CN102823778B - Functional feed additive special for experimental miniature pig - Google Patents
Functional feed additive special for experimental miniature pig Download PDFInfo
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- CN102823778B CN102823778B CN 201210354943 CN201210354943A CN102823778B CN 102823778 B CN102823778 B CN 102823778B CN 201210354943 CN201210354943 CN 201210354943 CN 201210354943 A CN201210354943 A CN 201210354943A CN 102823778 B CN102823778 B CN 102823778B
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Abstract
The invention relates to a functional feed additive special for an experimental miniature pig. The functional feed additive comprises a rhodiola rosea extract, a seabuckthorn extract, a ganoderma lucidum extract, a medlar extract, L-arginine, L-tryptophan, taurine, vitamin C, vitamin B1, vitamin B2, vitamin B6, niacin B3, and pantothenic acid B5. The above raw materials of the feed additive are added into a feed base and then uniformly mixed to form a functional feed for the miniature pig, and each additive can be added into the feed base to produce 1kg of the functional feed. The functional feed additive is formed by composing various edible and pharmaceutical Chinese herbal medicine extracts and some amino acids and vitamins as the feed nutrient components according to the stress features of the experimental miniature pig, and the principle and requirement of the production, experiment application, in combination of using the traditional Chinese medicine theory and stress biology principle, thus the functional feed additive can regulate the bodily function and metal state of the experimental miniature pig, alleviate the stress damage, promote repair after bodily stress, and improve the adaptability and the stress resistance.
Description
Technical field
The present invention relates to a kind of feed addictive, especially relate to a kind of functional feedstuff additive of testing the miniature pig special use.
Background technology
the experiment miniature pig is the up-and-coming youngster in animal used as test, itself and the mankind are at cardiovascular system, digestive system, skin texture, nutrition and drug metabolism, blood constituent, disease genesis mechanism aspect and the mankind have a lot of similarities, can be in order to set up multiple animal model of human disease in biomedical research, participate in the production of the important albumen of the mankind as bioreactor, and as mankind's xenogenesis organ, tissue, the first-selected donor of cell transplantation, purposes is very extensive, having very high experimental applications is worth, and the experiment miniature pig is small, body weight is still not as good as a normal adult human, in Baoding, administration, blood sampling, the operation of the normal experiments such as operation and feeding and management everyway have convenience, and docile disposition is arranged because of seed selection domestication, new drug evaluation and tumour have been widely used in, angiocardiopathy, diabetes, skin burn, dentistry, surgery, blood disease, hereditary disease, the research fields such as Nutrition and Metabolism disease, have wide market prospects.
Test small-sized swine rearing must meet the experimental animal feeding pertinent regulations and the experiment miniature pig production and application put into practice characteristics, its quality and situation could satisfy the particular requirement that scientific experiment is used, therefore and all different as common domestic pig and the miniature pig of economic animal, nutrition to the experiment miniature pig is kept except satisfying it, the Growth and reproduction three conventional needs of classes, also need the nutritional need under its stress situation of special concern.Be not subjected to interfering effects of drug in order to ensure research background, animal used as test generally can not medication, therefore in time replenish all kinds of anti-stress nutritions elements, can avoid produce and the experiment feeding period between stress Biological value accumulation cause miniature pig to enter inferior pathological state, the generation of prevention stress disease.
Summary of the invention
The objective of the invention is for a kind of functional feedstuff additive of testing the miniature pig special use is provided.To solve the Special experimental miniature pig functional feed that lacks at present.
this functional feedstuff additive system is according to experiment miniature pig physical stress characteristics and production, the rule of experimental applications and requirement, in conjunction with using tcm theory and stress Biological Principles, with the Chinese herbal medicine extract of multiple integration of drinking and medicinal herbs and partial amino-acid as feed nutrient, the vitamin compatibility forms, have the experiment of adjusting miniature pig body function and the state of mind, alleviate stress damage, the effect of repairing and improving adaptability and anti-stress ability after the promotion physical stress, can guarantee that health and the experimental applications of testing miniature pig are worth, effectively reduce the experiment miniature pig produce and the experimental applications process in due to the various losses that stress cause, and guarantee animal welfare.
Feed addictive of the present invention is mixed by the appended weight of following composition:
Described above additive adds in basal feed fully mixing to make the miniature pig functional feed, and every part of additive can be used for making the 1kg functional feed.
Compared with prior art, the functional feedstuff additive of experiment miniature pig of the present invention special use has the following advantages:
1, added anti-traditional Chinese medicine ingredients of stress, regulate fuselage state
In this additive, rhodiola root strengthening by means of tonics, tonifying kidney and strengthening yang, cardiac stimulant, enrich blood, invigorate blood circulation, be monarch drug in a prescription; The glossy ganoderma strengthening by means of tonics, strengthen the body resistance to consolidate the constitution, be ministerial drug; The fruit of Chinese wolfberry is nourishing liver and kidney, is adjutant; The sea-buckthorn promoting blood circulation to remove blood stasis, for making medicine, but above four flavor use in conjunction invigorating heart and liver kidneys, build up health, resist environmental stimuli, have simultaneously mental-tranquilization, dispersing stagnated hepatoqi, the effect such as promoting blood circulation and removing blood stasis, can alleviate a series of emotion-thought abnormals of the caused animal of environmental stimuli and body uncomfortable.
2, added anti-stress aminoacid ingredient
In this additive, arginine can promote the hormone release with synthesis to improve nitrogen balance, and have immunostimulation and thymus gland spread effect, stress the time replenish arginine can to increase albumen synthetic, reduce protein breakdown speed, alleviate the decline of body weight after Animal stress, strengthen humoral immunity and the cellular immune function of stressed animal, correct the immunologic function inhibition that glucocorticoid causes.Arginine also can by improving the plasma SOD level and reducing MDA content, reduce oxidative stress.
Tryptophan is the essential amino acid of animal body, is the large molecule amino acid of a kind of neutrality, is the second or the 3rd limiting amino acid of pig diet.Tryptophan participates in body protein and synthesizes and the metabolism network adjusting, also as the precursor of serotonin (5-HT), melatonin, tryptamines, NAD, NADP, nicotinic acid etc., participates in regulate intake and nervous activity.Tryptophan can be alleviated by the concentration of regulating brain nervous centralis serotonin temper, abnormal behaviour, provocative act and the oppressive mood etc. of animal.By its metabolite 5-HT and melatonin, tryptophan improves the immunologic function of animal indirectly, promote the generation of gamma globulin, promote marrow T lymphocyte precursor to be divided into the mature T lymphocyte, stablize polysome etc., there are some researches show that tryptophan reduces in dosage dependence mode stress be afterwards 1,2 and the 7d Plasma Cortisol Concentration, improve 7d blood plasma IGF-1 concentration, improves liver IGF-1 and IGFBP-3 mrna expression, reduces liver IGF-1R mrna expression.Tryptophan is kept the normal glucose tolerance to animal, and improving anti-stress ability has larger effect, and can reduce the attack of animal, alleviates the stress reaction that high density causes.
Taurine is a kind of conditionally essential amino acid; as a kind of active material of regulating the body normal physiological activity; have the osmotic pressure of keeping balance, regulate lipid digestion and absorb, improve immunity of organisms, strengthen the biological effect widely such as cell membrane resistance to oxidation, the normal performance of the physiological functions such as nerve, digestion, reproduction, cardiovascular, immunity and endocrine is had important regulating action.Anti-stress aspect; glucose homeostasis when taurine participates in keeping physical stress; play protective effect by the cardiac muscle cell that the regulating action of Ca2+ is damaged irritability; suppress the anti-oxidation stress ability that radical damage improves body; taurine is as one of free amino acid the abundantest in lymphocyte and granulocyte; can also improve specificity and the nospecific immunity of body, keep and improve the normal immunologic function of body.Taurine has anticonvulsant action, can regulate neuroendocrine disorder, increases the anti-stress level of animal body.Taurine can play osmotic adjust action in many organs such as central nervous system, blood platelet, skeletal muscle and heart of animal, keep homeostasis, is the endogenous anti-injury material of body.
3, added anti-stress vitamin ingredients
Vitamin C has definite anti-stress effect; can strengthen the immunity function of animal body, and participate in the immune response of cell and body directly, effectively remove a large amount of living radicals that produce under stressed condition; the protection biomembrane is avoided infringement, promotes reparation or the alleviation of stress damage.
The B family vitamin is mainly as coenzyme, various reactions in catalyzed carbon hydrate, fat and protein metabolism, under stress situation, B family vitamin consumption in animal body increases, and enteron aisle is to the absorption minimizing of vitamin, therefore need to replenish in order to animal antagonism stress situation, and between the vitamin of B family, synergy is arranged, should once replenish simultaneously multiple.Multiple in the B family vitamin also has certain mood regulation effect.Help alleviation stress under the abnormal mood such as depression, excitement of animal, the pressure that helps to releive is kept normal behavior.
Vitamin B1 can keep circulation, digestion, nerve and intramuscular normal function, adjusts GI function, and the coenzyme that consists of decarboxylase is participated in glycometabolism, and nerve fiber and the state of mind are had desirable influence.Vitamin B2 is the constituent of many important coenzyme classes in body, these enzymes transmit hydrogen in substance metabolism process in vivo, it or protein, sugar, fatty acid metabolism and energy utilization with form necessary material, can enhancing development, and can the alleviate depression state, promote that mood is gentle.
Vitamin B6 is the coenzyme of many important enzymes system in body, participate in synthetic, the metabolism of sulfur-containing amino acid of amino acid whose decarboxylation, tryptophan and the physiology courses such as metabolism of unrighted acid, play an important role in protein metabolism, the shortage of vitamin B6 will cause that tryptophan metabolism is disorderly, affect tryptophan transfer and turn to serotonin.
Nicotinic acid plays an important role in biological oxidation process, and to safeguarding the normal function of nervous system, digestive system and skin, expansion peripheral vessel and reduction serum cholesterol level also have effect.Nicotinic acid passes through to participate in carbohydrate in addition, fat, and energy discharge in protein metabolism, and have the function of regulating mood, help the promotion body and produce joyful sense.
Pantothenic acid is the composition of coacetylase, is indispensable composition in the energy i (in vivo) metabolism, is to form the necessary material of acetylcholine.Pantothenic acid helps the growth of keeping normal development and central nervous system, and adrenal normal function is extremely important for keeping.
The specific embodiment
Get gadol extract 4.2g; Hippophae rhamnoides 4.2g; Ganodenna Lucidum P.E 4.2g; Fructus lycii P.E 4.2g; L-arginine 11g; L-Trp 5g; Taurine 1g; Vitamin C 1g; B121mg; B210.5mg; B61.4mg; Nicotinic acid B370mg; Pantothenic acid B5 7mg adds abundant mixing in basal feed, enters after crushed mixer, makes the additive of fine granularity, can better be assimilated by the experiment miniature pig.
Claims (2)
1. test miniature pig dedicated functionality feed addictive for one kind, it is characterized in that this feed addictive is comprised of following material:
Gadol extract 4.2g;
Hippophae rhamnoides 4.2g;
Ganodenna Lucidum P.E 4.2g;
Fructus lycii P.E 4.2g;
L-arginine 11g;
L-Trp 5g;
Taurine 1g;
Vitamin C 1g;
Vitamin B1 21mg;
Vitamin B2 10.5mg;
Vitamin B6 1.4mg;
Nicotinic acid 70mg;
Pantothenic acid 7mg.
2. a kind of experiment miniature pig dedicated functionality feed addictive as described in right 1 is characterized in that: add in basal feed fully mixing to make the miniature pig functional feed above this additive, every part of additive can be used for making the 1kg functional feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201210354943 CN102823778B (en) | 2012-09-24 | 2012-09-24 | Functional feed additive special for experimental miniature pig |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210354943 CN102823778B (en) | 2012-09-24 | 2012-09-24 | Functional feed additive special for experimental miniature pig |
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| Publication Number | Publication Date |
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| CN102823778A CN102823778A (en) | 2012-12-19 |
| CN102823778B true CN102823778B (en) | 2013-06-26 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104256187A (en) * | 2014-10-11 | 2015-01-07 | 湖南赛诺生物科技有限责任公司 | Feed for DPF (Diesel Particulate Filter) medical donor pig and preparation method thereof |
| CN106615815A (en) * | 2016-12-30 | 2017-05-10 | 四川省旺达饲料有限公司 | Anti-stress preparation for pigs and preparation method thereof |
| CN113412883A (en) * | 2021-07-08 | 2021-09-21 | 吴江市田宇生物科技有限公司 | Functional feed additive special for experimental miniature pigs |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100647085B1 (en) * | 2005-02-18 | 2006-11-23 | 제일사료 주식회사 | The production method of taurine enriched pork by supplementation of feather meal and thereof the pork |
| DE102006014209A1 (en) * | 2006-03-25 | 2008-02-21 | Sonntag, Christoph | Water, useful e.g. as drinking water for cats, domestic animals or pets that needs to be coaxed to drink sufficient fluid, comprises a flavored syrup or concentrate of tuna fish, fish, seafood, veal, beef, pork or spaghetti |
| CN1973658A (en) * | 2006-10-17 | 2007-06-06 | 郭强繁 | Pig raising feed with balanced nutrients |
| CN101756027A (en) * | 2008-12-11 | 2010-06-30 | 天津瑞贝特科技发展有限公司 | Antiviral growth promoting premix feed and preparation method thereof |
| WO2011087708A1 (en) * | 2010-01-13 | 2011-07-21 | Dodds W Jean | Animal food compositions for promoting liver cleansing and mitigations of intestinal dysbiosis |
| CN101869222B (en) * | 2010-06-08 | 2012-06-27 | 浙江大学 | Feed additive for improving reproductive capacity of boar and preparation method thereof |
| CN101999545A (en) * | 2010-12-01 | 2011-04-06 | 北京资源亚太饲料科技有限公司 | Compound feed for lactating sows and preparation method thereof |
| WO2012125020A1 (en) * | 2011-03-14 | 2012-09-20 | N.V. Nutricia | Method for treating neurotrauma |
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