CN102822725A - Gelatinous cleaning agent for contact lenses - Google Patents
Gelatinous cleaning agent for contact lenses Download PDFInfo
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- CN102822725A CN102822725A CN2011800117823A CN201180011782A CN102822725A CN 102822725 A CN102822725 A CN 102822725A CN 2011800117823 A CN2011800117823 A CN 2011800117823A CN 201180011782 A CN201180011782 A CN 201180011782A CN 102822725 A CN102822725 A CN 102822725A
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- contact lenses
- detersive
- sex change
- silicone oil
- cleaning
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0031—Carpet, upholstery, fur or leather cleansers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/201—Monohydric alcohols linear
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2068—Ethers
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
- C11D3/3738—Alkoxylated silicones
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C13/00—Assembling; Repairing; Cleaning
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
- Detergent Compositions (AREA)
Abstract
The purpose of the present invention is to provide a cleaning agent for contact lenses that is easy to handle and exhibits an excellent cleaning effect against dirtiness caused by oily ingredients adhering to the surface of the contact lenses, specifically oily dirtiness caused by the adherence of eye makeup and the like (cosmetic dirtiness), when compared to conventional non-abrasive cleaning agents for contact lenses suited to cleaning by scrubbing. The purpose is achieved by providing a gelatinous cleaning agent for contact lenses that is characterized by containing polyether-modified silicone oil, a solubilizing agent, and a gelling agent.
Description
The cross reference of related application
The application requires Japanese patent application 2010-223356 number right of priority of submission on October 1st, 2010, through reference its full content is incorporated herein.
Technical field
The present invention relates to a kind of contact lenses and use the gel detersive.More specifically; The present invention relates to a kind of contact lenses and use the gel detersive; It is not only applicable to clean and is derived from the biosome that is attached to when wearing contact lenses on the contact lenses such as the oily dirt of discharge of eye, and is applicable to clean and is derived from the oily dirt (cosmetics dirt) that the cosmetics that are attached on the contact lenses such as eye are made up product.
Background technology
Generally speaking, contact lenses are divided into following big type: non-property of water-bearing contact lenses and property of water-bearing contact lenses.For non-property of water-bearing contact lenses, be purpose to improve the oxygen permeability, generally polysiloxane-based material is used for the constituent of ocular lens material.Yet in recent years, even for property of water-bearing contact lenses, from the security of eye, the polysiloxane-based material that will have higher level oxygen permeability was as constituent.The surface of said contact lenses has lipophilicity because of the polysiloxane-based material in the ocular lens material.Therefore, because affinity, oily dirt tends to easily be attached on the contact lenses.
Be attached to the dirt that is worn over the contact lenses on the eye and comprise protein and the lipid of biosome dirt as being derived from tear or discharge of eye, and the cosmetics dirt, it makes up product such as eye shadow and mascara with eye is representative.If continue to be worn on the contact lenses that have dirt on it on eyes; The water moisture retention of the lens surface that is then caused by tear can descend; And said then lens surface becomes dry, thereby for example when vision correction, can not obtain the suitable obstacle of correcting defects of vision even cause wearing sense decline and cause.In addition, dirt fixing or that be accumulated on the lens surface can become vegetative hotbed, thereby brings the risk that causes eye diseases.In addition, the oxygen supply of cornea can descend, thereby possibly have deleterious effect by the corneal cell.Consider this deleterious effect of the oily dirt on the contact lenses, expectation is regularly cleaned contact lenses and is kept clean.
Contact lenses about routine are used detersive, have the detersive that comprises surfactant or protease.For example, as long as detersive is used for property of water-bearing soft contact lens (hereinafter being called " SCL "), just there is the multi-functional solution of only forming by a kind of liquid and can contact lenses being cleaned, sterilize, preserve and wash.Because its simplicity, said multi-functional solution is widely used.Yet, consider health, preferably, should the reagent area of detersive with sterilization, preservation or flushing be separated, and should every kind of reagent be used for various processing as each special solution.In addition; In order to remove the dirt that is attached on the contact lenses effectively and in order to use contact lenses more comfortable and safely; So-called " scouring ", soon cleaner special drips on the contact lenses and is quite effective with pointing the operation of cleaning contact lenses then.That is,, then can the surface of contact lenses be kept to such an extent that more clean if use the contact lenses that are suitable for cleaning to use detersive.
The contact lenses that are applicable to scouring are to comprise the detersive of lapping compound as cleansing with detersive.For example, following detersive is available: the detersive (referring to patent documentation 1, or japanese kokai publication hei 05-19217 communique, through with reference to its disclosure is incorporated herein) that comprises inorganic particles; With comprise the detersive of bead like the bead processed by organic polymer (referring to patent documentation 2, or Japan special table 2004-511625 communique, through with reference to its disclosure is incorporated herein).Inorganic or the organic lapping compound that is included in the above-mentioned detersive tends to separation, sedimentation or aggegation, thereby makes and to be difficult to operate said detersive.In addition, can damage lens surface in some cases.
Clean under the situation of contact lenses at the detersive that contains lapping compound through use; The surface state that depends on contact lenses to be cleaned owing to said cleaning is worried the risk to the adverse effect of lens surface, even can not use the commercially available detersive that contains lapping compound at present.More specifically, about giving the contact lenses of water wettability and stain resistance through applying surface treatment to it, said surface-treated effect possibly peel off because of the physical action of lapping compound or lose.Therefore, be not suitable for using the detersive that contains lapping compound.
Replace containing the detersive of lapping compound; Clean the detersive that has applied the surface-treated contact lenses as being applicable to; Following detersive is disclosed: do not contain lapping compound and use lower alcohol as the gel detersive of cleansing (referring to patent documentation 3; TOHKEMY 2006-11418 communique is incorporated herein its disclosure through reference).Because the degreasing power of lower alcohol and solubilising power, said detersive have the cleaning effect of raising to the oily dirt that comprises the cosmetics dirt.
The prior art document
Patent documentation
Patent documentation 1: japanese kokai publication hei 05-19217 communique
Patent documentation 2: Japan special table 2004-511625 communique
Patent documentation 3: TOHKEMY 2006-11418 communique
Summary of the invention
Problem to be solved by this invention
The inventor pays close attention to following contact lenses: the hard contact lenses of oxygen permeability (hereinafter; Be also referred to as " RGPCL ") and silicone hydrogel contact lens is (hereinafter; Be also referred to as " SHCL "); From it being given water wettability and to the purpose of the stain resistance of protein etc., through plasma surface modification, graft polymerization etc. with its finishing or modification.If clean this glasses with disclosed detersive in the detersive that contains lapping compound such as patent documentation 1 and 2, then the effect of lens surface processing can peel off or lose because of the physical action of lapping compound.Therefore, be not suitable for using this detersive.
Under the situation of the detersive that contains lower alcohol described in the patent documentation 3, can clean that lens surface is modified or the above-mentioned RGPCL or the SHCL of modification, and the oily dirt on can the flush away lens surface.Yet the detersive described in the patent documentation 3 has the risk to the adverse effect of contact lenses because comprise as the alcohol of cleansing.Therefore, the possibility of the content of restriction alcohol is high.Simultaneously, particularly in recent years, developed the high water resistant cosmetic of water tolerance successively.Consider above-mentioned development, the detersive described in the patent documentation 3 is the serious cosmetics dirt of flush away suitably, and said cosmetics dirt possibly is attached to by the water resistant cosmetic of exploitation from now on the surface of contact lenses and cause.
The purpose of this invention is to provide a kind of contact lenses and use detersive; Its with do not contain lapping compound and be applicable to that the conventional contact lenses of scouring compare with detersive; Illustrate being attached to the oiliness composition dirt on the contact lens surface; Particularly make up the higher cleaning effect of the oily dirt (cosmetics dirt) that product etc. causes, and have excellent operation by being attached to eye on it.Another object of the present invention provides a kind of contact lenses and uses detersive, and it does not only have adverse effect to the lens surface of conventional RGPCL and SCL, and the RGPCL that its lens surface is modified or the lens surface of SHCL do not have adverse effect yet.
The means of dealing with problems
As result to the further investigation of many materials of can be used as cleansing such as surfactant and organic solvent; The inventor finds; If with comprising sex change silicone oil, or the silicone oil (polysiloxane-13 of the polyethers sex change of its sex change position possess hydrophilic property more specifically; The ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-; Or the like) detersive clean contact lenses, then said detersive does not have adverse effect to lens surface, and performance is particularly to the abundant cleaning effect of oily dirt.Accomplished the present invention based on this discovery.
Therefore,, provide a kind of contact lenses to use the gel detersive, it is characterized in that, comprise silicone oil, solubilizer and the jelling agent of polyethers sex change at least according to the present invention.
Preferably, said contact lenses are characterised in that with the gel detersive silicone oil of said polyethers sex change is the polysiloxane of polyoxyalkylene sex change.
Preferably, said contact lenses are characterised in that with the gel detersive silicone oil of said polyethers sex change is the ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-; And said solubilizer is lower alcohol and/or liquid polyol.
Preferably, said contact lenses are characterised in that with the gel detersive polyoxyalkylene in the ABn type segmented copolymer of said polydimethylsiloxane--polyoxyalkylene-is polyoxyethylene or gathers (ethylene oxide-propylene oxide) multipolymer; Said lower alcohol is ethanol, propyl alcohol, isopropyl alcohol or phenmethylol; And said liquid polyol is for being selected from monoethylene glycol, propylene glycol, DPG, at least a alcohol of 1,3 butylene glycol and glycerine.
Preferably, said contact lenses are characterised in that with the gel detersive amount of the silicone oil of said polyethers sex change is between 0.05w/w% and 0.50w/w%.
The invention effect
Detersive of the present invention comprises the silicone oil of polyethers sex change as cleansing; Therefore; Compare with detersive with the conventional contact lenses that do not contain lapping compound that are applicable to scouring; It is effective to be attached to aspect the oily dirt on the contact lens surface height in removing, no matter said oily dirt is derived from biosome or cosmetics.In addition, because detersive of the present invention does not comprise the composition that serves as lapping compound, so the influence minimum on the surface of the contact lenses that said detersive was handled through plasma surface modification, graft polymerization etc. its surface realizes the effective cleaning effect simultaneously.Therefore, because the surface of the contact lenses that expection is cleaned with detersive of the present invention can keep clean, thus when wearing contact lenses, can keep the water moisture retention of said lens surface because of tear, thus cause preventing the lens surface drying.Therefore, use that detersive of the present invention can avoid being caused by the oily dirt of contact lens surface with inferior problem: the sense of wearing of contact lenses descends, and about the obstacle of vision correction, the oxygen supply of the risk of eye diseases and cornea reduces.
Contact lenses of the present invention use the formulation of detersive to be gel, and therefore, contact lenses of the present invention have excellent sense of touch with detersive when cleaning, and can make its anelasticity on contact lenses high.Therefore, contact lenses detersive of the present invention has the cleaning effect that improves more.In addition, contact lenses of the present invention are in detersive and have full-bodied gel state, thereby even can not have drop and a spot of contact lenses also can clean contact lenses fully with detersive.As a result, can improve the operability of said contact lenses with detersive.
Embodiment
According to the present invention, provide a kind of contact lenses to use the gel detersive, it is characterized in that, comprise silicone oil, solubilizer and the jelling agent of polyethers sex change.
Comprise the of the present invention detersive of the silicone oil of polyethers sex change as cleansing; Particularly to having excellent cleaning effect owing to the cosmetics dirt that is attached to the enhanced water resistance cosmetics on the contact lenses, and be the gel detersive that is used to clean contact lenses.
The polysiloxane-based material that nearest contact lenses tend in its composition, have higher component ratio is to improve the oxygen supply of cornea.Because the surface of said glasses shows hydrophobicity, can easily be attached on it so have the oily dirt of high affinity.Particularly, as oily dirt, can comprise dirt: be included in the oiliness composition in the discharge of eye in the tear, cosmetics etc. with inferior type.Especially, the cosmetics dirt can easily be attached on the glasses, and can not easily remove, and causes variety of issue thus.Cosmetics comprise the various silicone materials of characteristics such as having excellent high water repellency, low irritant, hypotoxicity usually.Therefore, the silicone materials in the cosmetics has high affinity with the surface of the contact lenses that comprise identical polysiloxane-based material, thus make the cosmetics dirt can be attached to it securely and feasible being difficult to remove said dirt through washing.Especially, cosmetics such as eye woman's persona product has the water tolerance (waterproof) of reinforcement.Therefore, if conventional detersive is used to clean the dirt attached on the lens surface, then said dirt extends owing to the affinity between cosmetics dirt and the hydrophobic lens surface and launches.Not only can not remove dirt, and said dirt can be residual as oil film, thereby cause bluring or wearing sense on the lens surface to descend.
In order to remove because as the silicone materials of one of glasses composition and the affinity between the oiliness composition and attached to the oily dirt on the contact lenses, detergent package of the present invention contains the sex change silicone oil at the interface that acts on effectively between lens surface and the oily dirt as cleansing.Said sex change silicone oil has the dimethyl siloxane key as main chain (polysiloxane position), and has the structure of in main chain (backbone chain type) or side chain (side chain type), introducing the sex change position.By dimethyl silicone polymer be representative typical silicone oil with and to have hydrophobic sex change silicone oil be non-water-soluble at the sex change position.Therefore, be difficult to said silicone oil is blended into basically the contact lenses processed by the WS with in the detersive.In addition, even make it possible to silicone oil is contained in contact lenses with in the detersive through emulsifications such as surfactants, also not preferred above-mentioned silicone oil is because said silicone oil adheres to as oily dirt and remains on the lens surface.Therefore, according to the present invention, use the sex change silicone oil of its sex change position possess hydrophilic property.This hydrophilic sex change silicone oil has high surface, and will be separated with lens surface by the cosmetics dirt of hydrophobicity polysiloxane position solubilising because of the sex change hydrophilic site, so expection has the effect of removing the cosmetics dirt with effective and efficient manner.
In detersive of the present invention; For the sex change silicone oil of its sex change position possess hydrophilic property, use the silicone oil that is called following polyethers sex change: the dimethyl silicone polymer of the polysiloxane of polyoxyalkylene sex change, polyoxyalkylene sex change, dimethyl siloxane-oxygen alkylene multipolymer and polydimethylsiloxane--polyoxyalkylene-block copolymers.The water wettability of above-claimed cpd and oxyalkylene account for the ratio of mean molecular weight, and promptly the containing ratio at polyethers position (occupation rate) increases pro rata.Yet along with its solubleness in water improves, lipophilicity descends.Therefore, possibly there is the possibility that can not obtain to the abundant cleaning effect of oily dirt.That is, the hydrophilic/hydrophobic in sex change silicone oil molecule possibly exert an influence to the cleaning effect of oily dirt.For example, when in the polysiloxane of polyoxyalkylene sex change, aspect molecular weight, when the occupation rate height at polyethers position and the occupation rate at polysiloxane position are hanged down, because lipophilicity is low, so the cleaning effect of oily dirt is tended to diminish.For cleaning source is from the oily dirt of cosmetics effectively, the oily dirt that is particularly produced by the enhanced water resistance cosmetics expects that the polysiloxane of used polyethers sex change is developed appropriate lipophilicity.In order to develop the lipophilicity of this appropriateness, preferably, the polysiloxane of polyethers sex change has the hydrophobic grouping (lipophilic group) of abundant amount in molecule.Therefore, in preparation during detersive of the present invention, consider the silicone oil of following factor: the balance of the molecular weight at polysiloxane position and occupation rate, hydrophilic/hydrophobic, the structure of whole molecule with the polyethers sex change suitably selecting comprise.The silicone oil that is included in the preferred polyethers sex change in the detersive of the present invention is the polysiloxane of polyoxyalkylene sex change.
The molecular structure of the silicone oil of polyethers sex change is divided into following type haply: backbone chain type, in main chain, introduce the sex change position in this case; Side chain type is introduced the sex change position in this case in side chain; With side chain two tip type, in main chain (two ends) and side chain, all introduce the sex change position in this case.About backbone chain type, there is following type: single tip type, in an end of main chain, introduce the sex change position in this case; Two tip type are all introduced the sex change position in this case in two ends of main chain; With ABn type segmented copolymer, in main chain, alternately introduce the sex change position in this case.About above-mentioned molecular structure; Single tip type, two tip type, side chain type and side chain two tip type have wherein hydrophobicity polysiloxane position at the center; And water wettability sex change position is bonded to the structure of (terminal, side chain) around it, the hydrophobic interaction thereby the above-mentioned type tends to and display orientation property.Hydrophobic therein polysiloxane position is under the situation of hydrophobic surface orientation, and water wettability sex change position simultaneously maybe be in the direction orientation opposite with hydrophobic surface.Therefore, exist cleansing may not act on the possibility at the interface between lens surface and the oily dirt effectively.Therefore; For example; If comprise PEG32-methyl ether dimethyl silicone polymer (two tip type: KF-6004 is made by Shin-Etsu Chemial Co., Ltd), PEG10-dimethyl silicone polymer (side chain type: KF-6017 is made by Shin-Etsu Chemial Co., Ltd) etc. as cleansing; Even then said cleansing has the polysiloxane position that is applicable to the solubilising oily dirt, it is lower than ABn type that its cleaning effect also becomes.On the contrary, therein the sex change position is alternately introduced under the situation of the ABn type segmented copolymer in the main chain, said ABn type segmented copolymer has less orientation texture because the sex change position is present on the identical main chain.Therefore, polysiloxane position and sex change position have excellent effect to the interface between lens surface and the oily dirt separately, thereby make and can remove oily dirt with effective and efficient manner.
Therefore, the silicone oil that is included in the preferred polyethers sex change in the detersive of the present invention is the silicone oil of the polyethers sex change of ABn type segmented copolymer for its molecular structure, and polysiloxane and polyethers position alternately coexist as on the same main chain in said multipolymer.The ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-more preferably.The preferred instantiation that is used for detersive of the present invention can comprise polysiloxane-13 (polyethers position: polyoxyethylene or gather (ethylene oxide-propylene oxide) multipolymer).Polysiloxane-13 can comprise FZ-2222, FZ-2231, FZ-2233, FZ-2250 etc., is made by Dow Corning Toray Co., Ltd., and it can use separately or can use with above-mentioned two or more combination.
The use level of polysiloxane-13 is for example in 0.0005 to 5.0w/w% scope.If said amount less than 0.0005w/w%, then can not obtain sufficient cleaning effect.If said amount is greater than 5.0w/w%, then sense of touch significantly worsens when cleaning.Therefore, said amount is preferably in 0.001 to 1.00w/w% scope, or particularly preferably in 0.05 to 0.50w/w% the scope.Incidentally, the solubleness of polysiloxane-13 in water is low, and polysiloxane-13 is through suitable solubilizer dissolving.That is, in detersive of the present invention, comprise silicone oil such as the polysiloxane-13 of solubilizer with the sex change of dissolving polyethers.
As the solubilizer that in detersive of the present invention, uses, preferably use amphiphilic solvent.Particularly, can comprise lower alcohol, liquid polyol etc.Lower alcohol has Disinfection Effect, and generally as detersive or sanitizer.Therefore, even in the present invention, can expect that also lower alcohol can improve cleaning effect and provide anticorrosion and Disinfection Effect.Liquid polyol is also as osmotic pressure regulator, and can be expected at when cleaning finger is had moistening effect.As a result, for the solubilizer of detersive of the present invention, preferably use the combination of lower alcohol, liquid polyol or lower alcohol and liquid polyol.
Lower alcohol for example comprises ethanol, propyl alcohol, isopropyl alcohol, phenmethylol and other lower alcohol.The embodiment of liquid polyol is as comprising monoethylene glycol, propylene glycol, DPG, 1,3 butylene glycol, glycerine and other liquid polyol, and it can use separately, perhaps can use with above-mentioned two or more combination.
As the preferred embodiment of solubilizer of the present invention,, use respectively as the isopropyl alcohol of lower alcohol with as the 1,3 butylene glycol of liquid polyol when polysiloxane-13 during as the silicone oil of polyethers sex change, is considered its solubilising power and security alone or in combination.
Measure the use level of solubilizer based on the dissolubility of the silicone oil of polyethers sex change such as polysiloxane-13.Therefore, the use level of solubilizer does not receive special restriction, as long as silicone oil that can the sex change of solubilising polyethers.Yet, be purpose with the gel state of the agent that keeps clean, and consider that scouring to the influence of contact lenses, to security of eye etc., can limit the use level of solubilizer.When with liquid polyol effect solubilizer, can realize that based on same composition solubilising and osmotic pressure regulates both.Yet, in this case, the use level of solubilizer is limited in the amount of osmotic pressure in OK range that make.From preceding text, the use level of solubilizer is for example in 1.0 to 60.0w/w% scope.If said amount is less than 1.0w/w%, then the inadequate possibility of the solubilising of the silicone oil of polyethers sex change is high.If said amount is greater than 60.0w/w%, then infer the optical characteristics that not only is difficult to form and keeps gel state but also contact lenses deterioration significantly.For example, if the use level of solubilizer is big, then under the situation of RGPCL, ocular lens material deliquescing, and under the situation of property of water-bearing SCL/SHCL, ocular lens material expands or shrinks and distortion with water-soluble, perhaps causes other problems, and therefore has serious negative effect.Therefore, the use level of solubilizer is greatly not preferred.From preceding text, according to the present invention, the use level of solubilizer is preferably in 0.5 to 30.0w/w% scope, or particularly preferably in 1.0 to 25.0w/w% the scope.
In order to improve the operability of detersive of the present invention, said operability comprises the sense of touch when cleaning, and detersive of the present invention comprises jelling agent to become the form of gel detersive.Because said detersive is in the gel state, so improved the anelasticity of detersive on contact lenses.In addition, in this case, also give the sense of sliding, make it clean the cleaning effect of contact lenses and generation raising more easily detersive.In addition, during cleaning, do not have drop, and a small amount of detersive is enough to contact lenses are cleaned.As a result, improved the operability of detersive.
The embodiment of jelling agent is as comprising with inferior material: synthetic organic polymer such as carboxyl vinyl polymer; Gather (methyl) acrylic acid, gather (methyl) PAA and (methyl) alkyl acrylate copolymer; Alginic acid derivant such as sodium alginate; Natural gum is like xanthans and guar gum; Synthetic sodium silicate magnesium.Preferred carboxyl vinyl polymer and (methyl) alkyl acrylate copolymer of using.
The use level of jelling agent does not receive special restriction, as long as said amount is enough to the stable manner preparation and keeps gel state.For example, the use level of jelling agent is between about 0.05w/w% and about 10.0w/w%, or preferably between about 0.1w/w% and about 5.0w/w%.
Detersive of the present invention can comprise other surfactant with silicone oil such as the polysiloxane-13 as the polyethers sex change of cleansing.When comprising other surfactant in addition, make the silicone oil that is easier to solubilising polyethers sex change equably also produce the advantage of the use level that can reduce solubilizer such as lower alcohol or liquid polyol.
Surfactant does not receive special restriction, as long as it can keep gel state with stable manner.Following material is all available: anionic surfactant, cationic surfactant, non-ionic surfactant and zwitterionic surfactant.Can before use above-mentioned surfactant suitably be made up.In all surface activating agent, preferably use the combination of anionic surfactant, non-ionic surfactant or anionic surfactant and non-ionic surfactant.
The embodiment of anionic surfactant is as comprising alkyl sulfate such as lauryl sodium sulfate and dodecyltriethanolamine sulfate; Alkyl benzene sulfonate such as neopelex and dodecylbenzene sulfonic acid triethanolamine; Polyethylene oxide alkyl ethers sulfate such as polyoxyethylene sodium lauryl tri(oxyethyl) sulfate and polyoxyethylene lauryl ether sulfuric acid triethanolamine; Alpha-olefin sodium sulfonate such as alpha-olefin sodium sulfonate; Alkylphosphonic such as dodecylphosphoric acid sodium and dodecylphosphoric acid triethanolamine; Polyethylene oxide alkyl ethers phosphate such as polyoxyethylene lauryl ether sodium phosphate and polyoxyethylene lauryl ether nitranol etc.
The embodiment of non-ionic surfactant is as comprising polyethylene oxide alkyl ethers such as polyoxyethylene lauryl ether; Polyoxyethylene alkyl phenyl ether such as polyoxyethylene nonylplenyl ether; Polyoxyethylene PPOX alkyl ether such as polyoxyethylene PPOX cetyl ether; Alkanolamide such as polyoxyethylene PPOX block polymer, cocoanut fatty acid diethanolamide and lauric acid diethyl amide; Polyoxyethylene ketostearic acid triglyceride such as polyoxyethylene hydrogenated castor oil 60; The polyoxyethylene dehydrated sorbitol mono-fatty acid ester is as gathering D-sorbite 80 and alkyl poly glucoside etc.
The use level of surfactant and concentration do not receive special restriction, as long as said amount does not have not exciting eye of adverse effect and said concentration to contact lenses.For example, the use level of surfactant is between about 0.05w/w% and about 20.0w/w%, or preferably between about 0.1w/w% and about 5.0w/w%.If said amount is less than 0.05w/w%, then it is to silicone oil such as the solubilising of polysiloxane-13 and the contribution possibility deficiency of cleaning effect of polyethers sex change.If said amount greater than 20.0w/w%, then possibly be difficult to keep gel state in some cases.
For detersive of the present invention,, preferably when carrying out gelling, cooperate osmotic pressure regulator to regulate osmotic pressure according to the characteristic of used glasses.When detersive of the present invention was used for property of water-bearing SCL/SHCL, the adjusting of osmotic pressure produced the composition that suppresses detersive and gets in the glasses and the effect that keeps shape of glasses.When with lower alcohol as solubilizer when producing anticorrosion and Disinfection Effect, the adjusting of osmotic pressure has following advantage: can be with possibly keeping lower to the amount that glasses have a lower alcohol of adverse effect, and can keep anticorrosion and Disinfection Effect.
About osmotic pressure regulator, for example,, can also comprise with inferior nonionic osmotic pressure regulator: propylene glycol except already ionic osmotic pressure correctives such as sodium chloride, potassium chloride, sodium sulphate and sodium phosphate known aspect the ophthalmology; DPG; 1,3 butylene glycol; Glycerine; Amino acid such as trimethylglycine, glycocoll and alanine; Sugar alcohol such as xylitol and mannitol; Carbohydrate, for example monosaccharide such as glucose and fructose, disaccharides such as trehalose and the polysaccharide (it comprises cyclic polysaccharide class such as cyclodextrin) that comprises more than three kinds sugar.Can from above-mentioned substance, suitably select osmotic pressure regulator and use.With regard to the easy property that viscosity is regulated during with regard to gelling, preferred nonionic osmotic pressure regulator.Preferred especially propylene glycol and trimethylglycine.Propylene glycol and trimethylglycine are also known as NMF.Expect that they not only have the osmotic pressure regulating effect but also have moistening effect, therefore, because when cleaning, finger had good action but suitable.
About the use level of osmotic pressure regulator, so that all the osmotic pressure of gel detersives is for example at about 290mmol/kg and about 2, between the 000mmol/kg, or preferably at about 500mmol/kg and about 1, the amount interpolation osmotic pressure regulator between the 500mmol/kg.From being adjusted to the glasses of the property of water-bearing SCL/SHCL with 290mmol/kg osmotic pressure usually, preferably do not cause the osmotic pressure regulator use level of osmotic pressure, because easily detergent composition is brought in the glasses less than 290mmol/kg.If osmotic pressure is greater than 2,000mmol/kg, then because phenomenon of osmosis, the water cut when cleaning in the glasses descends, thereby causes the diameter of glasses to shrink.After cleaning, contact lenses absorb water thus once more and revert to original glasses diameter through flushing and dipping preservations such as contact lenses preservative agents.Yet during said process, contact lenses significantly are out of shape, thereby cause repeating to give stress to contact lenses.Therefore, preferably do not cause osmotic pressure greater than 2, the use level of the osmotic pressure regulator of 000mmol/kg is because said amount can cause the strength degradation of contact lenses etc.
The pH of detersive of the present invention does not receive special restriction.The pH of detersive of the present invention is for example between about 5 and about 9, preferably between 6 and 8, through using buffering agent or taking other means and it is suitably regulated.If the possibility that said pH less than 5 or greater than 9, then exists the material of stimulation eyes and contact lenses to affect adversely.
About buffering agent, can suitably select known buffering agent and use.For example, comprise with inferior buffering agent: through the buffering agent that combinations such as trishydroxymethylaminomethane, hydrochloric acid, citric acid are prepared; Through phosphoric acid and sodium phosphate are made up the buffering agent for preparing; Through citric acid and sodium phosphate are made up the buffering agent for preparing; And through boric acid and/or borax are made up the buffering agent for preparing.
The use level of buffering agent does not receive special restriction.For example, the use level of buffering agent is between about 0.1w/w% and about 10.0w/w%.If said amount is less than 0.1w/w%, then the stability of gained pH is not enough.Under the situation of said therein amount greater than 10.0w/w%, do not observe the remarkable stability of pH.In addition, in this case,, then variety of issue possibly produced such as buffering agent is separated out if said detersive is preserved at low temperatures.
Because jelling agent causes gelling, so can in detersive of the present invention, cooperate neutralizing agent.Neutralizing agent does not receive special restriction, as long as said neutralizing agent is used to promote the jelling agent gelling.For example, when carboxyl vinyl polymer is used as jelling agent, can be with sodium hydroxide solution as neutralizing agent.
Except mentioned component, can also in detersive of the present invention, further cooperate following composition, only otherwise infringement the object of the invention gets final product: preservative agent; The pH regulator agent; Sequestrant; Viscosity modifier; Exogenous enzymes such as protease and lipolytic enzyme; And various adjuvants.
Use above-mentioned various composition, and the silicone oil of polyethers sex change, solubilizer and jelling agent prepare detersive of the present invention.For example, prepare detersive of the present invention through carrying out following steps: prepare the solution that comprises jelling agent in the WS such as water or the damping fluid through jelling agent is added to; Prepare the solution that comprises cleansing in the solution that comprises jelling agent through subsequently the silicone oil of solubilizer and polyethers sex change being added to; Through being added in the solution that comprises cleansing, neutralizing agent prepares gelatinous solution; And through adding to the said WS in the gelatinous solution or carrying out other and operate and regulate total amount.When preparation detersive of the present invention, can be with in the water-soluble solution of osmotic pressure regulator.After adding solubilizer, can surfactant be added in the solution that comprises jelling agent.
The temperature of preparation detersive of the present invention does not receive special restriction, as long as said temperature does not make each composition volatilize or sex change.For example, temperature or preferably equals room temperature between 10 ℃ and 40 ℃.In preparation during detersive of the present invention, the incorporation time and the means of solution do not receive special restriction to mixing condition behind each composition as adding.Extensive available known solution mixing condition.Yet, when preparation comprises the solution of jelling agent, so that the mode that jelling agent is evenly dispersed in the WS is mixed.When preparation comprises the solution of cleansing, with the degree that is mixed into the silicone oil dissolving of walking to the polyethers sex change.
To use detersive of the present invention to clean the operation of contact lenses with the identical mode of operation of cleaning contact lenses with detersive with typical contact lenses.For example, carry out said operation through following steps: an amount of detersive of the present invention is dropped on the surface of contact lenses; And clean each faces about 10 seconds to about 30 seconds of contact lenses then with finger.After cleaning, can wash contact lenses.According to the kind of contact lenses, washed contact lenses about 5 seconds to about 30 seconds with tap water or special-purpose preservative agent, disappear until the residual sense of the sticking cunning relevant with detersive.
It is effective that detersive of the present invention is attached to aspect the oily dirt on the contact lens surface height in cleaning, no matter said oily dirt is biogenetic derivation or cosmetics source.Can operate the cleaning effect of confirming detersive of the present invention through carrying out above-mentioned scouring, wherein as described in the described embodiment hereinafter, for example use the contact lenses that have the oily dirt that manual work processes on its surface.
Contact lenses with detersive cleaning of the present invention do not receive special restriction.Can comprise various contact lenses such as hard contact lenses and hydrogel contact lens.In above-mentioned contact lenses, comprise that its lens surface is modified or the RGPCL and the SHCL of modification.
Through following examples the present invention is specified.Yet said embodiment is not intended to limit the present invention.Incidentally, in following examples, unless otherwise specified, otherwise the unit of use level is w/w%.
Embodiment
Prepare the detersive of the embodiment of the invention and the detersive of comparative example according to the components matching amount shown in the table 1.Estimate said detersive as follows.
1. the preparation of detersive
To through buffering agent, EDTA2Na and the osmotic pressure regulator suitably selected being dissolved in the solution that prepare in purifying waste water in right amount, interpolation is as the generating vinyl carboxylate based polyalcohol of jelling agent, and makes its even dispersion.Then, add solubilizer, surfactant and polysiloxane-13 successively.To wherein adding sodium hydrate aqueous solution with as the neutralizing agent that is used for gelling.In the gelatinous solution of preparation, add and purify waste water to obtain to amount to the detersive of 100g.
2. cleaning effect test
(1) making of artificial contamination's contact lenses
The test that will be attached with cosmetics (foundation cream, mascara, eye shadow (waterproof)) in advance is immersed in contact lenses in artificial contamination's liquid of being made up of known tear composition (protein, fat) and at 55 ℃ heated 5 hours down.Then, after under 70 ℃, contact lenses being flooded 16 hours in pure water, 50 ℃ down dry 6 hours to obtain artificial contamination's contact lenses.
(2) following glasses are used contact lenses as test:
RGPCL:SEED UV-1 is made by real pupil Co., Ltd.
RGPCL (surface treatment): SEED S-1, made by real pupil Co., Ltd.
SCL:ACUVUE2 (IV group) is made by Johson & Johnson
SHCL (surface treatment): O2 OPTIX (I group) is by the Solecare manufactured
(3) evaluation of cleaning effect
Before cleaning artificial contamination's contact lenses, measure the haze value (HGM-2DP makes by congratulating testing machine Co., Ltd.) of artificial contamination's contact lenses.Then, utilize every kind of detersive shown in the table 1 to clean artificial contamination's about 30 seconds of contact lenses (about 15 seconds every faces) with finger.About the flushing of the contact lenses after cleaning, under the situation of RGPCL, use flowing water (tap water).Under the situation of SCL and SHCL, use soft contact lens with preservative agent (SOFRINS is by the manufacturing of real pupil Co., Ltd.).Wash said contact lenses (10 to 20 seconds), disappear and air dry until the residual sense (stick-slip sense) relevant with each detersive.
Table 1
*1. isopropyl alcohol
*2.1.3-butylene glycol
*3. carboxyl vinyl polymer
*4. (methyl) alkyl acrylate base co-polymer
*5. alpha-olefin sodium sulfonate: Lipolan LB-440, make (purity 37%: the use level after purity converts) by Lion Corporation
*6. alkyl glucoside: Plantacare 2000UP, make (purity 50%: the use level after purity converts) by Ke Ningriben Co., Ltd.
*7. polyoxyethylene polyoxypropylene block copolymers: Pluronic F108, made by Asahi Denka Kogyo K. K
*8. propylene glycol
*9. trimethylglycine
Measure the haze value of the glasses after cleaning, and by computes soil release rate.In addition, the operability of the sense of touch when cleaning about comprising is carried out sensory evaluation.Table 2 shows the result.
Formula 1
Based on the soil release rate of calculating (%), as follows with five level evaluation cleaning effects.
More than the A:90%
A-:80% is above but less than 90%
B:60% is above but less than 80%
B-:40% is above but less than 60%
C: less than 40%
Based on three ranks as follows sense of touch and operability are carried out sensory evaluation.
A: clean easily, operability is good
B: common
C: be difficult to cleaning, operability is bad
Table 2
*1) in the detersive of comparative example 2, polysiloxane-13 can not be by solubilising.
*2) in comparative example 1 to 3, because 2, the hyperosmosis of 500mmol/kg is so under the situation of the SCL with high-moisture percentage, the diameter of glasses expands or contraction with water-soluble when cleaning, and when flushing, significantly is out of shape thus.
Preferred higher soil release rate (%).It is qualified that soil release rate more than 60% is made as, and all detersives of the embodiment of the invention are all qualified.
3. to the impact assessment of surface-treated contact lenses
About impact assessment, utilize organic compound to handle the lens surface of RGPCL (SEED S-1 is made by real pupil Co., Ltd.) and SHCL (O2OPTIX is by the Solecare manufactured), thereby cause water wettability being provided it to surface-treated contact lenses.Use has the gained glasses on hydrophile function surface.
The detersive that comprises lapping compound that proposes in detersive through the embodiment of the invention shown in the use table 3 and the reference example 1 (O2CLEAN is made by real pupil Co., Ltd.) is cleaned contact lenses with finger.One time circular treatment is made up of following steps: clean contact lenses with each detersive; With flowing water wash contact lenses (tap water: RGPCL), or for soft contact lens with preservative agent flushing (SOFRINS is made by real pupil Co., Ltd.: SCL, SHCL).After 10 times, 20 times and 30 circular treatment, estimate the water wettability of lens surface.Based on before and after the circular treatment, the variable quantity of the contact angle of lens surface, as follows with of the influence of five level evaluations to lens surface.
Below the A:10 degree
A-: spend to 20 degree greater than 10
B: spend to 30 degree greater than 20
B-: spend to 40 degree greater than 30
C: greater than 40 degree
Table 3
The variable quantity of preferred contact angle is less.If being changed to below 30 degree of contact angle, it is qualified then said variation to be made as.Whole detersives of the embodiment of the invention are all qualified.
Claims (5)
1. contact lenses are used the gel detersive, and it comprises silicone oil, solubilizer and the jelling agent of polyethers sex change.
2. contact lenses according to claim 1 are used the gel detersive, and the silicone oil of wherein said polyethers sex change is the polysiloxane of polyoxyalkylene sex change.
3. contact lenses according to claim 1 are used the gel detersive, and the silicone oil of wherein said polyethers sex change is the ABn type segmented copolymer of polydimethylsiloxane--polyoxyalkylene-; And said solubilizer is lower alcohol and/or liquid polyol.
4. contact lenses according to claim 3 are used the gel detersive, and the polyoxyalkylene in the ABn type segmented copolymer of wherein said polydimethylsiloxane--polyoxyalkylene-is polyoxyethylene or gathers (ethylene oxide-propylene oxide) multipolymer; Said lower alcohol is ethanol, propyl alcohol, isopropyl alcohol or phenmethylol; And said liquid polyol is for being selected from monoethylene glycol, propylene glycol, DPG, at least a alcohol in 1,3 butylene glycol and the glycerine.
5. use the gel detersive according to each described contact lenses in the claim 1 to 4, the content of the silicone oil of wherein said polyethers sex change is 0.05w/w% to 0.50w/w%.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010223356 | 2010-10-01 | ||
| JP2010-223356 | 2010-10-01 | ||
| PCT/JP2011/065370 WO2012043004A1 (en) | 2010-10-01 | 2011-07-05 | Gelatinous cleaning agent for contact lenses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102822725A true CN102822725A (en) | 2012-12-12 |
| CN102822725B CN102822725B (en) | 2013-10-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011800117823A Active CN102822725B (en) | 2010-10-01 | 2011-07-05 | Gelatinous cleaning agent for contact lenses |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JP4976607B2 (en) |
| KR (1) | KR101245997B1 (en) |
| CN (1) | CN102822725B (en) |
| HK (1) | HK1173230A1 (en) |
| MY (1) | MY159143A (en) |
| SG (1) | SG183211A1 (en) |
| WO (1) | WO2012043004A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106381241A (en) * | 2016-08-30 | 2017-02-08 | 东兴华鸿光学科技有限公司 | Cleaning degerming cream for glasses lenses |
| CN107929790A (en) * | 2017-11-08 | 2018-04-20 | 常州武城服饰有限公司 | A kind of multi-functional contact lenses conditioning liquid |
| TWI805841B (en) * | 2018-09-18 | 2023-06-21 | 日商日油股份有限公司 | Treatment solutions for contact lenses |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2014119502A1 (en) * | 2013-01-31 | 2017-01-26 | シャープ株式会社 | Cleaning fluid, cleaning tools and cleaning kit |
| KR101926226B1 (en) * | 2016-05-31 | 2019-02-26 | 한국화학연구원 | Alcohol-free detergent composition for glasses having excellent antibacterial property |
| KR102368898B1 (en) * | 2020-05-18 | 2022-03-02 | 주식회사 태경코엠 | Cleaner composition comprising alkanediol or ethylhexylglycerine |
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| JPH0117131B2 (en) * | 1981-08-13 | 1989-03-29 | Barnes Hind Inc | |
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| JP2006052319A (en) * | 2004-08-11 | 2006-02-23 | P & P F:Kk | Transparent gel-like cleanser |
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| CN1081669C (en) * | 1993-06-18 | 2002-03-27 | 聚合物技术公司 | Composition for cleaning and wetting contact lenses |
| US6872695B1 (en) * | 2000-10-06 | 2005-03-29 | Bausch & Lomb Incorporated | Method for in-eye cleaning of contact lens comprising polymeric beads |
| JP4803705B2 (en) * | 2004-05-26 | 2011-10-26 | 株式会社シード | Gel detergent for contact lenses |
| JP5179293B2 (en) * | 2008-08-25 | 2013-04-10 | 京楽産業．株式会社 | Game machine |
-
2011
- 2011-07-05 KR KR1020127019549A patent/KR101245997B1/en active IP Right Grant
- 2011-07-05 MY MYPI2012003167A patent/MY159143A/en unknown
- 2011-07-05 SG SG2012058467A patent/SG183211A1/en unknown
- 2011-07-05 JP JP2012510051A patent/JP4976607B2/en active Active
- 2011-07-05 CN CN2011800117823A patent/CN102822725B/en active Active
- 2011-07-05 WO PCT/JP2011/065370 patent/WO2012043004A1/en active Application Filing
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2013
- 2013-01-11 HK HK13100507.1A patent/HK1173230A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0117131B2 (en) * | 1981-08-13 | 1989-03-29 | Barnes Hind Inc | |
| JPH05179293A (en) * | 1991-12-26 | 1993-07-20 | Kao Corp | Detergent composition |
| JP2006052319A (en) * | 2004-08-11 | 2006-02-23 | P & P F:Kk | Transparent gel-like cleanser |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106381241A (en) * | 2016-08-30 | 2017-02-08 | 东兴华鸿光学科技有限公司 | Cleaning degerming cream for glasses lenses |
| CN107929790A (en) * | 2017-11-08 | 2018-04-20 | 常州武城服饰有限公司 | A kind of multi-functional contact lenses conditioning liquid |
| TWI805841B (en) * | 2018-09-18 | 2023-06-21 | 日商日油股份有限公司 | Treatment solutions for contact lenses |
| US11912964B2 (en) | 2018-09-18 | 2024-02-27 | Nof Corporation | Contact lens treatment solution |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1173230A1 (en) | 2013-05-10 |
| MY159143A (en) | 2016-12-15 |
| KR101245997B1 (en) | 2013-03-20 |
| WO2012043004A1 (en) | 2012-04-05 |
| JPWO2012043004A1 (en) | 2014-02-06 |
| CN102822725B (en) | 2013-10-30 |
| SG183211A1 (en) | 2012-09-27 |
| KR20120099289A (en) | 2012-09-07 |
| JP4976607B2 (en) | 2012-07-18 |
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