform (13) electrical connection;
Programmable Logic Controller, it is expanded input and is connected with touch screen, and signal output part is electrically connected with motor driver, electromagnetic valve;
The signal input part of motor driver is connected with Programmable Logic Controller, and signal output part is electrically connected with electric rotating machine (4), platform movement motor (11) respectively.
2. utilize the rolling device of the biological bolt described in claim 1 to prepare a method for biological bolt, it is characterized in that, comprising:
1) device power supply (DPS) is opened, by touch screen setting electric rotating machine (4) rotating speed, mobile platform (13) translational speed and the displacement of control section;
2) the moistening Biomaterials in Tissue Engineering Scaffolds of suitable shape and size will be cut, be placed on mobile platform (13), then core (12) two ends metal handle (18) are positioned in claw (15) respectively, start clamping button, core (12) is fixedly clamped by claw (15);
3) press touch screen and run button, stretching rotary apparatus runs, and the clamping-rotating device be connected with pneumatic tensioning slide unit (3) moves, and core (12) is straightened, and rotates under rotary apparatus drives;
4) mobile platform (13) is close to core (12) with setting speed, after Biomaterials in Tissue Engineering Scaffolds contacts with core (12), under liquid tension effect, material is attached to core (12) and goes up and start to rotate with core;
5) when Biomaterials in Tissue Engineering Scaffolds is coated in core (12) completely, mobile platform (13) halts after arriving setting displacement, after clamping-rotating device stops the rotation, claw (15) discharges automatically, mobile platform (13) and biological bolt return initial position together, and coiling process terminates.
3. the rolling device of biological bolt according to claim 1, is characterized in that, described equipment substrate (2), and below is provided with the feet (1) being convenient to put leveling and movement.
4. the rolling device of biological bolt according to claim 1, is characterized in that: equipment substrate (2), is made up of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210334421.9A CN102824196B (en) | 2012-09-11 | 2012-09-11 | Reeling device of biological bolt and manufacturing method thereof |
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|---|---|---|---|
| CN201210334421.9A CN102824196B (en) | 2012-09-11 | 2012-09-11 | Reeling device of biological bolt and manufacturing method thereof |
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| CN102824196B true CN102824196B (en) | 2015-05-27 |
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| CN106419988B (en) * | 2015-08-11 | 2019-04-12 | 陕西瑞盛生物科技有限公司 | A kind of fistula bolt rolling device and method for coiling for preventing from rolling adhesion |
| CN106419989B (en) * | 2015-08-11 | 2019-04-16 | 陕西瑞盛生物科技有限公司 | A kind of rolling device and method for coiling of biomaterial |
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| 任东林,胡邦.肛瘘的诊疗新进展.《2010中国结直肠肛门外科学术年会第十四届中日大肠肛门病学术会》.2010,323-326. * |
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| CN102824196A (en) | 2012-12-19 |
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