CN102822725B - Gelatinous cleaning agent for contact lenses - Google Patents
Gelatinous cleaning agent for contact lenses Download PDFInfo
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- CN102822725B CN102822725B CN2011800117823A CN201180011782A CN102822725B CN 102822725 B CN102822725 B CN 102822725B CN 2011800117823 A CN2011800117823 A CN 2011800117823A CN 201180011782 A CN201180011782 A CN 201180011782A CN 102822725 B CN102822725 B CN 102822725B
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- Prior art keywords
- contact lenses
- detersive
- sex change
- silicone oil
- cleaning
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0031—Carpet, upholstery, fur or leather cleansers
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/201—Monohydric alcohols linear
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2068—Ethers
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
- C11D3/3738—Alkoxylated silicones
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C13/00—Assembling; Repairing; Cleaning
Abstract
The purpose of the present invention is to provide a cleaning agent for contact lenses that is easy to handle and exhibits an excellent cleaning effect against dirtiness caused by oily ingredients adhering to the surface of the contact lenses, specifically oily dirtiness caused by the adherence of eye makeup and the like (cosmetic dirtiness), when compared to conventional non-abrasive cleaning agents for contact lenses suited to cleaning by scrubbing. The purpose is achieved by providing a gelatinous cleaning agent for contact lenses that is characterized by containing polyether-modified silicone oil, a solubilizing agent, and a gelling agent.
Description
The cross reference of related application
The application requires Japanese patent application 2010-223356 number right of priority of submission on October 1st, 2010, by reference its full content is incorporated herein.
Technical field
The present invention relates to a kind of contact lenses gel detersive.More specifically, the present invention relates to a kind of contact lenses gel detersive, it is not only applicable to clean and is derived from the biosome that is attached to when wearing contact lenses on the contact lenses such as the oily dirt of discharge of eye, and is applicable to clean and is derived from the oily dirt (cosmetics dirt) that the cosmetics that are attached on the contact lenses such as eye are made up product.
Background technology
Generally speaking, contact lenses are divided into following large class: non-property of water-bearing contact lenses and property of water-bearing contact lenses.For non-property of water-bearing contact lenses, to improve the oxygen permeability as purpose, generally polysiloxane-based material is used for the constituent of ocular lens material.Yet, in recent years, even for property of water-bearing contact lenses, from the security of eye, will have the polysiloxane-based material of higher level oxygen permeability as constituent.The surface of described contact lenses has lipophilicity because of the polysiloxane-based material in the ocular lens material.Therefore, because affinity, oily dirt tends to easily be attached on the contact lenses.
Be attached to the dirt that is worn over the contact lenses on the eye and comprise protein and the lipid of biosome dirt as being derived from tear or discharge of eye, and the cosmetics dirt, it makes up product such as eye shadow and mascara as representative take eye.If continue to be worn on the contact lenses that have dirt on it on eyes, the water moisture retention of the lens surface that is then caused by tear can descend, and then described lens surface becomes dry, thereby for example can not obtain the suitable obstacle of correcting defects of vision even cause wearing sense decline and cause when vision correction.In addition, dirt fixing or that be accumulated on the lens surface can become vegetative hotbed, thereby brings the risk that causes eye diseases.In addition, the oxygen supply of cornea can descend, thereby may have deleterious effect by the corneal cell.Consider this deleterious effect of the oily dirt on the contact lenses, expectation is with the contact lenses periodic cleaning and keep clean.
About the contact lenses detersive of routine, there is the detersive that comprises surfactant or protease.For example, as long as detersive is used for property of water-bearing soft contact lens (hereinafter being called " SCL "), just there is the multi-functional solution that is only formed by a kind of liquid and contact lenses can be cleaned, sterilize, preserve and wash.Because its simplicity, described multi-functional solution is widely used.Yet, consider health, preferably, the reagent area of detersive with sterilization, preservation or flushing should be separated, and every kind of reagent should be used for various processing as each special solution.In addition, in order effectively to remove the dirt that is attached on the contact lenses and in order to use contact lenses more comfortable and safely, so-called " scouring ", soon cleaner special drips on the contact lenses and is quite effective with pointing the operation of cleaning contact lenses then.That is, if use the contact lenses detersive that is suitable for cleaning, then the surface of contact lenses can be kept to such an extent that more clean.
The contact lenses detersive that is applicable to clean is to comprise lapping compound as the detersive of cleansing.For example, following detersive is available: the detersive (referring to patent documentation 1, or Japanese kokai publication hei 05-19217 communique, by with reference to its disclosure is incorporated herein) that comprises inorganic particles; With comprise the detersive of bead such as the bead made by organic polymer (referring to patent documentation 2, or Japanese Unexamined Patent Application Publication 2004-511625 communique, by with reference to its disclosure is incorporated herein).Inorganic or the organic lapping compound that is included in the above-mentioned detersive tends to separation, sedimentation or aggegation, thereby so that is difficult to operate described detersive.In addition, can damage lens surface in some cases.
Clean in the situation of contact lenses at the detersive that contains lapping compound by usefulness, the surface state that depends on contact lenses to be cleaned owing to described cleaning is worried the risk to the adverse effect of lens surface, even can not use the at present commercially available detersive that contains lapping compound.More specifically, about giving the contact lenses of water wettability and stain resistance by applying surface treatment to it, described surface-treated effect may peel off because of the physical action of lapping compound or lose.Therefore, be not suitable for using the detersive that contains lapping compound.
Replace containing the detersive of lapping compound, as being applicable to clean the detersive that has applied the surface-treated contact lenses, following detersive is disclosed: do not contain lapping compound and use lower alcohol as the gel detersive of cleansing (referring to patent documentation 3, TOHKEMY 2006-11418 communique is incorporated herein its disclosure by reference).Because the degreasing power of lower alcohol and solubilising power, described detersive have the cleaning effect of raising to the oily dirt that comprises the cosmetics dirt.
The prior art document
Patent documentation
Patent documentation 1: Japanese kokai publication hei 05-19217 communique
Patent documentation 2: Japanese Unexamined Patent Application Publication 2004-511625 communique
Patent documentation 3: TOHKEMY 2006-11418 communique
Summary of the invention
Problem to be solved by this invention
The inventor pays close attention to following contact lenses: the hard contact lenses of oxygen permeability (hereinafter, be also referred to as " RGPCL ") and silicone hydrogel contact lens is (hereinafter, be also referred to as " SHCL "), for it being given water wettability and to the purpose of the stain resistance of protein etc., by plasma surface modification, graft polymerization etc. with its finishing or modification.If clean this glasses with disclosed detersive in the detersive that contains lapping compound such as patent documentation 1 and 2, then the effect of lens surface processing can peel off or lose because of the physical action of lapping compound.Therefore, be not suitable for using this detersive.
In the situation of the detersive that contains lower alcohol described in the patent documentation 3, can clean that lens surface is modified or above-mentioned RGPCL or the SHCL of modification, and the oily dirt on can the flush away lens surface.Yet the detersive described in the patent documentation 3 is because comprise the risk that has as the alcohol of cleansing the adverse effect of contact lenses.Therefore, the possibility of the content of restriction alcohol is high.Simultaneously, particularly in recent years, developed successively the high water resistant cosmetic of water tolerance.Consider above-mentioned development, the detersive described in the patent documentation 3 is the serious cosmetics dirt of flush away suitably, and described cosmetics dirt may be attached to by the water resistant cosmetic of Future Development on the surface of contact lenses and cause.
The purpose of this invention is to provide a kind of contact lenses detersive, it is compared with detersive with the conventional contact lenses that do not contain lapping compound and be applicable to clean, illustrate being attached to the oiliness composition dirt on the contact lens surface, particularly make up the higher cleaning effect of the oily dirt (cosmetics dirt) that product etc. causes by being attached to eye on it, and have excellent operability.Another object of the present invention provides a kind of contact lenses detersive, and it does not only have adverse effect to the lens surface of conventional RGPCL and SCL, and the RGPCL that its lens surface is modified or the lens surface of SHCL do not have adverse effect yet.
The means of dealing with problems
As the result to the further investigation of many materials of can be used as cleansing such as surfactant and organic solvent, the inventor finds, if with comprising sex change silicone oil, or more specifically its sex change position has the silicone oil (polysiloxane-13 of hydrophilic polyethers sex change; The ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-; Etc.) detersive clean contact lenses, then described detersive does not have adverse effect to lens surface, and performance is particularly to the abundant cleaning effect of oily dirt.Finished the present invention based on this discovery.
Therefore, according to the present invention, provide a kind of contact lenses gel detersive, it is characterized in that, comprise silicone oil, solubilizer and the jelling agent of at least polyethers sex change.
Preferably, described contact lenses are characterised in that with the gel detersive silicone oil of described polyethers sex change is the polysiloxane of polyoxyalkylene sex change.
Preferably, described contact lenses are characterised in that with the gel detersive silicone oil of described polyethers sex change is the ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-; And described solubilizer is lower alcohol and/or liquid polyol.
Preferably, described contact lenses are characterised in that with the gel detersive polyoxyalkylene in the ABn type segmented copolymer of described polydimethylsiloxane--polyoxyalkylene-is polyoxyethylene or poly-(ethylene oxide-propylene oxide) multipolymer; Described lower alcohol is ethanol, propyl alcohol, isopropyl alcohol or phenmethylol; And described liquid polyol is for being selected from ethylene glycol, propylene glycol, dipropylene glycol, at least a alcohol of 1,3-BDO and glycerine.
Preferably, described contact lenses are characterised in that with the gel detersive amount of the silicone oil of described polyethers sex change is between 0.05w/w% and 0.50w/w%.
The invention effect
Detersive of the present invention comprises the silicone oil of polyethers sex change as cleansing, therefore, compare with detersive with the conventional contact lenses that do not contain lapping compound that are applicable to clean, it is effective to be attached to aspect the oily dirt on the contact lens surface height in removing, no matter described oily dirt is derived from biosome or cosmetics.In addition, because detersive of the present invention does not comprise the composition that serves as lapping compound, so the impact minimum on the surface of the contact lenses that described detersive was processed by plasma surface modification, graft polymerization etc. its surface realizes the effective cleaning effect simultaneously.Therefore, because the surface of the contact lenses that expection is cleaned with detersive of the present invention can keep clean, thus when wearing contact lenses, can keep because of tear the water moisture retention of described lens surface, thus cause preventing the lens surface drying.Therefore, use that detersive of the present invention can avoid being caused by the oily dirt of contact lens surface with inferior problem: the sense of wearing of contact lenses descends, and about the obstacle of vision correction, the oxygen supply of the risk of eye diseases and cornea reduces.
Contact lenses of the present invention are gel with the formulation of detersive, and therefore, contact lenses of the present invention have excellent sense of touch with detersive when cleaning, and can make its anelasticity on contact lenses high.Therefore, contact lenses detersive of the present invention has the cleaning effect that more improves.In addition, contact lenses of the present invention are in detersive and have full-bodied gel state, thereby even can not have drop and a small amount of contact lenses also can clean fully contact lenses with detersive.As a result, can improve the operability that described contact lenses are used detersive.
Embodiment
According to the present invention, a kind of contact lenses gel detersive is provided, it is characterized in that, comprise silicone oil, solubilizer and the jelling agent of polyethers sex change.
Comprise the silicone oil of polyethers sex change as the detersive of the present invention of cleansing, particularly to having excellent cleaning effect owing to the cosmetics dirt that is attached to the enhanced water resistance cosmetics on the contact lenses, and be for the gel detersive of cleaning contact lenses.
Nearest contact lenses tend to have the polysiloxane-based material of higher component ratio to improve the oxygen supply of cornea in its composition.Because the surface of described glasses shows hydrophobicity, can easily be attached on it so have the oily dirt of high affinity.Particularly, as oily dirt, can comprise the dirt with inferior type: be included in the oiliness composition in the discharge of eye in the tear, cosmetics etc.Especially, the cosmetics dirt can easily be attached on the glasses, and can not easily remove, and causes thus variety of issue.Cosmetics comprise the various silicone materials of characteristics such as having excellent high water repellency, low irritant, hypotoxicity usually.Therefore, the silicone materials in the cosmetics has high affinity with the surface of the contact lenses that comprise identical polysiloxane-based material, thereby so that the cosmetics dirt is can be securely attached to it and so that be difficult to remove described dirt by washing.Especially, cosmetics such as eye woman's persona product has the water tolerance (waterproof) of reinforcement.Therefore, if conventional detersive is used for cleaning the dirt that is attached on the lens surface, then described dirt extends owing to the affinity between cosmetics dirt and the hydrophobic lens surface and launches.Not only can not remove dirt, and described dirt can be residual as oil film, thereby cause bluring or wearing sense on the lens surface to descend.
Be attached to the oily dirt on the contact lenses in order to remove because as the silicone materials of one of glasses composition and the affinity between the oiliness composition, detergent package of the present invention contains the sex change silicone oil at the interface that effectively acts between lens surface and the oily dirt as cleansing.Described sex change silicone oil has the dimethyl siloxane key as main chain (polysiloxane position), and has the structure of introducing the sex change position in main chain (backbone chain type) or side chain (side chain type).By dimethyl silicone polymer be representative typical silicone oil with and to have hydrophobic sex change silicone oil be non-water-soluble at the sex change position.Therefore, being difficult to that described silicone oil is blended into the contact lenses of basically being made by aqueous solution uses in the detersive.In addition, even make it possible to silicone oil is contained in contact lenses with in the detersive by emulsifications such as surfactants, also not preferred above-mentioned silicone oil is because described silicone oil adheres to as oily dirt and remains on the lens surface.Therefore, according to the present invention, use its sex change position to have hydrophilic sex change silicone oil.This hydrophilic sex change silicone oil has high surface, and will be separated with lens surface by the cosmetics dirt of hydrophobicity polysiloxane position solubilising because of the sex change hydrophilic site, so expection has the effect of removing the cosmetics dirt in effective mode.
In detersive of the present invention, have hydrophilic sex change silicone oil for its sex change position, use the silicone oil that is called following polyethers sex change: the dimethyl silicone polymer of the polysiloxane of polyoxyalkylene sex change, polyoxyalkylene sex change, dimethyl siloxane-oxygen alkylene multipolymer and polydimethylsiloxane--polyoxyalkylene-block copolymers.The water wettability of above-claimed cpd and oxyalkylene account for the ratio of mean molecular weight, and namely the containing ratio at polyethers position (occupation rate) increases pro rata.Yet along with its solubleness in water improves, lipophilicity descends.Therefore, may there be the possibility that can not obtain the abundant cleaning effect of oily dirt.That is, the hydrophilic/hydrophobic in the sex change silicone molecule may exert an influence to the cleaning effect of oily dirt.For example, when in the polysiloxane of polyoxyalkylene sex change, aspect molecular weight, when the occupation rate height at polyethers position and the occupation rate at polysiloxane position are hanged down, because lipophilicity is low, so the cleaning effect of oily dirt is tended to diminish.For cleaning source is from the oily dirt of cosmetics effectively, the oily dirt that is particularly produced by the enhanced water resistance cosmetics expects that the polysiloxane of used polyethers sex change is developed appropriate lipophilicity.In order to develop the lipophilicity of this appropriateness, preferably, the polysiloxane of polyethers sex change has the hydrophobic grouping (lipophilic group) of abundant amount in molecule.Therefore, in preparation during detersive of the present invention, consider that following factor is with the silicone oil of the polyethers sex change suitably selecting comprise: the balance of the molecular weight at polysiloxane position and occupation rate, hydrophilic/hydrophobic, whole molecular structures.The silicone oil that is included in the preferred polyethers sex change in the detersive of the present invention is the polysiloxane of polyoxyalkylene sex change.
The molecular structure of the silicone oil of polyethers sex change is divided into haply with Types Below: backbone chain type, in main chain, introduce in this case the sex change position; Side chain type is introduced the sex change position in this case in side chain; With side chain two tip type, in main chain (two ends) and side chain, all introduce the sex change position in this case.About backbone chain type, exist with Types Below: single tip type, in an end of main chain, introduce in this case the sex change position; Two tip type are all introduced the sex change position in this case in two ends of main chain; With ABn type segmented copolymer, in main chain, alternately introduce in this case the sex change position.About above-mentioned molecular structure, single tip type, two tip type, side chain type and side chain two tip type have wherein hydrophobicity polysiloxane position at the center, and water wettability sex change position is bonded to the structure of (terminal, side chain) around it, the hydrophobic interaction thereby the above-mentioned type tends to and display orientation.Hydrophobic polysiloxane position is in the situation of hydrophobic surface orientation therein, and water wettability sex change position simultaneously may be in the direction orientation opposite with hydrophobic surface.Therefore, exist cleansing may not effectively act on the possibility at the interface between lens surface and the oily dirt.Therefore, for example, if comprise PEG32-methyl ether dimethyl silicone polymer (two tip type: KF-6004, made by Shin-Etsu Chemial Co., Ltd), PEG10-dimethyl silicone polymer (side chain type: KF-6017, made by Shin-Etsu Chemial Co., Ltd) etc. as cleansing, even then described cleansing has the polysiloxane position that is applicable to the solubilising oily dirt, it is lower than ABn type that its cleaning effect also becomes.On the contrary, therein the sex change position is alternately introduced in the situation of the ABn type segmented copolymer in the main chain, described ABn type segmented copolymer has less orientation texture because the sex change position is present on the identical main chain.Therefore, polysiloxane position and sex change position have excellent effect to the interface between lens surface and the oily dirt separately, thereby so that can remove oily dirt in effective mode.
Therefore, the silicone oil that is included in the preferred polyethers sex change in the detersive of the present invention is the silicone oil of the polyethers sex change of ABn type segmented copolymer for its molecular structure, and polysiloxane and polyethers position alternately coexist as on the same main chain in described multipolymer.The ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-more preferably.The preferred instantiation that is used for detersive of the present invention can comprise polysiloxane-13 (polyethers position: polyoxyethylene or poly-(ethylene oxide-propylene oxide) multipolymer).Polysiloxane-13 can comprise FZ-2222, FZ-2231, FZ-2233, FZ-2250 etc., is made by Dow Corning Toray Co., Ltd., and it can use separately or can be with above-mentioned two or more being used in combination.
The use level of polysiloxane-13 is for example in 0.0005 to 5.0w/w% scope.If described amount less than 0.0005w/w%, then can not obtain sufficient cleaning effect.If described amount is greater than 5.0w/w%, then sense of touch significantly worsens when cleaning.Therefore, described amount is preferably in 0.001 to 1.00w/w% scope, or particularly preferably in 0.05 to 0.50w/w% the scope.Incidentally, the solubleness of polysiloxane-13 in water is low, and polysiloxane-13 is by suitable solubilizer dissolving.That is, in detersive of the present invention, comprise solubilizer with silicone oil such as the polysiloxane-13 of the sex change of dissolving polyethers.
As the solubilizer that in detersive of the present invention, uses, preferably use amphiphilic solvent.Particularly, can comprise lower alcohol, liquid polyol etc.Lower alcohol has Disinfection Effect, and generally as detersive or sanitizer.Therefore, even in the present invention, can expect that also lower alcohol can improve cleaning effect and provide anticorrosion and Disinfection Effect.Liquid polyol is also as osmotic pressure regulator, and can be expected at when cleaning finger is had moistening effect.As a result, for the solubilizer of detersive of the present invention, preferably use the combination of lower alcohol, liquid polyol or lower alcohol and liquid polyol.
Lower alcohol for example comprises ethanol, propyl alcohol, isopropyl alcohol, phenmethylol and other lower alcohol.The example of liquid polyol for example comprises ethylene glycol, propylene glycol, dipropylene glycol, 1,3-BDO, glycerine and other liquid polyol, and it can use separately, perhaps can be with above-mentioned two or more being used in combination.
As the preferred embodiment of solubilizer of the present invention, when polysiloxane-13 during as the silicone oil of polyethers sex change, is considered its solubilising power and security, use respectively as the isopropyl alcohol of lower alcohol with as the 1,3-BDO of liquid polyol alone or in combination.
Measure the use level of solubilizer based on the dissolubility of the silicone oil of polyethers sex change such as polysiloxane-13.Therefore, the use level of solubilizer is not particularly limited, as long as silicone oil that can the sex change of solubilising polyethers.Yet, take the gel state of the agent that keeps clean as purpose, and consider the impact of cleaning contact lenses, to the security of eye etc., can limit the use level of solubilizer.When with liquid polyol effect solubilizer, can realize that based on same composition solubilising and osmotic pressure regulates both.Yet, in this case, the use level of solubilizer is limited in so that the amount of osmotic pressure in OK range.From above, the use level of solubilizer is for example in 1.0 to 60.0w/w% scope.If described amount is less than 1.0w/w%, then the inadequate possibility of the solubilising of the silicone oil of polyethers sex change is high.If described amount is greater than 60.0w/w%, then infer not only to be difficult to form and to keep the optical characteristics of gel state but also contact lenses can be deteriorated significantly.For example, if the use level of solubilizer is large, then in the situation of RGPCL, ocular lens material deliquescing, and in the situation of property of water-bearing SCL/SHCL, ocular lens material perhaps causes other problems, and therefore has serious negative effect with water-soluble swollen or shrink and distortion.Therefore, the use level of solubilizer is greatly not preferred.From above, according to the present invention, the use level of solubilizer is preferably in 0.5 to 30.0w/w% scope, or particularly preferably in 1.0 to 25.0w/w% the scope.
In order to improve the operability of detersive of the present invention, described operability comprises the sense of touch when cleaning, and detersive of the present invention comprises jelling agent to become the form of gel detersive.Because described detersive is in the gel state, so improved the anelasticity of detersive on contact lenses.In addition, in this case, also give the sense of sliding to detersive, so that the cleaning effect that its easier scouring contact lenses and generation improve.In addition, during cleaning, do not have drop, and a small amount of detersive is enough to contact lenses are cleaned.As a result, improved the operability of detersive.
The example of jelling agent for example comprises with inferior material: synthetic organic polymer such as carboxyl vinyl polymer; Poly-(methyl) acrylic acid, poly-(methyl) PAA and (methyl) alkyl acrylate copolymer; Alginic acid derivant such as sodium alginate; Natural gum is such as xanthans and guar gum; Synthetic sodium silicate magnesium.Preferred carboxyl vinyl polymer and (methyl) alkyl acrylate copolymer of using.
The use level of jelling agent is not particularly limited, as long as described amount is enough to prepare and keep gel state in stable mode.For example, the use level of jelling agent is between about 0.05w/w% and about 10.0w/w%, or preferably between about 0.1w/w% and about 5.0w/w%.
Detersive of the present invention can comprise other surfactant with silicone oil such as the polysiloxane-13 as the polyethers sex change of cleansing.When comprising in addition other surfactant, so that be easier to the silicone oil of equably solubilising polyethers sex change and the advantage that generation can reduce the use level of solubilizer such as lower alcohol or liquid polyol.
Surfactant is not particularly limited, as long as it can keep gel state in stable mode.Following material is all available: anionic surfactant, cationic surfactant, non-ionic surfactant and zwitterionic surfactant.Can before use above-mentioned surfactant suitably be made up.In all surface activating agent, preferably use the combination of anionic surfactant, non-ionic surfactant or anionic surfactant and non-ionic surfactant.
The example of anionic surfactant for example comprises alkyl sulfate such as lauryl sodium sulfate and dodecyltriethanolamine sulfate; Alkyl benzene sulfonate such as neopelex and dodecylbenzene sulfonic acid triethanolamine; Polyethylene oxide alkyl ethers sulfate such as polyoxyethylene sodium lauryl tri(oxyethyl) sulfate and polyoxyethylene lauryl ether sulfuric acid triethanolamine; Alpha-olefin sodium sulfonate such as alpha-olefin sodium sulfonate; Alkylphosphonic such as dodecylphosphoric acid sodium and dodecylphosphoric acid triethanolamine; Polyethylene oxide alkyl ethers phosphate such as polyoxyethylene lauryl ether sodium phosphate and polyoxyethylene lauryl ether nitranol etc.
The example of non-ionic surfactant for example comprises polyethylene oxide alkyl ethers such as polyoxyethylene lauryl ether; Polyoxyethylene alkyl phenyl ether such as polyoxyethylene nonylplenyl ether; Polyoxyethylene PPOX alkyl ether such as polyoxyethylene PPOX cetyl ether; Alkanolamide such as polyoxyethylene PPOX block polymer, cocoanut fatty acid diethanolamide and lauric acid diethyl amide; Polyoxyethylene ketostearic acid triglyceride such as polyoxyethylene hydrogenated castor oil 60; The polyoxyethylene dehydrated sorbitol mono-fatty acid ester is such as poly-D-sorbite 80 and alkyl poly glucoside etc.
Use level and the concentration of surfactant are not particularly limited, as long as described amount does not have not exciting eye of adverse effect and described concentration to contact lenses.For example, the use level of surfactant is between about 0.05w/w% and about 20.0w/w%, or preferably between about 0.1w/w% and about 5.0w/w%.If described amount is less than 0.05w/w%, then it is to silicone oil such as the solubilising of polysiloxane-13 and the contribution possibility deficiency of cleaning effect of polyethers sex change.If described amount greater than 20.0w/w%, then may be difficult to keep gel state in some cases.
For detersive of the present invention, according to the characteristic of used glasses, preferably when carrying out gelling, cooperate osmotic pressure regulator to regulate osmotic pressure.When detersive of the present invention was used for property of water-bearing SCL/SHCL, the adjusting of osmotic pressure produced the composition that suppresses detersive and enters in the glasses and the effect that keeps shape of glasses.When with lower alcohol as solubilizer when producing anticorrosion and Disinfection Effect, the adjusting of osmotic pressure has following advantage: can will may keep lower to the amount that glasses have a lower alcohol of adverse effect, and can keep anticorrosion and Disinfection Effect.
About osmotic pressure regulator, for example, except already ionic osmotic pressure correctives such as sodium chloride, potassium chloride, sodium sulphate and sodium phosphate known aspect the ophthalmology, can also comprise with inferior nonionic osmotic pressure regulator: propylene glycol; Dipropylene glycol; 1,3-BDO; Glycerine; Amino acid such as trimethylglycine, glycocoll and alanine; Sugar alcohol such as xylitol and mannitol; Carbohydrate, for example monosaccharide such as glucose and fructose, disaccharides such as trehalose and the polysaccharide (it comprises cyclic polysaccharide class such as cyclodextrin) that comprises more than three kinds sugar.Can from above-mentioned substance, suitably select osmotic pressure regulator and use.With regard to the easiness that viscosity is regulated during with regard to gelling, preferred nonionic osmotic pressure regulator.Particularly preferably propylene glycol and trimethylglycine.Propylene glycol and trimethylglycine are also known as NMF.Expect that they not only have the osmotic pressure regulating effect but also have moistening effect, therefore, because when cleaning, finger had good action but suitable.
About the use level of osmotic pressure regulator, so that all the osmotic pressure of gel detersives is for example at about 290mmol/kg and about 2, between the 000mmol/kg, or preferably at about 500mmol/kg and about 1, the amount interpolation osmotic pressure regulator between the 500mmol/kg.From usually being adjusted to the glasses of the property of water-bearing SCL/SHCL with 290mmol/kg osmotic pressure, preferably do not cause osmotic pressure less than the osmotic pressure regulator use level of 290mmol/kg, because easily detergent composition is brought in the glasses.If osmotic pressure is greater than 2,000mmol/kg, then owing to phenomenon of osmosis, the water cut when cleaning in the glasses descends, thereby causes the diameter of glasses to shrink.After cleaning, contact lenses again absorb thus water and revert to original glasses diameter by flushing and dipping preservations such as contact lenses preservative agents.Yet during said process, contact lenses significantly are out of shape, thereby cause repeating to give stress to contact lenses.Therefore described amount, preferably do not cause osmotic pressure greater than the use level of the osmotic pressure regulator of 2,000mmol/kg, because can cause degradation under the intensity of contact lenses.
The pH of detersive of the present invention is not particularly limited.The pH of detersive of the present invention is for example between about 5 and about 9, preferably between 6 and 8, by using buffering agent or taking other means and it is suitably regulated.If the possibility that described pH less than 5 or greater than 9, then exists the material of stimulation eyes and contact lenses to affect adversely.
About buffering agent, can suitably select known buffering agent and use.For example, comprise with inferior buffering agent: by the buffering agent that the combinations such as trishydroxymethylaminomethane, hydrochloric acid, citric acid are prepared; By phosphoric acid and sodium phosphate are made up the buffering agent for preparing; By citric acid and sodium phosphate are made up the buffering agent for preparing; And by boric acid and/or borax are made up the buffering agent for preparing.
The use level of buffering agent is not particularly limited.For example, the use level of buffering agent is between about 0.1w/w% and about 10.0w/w%.If described amount is less than 0.1w/w%, then the stability of gained pH is not enough.In the situation of described amount greater than 10.0w/w%, do not observe the remarkable stability of pH therein.In addition, in this case, if described detersive is preserved at low temperatures, then variety of issue may be produced such as buffering agent is separated out.
Because jelling agent causes gelling, so can in detersive of the present invention, cooperate neutralizing agent.Neutralizing agent is not particularly limited, as long as described neutralizing agent is used for promoting the jelling agent gelling.For example, when carboxyl vinyl polymer is used as jelling agent, can be with sodium hydroxide solution as neutralizing agent.
Except mentioned component, can also further cooperate following composition in the detersive of the present invention, however damaging purpose of the present invention gets final product: preservative agent; PH adjusting agent; Sequestrant; Viscosity modifier; Exogenous enzymes such as protease and lipolytic enzyme; And various adjuvants.
Use above-mentioned various composition, and the silicone oil of polyethers sex change, solubilizer and jelling agent prepare detersive of the present invention.For example, prepare detersive of the present invention by carrying out following steps: prepare the solution that comprises jelling agent in aqueous solution such as water or the damping fluid by jelling agent is added to; Prepare the solution that comprises cleansing in the solution that comprises jelling agent by subsequently the silicone oil of solubilizer and polyethers sex change being added to; By being added in the solution that comprises cleansing, neutralizing agent prepares gelatinous solution; And operate to regulate total amount by adding to described aqueous solution in the gelatinous solution or carrying out other.When preparation detersive of the present invention, can be with in the water-soluble solution of osmotic pressure regulator.After adding solubilizer, surfactant can be added in the solution that comprises jelling agent.
The temperature of preparation detersive of the present invention is not particularly limited, as long as described temperature is not so that each composition volatilization or sex change.For example, temperature or preferably equals room temperature between 10 ℃ and 40 ℃.In preparation during detersive of the present invention, incorporation time and the means of solution are not particularly limited mixing condition behind each composition as adding.Extensive available known solution mixing condition.Yet, when preparation comprises the solution of jelling agent, so that the mode that jelling agent is evenly dispersed in the aqueous solution is mixed.When preparation comprises the solution of cleansing, the degree of the silicone oil dissolving of walking to the polyethers sex change will be mixed into.
With with clean the operation that the identical mode of the operation of contact lenses use detersive scouring contact lenses of the present invention with typical contact lenses with detersive.For example, carry out as follows described operation: an amount of detersive of the present invention is dropped on the surface of contact lenses; And then clean each faces about 10 seconds to about 30 seconds of contact lenses with finger.After cleaning, can wash contact lenses.According to the kind of contact lenses, washed contact lenses about 5 seconds to about 30 seconds with tap water or special-purpose preservative agent, until the residual sense of the stick-slip relevant with detersive disappears.
It is effective that detersive of the present invention is attached to aspect the oily dirt on the contact lens surface height in cleaning, no matter described oily dirt is biogenetic derivation or cosmetics source.Can operate to confirm by carrying out above-mentioned scouring the cleaning effect of detersive of the present invention, wherein described in hereinafter described embodiment, for example use the contact lenses that have the oily dirt of manually making on its surface.
Contact lenses with detersive cleaning of the present invention are not particularly limited.Can comprise various contact lenses such as hard contact lenses and hydrogel contact lens.In above-mentioned contact lenses, comprise that its lens surface is modified or RGPCL and the SHCL of modification.
By following examples the present invention is specifically described.Yet described embodiment is not intended to limit the present invention.Incidentally, in following examples, unless otherwise specified, otherwise the unit of use level is w/w%.
Embodiment
Prepare the detersive of the embodiment of the invention and the detersive of comparative example according to the components matching amount shown in the table 1.Estimate as follows described detersive.
1. the preparation of detersive
To by buffering agent, EDTA2Na and the osmotic pressure regulator suitably selected being dissolved in the solution that prepare in purifying waste water in right amount, interpolation is as the generating vinyl carboxylate based polyalcohol of jelling agent, and makes its Uniform Dispersion.Then, add successively solubilizer, surfactant and polysiloxane-13.To wherein adding sodium hydrate aqueous solution with as the neutralizing agent that is used for gelling.In the gelatinous solution of preparation, add the detersive of purifying waste water to obtain to amount to 100g.
2. cleaning effect test
(1) making of artificial contamination's contact lenses
The test that will be attached with in advance cosmetics (foundation cream, mascara, eye shadow (waterproof)) is immersed in contact lenses in the artificial contamination's liquid that is comprised of known tear composition (protein, fat) and under 55 ℃ heated 5 hours.Then, after under 70 ℃, contact lenses being flooded 16 hours in pure water, 50 ℃ lower dry 6 hours to obtain artificial contamination's contact lenses.
(2) following glasses are used contact lenses as testing:
RGPCL:SEED UV-1 is made by real pupil Co., Ltd.
RGPCL (surface treatment): SEED S-1, made by real pupil Co., Ltd.
SCL:ACUVUE2 (IV group) is made by Johson ﹠ Johnson
SHCL (surface treatment): O2 OPTIX (I group) is made by Solecare company
(3) evaluation of cleaning effect
Before cleaning artificial contamination's contact lenses, measure the haze value (HGM-2DP makes by congratulating testing machine Co., Ltd.) of artificial contamination's contact lenses.Then, utilize every kind of detersive shown in the table 1 to clean artificial contamination's about 30 seconds of contact lenses (about 15 seconds every faces) with finger.About the flushing of the contact lenses after cleaning, in the situation of RGPCL, use flowing water (tap water).In the situation of SCL and SHCL, use soft contact lens with preservative agent (SOFRINS is made by real pupil Co., Ltd.).Wash described contact lenses (10 to 20 seconds), until the residual sense (stick-slip sense) relevant with each detersive disappears and be natural drying.
Table 1
*1. isopropyl alcohol
*2.1.3-butylene glycol
*3. carboxyl vinyl polymer
*4. (methyl) alkyl acrylate base co-polymer
*5. alpha-olefin sodium sulfonate: Lipolan LB-440, make (purity 37%: the use level after purity converts) by Lion Corporation
*6. alkyl glucoside: Plantacare 2000UP, make (purity 50%: the use level after purity converts) by Ke Ningriben Co., Ltd.
*7. polyoxyethylene polyoxypropylene block copolymers: Pluronic F108, made by Asahi Denka Kogyo K. K
*8. propylene glycol
*9. trimethylglycine
Measure the haze value of the glasses after cleaning, and calculate the soil release rate by following formula.In addition, the operability of the sense of touch when cleaning about comprising is carried out sensory evaluation.Table 2 shows the result.
Formula 1
Based on the soil release rate (%) of calculating, as follows with five level evaluation cleaning effects.
More than the A:90%
A-:80% is above but less than 90%
B:60% is above but less than 80%
B-:40% is above but less than 60%
C: less than 40%
Based on three ranks as follows sense of touch and operability are carried out sensory evaluation.
A: easy cleaning, operability is good
B: common
C: be difficult to cleaning, operability is bad
Table 2
*1) in the detersive of comparative example 2, polysiloxane-13 can not be by solubilising.
*2) in comparative example 1 to 3, because the hyperosmosis of 2,500mmol/kg, so in the situation of the SCL with high-moisture percentage, the diameter of glasses expands or contraction with water-soluble when cleaning, and significantly is out of shape when flushing thus.
Preferred higher soil release rate (%).It is qualified that soil release rate more than 60% is made as, and all detersives of the embodiment of the invention are all qualified.
3. the impact assessment of the contact lenses processed of effects on surface
The impact assessment of the contact lenses of processing about effects on surface, utilize organic compound to process RGPCL (SEED S-1, made by real pupil Co., Ltd.) and the lens surface of SHCL (O2OPTIX is by the manufacturing of Solecare company), thereby cause providing water wettability to it.Use has the gained glasses on hydrophile function surface.
The detersive that comprises lapping compound that proposes in detersive by the embodiment of the invention shown in the use table 3 and the reference example 1 (O2CLEAN is made by real pupil Co., Ltd.) is cleaned contact lenses with finger.One time circular treatment is comprised of following steps: clean contact lenses with each detersive; With flowing water wash contact lenses (tap water: RGPCL), or for soft contact lens with preservative agent flushing (SOFRINS is made by real pupil Co., Ltd.: SCL, SHCL).After 10 times, 20 times and 30 circular treatment, estimate the water wettability of lens surface.Based on before and after the circular treatment, the variable quantity of the contact angle of lens surface, as follows with the impact of five level evaluations on lens surface.
Below the A:10 degree
A-: spend to 20 degree greater than 10
B: spend to 30 degree greater than 20
B-: spend to 40 degree greater than 30
C: greater than 40 degree
Table 3
The variable quantity of preferred contact angle is less.If being changed to below 30 degree of contact angle, it is qualified then described variation to be made as.Whole detersives of the embodiment of the invention are all qualified.
Claims (5)
1. contact lenses gel detersive, it comprises silicone oil, solubilizer and jelling agent as the polyethers sex change of ABn type segmented copolymer.
2. contact lenses according to claim 1 gel detersive, the silicone oil of wherein said polyethers sex change as ABn type segmented copolymer are the polysiloxane as the polyoxyalkylene sex change of ABn type segmented copolymer.
3. contact lenses according to claim 1 gel detersive, the silicone oil of wherein said polyethers sex change as ABn type segmented copolymer is the ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-; And described solubilizer is lower alcohol and/or liquid polyol.
4. contact lenses according to claim 3 gel detersive, the polyoxyalkylene in the ABn type segmented copolymer of wherein said polydimethylsiloxane--polyoxyalkylene-are polyoxyethylene or poly-(ethylene oxide-propylene oxide) multipolymer; Described lower alcohol is ethanol, propyl alcohol, isopropyl alcohol or phenmethylol; And described liquid polyol is at least a alcohol that is selected from ethylene glycol, propylene glycol, dipropylene glycol, 1,3-BDO and the glycerine.
5. each described contact lenses gel detersive in 4 according to claim 1, the content of the silicone oil of wherein said polyethers sex change as ABn type segmented copolymer is 0.05w/w% to 0.50w/w%.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010223356 | 2010-10-01 | ||
| JP2010-223356 | 2010-10-01 | ||
| PCT/JP2011/065370 WO2012043004A1 (en) | 2010-10-01 | 2011-07-05 | Gelatinous cleaning agent for contact lenses |
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| Publication Number | Publication Date |
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| CN102822725A CN102822725A (en) | 2012-12-12 |
| CN102822725B true CN102822725B (en) | 2013-10-30 |
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| CN2011800117823A Active CN102822725B (en) | 2010-10-01 | 2011-07-05 | Gelatinous cleaning agent for contact lenses |
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| JP (1) | JP4976607B2 (en) |
| KR (1) | KR101245997B1 (en) |
| CN (1) | CN102822725B (en) |
| HK (1) | HK1173230A1 (en) |
| MY (1) | MY159143A (en) |
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| JPWO2014119502A1 (en) * | 2013-01-31 | 2017-01-26 | シャープ株式会社 | Cleaning fluid, cleaning tools and cleaning kit |
| KR101926226B1 (en) * | 2016-05-31 | 2019-02-26 | 한국화학연구원 | Alcohol-free detergent composition for glasses having excellent antibacterial property |
| CN106381241A (en) * | 2016-08-30 | 2017-02-08 | 东兴华鸿光学科技有限公司 | Cleaning degerming cream for glasses lenses |
| CN107929790A (en) * | 2017-11-08 | 2018-04-20 | 常州武城服饰有限公司 | A kind of multi-functional contact lenses conditioning liquid |
| US11912964B2 (en) | 2018-09-18 | 2024-02-27 | Nof Corporation | Contact lens treatment solution |
| KR102368898B1 (en) * | 2020-05-18 | 2022-03-02 | 주식회사 태경코엠 | Cleaner composition comprising alkanediol or ethylhexylglycerine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006052319A (en) * | 2004-08-11 | 2006-02-23 | P & P F:Kk | Transparent gel-like cleanser |
| JP5179293B2 (en) * | 2008-08-25 | 2013-04-10 | 京楽産業．株式会社 | Game machine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4374745A (en) * | 1981-08-13 | 1983-02-22 | Barnes-Hind Pharmaceuticals, Inc. | Cleaning compositions |
| JPH05179293A (en) * | 1991-12-26 | 1993-07-20 | Kao Corp | Detergent composition |
| ES2144525T3 (en) * | 1993-06-18 | 2000-06-16 | Polymer Technology Corp | COMPOSITION FOR CLEANING AND WETTING CONTACT LENSES. |
| US6872695B1 (en) * | 2000-10-06 | 2005-03-29 | Bausch & Lomb Incorporated | Method for in-eye cleaning of contact lens comprising polymeric beads |
| JP4803705B2 (en) * | 2004-05-26 | 2011-10-26 | 株式会社シード | Gel detergent for contact lenses |
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- 2011-07-05 JP JP2012510051A patent/JP4976607B2/en active Active
- 2011-07-05 CN CN2011800117823A patent/CN102822725B/en active Active
- 2011-07-05 WO PCT/JP2011/065370 patent/WO2012043004A1/en active Application Filing
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006052319A (en) * | 2004-08-11 | 2006-02-23 | P & P F:Kk | Transparent gel-like cleanser |
| JP5179293B2 (en) * | 2008-08-25 | 2013-04-10 | 京楽産業．株式会社 | Game machine |
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| KR101245997B1 (en) | 2013-03-20 |
| CN102822725A (en) | 2012-12-12 |
| MY159143A (en) | 2016-12-15 |
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| JP4976607B2 (en) | 2012-07-18 |
| JPWO2012043004A1 (en) | 2014-02-06 |
| SG183211A1 (en) | 2012-09-27 |
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| HK1173230A1 (en) | 2013-05-10 |
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